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PMIDDataArticle TitleCitationOrganizationSD Files Download
2783816916Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines.EBIBioorg Med Chem 25: 11-19 (2017)University of Pavia2D 3D TSV
2776967166Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy.EBIBioorg Med Chem 25: 27-37 (2017)Tsinghua University2D 3D TSV
2802945850Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HTEBIBioorg Med Chem 25: 38-52 (2017)Universit£ de Montr£al2D 3D TSV
277696705Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents.EBIBioorg Med Chem 25: 58-66 (2017)University of Kentucky2D 3D TSV
283409889Rational design, synthesis, and structure-activity relationships of 5-amino-1H-pyrazole-4-carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.EBIBioorg Med Chem 25: 67-74 (2017)Advinus Therapeutics Ltd2D 3D TSV
2777118049Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors.EBIBioorg Med Chem 25: 75-83 (2017)Central China Normal University2D 3D TSV
277806187Synthesis, structure-activity relationship and molecular docking of 3-oxoaurones and 3-thioaurones as acetylcholinesterase and butyrylcholinesterase inhibitors.EBIBioorg Med Chem 25: 100-106 (2017)University of Gujrat2D 3D TSV
2778907515Strategy for designing selectivea-l-rhamnosidase inhibitors: Synthesis and biological evaluation of l-DMDP cyclic isothioureas.EBIBioorg Med Chem 25: 107-115 (2017)University of Toyama2D 3D TSV
2781043849Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains.EBIBioorg Med Chem 25: 138-152 (2017)Shandong University2D 3D TSV
2834098710Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents.EBIBioorg Med Chem 25: 166-174 (2017)Soochow University2D 3D TSV
2781044030Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors.EBIBioorg Med Chem 25: 187-201 (2017)Astellas Pharma Inc.2D 3D TSV
2782555318Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists.EBIBioorg Med Chem 25: 254-260 (2017)Jiangxi University of Traditional Chinese Medicine2D 3D TSV
2786564562Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HTEBIBioorg Med Chem 25: 293-304 (2017)Sumitomo Dainippon Pharma Co., Ltd.2D 3D TSV
2784279866Synthesis, COX-1/2 inhibition activities and molecular docking study of isothiazolopyridine derivatives.EBIBioorg Med Chem 25: 316-326 (2017)Wroclaw Medical University2D 3D TSV
2784279742NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids.EBIBioorg Med Chem 25: 350-359 (2017)University of Regensburg2D 3D TSV
2785623619Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors.EBIBioorg Med Chem 25: 360-371 (2017)South China University of Technology2D 3D TSV
2785623711Synthesis, anticancer, and docking studies of salicyl-hydrazone analogues: A novel series of small potent tropomyosin receptor kinase A inhibitors.EBIBioorg Med Chem 25: 389-396 (2017)Dongguk University2D 3D TSV
2785623817Evaluation of known and novel inhibitors of Orai1-mediated store operated CaEBIBioorg Med Chem 25: 440-449 (2017)The University of Queensland2D 3D TSV
2788451224Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors.EBIBioorg Med Chem 25: 458-470 (2017)China Pharmaceutical University2D 3D TSV
2787625060Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHEBIBioorg Med Chem 25: 471-482 (2017)Jagiellonian University Medical College2D 3D TSV
2791494836Triazolopyridine ethers as potent, orally active mGluEBIBioorg Med Chem 25: 496-513 (2017)Bristol-Myers Squibb2D 3D TSV
278879644Anti-inflammatory tetraquinane diterpenoids from a Crinipellis species.EBIBioorg Med Chem 25: 514-522 (2017)University of Kaiserslautern2D 3D TSV
2791494711Synthesis and binding monitoring of a new nanomolar PAMAM-based matrix metalloproteinases inhibitor (MMPIs).EBIBioorg Med Chem 25: 523-527 (2017)University of Florence2D 3D TSV
2791961160Discovery of 4-sulfamoyl-phenyl-▀-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors.EBIBioorg Med Chem 25: 539-544 (2017)National Institute of Pharmaceutical Education and Research (NIPER)2D 3D TSV
2791494950Anion inhibition profiles of the┐-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics.EBIBioorg Med Chem 25: 575-580 (2017)Italy; Universit£ degliStudi di Firenze2D 3D TSV
278892877Structure-activity relationship study of a small cyclic peptide H-c[Lys-Pro-Glu]-Arg-OH: a potent inhibitor of Vascular Endothelial Growth Factor interaction with Neuropilin-1.EBIBioorg Med Chem 25: 597-602 (2017)University of Warsaw2D 3D TSV
2790875532Synthesis, evaluation and molecular modelling studies of 2-(carbazol-3-yl)-2-oxoacetamide analogues as a new class of potential pancreatic lipase inhibitors.EBIBioorg Med Chem 25: 609-620 (2017)Birla Institute of Technology and Science Pilani (Pilani Campus)2D 3D TSV
2790875255N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.EBIBioorg Med Chem 25: 633-645 (2017)University of Ljubljana2D 3D TSV
2793934522Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4).EBIBioorg Med Chem 25: 646-657 (2017)University of Bergen2D 3D TSV
2791646836Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile.EBIBioorg Med Chem 25: 665-676 (2017)Beni-Suef University2D 3D TSV
2793934752Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.EBIBioorg Med Chem 25: 677-683 (2017)Universit£ degli Studi di Firenze2D 3D TSV
2792353539Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.EBIBioorg Med Chem 25: 714-726 (2017)Sichuan University2D 3D TSV
2796499542Synthesis and optimization of novela-phenylglycinamides as selective TRPM8 antagonists.EBIBioorg Med Chem 25: 727-742 (2017)Kissei Pharmaceutical Co., Ltd.2D 3D TSV
2795592616Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies.EBIBioorg Med Chem 25: 750-758 (2017)Shenyang Pharmaceutical University2D 3D TSV
279560378Design and synthesis of phosphoryl-substituted diphenylpyrimidines (Pho-DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors: Targeted treatment of B lymphoblastic leukemia cell lines.EBIBioorg Med Chem 25: 765-772 (2017)Dalian Medical University2D 3D TSV
2795603510Synthesis and characterization of novel, conjugated, fluorescent DNJ derivatives fora-glucosidase recognition.EBIBioorg Med Chem 25: 773-778 (2017)Shibaura Institute of Technology2D 3D TSV
2795603938Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists.EBIBioorg Med Chem 25: 805-812 (2017)Research Triangle Institute2D 3D TSV
280893508Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.EBIBioorg Med Chem 25: 813-824 (2017)Northern Illinois University2D 3D TSV
27989417341-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability.EBIBioorg Med Chem 25: 825-837 (2017)University of M£nster2D 3D TSV
2801120465Structure-guided development of covalent TAK1 inhibitors.EBIBioorg Med Chem 25: 838-846 (2017)Harvard Medical School2D 3D TSV
28024887525-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.EBIBioorg Med Chem 25: 857-863 (2017)Riga Technical University2D 3D TSV
2801120221Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors.EBIBioorg Med Chem 25: 886-896 (2017)Shenyang Pharmaceutical University2D 3D TSV
280112053Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation.EBIBioorg Med Chem 25: 1004-1013 (2017)Columbia University2D 3D TSV
2801120636Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.EBIBioorg Med Chem 25: 1030-1041 (2017)Sichuan University2D 3D TSV
280418011A one-pot laccase-catalysed synthesis of coumestan derivatives and their anticancer activity.EBIBioorg Med Chem 25: 1172-1182 (2017)CSIR Biosciences2D 3D TSV
280437783Neuritogenic activity of bi-functional bis-tryptoline triazole.EBIBioorg Med Chem 25: 1195-1201 (2017)Chiang Mai University2D 3D TSV
2805740776Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.EBIBioorg Med Chem 25: 1202-1218 (2017)Georgia Institute of Technology2D 3D TSV
280655008Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker.EBIBioorg Med Chem 25: 1227-1234 (2017)Nagoya City University2D 3D TSV
280621958Development of new inhibitors for N-acylethanolamine-hydrolyzing acid amidase as promising tool against bladder cancer.EBIBioorg Med Chem 25: 1242-1249 (2017)Italy; Universit£ Vita-Salute San Raffaele2D 3D TSV
2806378436New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HTEBIBioorg Med Chem 25: 1250-1259 (2017)Universit£ di Catania2D 3D TSV
2805740844Dithiocarbamates effectively inhibit the▀-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa.EBIBioorg Med Chem 25: 1260-1265 (2017)Universit£ degli Studi di Firenze2D 3D TSV
2806550138Synthesis, docking, cytotoxicity, and LTAEBIBioorg Med Chem 25: 1277-1285 (2017)Mansoura University2D 3D TSV
2806549984Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors.EBIBioorg Med Chem 25: 1286-1293 (2017)Kurukshetra University2D 3D TSV
2808958978Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives.EBIBioorg Med Chem 25: 1352-1363 (2017)Bezmialem Vakif University2D 3D TSV
2812644058Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes.EBIBioorg Med Chem 25: 1423-1430 (2017)University of New Mexico2D 3D TSV
280942209Molecular docking, discovery, synthesis, and pharmacological properties of new 6-substituted-2-(3-phenoxyphenyl)-4-phenyl quinoline derivatives; an approach to developing potent DNA gyrase inhibitors/antibacterial agents.EBIBioorg Med Chem 25: 1448-1455 (2017)VIT University2D 3D TSV
28111158100Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties.EBIBioorg Med Chem 25: 1456-1464 (2017)Abant Izzet Baysal University2D 3D TSV
28118956150Design and synthesis of potent substrate-based inhibitors of the Trypanosoma cruzi dihydroorotate dehydrogenase.EBIBioorg Med Chem 25: 1465-1470 (2017)Nagasaki University2D 3D TSV
2812643927Design, synthesis and evaluation of some N-methylenebenzenamine derivatives as selective acetylcholinesterase (AChE) inhibitor and antioxidant to enhance learning and memory.EBIBioorg Med Chem 25: 1471-1480 (2017)Indian Institute of Technology (Banaras Hindu University)2D 3D TSV
281299912Identification of allosteric binding sites for PI3Ka oncogenic mutant specific inhibitor design.EBIBioorg Med Chem 25: 1481-1486 (2017)Johns Hopkins University School of Medicine2D 3D TSV
281171219Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPAR┐ and SUR agonists.EBIBioorg Med Chem 25: 1496-1513 (2017)Al-Azhar University2D 3D TSV