Search and Browse
Download
Enter Data
Search by PubMed Identification
| PMID | Data | Article Title | Citation | Organization | Data Download |
|---|---|---|---|---|---|
| 995128 | 168 | Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes. |
Mol Pharmacol 12: 800-12 (1976) | TBA | 2D 3D TSV |
| 950651 | 6 | Synthesis and properties of 2-S-(N,N-dialkylamino)ethyl)thio-1,3,2-dioxaphosphorinane 2-oxide and of the corresponding quaternary derivatives as potential nontoxic antiglaucoma agents. |
J Med Chem 19: 810-3 (1976) | TBA | 2D 3D TSV |
| 926113 | 5 | Synthesis and biological action of two glucocorticoid alkylating agents. |
J Med Chem 20: 1134-9 (1978) | TBA | 2D 3D TSV |
| 915907 | 6 | Proteinase inhibitors. I. Inhibitors of elastase. |
J Med Chem 20: 1464-8 (1977) | TBA | 2D 3D TSV |
| 903914 | 7 | Synthesis and evaluation of alpha-hydroxythiol esters as antitumor agents and glyoxalase I inhibitors. |
J Med Chem 20: 1239-42 (1977) | TBA | 2D 3D TSV |
| 894682 | 12 | Stereochemical studies on medicinal agents. 23. Synthesis and biological evaluation of 6-amino derivatives of naloxone and naltrexone. |
J Med Chem 20: 1100-2 (1977) | TBA | 2D 3D TSV |
| 874952 | 1 | New inhibitors of steroid 11beta-hydroxylase. Structure--activity relationship studies of metyrapone-like compounds. |
J Med Chem 20: 762-6 (1977) | TBA | 2D 3D TSV |
| 850237 | 38 | Synthesis and structure-activity relationships of bestatin analogues, inhibitors of aminopeptidase B. |
J Med Chem 20: 510-5 (1977) | TBA | 2D 3D TSV |
| 850236 | 1 | Inhibition of histidine decarboxylase. Derivatives of histidine. |
J Med Chem 20: 506-9 (1977) | TBA | 2D 3D TSV |
| 782880 | 21 | Influence of side-chain structure of aliphatic amino acids on binding to isoleucyl-tRNA synthetase from Escherichia coli MRE 600. |
Eur J Biochem 66: 147-55 (1976) | Gesellschaft Fur Molekularbiolische Forschung mbH | 2D 3D TSV |
| 722762 | 2 | Effects of thiophene analogues of chloroamphetamines on central serotonergic mechanisms. |
J Med Chem 21: 978-81 (1979) | TBA | 2D 3D TSV |
| 722731 | 1 | Prodrugs of 9-beta-D-arabinofuranosyladenine. 1. Synthesis and evaluation of some 5'-(O-acyl) derivatives. |
J Med Chem 21: 1218-21 (1979) | TBA | 2D 3D TSV |
| 722719 | 1 | Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents. |
J Med Chem 21: 1137-40 (1979) | TBA | 2D 3D TSV |
| 722718 | 56 | Structure-activity relationships for the inhibition of acrosin by benzamidine derivatives. |
J Med Chem 21: 1132-6 (1979) | TBA | 2D 3D TSV |
| 722711 | 5 | Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis. |
J Med Chem 21: 1007-11 (1979) | TBA | 2D 3D TSV |
| 671460 | 122 | Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. |
J Med Chem 21: 613-23 (1978) | TBA | 2D 3D TSV |
| 660589 | 3 | Inactivation of trypsin-like proteases by sulfonylation. Variation of positively charged group and inhibitor length. |
J Med Chem 21: 456-9 (1978) | TBA | 2D 3D TSV |
| 619149 | 20 | Analogues of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site. |
J Med Chem 21: 50-5 (1978) | TBA | 2D 3D TSV |
| 592342 | 45 | Hypolipidemic activity of 5-aryl-3-methylvaleric acid derivatives. |
J Med Chem 20: 1705-8 (1978) | TBA | 2D 3D TSV |
| 592327 | 104 | Potent reversible anticholinesterase agents. Bis- and mono-N-substituted benzoquinolinium halides. |
J Med Chem 20: 1617-23 (1978) | TBA | 2D 3D TSV |
| 576620 | 15 | Quantitative correlations between albumin binding constants and chromatographic Rm values of phenothiazine derivatives. |
J Med Chem 20: 430-9 (1977) | TBA | 2D 3D TSV |
| 559765 | 2 | Vitamin B6 antagonists obtained by replacing or modifying the 2-methyl group. |
J Med Chem 20: 745-9 (1977) | TBA | 2D 3D TSV |
| 557561 | 3 | 4-Halovinyl- and 4-ethynyl-4-deformylpyridoxal derivatives and related analogues as potentially irreversible antagonists of vitamin B6. |
J Med Chem 20: 567-72 (1977) | TBA | 2D 3D TSV |
| 556774 | 58 | Inhibition of acetylcholinesterase by thiamine. A structure-function study. |
J Med Chem 20: 161-4 (1977) | TBA | 2D 3D TSV |
| 556772 | 1 | Antagonists of vitamin B6. Simultaneous and stepwise modification of the 2 and 4 positions. |
J Med Chem 20: 1-5 (1977) | TBA | 2D 3D TSV |
| 533888 | 1 | Synthesis and biological evaluation of 9,11-azo-13-oxa-15-hydroxyprostanoic acid, a potent inhibitor of platelet aggregation. |
J Med Chem 22: 1402-8 (1980) | TBA | 2D 3D TSV |
| 533882 | 1 | Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 5. Conformationally mobile analogues derived by furan ring opening. |
J Med Chem 22: 1347-54 (1980) | TBA | 2D 3D TSV |
| 513062 | 2 | 4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol, an extremely potent respresentative of a new analgesic series. |
J Med Chem 22: 1157-8 (1979) | TBA | 2D 3D TSV |
| 490549 | 4 | Synthesis and biological properties of N2-substituted spin-labeled analogues of actinomycin D. |
J Med Chem 22: 1051-5 (1979) | TBA | 2D 3D TSV |
| 490541 | 1 | Synthesis and antiestrogenic activity of [3,4-dihydro-2-(4-methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]-phenyl]methanone, methanesulfonic acid salt. |
J Med Chem 22: 962-6 (1979) | TBA | 2D 3D TSV |
| 459687 | 7 | Evidence for two types of binding of 3H-gaba and 3H-muscimol in rat cerebral cortex and cerebellum. |
Life Sci 24: 1849-54 (1979) | TBA | 2D 3D TSV |
| 458818 | 26 | Design of species- or isozyme-specific enzyme inhibitors. 1. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase. |
J Med Chem 22: 621-31 (1979) | TBA | 2D 3D TSV |
| 430474 | 2 | trans-5-(3,3,3-Trifluoro-1-propenyl-)-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase. |
J Med Chem 22: 339-40 (1979) | TBA | 2D 3D TSV |
| 430054 | 14 | Characterization of the binding of [3H]muscimol, a potent gamma-aminobutyric acid agonist, to rat brain synaptosomal membranes using a filtration assay. |
J Neurochem 32: 713-8 (1979) | TBA | 2D 3D TSV |
| 423213 | 22 | Inhibition of gastric acid secretion by 1,8-naphthyridin-2(1H)-ones. |
J Med Chem 22: 301-6 (1979) | TBA | 2D 3D TSV |
| 423205 | 119 | Cyclic amidine inhibitors of indolamine N-methyltransferase. |
J Med Chem 22: 237-47 (1979) | TBA | 2D 3D TSV |
| 423204 | 2 | Coenzyme--substrate adducts as inhibitors of mouse liver 3,4-dihydroxyphenylalanine decarboxylase. |
J Med Chem 22: 233-7 (1979) | TBA | 2D 3D TSV |
| 423172 | 1 | Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid. |
J Med Chem 22: 109-11 (1979) | TBA | 2D 3D TSV |
| 410930 | 15 | Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship. |
J Med Chem 20: 1469-73 (1977) | TBA | 2D 3D TSV |
| 409842 | 24 | Methotrexate analogues. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogues. |
J Med Chem 20: 1323-7 (1977) | TBA | 2D 3D TSV |
| 323484 | 8 | Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates. |
J Med Chem 20: 669-73 (1977) | TBA | 2D 3D TSV |
| 321782 | 9 | A manual method for applying the Hansch approach to drug design. |
J Med Chem 20: 463-9 (1977) | TBA | 2D 3D TSV |
| 319234 | 1 | Quantitative structure-activity relationships of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines. |
J Med Chem 20: 96-102 (1977) | TBA | 2D 3D TSV |
| 282646 | 50 | Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. |
Proc Natl Acad Sci U S A 75: 6290-4 (1978) | TBA | 2D 3D TSV |
| 231655 | 18 | Design of species- or isozyme-specific enzyme inhibitors. 3. Species and isozymic differences between mammalian and bacterial adenylate kinases in substituent tolerance in an enzyme-substrate complex. |
J Med Chem 22: 1529-32 (1980) | TBA | 2D 3D TSV |
| 231654 | 16 | Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines. |
J Med Chem 22: 1493-7 (1979) | TBA | 2D 3D TSV |
| 219196 | 15 | 3-Substituted pyrazole derivatives as inhibitors and inactivators of liver alcohol dehydrogenase. |
J Med Chem 22: 356-9 (1979) | TBA | 2D 3D TSV |
| 218015 | 16 | Paradoxical effects of N-cyanoalkyl substituents upon the activities of several classes of opioids. |
J Med Chem 22: 328-31 (1979) | TBA | 2D 3D TSV |
| 218012 | 12 | Deoxymorphines: role of the phenolic hydroxyl in antinociception and opiate receptor interactions. |
J Med Chem 22: 256-9 (1979) | TBA | 2D 3D TSV |
| 209186 | 19 | Conformation of 2,9-dimethyl-3'-hydroxy-5-phenyl-6,7-genzomorphan and its relation to other analgetics and enkephalin. |
J Med Chem 21: 600-6 (1978) | TBA | 2D 3D TSV |
| 207868 | 36 | Analgesics. 1. Synthesis and analgesic properties of N-sec-alkyl- and N-tert-alkylnormorphines. |
J Med Chem 21: 415-22 (1978) | TBA | 2D 3D TSV |
| 206698 | 2 | Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone. |
J Med Chem 21: 398-400 (1978) | TBA | 2D 3D TSV |
| 199727 | 8 | Synthesis of beta-spiro[pyrrolidinoindolines], their binding to the glycine receptor, and in vivo biological acitivity. |
J Med Chem 20: 1448-51 (1977) | TBA | 2D 3D TSV |
| 197237 | 3 | 3-Hydroxy-17-aralkylmorphinans as potential opiate receptor-site-directed alkylating agents. |
J Med Chem 20: 1020-4 (1977) | TBA | 2D 3D TSV |
| 189031 | 1 | Inhibition of squalene synthetase by farnesyl pyrophosphate analogues. |
J Med Chem 20: 243-9 (1977) | TBA | 2D 3D TSV |
| 184284 | 1 | Synthesis and biological properties of some spin-labeled 9-aminoacridines. |
J Med Chem 19: 994-8 (1976) | TBA | 2D 3D TSV |
| 152812 | 69 | Inhibition of four human serine proteases by substituted benzamidines. |
J Med Chem 21: 1202-7 (1979) | TBA | 2D 3D TSV |
| 117107 | 1 | Folate antagonists. 15. 2,3-Diamino-6-(2-naphthylsulfonyl)quinazoline and related 2,4-diamino-6-[(phenyl and naphthyl)sulfinyl and sulfonyl]quinazolines, a potent new class of antimetabolites with phenomenal antimalarial activity. |
J Med Chem 22: 1247-57 (1979) | TBA | 2D 3D TSV |
| 114660 | 8 | 5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase. |
J Med Chem 22: 1137-9 (1979) | TBA | 2D 3D TSV |
| 110934 | 12 | Synthesis and biological activity of 8-oxadihydropteridines. |
J Med Chem 22: 741-3 (1979) | TBA | 2D 3D TSV |
| 110931 | 2 | Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate. |
J Med Chem 22: 618-21 (1979) | TBA | 2D 3D TSV |
| 109618 | 9 | N-(2-Cyanoethyl) derivatives of meperidine, ketobemidone, and a potent 6,7-benzomorphan. |
J Med Chem 22: 889-90 (1979) | TBA | 2D 3D TSV |
| 109616 | 9 | Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues. |
J Med Chem 22: 869-74 (1979) | TBA | 2D 3D TSV |
| 106122 | 3 | Enzyme affinity of the 5,6-dihydro derivatives of the substrate and product of thymidylate synthetase catalysis. |
J Med Chem 22: 319-21 (1979) | TBA | 2D 3D TSV |
| 73588 | 5 | Quantum chemical studies of N-substituent variation in the oxymorphone series of opiate narcotics. |
J Med Chem 21: 101-6 (1978) | TBA | 2D 3D TSV |
| 42798 | 4 | Ultraviolet photoelectron spectroscopy of cyclic amidines. 1. Electronic structure of some alpha-adrenergic benzylimidazolines. |
J Med Chem 22: 1290-5 (1979) | TBA | 2D 3D TSV |
| 40029 | 1 | Absolute configuration of glycerol derivatives. 7. Enantiomers of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzodioxane (WB-4101), a potent competitive alpha-adrenergic antagonist. |
J Med Chem 22: 1125-7 (1979) | TBA | 2D 3D TSV |
| 40025 | 4 | Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase. |
J Med Chem 22: 1011-4 (1979) | TBA | 2D 3D TSV |
| 37098 | 14 | Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors. |
Eur J Pharmacol 55: 323-6 (1979) | TBA | 2D 3D TSV |
| 31487 | 3 | Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine. |
J Med Chem 21: 952-7 (1978) | TBA | 2D 3D TSV |
| 31485 | 8 | Nondepressant beta-adrenergic blocking agents. 1. Substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols. |
J Med Chem 21: 913-22 (1978) | TBA | 2D 3D TSV |
| 31484 | 4 | Stereoelectronic factors in the binding of substrate analogues and inhibitors to purine nucleoside phosphorylase isolated from human erythrocytes. |
J Med Chem 21: 877-82 (1979) | TBA | 2D 3D TSV |
| 22757 | 12 | Antidepressant agents. 9. 3,3-Diphenylcyclobutylamines, a new class of central stimulants. |
J Med Chem 21: 78-82 (1978) | TBA | 2D 3D TSV |
| 20632 | 7 | Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding. |
Proc Natl Acad Sci U S A 74: 3805-9 (1977) | TBA | 2D 3D TSV |
| 17827 | 156 | Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors. |
Mol Pharmacol 13: 454-73 (1977) | TBA | 2D 3D TSV |
| 17749 | 5 | Absolute configuration of glycerol derivatives. 4. Synthesis and pharmacological activity of chiral 2-alkylaminomethylbenzodioxans, competitive alpha-adrenergic antagonists. |
J Med Chem 20: 880-5 (1977) | TBA | 2D 3D TSV |
| 8699 | 51 | Beta adrenergic receptor binding in membrane preparations from mammalian brain. |
Mol Pharmacol 12: 568-80 (1976) | TBA | 2D 3D TSV |
| 7724 | 61 | Alpha-noradrenergic receptor binding in mammalian brain: differential labeling of agonist and antagonist states. |
Life Sci 19: 69-76 (1976) | TBA | 2D 3D TSV |
| 2778 | 28 | Synthesis and enzymic activity of some novel xanthine oxidase inhibitors. 3-Substituted 5,7-dihydroxypyrazolo(1,5-alpha)pyrimidines. |
J Med Chem 19: 291-6 (1976) | TBA | 2D 3D TSV |
| 1535 | 2 | Conformationally restricted analogs of histamine H1 receptor antagonists: trans and cis-1-benzyl-3-dimethylamino-6-phenylpiperidine. |
J Med Chem 19: 117-22 (1976) | TBA | 2D 3D TSV |
Curated by BindingDB
Curated by ChEMBL