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1997328 39 Structural requirements for the binding of the pituitary adenylate-cyclase-activating peptide to receptors and adenylate-cyclase activation in pancreatic and neuronal membranes.BDB Eur J Biochem 195: 535-41 (1991) Université Libre de Bruxelles 2D 3D TSV
1995903 49 Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues.EBI J Med Chem 34: 798-806 (1991) Purdue University 2D 3D TSV
1995900 4 Romazarit: a potential disease-modifying antirheumatic drug.EBI J Med Chem 34: 772-7 (1991) Roche Products Limited 2D 3D TSV
1995895 6 Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake.EBI J Med Chem 34: 702-5 (1991) University of Maryland 2D 3D TSV
1995893 81 Muscarinic cholinergic agonists and antagonists of the 3-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine type. Synthesis and structure-activity relationships.EBI J Med Chem 34: 687-92 (1991) Ferrosan A/S 2D 3D TSV
1995891 9 Configuration and preferential solid-state conformations of perindoprilat (S-9780). Comparison with the crystal structures of other ACE inhibitors and conclusions related to structure-activity relationships.EBI J Med Chem 34: 663-9 (1991) Institut de Chimie des Substances Naturelles 2D 3D TSV
1995889 14 4',5'-unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase.EBI J Med Chem 34: 647-56 (1991) Merrell Dow Research Institute 2D 3D TSV
1995887 14 Renin inhibitory peptides. Incorporation of polar, hydrophilic end groups into an active renin inhibitory peptide template and their evaluation in a human renin infused rat model and in conscious sodium-depleted monkeys.EBI J Med Chem 34: 633-42 (1991) Upjohn Company 2D 3D TSV
1995886 15 Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase.EBI J Med Chem 34: 624-8 (1991) Pfizer Inc 2D 3D TSV
1995885 15 Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds.EBI J Med Chem 34: 616-24 (1991) Dainippon Pharmaceutical Company, Ltd. 2D 3D TSV
1995884 4 Synthesis and biological activity of 5,11-methylenetetrahydro-5- deazahomofolic acid.EBI J Med Chem 34: 611-6 (1991) Duquesne University 2D 3D TSV
1995880 8 Synthesis and biological activity of methotrexate analogues with two acid groups and a hydrophobic aromatic ring in the side chain.EBI J Med Chem 34: 574-9 (1991) Harvard Medical School 2D 3D TSV
1995876 9 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 14. 2,3-Dihydro-1-(2,4-diamino-5-pyrimidyl)-1H-indenes as conformationally restricted analogues of trimethoprim.EBI J Med Chem 34: 550-5 (1991) Wellcome Research Laboratories 2D 3D TSV
1995872 5 Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors.EBI J Med Chem 34: 511-7 (1991) University of Calgary 2D 3D TSV
1995871 25 A 3-D model for 5-HT1A-receptor agonists based on stereoselective methyl-substituted and conformationally restricted analogues of 8-hydroxy-2-(dipropylamino)tetralin.EBI J Med Chem 34: 497-510 (1991) Uppsala University 2D 3D TSV
1995868 4 The renewed potential for folate antagonists in contemporary cancer chemotherapy.EBI J Med Chem 34: 479-85 (1991) Parke-Davis Pharmaceutical Research Division 2D 3D TSV
1994002 59 Antagonist binding profiles of five cloned human muscarinic receptor subtypes.BDB J Pharmacol Exp Ther 256: 727-33 (1991) National Institute of Neurological Disorders and Stroke 2D 3D TSV
1992155 30 Design of potent protein kinase inhibitors using the bisubstrate approach.EBI J Med Chem 34: 73-8 (1991) URA CNRS 1309 2D 3D TSV
1992151 10 Design of a well-absorbed renin inhibitor.EBI J Med Chem 34: 469-71 (1991) Abbott Laboratories 2D 3D TSV
1992150 60 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.EBI J Med Chem 34: 466-9 (1991) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1992149 15 Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.EBI J Med Chem 34: 463-6 (1991) Warner-Lambert Company 2D 3D TSV
1992147 10 trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline.EBI J Med Chem 34: 455-7 (1991) Abbott Laboratories 2D 3D TSV
1992145 5 Design, synthesis, and physicochemical properties of a novel, conformationally restricted 2,3-dihydro-1,3,4-thiadiazole-containing angiotensin converting enzyme inhibitor which is preferentially eliminated by the biliary route in rats.EBI J Med Chem 34: 439-47 (1991) Research and Development Laboratories 2D 3D TSV
1992139 89 Disubstituted tetrahydrofurans and dioxolanes and PAF antagonists.EBI J Med Chem 34: 373-86 (1991) J. Uriach & Cía. S.A. 2D 3D TSV
1992138 9 Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors.EBI J Med Chem 34: 367-73 (1991) Warner-Lambert Company 2D 3D TSV
1992137 23 Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus.EBI J Med Chem 34: 357-66 (1991) Warner-Lambert Company 2D 3D TSV
1992129 27 Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones.EBI J Med Chem 34: 291-8 (1991) Pfizer Inc 2D 3D TSV
1992127 6 2,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines.EBI J Med Chem 34: 276-81 (1991) Purdue University 2D 3D TSV
1992126 54 Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives.EBI J Med Chem 34: 267-76 (1991) Takeda Chemical Industries, Ltd 2D 3D TSV
1992122 6 Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate.EBI J Med Chem 34: 227-34 (1991) Institute 2D 3D TSV
1992121 13 Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.EBI J Med Chem 34: 222-7 (1991) University of South Alabama 2D 3D TSV
1992118 5 Analogues of methotrexate and aminopterin with gamma-methylene and gamma-cyano substitution of the glutamate side chain: synthesis and in vitro biological activity.EBI J Med Chem 34: 203-8 (1991) Institute 2D 3D TSV
1992113 12 1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 3.1 Synthesis and biological properties of aminodeoxystatine and difluorostatone derivatives.EBI J Med Chem 34: 151-7 (1991) ICI Pharmaceuticals Group 2D 3D TSV
1992112 53 Novel 5-HT3 antagonists. Indole oxadiazoles.EBI J Med Chem 34: 140-51 (1991) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1988661 44 In vitro pharmacological profile of a novel structural class of oxytocin antagonists.BDB J Pharmacol Exp Ther 256: 304-8 (1991) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
1987453 10 [3H]cytisine binding to nicotinic cholinergic receptors in brain.BDB Mol Pharmacol 39: 9-12 (1991) Georgetown University 2D 3D TSV
1982626 30 Neurochemical profile of eltoprazine.BDB Drug Metabol Drug Interact 8: 85-114 (1990) Duphar B.V. 2D 3D TSV
1977911 1 Potent anticonflict activity and lessening of memory impairment with a series of novel [1]benzothieno[2,3-c]pyridines and 1,2,3,4-tetrahydro[1]benzothieno[2,3-c]pyridines.EBI J Med Chem 33: 3110-6 (1990) Asahi Chemical Industry Company, Ltd. 2D 3D TSV
1977909 36 Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of [beta-(Aroylamino)ethyl]piperazines and -piperidines and [2-[(Arylamino)carbonyl]ethyl]piperazines, -pyrazinopyridoindoles, and -pyrazinoisoquinolines. A new class of potent H1 antagonists.EBI J Med Chem 33: 2970-6 (1990) Central Drug Research Institute 2D 3D TSV
1977908 10 (R)-4-oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex.EBI J Med Chem 33: 2961-3 (1990) Merrell Dow Research Institute 2D 3D TSV
1977907 33 (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist.EBI J Med Chem 33: 2948-50 (1990) Abbott Laboratories 2D 3D TSV
1976813 83 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity.EBI J Med Chem 33: 2899-905 (1990) Wyeth-Ayerst Research 2D 3D TSV
1976812 62 Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity.EBI J Med Chem 33: 2883-91 (1990) Berlex Laboratories 2D 3D TSV
1975644 47 Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.BDB Nature 347: 146-51 (1990) U. 109 2D 3D TSV
1975275 113 Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor.EBI J Med Chem 33: 2421-9 (1990) University of Oregon 2D 3D TSV
1975274 16 Synthesis and dopamine receptor affinities of 2-(4-fluoro-3- hydroxyphenyl)ethylamine and N-substituted derivatives.EBI J Med Chem 33: 2408-12 (1990) University of Camerino 2D 3D TSV
1973734 16 Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study.EBI J Med Chem 33: 2305-9 (1990) Astra Research Centre AB 2D 3D TSV
1973733 17 Conformational analysis and structure-activity relationships of selective dopamine D-1 receptor agonists and antagonists of the benzazepine series.EBI J Med Chem 33: 2197-204 (1990) Royal Danish School of Pharmacy 2D 3D TSV
1972964 40 Design and synthesis of highly potent and selective cyclic dynorphin A analogues.EBI J Med Chem 33: 1874-9 (1990) University of Arizona 2D 3D TSV
1971309 31 Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.EBI J Med Chem 33: 1800-5 (1990) Northeastern University 2D 3D TSV
1971308 22 trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist.EBI J Med Chem 33: 1756-64 (1990) Purdue University 2D 3D TSV
1969484 38 Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds.EBI J Med Chem 33: 1155-63 (1990) Astra Research Centre AB 2D 3D TSV
1969483 11 Dehydrogenase binding by tiazofurin anabolites.EBI J Med Chem 33: 1123-7 (1990) University of Rochester Medical Center 2D 3D TSV
1968985 56 Characteristics of 125I-iodocyanopindolol binding to beta-adrenergic and serotonin-1B receptors of rat brain: selectivity of beta-adrenergic agents.BDB Jpn J Pharmacol 52: 195-200 (1990) Niigata College of Pharmacy 2D 3D TSV
1968512 18 Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model.EBI J Med Chem 33: 1015-22 (1990) University of Lund 2D 3D TSV
1967654 12 Synthesis and immunosuppressive activity of some side-chain variants of mycophenolic acid.EBI J Med Chem 33: 833-8 (1990) Syntex Research 2D 3D TSV
1967653 2 Analogues of carbamyl aspartate as inhibitors of dihydroorotase: preparation of boronic acid transition-state analogues and a zinc chelator carbamylhomocysteine.EBI J Med Chem 33: 819-23 (1990) Mayo Clinic 2D 3D TSV
1967652 27 Chloro-substituted, sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.EBI J Med Chem 33: 809-14 (1990) Vanderbilt University 2D 3D TSV
1967651 2 Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA).EBI J Med Chem 33: 703-10 (1990) Purdue University 2D 3D TSV
1967318 8 Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers.EBI J Med Chem 33: 445-50 (1990) Warner-Lambert Company 2D 3D TSV
1967317 11 Histamine H3 ligands: just pharmacological tools or potential therapeutic agents?EBI J Med Chem 33: 4-11 (1990) Vrije Universiteit 2D 3D TSV
1967314 35 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines: a novel class of compounds with central dopamine agonist properties.EBI J Med Chem 33: 311-7 (1990) Warner-Lambert Company 2D 3D TSV
1967313 21 Synthesis and beta-adrenergic antagonist activity of stereoisomeric practolol and propranolol derivatives.EBI J Med Chem 33: 216-23 (1990) University of California 2D 3D TSV
1967312 91 Synthesis and structure-activity relationships of dynorphin A-(1-8) amide analogues.EBI J Med Chem 33: 206-12 (1990) Eisai Co., Ltd 2D 3D TSV
1963602 44 NMDA receptor agonists derived from ibotenic acid. Preparation, neuroexcitation and neurotoxicity.BDB Eur J Pharmacol 189: 381-91 (1990) Royal Danish School of Pharmacy 2D 3D TSV
1956054 27 Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.EBI J Med Chem 34: 3340-2 (1991) Roche Products Ltd 2D 3D TSV
1956050 18 Gossypol and derivatives: a new class of aldose reductase inhibitors.EBI J Med Chem 34: 3301-5 (1991) University of New Mexico School of Medicine 2D 3D TSV
1956045 88 Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites.EBI J Med Chem 34: 3267-80 (1991) E. Merck Darmstadt 2D 3D TSV
1956044 115 Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype.EBI J Med Chem 34: 3248-60 (1991) Warner-Lambert Company 2D 3D TSV
1956042 39 Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands.EBI J Med Chem 34: 3235-41 (1991) Research Biochemicals Inc. 2D 3D TSV
1956041 28 Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors.EBI J Med Chem 34: 3229-34 (1991) Alcon Laboratories Inc 2D 3D TSV
1956039 34 (Aminoalkyl)carbamates of forskolin: intermediates for the synthesis of functionalized derivatives of forskolin with different specificities for adenylyl cyclase and the glucose transporter.EBI J Med Chem 34: 3204-12 (1991) Food and Drug Administration 2D 3D TSV
1956038 21 Synthesis and ocular antihypertensive activity of new imidazolidine derivatives containing a beta-blocking side chain.EBI J Med Chem 34: 3197-204 (1991) Institut de Pharmacologie (UA 589 CNRS) 2D 3D TSV
1956033 121 Synthesis, molecular modeling studies, and muscarinic receptor activity of azaprophen analogues.EBI J Med Chem 34: 3164-71 (1991) Research Triangle Institute 2D 3D TSV
1955879 2 Bisbenzylisoquinoline AlkaloidsEBI J Nat Prod 54: 645-749 (1991) TBA 2D 3D TSV
1930610 41 Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors.BDB Neuropsychopharmacology 5: 43-7 (1991) Eli Lilly and Company 2D 3D TSV
1920365 8 [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane: high-affinity SPECT radiotracer of monoamine reuptake sites in brain.EBI J Med Chem 34: 3144-6 (1991) Research Biochemicals Inc. 2D 3D TSV
1920361 52 Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro.EBI J Med Chem 34: 3114-25 (1991) SmithKline Beecham Pharmaceuticals Research and Development 2D 3D TSV
1920360 13 Nonpeptidic angiotensin II antagonists: synthesis and in vitro activity of a series of novel naphthalene and tetrahydronaphthalene derivatives.EBI J Med Chem 34: 3105-14 (1991) Ciba-Geigy Limited 2D 3D TSV
1920359 40 Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides.EBI J Med Chem 34: 3098-105 (1991) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
1920350 22 Muscarinic receptor binding profile of para-substituted caramiphen analogues.EBI J Med Chem 34: 2984-9 (1991) Virginia Commonwealth University 2D 3D TSV
1910091 7 Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2 antagonists. Semicarbazone omega-chains.EBI J Med Chem 34: 2882-91 (1991) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
1910089 30 Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.BDB J Med Chem 34: 2852-7 (1991) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1909177 6 Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase.BDB Biochemistry 30: 8480-7 (1991) Arizona State University 2D 3D TSV
1908523 7 Targeting 5'-deoxy-5'-(methylthio)adenosine phosphorylase by 5'-haloalkyl analogues of 5'-deoxy-5'-(methylthio)adenosine.EBI J Med Chem 34: 2600-6 (1991) Institute 2D 3D TSV
1908522 5 Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.EBI J Med Chem 34: 2504-20 (1991) Wyeth-Ayerst Research 2D 3D TSV
1908521 106 Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists.EBI J Med Chem 34: 2477-83 (1991) Centre de Recherches de Vitry Alfortville Rh£ne-Poulenc Rorer 2D 3D TSV
1906108 27 Relative structure-inhibition analyses of the N-benzoyl and N-(phenylsulfonyl) amino acid aldose reductase inhibitors.EBI J Med Chem 34: 2120-6 (1991) Auburn University 2D 3D TSV
1903450 34 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones.EBI J Med Chem 34: 1560-70 (1991) Sterling Research Group 2D 3D TSV
1901912 1 Quinazolineacetic acids and related analogues as aldose reductase inhibitors.EBI J Med Chem 34: 1492-503 (1991) Wyeth-Ayerst Research 2D 3D TSV
1901910 87 New inhibitors of human renin that contain novel replacements at the P2 site.EBI J Med Chem 34: 1258-71 (1991) Warner-Lambert Company 2D 3D TSV
1900533 30 Antinociceptive (aminoalkyl)indoles.EBI J Med Chem 34: 1099-110 (1991) Sterling Research Group 2D 3D TSV
1900532 44 A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.EBI J Med Chem 34: 1011-8 (1991) Pfizer Inc 2D 3D TSV
1899453 74 On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase.EBI J Med Chem 34: 46-54 (1991) Pomona College 2D 3D TSV
1899452 90 Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.EBI J Med Chem 34: 108-22 (1991) Pfizer Inc 2D 3D TSV
1895310 9 A selective, reversible, competitive inhibitor of monoamine oxidase A containing no nitrogen, with negligible potentiation of tyramine-induced blood pressure rise.EBI J Med Chem 34: 2931-3 (1991) Burroughs Wellcome Co. 2D 3D TSV
1895309 27 Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors.EBI J Med Chem 34: 2928-31 (1991) Nova Pharmaceutical Corporation 2D 3D TSV
1895308 9 Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists.EBI J Med Chem 34: 2919-22 (1991) Exploratory Chemistry Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1895306 13 Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogues of 1-methylisoguanosine.EBI J Med Chem 34: 2892-8 (1991) Griffith University 2D 3D TSV
1895305 75 N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor.EBI J Med Chem 34: 2877-82 (1991) University of South Florida 2D 3D TSV
1895300 15 Modification of the enkephalin"message" with an artificial polycationic C-terminus.EBI J Med Chem 34: 2816-21 (1991) Case Western Reserve University 2D 3D TSV
1895299 59 Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety.EBI J Med Chem 34: 2804-15 (1991) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
1895294 14 Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid.EBI J Med Chem 34: 2746-54 (1991) University of South Alabama 2D 3D TSV
1895293 44 Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor.EBI J Med Chem 34: 2726-35 (1991) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
1895292 16 Synthesis, ligand binding, QSAR, and CoMFA study of 3 beta-(p-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters.EBI J Med Chem 34: 2719-25 (1991) Research Triangle Institute 2D 3D TSV
1895289 8 Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.EBI J Med Chem 34: 2692-701 (1991) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1895288 23 New aromatase inhibitors. Synthesis and biological activity of pyridyl-substituted tetralone derivatives.EBI J Med Chem 34: 2685-91 (1991) Universität des Saarlandes 2D 3D TSV
1875353 14 Acyclic analogues of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): conformationally mobile inhibitors of vesicular acetylcholine transport.EBI J Med Chem 34: 2638-43 (1991) University of Minnesota 2D 3D TSV
1875352 12 Synthesis, stereochemistry, and biological activity of the 1-(1-phenyl-2-methylcyclohexyl)piperidines and the 1-(1-phenyl-4-methylcyclohexyl)piperidines. Absolute configuration of the potent trans-(-)-1-(1-phenyl-2-methylcyclohexyl)piperidine.EBI J Med Chem 34: 2615-23 (1991) Istituto Superiore di Sanità 2D 3D TSV
1875350 20 Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.EBI J Med Chem 34: 2579-88 (1991) Purdue University 2D 3D TSV
1875349 94 Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.EBI J Med Chem 34: 2570-9 (1991) Ciba-Geigy Corporation 2D 3D TSV
1875348 65 Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.EBI J Med Chem 34: 2525-47 (1991) E. I. du Pont de Nemours & Company, Inc. 2D 3D TSV
1875347 23 Synthesis and biochemical studies of 16- or 19-substituted androst-4-enes as aromatase inhibitors.EBI J Med Chem 34: 2496-504 (1991) Tohoku College of Pharmacy 2D 3D TSV
1875346 17 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivatives.EBI J Med Chem 34: 2489-95 (1991) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
1875344 9 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 8. Side chain ether analogues of lovastatin.EBI J Med Chem 34: 2474-7 (1991) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
1875343 7 Synthesis and evaluation of antiinflammatory activities of a series of corticosteroid 17 alpha-esters containing a functional group.EBI J Med Chem 34: 2468-73 (1991) Mitsubishi Kasei Corporation 2D 3D TSV
1875338 7 Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist properties.EBI J Med Chem 34: 2410-4 (1991) Searle R & D and MCR 2D 3D TSV
1875337 10 Synthesis and biological activity of angiotensin II analogues containing a Val-His replacement, Val psi[CH(CONH2)NH]His.EBI J Med Chem 34: 2402-10 (1991) Berlex Laboratories 2D 3D TSV
1875334 16 Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity.EBI J Med Chem 34: 2344-56 (1991) Upjohn Company 2D 3D TSV
1875333 132 Cholinergic activity of acetylenic imidazoles and related compounds.EBI J Med Chem 34: 2314-27 (1991) Upjohn Company 2D 3D TSV
1875332 33 HIV protease: a novel chemotherapeutic target for AIDS.EBI J Med Chem 34: 2305-14 (1991) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1874734 53 The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.BDB J Biol Chem 266: 15771-81 (1991) Laboratoires Glaxo 2D 3D TSV
1868065 5 Role of the four conserved histidine residues in the amidotransferase domain of carbamoyl phosphate synthetase.BDB Biochemistry 30: 7901-7 (1991) Texas A&M University 2D 3D TSV
1857334 1 Cloning and expression of an A1 adenosine receptor from rat brain.BDB Mol Pharmacol 40: 1-7 (1991) National Institute of Mental Health 2D 3D TSV
1851847 22 Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists.EBI J Med Chem 34: 1751-3 (1991) Rochester 2D 3D TSV
1851846 23 Role of spacer and address components in peptidomimetic delta opioid receptor antagonists related to naltrindole.EBI J Med Chem 34: 1715-20 (1991) University of Minnesota 2D 3D TSV
1851845 17 Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 4. Addition of chromone moiety enhances leukotriene D4 receptor binding affinity.EBI J Med Chem 34: 1704-7 (1991) Rhone-Poulenc Rorer Central Research 2D 3D TSV
1851843 96 Synthesis and structure-activity relationships of deltorphin analogues.EBI J Med Chem 34: 1656-61 (1991) University of Ferrara 2D 3D TSV
1849997 42 Function of negative charge in the"address domain" of deltorphins.EBI J Med Chem 34: 1350-5 (1991) National Institute of Environmental Health Sciences 2D 3D TSV
1849996 7 Synthesis and biochemical evaluation of baclofen analogues locked in the baclofen solid-state conformation.EBI J Med Chem 34: 1307-13 (1991) Centre de Neurochimie du CNRS 2D 3D TSV
1849995 12 Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine.EBI J Med Chem 34: 1292-6 (1991) University of Minnesota 2D 3D TSV
1849993 13 Peptide leukotrienes: current status of research.EBI J Med Chem 34: 1235-42 (1991) ICI Pharmaceuticals Group 2D 3D TSV
1848629 42 gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands.BDB J Pharmacol Exp Ther 256: 1154-60 (1991) Georgetown University 2D 3D TSV
1848295 33 Identification and exploitation of the sigma-opiate pharmacophore.EBI J Med Chem 34: 1094-8 (1991) Virginia Commonwealth University 2D 3D TSV
1848293 24 Studies on (H(+)-K+)-ATPase inhibitors of gastric acid secretion. Prodrugs of 2-[(2-pyridinylmethyl)sulfinyl]benzimidazole proton-pump inhibitors.EBI J Med Chem 34: 1049-62 (1991) Upjohn Company 2D 3D TSV
1848292 116 Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity.EBI J Med Chem 34: 1028-36 (1991) ICI Pharmaceuticals Group 2D 3D TSV
1847432 13 New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics.EBI J Med Chem 34: 827-41 (1991) Anaquest, Inc. 2D 3D TSV
1847426 56 Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.EBI J Med Chem 34: 518-25 (1991) Warner-Lambert Company 2D 3D TSV
1846921 56 (2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics.EBI J Med Chem 34: 397-403 (1991) Zambeletti Research Laboratories 2D 3D TSV
1846919 26 Highly selective kappa opioid analgesics. 4. Synthesis of some conformationally restricted naphthalene derivatives with high receptor affinity and selectivity.EBI J Med Chem 34: 190-4 (1991) Parke-Davis Research Unit 2D 3D TSV
1846918 12 2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists.EBI J Med Chem 34: 181-9 (1991) ICI Pharmaceuticals Group 2D 3D TSV
1840645 85 Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine.BDB Nature 350: 610-4 (1991) University of Toronto 2D 3D TSV
1836757 5 Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.BDB EMBO J 10: 4017-23 (1991) University of Heidelberg 2D 3D TSV
1833546 47 Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands.EBI J Med Chem 34: 2946-53 (1991) Abbott Laboratories 2D 3D TSV
1831904 27 Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.BDB Proc Natl Acad Sci U S A 88: 7491-5 (1991) Duke University 2D 3D TSV
1829485 15 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 1. (+/-)-(3-pyridinylbicycloheptyl)alkanoic acids.EBI J Med Chem 34: 1790-7 (1991) Ciba-Geigy Corporation 2D 3D TSV
1828505 19 Characterization and distribution of [125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain.BDB J Pharmacol Exp Ther 257: 1253-63 (1991) University of Pennsylvania 2D 3D TSV
1827843 27 Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors.EBI J Med Chem 34: 1612-24 (1991) University of California 2D 3D TSV
1826762 58 Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.BDB Nature 350: 614-9 (1991) University of Toronto 2D 3D TSV
1826745 4 Novel synthesis and biochemical properties of an [125I]-labeled photoaffinity probe for thromboxane A2/prostaglandin H2 receptors.EBI J Med Chem 34: 1511-4 (1991) Eli Lilly and Company 2D 3D TSV
1825337 22 Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.EBI J Med Chem 34: 725-36 (1991) Ciba-Geigy Corporation 2D 3D TSV
1825116 36 Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding.EBI J Med Chem 34: 86-9 (1991) Pfizer Inc 2D 3D TSV
1825115 16 Antidopaminergic effects of the stereoisomers of N-[(1-alkyl-2- pyrrolidinyl)methyl]-5-sulfamoylbenzamides and -2,3-dihydrobenzofuran-7-carboxamides.EBI J Med Chem 34: 261-7 (1991) Yoshitomi Pharmaceutical Industries Ltd 2D 3D TSV
1812212 5 Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C.EBI J Nat Prod 54: 1595-600 Sanofi Recherche 2D 3D TSV
1800642 2 Methylpendolmycin, an indolactam from a Nocardiopsis sp.EBI J Nat Prod 54: 1440-3 Sterling Research Group 2D 3D TSV
1766006 8 Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.EBI J Med Chem 34: 3399-402 (1992) Mayo Clinic 2D 3D TSV
1766005 5 Examination of HIV-1 protease secondary structure specificity using conformationally constrained inhibitors.EBI J Med Chem 34: 3395-9 (1992) University of Illinois 2D 3D TSV
1766003 18 Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.EBI J Med Chem 34: 3388-90 (1992) University of South Florida 2D 3D TSV
1766000 90 Cholecystokinin antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors.EBI J Med Chem 34: 3350-9 (1992) Abbott Laboratories 2D 3D TSV
1738153 45 A novel class of enkephalinase inhibitors containing a C-terminal sulfo group.EBI J Med Chem 35: 602-8 (1992) Dainippon Pharmaceutical Co., Ltd 2D 3D TSV
1738152 21 Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.EBI J Med Chem 35: 590-601 (1992) University of Illinois 2D 3D TSV
1738151 69 QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.EBI J Med Chem 35: 584-9 (1992) University of Illinois 2D 3D TSV
1738148 16 Renin inhibitory pentols showing improved enteral bioavailability.EBI J Med Chem 35: 559-67 (1992) Hoechst AG 2D 3D TSV
1738141 64 Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain.EBI J Med Chem 35: 457-65 (1992) Pfizer Inc 2D 3D TSV
1738140 26 alpha-Keto amide inhibitors of aminopeptidases.EBI J Med Chem 35: 451-6 (1992) University of Wisconsin-Madison 2D 3D TSV
1738138 62 Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.EBI J Med Chem 35: 407-22 (1992) NIDDK 2D 3D TSV
1738111 26 Characterization of 5-hydroxytryptamine1B receptors in rat spinal cord via [125I]iodocyanopindolol binding and inhibition of [3H]-5-hydroxytryptamine release.BDB J Pharmacol Exp Ther 260: 614-26 (1992) University of Texas 2D 3D TSV
1732557 20 Improvements in the minimum binding sequence of C5a: examination of His-67.EBI J Med Chem 35: 402-6 (1992) Abbott Laboratories 2D 3D TSV
1732551 6 Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.EBI J Med Chem 35: 332-7 (1992) Southern Research Institute 2D 3D TSV
1732550 12 New neplanocin analogues. 1. Synthesis of 6'-modified neplanocin A derivatives as broad-spectrum antiviral agents.EBI J Med Chem 35: 324-31 (1992) Toyo Jozo Company, Ltd. 2D 3D TSV
1732549 4 Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.EBI J Med Chem 35: 320-4 (1992) SRI International 2D 3D TSV
1732545 27 Phenyl-substituted analogues of oxotremorine as muscarinic antagonists.EBI J Med Chem 35: 285-94 (1992) University of Uppsala 2D 3D TSV
1732541 60 Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects.EBI J Med Chem 35: 241-52 (1992) Hokkaido University 2D 3D TSV
1732540 10 Structure-function studies in a series of carboxyl-terminal octapeptide analogues of anaphylatoxin C5a.EBI J Med Chem 35: 220-3 (1992) Abbott Laboratories 2D 3D TSV
1732537 3 Stereoselective LSD-like activity in d-lysergic acid amides of (R)- and (S)-2-aminobutane.EBI J Med Chem 35: 203-11 (1992) Purdue University 2D 3D TSV
1732534 8 Total synthesis of uracil analogues of sinefungin.EBI J Med Chem 35: 63-7 (1992) CNRS 2D 3D TSV
1732532 139 Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivatives.EBI J Med Chem 35: 28-38 (1992) Rotta Research Laboratorium 2D 3D TSV
1732531 88 Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.EBI J Med Chem 35: 2-14 (1992) Warner-Lambert Company 2D 3D TSV
1732526 101 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.BDB J Med Chem 35: 177-84 (1992) Roche Products Limited 2D 3D TSV
1732525 11 Heteroatom analogues of bemoradan: chemistry and cardiotonic activity of 1,4-benzothiazinylpyridazinones.EBI J Med Chem 35: 172-6 (1992) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
1732523 46 Preparation and biological activities of potential vasopressin photoaffinity labels.EBI J Med Chem 35: 151-7 (1992) University of Sherbrooke 2D 3D TSV
1732522 42 Muscarinic activity of the thiolactone, lactam, lactol, and thiolactol analogues of pilocarpine and a hypothetical model for the binding of agonists to the m1 receptor.EBI J Med Chem 35: 15-27 (1992) Sandoz Pharma Ltd 2D 3D TSV
1732521 12 N-modified analogues of cocaine: synthesis and inhibition of binding to the cocaine receptor.EBI J Med Chem 35: 141-4 (1992) Research Triangle Institute 2D 3D TSV
1732520 21 2 beta-substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor.EBI J Med Chem 35: 135-40 (1992) Research Triangle Institute 2D 3D TSV
1732519 15 Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl)indole agonists of the cannabinoid receptor.EBI J Med Chem 35: 124-35 (1992) Sterling Research Group 2D 3D TSV
1732516 6 Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans delta 24-sterol methyltransferase.EBI J Med Chem 35: 100-6 (1992) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
1731937 20 Reversal of enzyme regiospecificity with alternative substrates for aspartokinase I from Escherichia coli.BDB Biochemistry 31: 799-805 (1992) University of Akron 2D 3D TSV
1720175 8 Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes.EBI J Med Chem 34: 3305-9 (1991) Veterans Affairs Medical Center 2D 3D TSV
1716683 16 2-Pyridinone derivatives: a new class of nonnucleoside, HIV-1-specific reverse transcriptase inhibitors.BDB J Med Chem 34: 2922-5 (1991) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1716682 64 Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-a receptor agonists.EBI J Med Chem 34: 2837-42 (1991) Abbott Laboratories 2D 3D TSV
1714957 12 Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.EBI J Med Chem 34: 2430-8 (1991) Hebrew University of Jerusalem 2D 3D TSV
1714956 17 Novel gonadotropin-releasing hormone antagonists: peptides incorporating modified N omega-cyanoguanidino moieties.EBI J Med Chem 34: 2395-402 (1991) Salk Institute 2D 3D TSV
1712396 5 Potent inhibitory effect of a series of modified cyclodextrin sulfates (mCDS) on the replication of HIV-1 in vitro.EBI J Med Chem 34: 2301-4 (1991) Tanabe Seiyaku Co., Ltd 2D 3D TSV
1712395 43 Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones.BDB J Med Chem 34: 2231-41 (1991) Boehringer Ingelheim Pharmaceuticals Inc 2D 3D TSV
1710653 155 Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.EBI J Nat Prod 54: 143-54 University of Illinois 2D 3D TSV
1706716 29 Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.BDB J Biol Chem 266: 6365-9 (1991) Duke University 2D 3D TSV
1706470 9 Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors.BDB Mol Pharmacol 39: 346-51 (1991) Abbott Laboratories 2D 3D TSV
1705574 2 Differential Inhibition of Reverse Transcriptase and Various DNA Polymerases by Digallic Acid and Its DerivativesEBI J Nat Prod 53: 1234-1240 (1990) TBA 2D 3D TSV
1704434 16 Pharmacologic comparison of selected agonists for the M1 muscarinic receptor in transfected murine fibroblast cells (B82).BDB J Pharmacol Exp Ther 256: 689-94 (1991) University of Arizona 2D 3D TSV
1701834 20 Boc-Trp-Orn(Z)-Asp-NH2 and derivatives: a new family of CCK antagonists.EBI J Med Chem 33: 3199-204 (1991) University of Paris 2D 3D TSV
1700123 26 Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists.EBI J Med Chem 33: 2950-2 (1990) Abbott Laboratories 2D 3D TSV
1697345 3 5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity.EBI J Med Chem 33: 2481-7 (1990) Institute for Medical Research 2D 3D TSV
1695682 41 Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists.EBI J Med Chem 33: 2101-8 (1990) Istituto De Angeli 2D 3D TSV
1694546 64 Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors.EBI J Med Chem 33: 1906-10 (1990) Vanderbilt University 2D 3D TSV
1694545 28 Potent and highly selective neurokinin antagonists.EBI J Med Chem 33: 1848-51 (1990) Glaxo Group Research Ltd. 2D 3D TSV
1684995 27 (+/-)-3-Allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3- benzazepin, a new high-affinity D1 dopamine receptor ligand: synthesis and structure-activity relationship.EBI J Med Chem 34: 3366-71 (1992) Northeastern University 2D 3D TSV
1683407 32 Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone.EBI J Med Chem 34: 3316-28 (1991) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
1681106 27 Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds.EBI J Med Chem 34: 3085-90 (1991) Pfizer Inc 2D 3D TSV
1680195 23 Dopamine autoreceptor agonists as potential antipsychotics. 3.6-Propyl-4,5,5a,6,7,8-hexahydrothiazolo[4,5-f]quinolin-2-amine.EBI J Med Chem 34: 2736-46 (1991) Warner-Lambert Company 2D 3D TSV
1676759 12 Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone.EBI J Med Chem 34: 2242-7 (1991) University of Santiago de Compostela 2D 3D TSV
1676758 12 Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists.EBI J Med Chem 34: 2023-30 (1991) H. Lundbeck A/S 2D 3D TSV
1676428 47 Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.BDB J Med Chem 34: 1896-907 (1991) Hebrew University of Jerusalem 2D 3D TSV
1676427 21 1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents.EBI J Med Chem 34: 1860-6 (1991) Pfizer Inc 2D 3D TSV
1676426 1 Structure/activity and molecular modeling studies of the lophotoxin family of irreversible nicotinic receptor antagonists.EBI J Med Chem 34: 1798-804 (1991) University of California San Diego 2D 3D TSV
1676425 9 Substituent effect on the stereochemistry of H2-receptor antagonists of the phenylformamidine series. A conformation-dependent mode of interaction with the H2 receptor.EBI J Med Chem 34: 1772-6 (1991) Research Laboratories of Istituto De Angeli 2D 3D TSV
1674541 24 Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D-2 antagonist activity.EBI J Med Chem 34: 1707-14 (1991) Harvard Medical School 2D 3D TSV
1673158 9 Optical isomers of rocastine and close analogues: synthesis and H1 antihistaminic activity of its enantiomers and their structural relationship to the classical antihistamines.EBI J Med Chem 34: 1314-28 (1991) A.H. Robins Company 2D 3D TSV
1672158 40 Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of substituted (R)-N-[(1-benzyl-2-pyrrolidinyl)methyl]benzamides. Relations to other side chain congeners.EBI J Med Chem 34: 948-55 (1991) Astra Research Centre AB 2D 3D TSV
1672156 81 Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.EBI J Med Chem 34: 1068-72 (1991) Hoechst-Roussel Pharmaceuticals Inc 2D 3D TSV
1672155 14 Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.EBI J Med Chem 34: 1063-8 (1991) National Institute of Diabetes 2D 3D TSV
1671705 126 Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors.EBI J Med Chem 34: 705-17 (1991) Syntex Research 2D 3D TSV
1671420 49 Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines.EBI J Med Chem 34: 457-61 (1991) Schering-Plough Corporation 2D 3D TSV
1671419 48 Rationally designed"dipeptoid" analogues of CCK. alpha-Methyltryptophan derivatives as highly selective and orally active gastrin and CCK-B antagonists with potent anxiolytic properties.EBI J Med Chem 34: 404-14 (1991) Parke-Davis Research Unit 2D 3D TSV
1671416 15 Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones.EBI J Med Chem 34: 248-56 (1991) Warner-Lambert Company 2D 3D TSV
1671415 24 R and S enantiomers of 11-hydroxy- and 10,11-dihydroxy-N-allylnoraporphine: synthesis and affinity for dopamine receptors in rat brain tissue.EBI J Med Chem 34: 24-8 (1991) Northeastern University 2D 3D TSV
1671414 10 Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds.EBI J Med Chem 34: 194-7 (1991) Istituto Superiore di Sanità 2D 3D TSV
1662725 48 Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands.EBI J Med Chem 34: 3360-5 (1992) Virginia Commonwealth University 2D 3D TSV
1662620 12 Characterization of a guanosine-nucleotide-binding-protein-coupled receptor for pituitary adenylate-cyclase-activating polypeptide on plasma membranes from rat brain.BDB Eur J Biochem 202: 951-8 (1991) Georg-August-University 2D 3D TSV
1661335 95 Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins.BDB J Recept Res 11: 891-907 (1991) Center for Bio-Pharmaceutical Sciences 2D 3D TSV
1659638 8 Synthesis and pharmacological evaluation of ether and related analogues of delta 8-, delta 9-, and delta 9,11-tetrahydrocannabinol.EBI J Med Chem 34: 3310-6 (1991) Virginia Commonwealth University 2D 3D TSV
1659636 51 Structure/activity studies related to 2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]acetamides: a novel series of potent and selective kappa-opioid agonists.EBI J Med Chem 34: 3149-58 (1991) ICI Pharmaceuticals Group 2D 3D TSV
1656045 26 Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity.EBI J Med Chem 34: 3125-32 (1991) Clinical Research Institute of Montreal 2D 3D TSV
1656044 18 Synthesis and receptor binding of enantiomeric N-substituted cis-N-[2-(3,4-dichlorophenyl)ethyl]-2-(1-pyrrolidinyl)cyclohexylamines as high-affinity sigma receptor ligands.EBI J Med Chem 34: 3058-65 (1991) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
1656043 4 New 5H-pyridazino[4,5-b]indole derivatives. Synthesis and studies as inhibitors of blood platelet aggregation and inotropics.EBI J Med Chem 34: 3023-9 (1991) Universidad de Navarra 2D 3D TSV
1656041 75 Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.EBI J Med Chem 34: 2962-83 (1991) Hoechst AG 2D 3D TSV
1656026 160 Characterization of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line.BDB J Pharmacol Exp Ther 259: 323-9 (1991) University of Nebraska 2D 3D TSV
1654492 20 Peripheral-type benzodiazepine receptors in human cerebral cortex, kidney, and colon.BDB Life Sci 49: 1155-61 (1991) Technion-Israel Institute of Technology 2D 3D TSV
1654430 51 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.EBI J Med Chem 34: 2906-16 (1991) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
1654429 2 Synthesis and biological evaluation of 4-purinylpyrrolidine nucleosides.EBI J Med Chem 34: 2787-97 (1991) University of Minnesota 2D 3D TSV
1652050 19 Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.BDB Mol Pharmacol 40: 143-8 (1991) Seattle Veterans Affairs Medical Center 2D 3D TSV
1652026 43 Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity.EBI J Med Chem 34: 2633-8 (1991) Virginia Commonwealth University 2D 3D TSV
1652025 45 (1S)-1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinoline and heterocycle-condensed tetrahydropyridine derivatives: members of a novel class of very potent kappa opioid analgesics.EBI J Med Chem 34: 2624-33 (1991) Zambeletti Research Laboratories 2D 3D TSV
1652024 4 Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride.EBI J Med Chem 34: 2607-15 (1991) Yale University 2D 3D TSV
1652023 179 Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.EBI J Med Chem 34: 2561-9 (1991) Abbott Laboratories 2D 3D TSV
1652022 18 3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies.EBI J Med Chem 34: 2557-60 (1991) Laboratoire de Pharmacie Chimique, Facult� de Pharmacie, Lille, France. 2D 3D TSV
1652019 12 Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers.EBI J Med Chem 34: 2438-44 (1991) University of Washington 2D 3D TSV
1652014 44 Sulfonylbenzoyl-nitrostyrenes: potential bisubstrate type inhibitors of the EGF-receptor tyrosine protein kinase.EBI J Med Chem 34: 2328-37 (1991) Ciba-Geigy Ltd 2D 3D TSV
1650832 7 Competition of leukotrienes and ICI-198,615 for [3H]LTD4 binding sites in guinea pig lung membranes suggests the involvement of two LTD4 receptor subtypes.BDB J Pharmacol Exp Ther 258: 531-6 (1991) Pfizer Inc 2D 3D TSV
1648621 55 (Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.EBI J Med Chem 34: 2176-86 (1991) ICI Pharmaceuticals Group 2D 3D TSV
1648141 21 Naphtho and benzo analogues of the kappa opioid agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide.EBI J Med Chem 34: 1891-6 (1991) University of Notre Dame 2D 3D TSV
1648140 14 Radiosynthesis of sigma receptor ligands for positron emission tomography: 11C- and 18F-labeled guanidines.EBI J Med Chem 34: 1867-70 (1991) Institutions 2D 3D TSV
1648139 34 Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors.EBI J Med Chem 34: 1855-9 (1991) Virginia Commonwealth University 2D 3D TSV
1648138 33 Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands.EBI J Med Chem 34: 1850-4 (1991) Universitá di Catania 2D 3D TSV
1648137 30 Topographically designed analogues of [D-Pen,D-Pen5]enkephalin.EBI J Med Chem 34: 1823-30 (1991) University of Arizona 2D 3D TSV
1648136 12 An approach to the design of receptor-type-selective non-peptide antagonists of peptidergic receptors: delta opioid antagonists.EBI J Med Chem 34: 1757-62 (1991) University of Minnesota 2D 3D TSV
1646322 13 Pharmacological profiles for rat cortical M1 and M2 muscarinic receptors using selective antagonists: comparison with N1E-115 muscarinic receptors.BDB J Pharmacol Exp Ther 257: 1121-9 (1991) Mayo Clinic 2D 3D TSV
1635066 17 Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.EBI J Med Chem 35: 2697-703 (1992) Istituto Chimico Internazionale Dr. G. Rende 2D 3D TSV
1635064 8 Nonpeptide angiotensin II receptor antagonists: synthetic and computational chemistry of N-[[4-[2-(2H-tetrazol-5-yl)-1-cycloalken-1- yl]phenyl]methyl]imidazole derivatives and their in vitro activity.EBI J Med Chem 35: 2658-67 (1992) Eli Lilly and Company 2D 3D TSV
1635061 4 N-[4-[[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-6- yl)methyl]amino]benzoyl]-L-glutamic acid, a novel A-ring analogue of 2-desamino-5,8-dideazafolic acid.EBI J Med Chem 35: 2626-30 (1992) Harvard Medical School 2D 3D TSV
1635058 50 Rationally designed"dipeptoid" analogues of CCK. Acid mimics of the potent and selective non-peptide CCK-B receptor antagonist CI-988.EBI J Med Chem 35: 2573-81 (1992) Parke-Davis Neuroscience Research Centre 2D 3D TSV
1635057 48 Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.EBI J Med Chem 35: 2562-72 (1992) Parke-Davis Pharmaceutical Research Division of Warner-Lambert Co. 2D 3D TSV
1635055 7 Synthesis and X-ray crystallographic analysis of quinazolinone cholecystokinin/gastrin receptor ligands.EBI J Med Chem 35: 2534-42 (1992) Eli Lilly and Company 2D 3D TSV
1635054 17 A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.EBI J Med Chem 35: 2525-33 (1992) Merck Research Laboratories 2D 3D TSV
1635053 47 5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.EBI J Med Chem 35: 2501-24 (1992) Wyeth-Ayerst Research 2D 3D TSV
1620241 6 SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum.BDB Naunyn Schmiedebergs Arch Pharmacol 345: 387-93 (1992) Sandoz Pharma Ltd 2D 3D TSV
1619622 51 Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.EBI J Med Chem 35: 2497-500 (1992) Research Triangle Institute 2D 3D TSV
1619616 94 Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands.EBI J Med Chem 35: 2392-406 (1992) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
1619615 71 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.EBI J Med Chem 35: 2363-8 (1992) Universit£ di Camerino 2D 3D TSV
1613758 95 (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.EBI J Med Chem 35: 2342-5 (1992) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1613755 12 Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.EBI J Med Chem 35: 2321-7 (1992) Institute of Cancer Research 2D 3D TSV
1613754 2 Structural studies on bio-active compounds. 20. Molecular modeling and crystallographic studies on methylbenzoprim, a potent inhibitor of dihydrofolate reductase.EBI J Med Chem 35: 2315-20 (1992) Aston University 2D 3D TSV
1613751 68 Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines .EBI J Med Chem 35: 2274-83 (1992) Novo Nordisk CNS Division 2D 3D TSV
1613750 46 Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects.EBI J Med Chem 35: 2253-60 (1992) Yamasa Shoyu Co., Ltd 2D 3D TSV
1613748 8 Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.EBI J Med Chem 35: 2231-8 (1992) Freie Universit£t Berlin 2D 3D TSV
1613747 10 Synthesis and aromatase inhibition of 3-cycloalkyl-substituted 3-(4-aminophenyl)piperidine-2,6-diones.EBI J Med Chem 35: 2210-4 (1992) Universität des Saarlandes 2D 3D TSV
1613746 48 Synthesis and muscarinic receptor activity of ester derivatives of 2-substituted 2-azabicyclo[2.2.1]heptan-5-ol and -6-ol.EBI J Med Chem 35: 2184-91 (1992) Research Triangle Institute 2D 3D TSV
1613745 1 Synthesis of carbon-11 labeled iodinated cocaine derivatives and their distribution in baboon brain measured using positron emission tomography.EBI J Med Chem 35: 2178-83 (1992) Brookhaven National Laboratory 2D 3D TSV
1613744 69 Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.EBI J Med Chem 35: 2169-77 (1992) Pfizer Inc 2D 3D TSV
1613743 29 Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives.EBI J Med Chem 35: 2155-62 (1992) Pfizer Inc 2D 3D TSV
1610807 6 Interaction of flexible analogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and of N-methyl-4-phenylpyridinium with highly purified monoamine oxidase A and B.BDB Biochemistry 31: 5611-5 (1992) University of California San Francisco 2D 3D TSV
1597860 24 Renin inhibitors containing C-termini derived from mercaptoheterocycles.EBI J Med Chem 35: 2103-12 (1992) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
1597859 14 Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted- pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones.EBI J Med Chem 35: 2095-103 (1992) Warner-Lambert Company 2D 3D TSV
1597858 56 Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors.EBI J Med Chem 35: 2085-94 (1992) Tanabe Seiyaku Co., Ltd 2D 3D TSV
1597856 20 Ester and amide derivatives of E64c as inhibitors of platelet calpains.EBI J Med Chem 35: 2048-54 (1992) State University of New York Health Science Center 2D 3D TSV
1597855 194 Cyclic RGD peptide analogues as antiplatelet antithrombotics.EBI J Med Chem 35: 2040-8 (1992) Genentech 2D 3D TSV
1597853 2 A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.EBI J Med Chem 35: 1978-86 (1992) National Cancer Institute-Frederick 2D 3D TSV
1593278 1 Metabolism of the Catharanthus Alkaloids: from Streptomyces griseus to Monoamine Oxidase BEBI J Nat Prod 55: 269-284 (1992) TBA 2D 3D TSV
1588567 18 Synthesis and pharmacological investigation of the enantiomers of muscarone and allomuscarone.EBI J Med Chem 35: 1915-20 (1992) Istituto Chimico-Farmaceutico dell'Università 2D 3D TSV
1588560 19 Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter.EBI J Med Chem 35: 1813-7 (1992) Research Triangle Institute 2D 3D TSV
1588558 9 4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase.EBI J Med Chem 35: 1782-91 (1992) University of Kansas 2D 3D TSV
1588555 83 C-terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties.EBI J Med Chem 35: 1735-46 (1992) Abbott Laboratories 2D 3D TSV
1588554 66 Nonpeptide renin inhibitors employing a novel 3-aza(or oxa)-2,4-dialkyl glutaric acid moiety as a P2/P3 amide bond replacement.EBI J Med Chem 35: 1722-34 (1992) Abbott Laboratories 2D 3D TSV
1588553 32 1,2,3-trisubstituted cyclopropanes as conformationally restricted peptide isosteres: application to the design and synthesis of novel renin inhibitors.EBI J Med Chem 35: 1710-21 (1992) University of Texas 2D 3D TSV
1588552 30 HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity.BDB J Med Chem 35: 1702-9 (1992) Merck Research Laboratories 2D 3D TSV
1588551 21 Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.BDB J Med Chem 35: 1685-701 (1992) Merck Research Laboratories 2D 3D TSV
1588550 10 Definition and display of steric, hydrophobic, and hydrogen-bonding properties of ligand binding sites in proteins using Lee and Richards accessible surface: validation of a high-resolution graphical tool for drug design.EBI J Med Chem 35: 1671-84 (1992) Ciba-Geigy Corporation 2D 3D TSV
1588549 9 Antiandrogenic steroidal sulfonyl heterocycles. Utility of electrostatic complementarity in defining bioisosteric sulfonyl heterocycles.EBI J Med Chem 35: 1663-70 (1992) Sterling Winthrop Pharmaceuticals Research Division 2D 3D TSV
1586393 43 Localization and function of the D3 dopamine receptor.BDB Arzneimittelforschung 42: 224-30 (1992) U. 109 2D 3D TSV
1578493 103 Analogues of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor.EBI J Med Chem 35: 1650-62 (1992) American Cyanamid Company 2D 3D TSV
1578488 74 Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents.EBI J Med Chem 35: 1609-17 (1992) Warner-Lambert Company 2D 3D TSV
1578487 12 Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-oEBI J Med Chem 35: 1605-9 (1992) Warner-Lambert Company 2D 3D TSV
1578486 53 Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.EBI J Med Chem 35: 1597-605 (1992) Georgia Institute of Technology 2D 3D TSV
1578485 19 Synthesis and evaluation of a new series of mechanism-based aromatase inhibitors.EBI J Med Chem 35: 1588-97 (1992) Centre de Recherches Roussel-Uclaf 2D 3D TSV
1578484 26 Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation.EBI J Med Chem 35: 1578-88 (1992) Harvard Medical School 2D 3D TSV
1578483 36 Rationally designed"dipeptoid" analogues of CCK. A Free-Wilson/Fujita-Ban analysis of some alpha-methyltryptophan derivatives as CCK-B antagonists.EBI J Med Chem 35: 1572-7 (1992) Parke-Davis Neuroscience Research Centre 2D 3D TSV
1578481 5 Structure-activity studies of a novel bicyclic oxytocin antagonist.EBI J Med Chem 35: 1558-63 (1992) University of Arizona 2D 3D TSV
1578480 26 Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors.EBI J Med Chem 35: 1550-7 (1992) Abbott Laboratories 2D 3D TSV
1578479 24 Analogues of the muscarinic agent 2'-methylspiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]: synthesis and pharmacology.EBI J Med Chem 35: 1541-50 (1992) Uppsala University 2D 3D TSV
1578478 30 Novel antagonists of the 5-HT3 receptor. Synthesis and structure-activity relationships of (2-alkoxybenzoyl)ureas.EBI J Med Chem 35: 1515-20 (1992) Wyeth Research 2D 3D TSV
1573641 60 SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.EBI J Med Chem 35: 1486-9 (1992) Searle Research and Development 2D 3D TSV
1573640 54 Amide bond replacements incorporated into CCK-B selective"dipeptoids".EBI J Med Chem 35: 1472-84 (1992) Parke-Davis Neuroscience Research Center 2D 3D TSV
1573639 17 Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues.EBI J Med Chem 35: 1451-7 (1992) Warner-Lambert Company 2D 3D TSV
1573636 28 Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogues.EBI J Med Chem 35: 1429-34 (1992) Pfizer Inc 2D 3D TSV
1573634 5 Inhibition of pig kidney L-aromatic amino acid decarboxylase by 2,3-methano-m-tyrosines.EBI J Med Chem 35: 1410-7 (1992) University of Georgia 2D 3D TSV
1573633 15 Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.EBI J Med Chem 35: 1399-410 (1992) Wellcome Research Laboratories 2D 3D TSV
1573631 16 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity.EBI J Med Chem 35: 1339-44 (1992) Ciba-Geigy AG 2D 3D TSV
1567835 4 Steady-state kinetic mechanism of Ras farnesyl:protein transferase.BDB Biochemistry 31: 3800-7 (1992) Merck Research Laboratories 2D 3D TSV
1565658 57 Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.BDB Proc Natl Acad Sci U S A 89: 3630-4 (1992) Synaptic Pharmaceutical Corporation 2D 3D TSV
1560443 32 Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides.EBI J Med Chem 35: 1318-20 (1992) Syntex Research 2D 3D TSV
1560441 35 Muscarinic receptor subtype specificity of (N,N-dialkylamino)alkyl 2-cyclohexyl-2-phenylpropionates: cylexphenes (cyclohexyl-substituted aprophen analogues).EBI J Med Chem 35: 1290-5 (1992) Institute of Research 2D 3D TSV
1560440 42 Synthesis and muscarinic activities of quinuclidin-3-yltriazole and -tetrazole derivatives.EBI J Med Chem 35: 1280-90 (1992) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
1554381 19 Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.BDB Biochem Pharmacol 43: 1089-93 (1992) National Institutes of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
1552513 36 Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity.BDB J Med Chem 35: 994-1001 (1992) Roche Products Limited 2D 3D TSV
1552510 178 Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter.EBI J Med Chem 35: 969-81 (1992) Research Triangle Institute 2D 3D TSV
1552504 8 Selective irreversible inhibitors of aldose reductase.EBI J Med Chem 35: 1117-20 (1992) Ohio State University 2D 3D TSV
1552502 74 Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.EBI J Med Chem 35: 1102-8 (1992) University of South Carolina 2D 3D TSV
1552500 28 Synthesis of alkoxy-substituted diaryl compounds and correlation of ring separation with inhibition of tubulin polymerization: differential enhancement of inhibitory effects under suboptimal polymerization reaction conditions.EBI J Med Chem 35: 1058-67 (1992) National Cancer Institute-Bethesda 2D 3D TSV
1552499 23 Hybrid cholecystokinin-A antagonists based on molecular modeling of lorglumide and L-364,718.EBI J Med Chem 35: 1042-9 (1992) Center for Bio-Pharmaceutical Sciences 2D 3D TSV
1552498 55 Renin inhibitors containing alpha-heteroatom amino acids as P2 residues.EBI J Med Chem 35: 1032-42 (1992) Warner-Lambert Company 2D 3D TSV
1552497 38 Novel 5-HT3 antagonists: indol-3-ylspiro(azabicycloalkane-3,5'(4'H)-oxazoles).EBI J Med Chem 35: 1019-31 (1992) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1548683 7 Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogues of trioxifene, [3,4-dihydro-2-(4- methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]- phenyl]methanone.EBI J Med Chem 35: 931-8 (1992) Eli Lilly and Company 2D 3D TSV
1548682 126 8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.EBI J Med Chem 35: 924-30 (1992) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1548680 12 Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.EBI J Med Chem 35: 911-6 (1992) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1548679 20 Development of high-affinity 5-HT3 receptor antagonists. 2. Two novel tricyclic benzamides.EBI J Med Chem 35: 903-11 (1992) Rh£ne-Poulenc Rorer Central Research 2D 3D TSV
1548678 5 5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a new class of monoamine oxidase-B inactivators.EBI J Med Chem 35: 885-9 (1992) Northwestern University 2D 3D TSV
1548677 23 New nonpeptide angiotensin II receptor antagonists. 1. Synthesis, biological properties, and structure-activity relationships of 2-alkyl benzimidazole derivatives.EBI J Med Chem 35: 877-85 (1992) ICI Pharmaceuticals Group 2D 3D TSV
1548676 28 Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.EBI J Med Chem 35: 847-58 (1992) Agouron Pharmaceuticals Inc 2D 3D TSV
1548675 10 Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors.EBI J Med Chem 35: 833-46 (1992) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1548674 13 New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin.EBI J Med Chem 35: 823-32 (1992) Wyeth-Ayerst Research 2D 3D TSV
1542100 67 Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity.EBI J Med Chem 35: 734-40 (1992) Virginia Commonwealth University 2D 3D TSV
1542094 20 4-substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists.EBI J Med Chem 35: 676-83 (1992) J. Uriach & Cía. S.A. 2D 3D TSV
1542092 38 Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones.EBI J Med Chem 35: 641-62 (1992) Boehringer Ingelheim Pharmaceuticals Inc 2D 3D TSV
1542091 38 A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.EBI J Med Chem 35: 629-35 (1992) Center for Bio-Pharmaceutical Sciences 2D 3D TSV
1535661 24 Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site.EBI J Med Chem 35: 2369-74 (1992) Polish Academy of Sciences 2D 3D TSV
1535660 14 Conformational analysis of dopamine D-2 receptor antagonists of the benzamide series in relation to a recently proposed D-2 receptor-interaction model.EBI J Med Chem 35: 2355-63 (1992) University of Lund 2D 3D TSV
1535377 5 Synthesis and thromboxane A2/prostaglandin H2 receptor antagonistic activity of phenol derivatives.EBI J Med Chem 35: 2202-9 (1992) Takeda Chemical Industries, Ltd 2D 3D TSV
1534585 8 Benzofuran bioisosteres of hallucinogenic tryptamines.EBI J Med Chem 35: 2061-4 (1992) Purdue University 2D 3D TSV
1534584 59 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor.EBI J Med Chem 35: 1954-68 (1992) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1534126 35 Affinity of human growth hormone-releasing factor (1-29)NH2 analogues for GRF binding sites in rat adenopituitary.EBI J Med Chem 35: 1864-9 (1992) Notre-Dame Hospital Research 2D 3D TSV
1534125 1 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site.EBI J Med Chem 35: 1791-9 (1992) Marion Merrell Dow Research Institute 2D 3D TSV
1533424 20 Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.EBI J Med Chem 35: 1466-71 (1992) Research Biochemicals Inc. 2D 3D TSV
1531365 7 A study on the contribution of the 1-phenyl substituent to the molecular electrostatic potentials of some benzazepines in relation to selective dopamine D-1 receptor activity.EBI J Med Chem 35: 502-7 (1992) University of Lund 2D 3D TSV
1531364 42 Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors.EBI J Med Chem 35: 423-30 (1992) University of Pennsylvania 2D 3D TSV
1531075 13 (+/-)-3-allyl-7-halo-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines as selective high affinity D1 dopamine receptor antagonists: synthesis and structure-activity relationship.EBI J Med Chem 35: 67-72 (1992) Northeastern University 2D 3D TSV
1527792 55 Specific inhibition of HIV-1 protease by boronated porphyrins.EBI J Med Chem 35: 3426-8 (1992) University of California 2D 3D TSV
1527791 8 Synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.EBI J Med Chem 35: 3388-93 (1992) British Bio-technology Limited 2D 3D TSV
1527788 4 3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine.EBI J Med Chem 35: 3369-72 (1992) Purdue University 2D 3D TSV
1527787 11 Synthesis and biological activity of ketomethylene pseudopeptide analogues as thrombin inhibitors.EBI J Med Chem 35: 3364-9 (1992) Thrombosis Research Institute 2D 3D TSV
1527785 6 Synthesis and antibronchospastic activity of 8-alkoxy- and 8-(alkylamino)imidazo[1,2-a]pyrazines.EBI J Med Chem 35: 3353-8 (1992) URA CNRS 1111 2D 3D TSV
1527782 8 Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors.EBI J Med Chem 35: 3331-41 (1992) National Research Council of Canada 2D 3D TSV
1517742 9 Inhibition of Angiotensin-I-Converting Enzyme by Tetrahydroxyxanthones Isolated from Tripterospermum lanceolatumEBI J Nat Prod 55: 691-695 (1992) TBA 2D 3D TSV
1513320 26 Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor.BDB Mol Pharmacol 42: 180-5 (1992) Synaptic Pharmaceutical Corporation 2D 3D TSV
1507212 42 Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.EBI J Med Chem 35: 3270-9 (1992) University of Uppsala 2D 3D TSV
1507211 28 Conformationally restrained, chiral (phenylisopropyl)amino-substituted pyrazolo[3,4-d]pyrimidines and purines with selectivity for adenosine A1 and A2 receptors.EBI J Med Chem 35: 3263-9 (1992) Marion Merrell Dow Research Institute 2D 3D TSV
1507209 7 Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles.EBI J Med Chem 35: 3239-46 (1992) Vrije Universiteit 2D 3D TSV
1507204 18 Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity.EBI J Med Chem 35: 3148-55 (1992) DuPont Pharmaceuticals Company 2D 3D TSV
1507203 96 Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.EBI J Med Chem 35: 3141-7 (1992) University of South Carolina 2D 3D TSV
1507200 40 1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives.EBI J Med Chem 35: 3115-29 (1992) Pfizer Inc 2D 3D TSV
1507199 8 Synthesis and pharmacological evaluation of enantiomerically pure 4-deoxy-4-fluoromuscarines.EBI J Med Chem 35: 3102-10 (1992) C.N.R.-Centro Studio Sostanze Organiche Naturali 2D 3D TSV
1507198 11 Mapping the binding site of tissue kallikrein: preparation and testing of all possible substrate analog inhibitors homologous with the sequence of kininogen between Ser386 and Gln392.EBI J Med Chem 35: 3094-102 (1992) University Hospital 2D 3D TSV
1501235 11 Penicillin derived C2-symmetric dimers as novel inhibitors of HIV-1 proteinase.EBI J Med Chem 35: 3080-1 (1992) Glaxo Group Research Limited 2D 3D TSV
1501234 111 Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.EBI J Med Chem 35: 3066-75 (1992) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1501233 7 2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2,3-oxidosqualene cyclase.EBI J Med Chem 35: 3050-8 (1992) Istituto di Chimica Farmaceutica Applicata 2D 3D TSV
1501231 1 PgH2 analogs as potential antiplatelet derivatives.EBI J Med Chem 35: 3033-9 (1992) University of Illinois 2D 3D TSV
1501230 8 Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors.EBI J Med Chem 35: 3027-33 (1992) Merck Research Laboratories 2D 3D TSV
1501226 2 Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).EBI J Med Chem 35: 3002-6 (1992) Southern Research Institute 2D 3D TSV
1501221 18 Design and synthesis of some substrate analogue inhibitors of phospholipase A2 and investigations by NMR and molecular modeling into the binding interactions in the enzyme-inhibitor complex.EBI J Med Chem 35: 2939-51 (1992) Fisons plc 2D 3D TSV
1501220 52 Synthesis and biological activity of CCK heptapeptide analogues. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo.EBI J Med Chem 35: 2919-28 (1992) Abbott Laboratories 2D 3D TSV
1501121 12 Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist.BDB J Pharmacol Exp Ther 262: 759-68 (1992) Sanofi Recherche 2D 3D TSV
1495020 14 Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis.EBI J Med Chem 35: 2912-5 (1992) Pennsylvania State University 2D 3D TSV
1495019 57 Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.EBI J Med Chem 35: 2881-90 (1992) Hokkaido University 2D 3D TSV
1495016 3 2-Substituted 1-azabicycloalkanes, a new class of non-opiate antinociceptive agents.EBI J Med Chem 35: 2855-63 (1992) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
1495014 36 Stereoisomers of ketoconazole: preparation and biological activity.EBI J Med Chem 35: 2818-25 (1992) Syntex Research 2D 3D TSV
1495013 24 N-methylated analogs of Ac[Nle28,31]CCK(26-33): synthesis, activity, and receptor selectivity.EBI J Med Chem 35: 2806-11 (1992) Hadassah-University Hospital 2D 3D TSV
1495010 19 Inhibitors of human renin with C-termini derived from amides and esters of alpha-mercaptoalkanoic acids.EBI J Med Chem 35: 2772-81 (1992) Merck Research Laboratories 2D 3D TSV
1495009 32 Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents.EBI J Med Chem 35: 2761-8 (1992) ICI Pharmaceuticals Group 2D 3D TSV
1479591 8 Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor.EBI J Med Chem 35: 4914-7 (1993) Searle Research & Development 2D 3D TSV
1479590 73 Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding.EBI J Med Chem 35: 4903-10 (1993) Virginia Commonwealth University 2D 3D TSV
1479589 36 5-HT3 receptor antagonists. 1. New quinoline derivatives.EBI J Med Chem 35: 4893-902 (1992) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1479587 4 ATP-citrate lyase as a target for hypolipidemic intervention. Sulfoximine and 3-hydroxy-beta-lactam containing analogues of citric acid as potential tight-binding inhibitors.EBI J Med Chem 35: 4875-84 (1992) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
1479586 8 New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones.EBI J Med Chem 35: 4866-74 (1992) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1479581 11 Inhibition of human leukocyte elastase by N-substituted peptides containing alpha,alpha-difluorostatone residues at P1.EBI J Med Chem 35: 4795-808 (1993) Boehringer Ingelheim Pharmaceuticals Inc 2D 3D TSV
1479580 10 Synthesis and physicochemical properties of sulfamate derivatives as topical antiglaucoma agents.EBI J Med Chem 35: 4790-4 (1992) A.H. Robins Company 2D 3D TSV
1479375 215 Protein-Tyrosine Kinase Inhibition: Mechanism-Based Discovery of Antitumor AgentsEBI J Nat Prod 55: 1529-1560 (1992) TBA 2D 3D TSV
1469704 5 Structure-activity relationship studies of cocaine: replacement of the C-2 ester group by vinyl argues against H-bonding and provides an esterase-resistant, high-affinity cocaine analogue.EBI J Med Chem 35: 4764-6 (1993) Mayo Foundation 2D 3D TSV
1469703 14 Dihydropyrimidine angiotensin II receptor antagonists.EBI J Med Chem 35: 4751-63 (1993) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
1469699 12 Synthesis, configuration, and activity of isomeric 2-phenyl-2-(N-piperidinyl)bicyclo[3.1.0]hexanes at phencyclidine and sigma binding sites.EBI J Med Chem 35: 4704-12 (1993) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
1469697 37 Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites.EBI J Med Chem 35: 4683-9 (1993) National Institute on Drug Abuse 2D 3D TSV
1469694 22 Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors.EBI J Med Chem 35: 4640-2 (1993) Merck Research Laboratories 2D 3D TSV
1469689 9 Dihydroxynitrobenzaldehydes and hydroxymethoxynitrobenzaldehydes: synthesis and biological activity as catechol-O-methyltransferase inhibitors.EBI J Med Chem 35: 4584-8 (1993) Instituto de Química Orgánica General (CSIC) 2D 3D TSV
1469688 31 2-(N'-aralkylidenehydrazino)adenosines: potent and selective coronary vasodilators.EBI J Med Chem 35: 4562-6 (1993) University of South Florida 2D 3D TSV
1469687 42 2-(N'-alkylidenehydrazino)adenosines: potent and selective coronary vasodilators.EBI J Med Chem 35: 4557-61 (1993) University of South Florida 2D 3D TSV
1469686 53 Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives.EBI J Med Chem 35: 4542-8 (1993) Eisai Co., Ltd 2D 3D TSV
1464308 17 The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family.BDB EMBO J 11: 4779-86 (1992) CNRS 2D 3D TSV
1447752 28 Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.EBI J Med Chem 35: 4503-5 (1992) Pfizer Inc 2D 3D TSV
1447744 2 A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase.EBI J Med Chem 35: 4450-4 (1992) Princeton University 2D 3D TSV
1447743 3 Synthesis and biological activity of 4-(diphenylmethyl)-alpha-[(4-quinolinyloxy)methyl]-1-piperazineethanol and related compounds.EBI J Med Chem 35: 4442-9 (1992) Warner-Lambert Company 2D 3D TSV
1447739 43 Acyl-CoA:cholesterol O-acyl transferase (ACAT) inhibitors. 1. 2-(Alkylthio)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.EBI J Med Chem 35: 4384-92 (1992) Rhone-Poulenc Rorer 2D 3D TSV
1447738 26 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-(3-(3-pyridinyl) propyl)octanoic acid and analogs.EBI J Med Chem 35: 4373-83 (1992) Ciba-Geigy Corporation 2D 3D TSV
1447737 7 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 3. Pyridinylalkyl-substituted 8-[(arylsulfonyl)amino]octanoic acids.EBI J Med Chem 35: 4366-72 (1992) Ciba-Geigy Corporation 2D 3D TSV
1447736 17 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 2. Synthesis and biological activity of 8-(benzenesulfonamido)-7-(3-pyridinyl)octaonic acid and related compounds.EBI J Med Chem 35: 4362-5 (1992) Ciba-Geigy Corporation 2D 3D TSV
1447735 17 Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes.EBI J Med Chem 35: 4334-43 (1992) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
1447734 29 Effect of conformational mobility and hydrogen-bonding interactions on the selectivity of some guanidinoaryl-substituted mechanism-based inhibitors of trypsin-like serine proteases.EBI J Med Chem 35: 4297-305 (1992) University of Illinois 2D 3D TSV
1433225 18 Analogs of CCK incorporating conformationally constrained replacements for Asp32.EBI J Med Chem 35: 4249-52 (1992) Roche Research Center 2D 3D TSV
1433224 1 Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.EBI J Med Chem 35: 4238-48 (1992) Warner-Lambert Company 2D 3D TSV
1433220 12 Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.EBI J Med Chem 35: 4180-4 (1992) University of Rhode Island 2D 3D TSV
1433219 9 Synthesis of novel MPTP analogs as potential monoamine oxidase B (MAO-B) inhibitors.EBI J Med Chem 35: 4165-74 (1992) Virginia Polytechnic Institute and State University 2D 3D TSV
1433218 3 Guanidinophenyl-substituted enol lactones as selective, mechanism-based inhibitors of trypsin-like serine proteases.EBI J Med Chem 35: 4150-9 (1992) University of Illinois 2D 3D TSV
1433217 31 Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.EBI J Med Chem 35: 4143-9 (1992) National Institute of Diabetes 2D 3D TSV
1433215 88 (Pyridylcyanomethyl)piperazines as orally active PAF antagonists.EBI J Med Chem 35: 4118-34 (1992) J. Uriach & C£a.S.A. 2D 3D TSV
1433214 7 Inhibition of hog liver folylpolyglutamate synthetase by 5-substituted 5,8-dideaza analogues of folic acid bearing a terminal L-ornithine residue.EBI J Med Chem 35: 4078-85 (1992) Medical University of South Carolina 2D 3D TSV
1433212 59 Synthesis, chemical, and biological properties of vinylogous hydroxamic acids: dual inhibitors of 5-lipoxygenase and IL-1 biosynthesis.EBI J Med Chem 35: 4061-8 (1992) DuPont Pharmaceuticals Company 2D 3D TSV
1433210 35 New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)quinoline derivatives.EBI J Med Chem 35: 4027-38 (1992) ICI Pharmaceuticals Group 2D 3D TSV
1433209 58 Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore.EBI J Med Chem 35: 4011-9 (1992) Eli Lilly and Company 2D 3D TSV
1433207 22 6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists.EBI J Med Chem 35: 3984-90 (1992) University of Göteborg 2D 3D TSV
1433205 8 4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121).EBI J Med Chem 35: 3973-6 (1992) Merck Research Laboratories 2D 3D TSV
1433204 10 Design and synthesis of a C7 mimetic for the predicted gamma-turn conformation found in several constrained RGD antagonists.EBI J Med Chem 35: 3970-2 (1992) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
1433203 20 Investigation of conformational specificity at GPIIb/IIIa: evaluation of conformationally constrained RGD peptides.EBI J Med Chem 35: 3962-9 (1992) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
1433199 12 Stabilization of the N-terminal residues of luteinizing hormone-releasing hormone agonists and the effect on pharmacokinetics.EBI J Med Chem 35: 3890-4 (1992) Abbott Laboratories 2D 3D TSV
1433195 55 Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.EBI J Med Chem 35: 3858-72 (1992) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
1433194 12 4-substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors.EBI J Med Chem 35: 3822-31 (1992) Merck Research Laboratories 2D 3D TSV
1433193 7 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs.EBI J Med Chem 35: 3813-21 (1992) Merck Research Laboratories 2D 3D TSV
1433192 27 New hydroxyethylamine HIV protease inhibitors that suppress viral replication.EBI J Med Chem 35: 3803-12 (1992) University of Wisconsin-Madison 2D 3D TSV
1433191 25 Analogs of Ac-CCK-7 incorporating dipeptide mimics in place of Met28-Gly29.EBI J Med Chem 35: 3774-83 (1992) Roche Research Center 2D 3D TSV
1433190 43 Highly potent, orally active diester macrocyclic human renin inhibitors.EBI J Med Chem 35: 3755-73 (1992) Merck Research Laboratories 2D 3D TSV
1433188 7 Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol.EBI J Med Chem 35: 3731-44 (1992) Merck Research Laboratories 2D 3D TSV
1433184 7 Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.EBI J Med Chem 35: 3714-7 (1992) Abbott Laboratories 2D 3D TSV
1433183 32 Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors.EBI J Med Chem 35: 3705-13 (1992) University of Saskatchewan 2D 3D TSV
1433182 11 Conformational analysis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide) and discovery of potent 5-alkyl derivatives.EBI J Med Chem 35: 3699-704 (1992) Institute of Cancer Research 2D 3D TSV
1433181 39 Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.EBI J Med Chem 35: 3691-8 (1992) Warner-Lambert Company 2D 3D TSV
1433179 13 5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities.EBI J Med Chem 35: 3678-85 (1992) Duquesne University 2D 3D TSV
1433176 26 Truncated, branched, and/or cyclic analogues of neuropeptide Y: importance of the pancreatic peptide fold in the design of specific Y2 receptor ligands.EBI J Med Chem 35: 3653-9 (1992) Salk Institute 2D 3D TSV
1433175 2 Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase.EBI J Med Chem 35: 3648-52 (1992) University of Minnesota 2D 3D TSV
1433172 30 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.EBI J Med Chem 35: 3625-32 (1992) Pfizer Inc 2D 3D TSV
1431946 28 Displacement Activity of Bisbenzylisoquinoline Alkaloids at Striatal 3H-SCH 23390 and 3H-Raclopride Binding SitesEBI J Nat Prod 55: 1281-1286 (1992) TBA 2D 3D TSV
1431940 6 Brominated polyacetylenic acids from the marine sponge Xestospongia muta: inhibitors of HIV protease.EBI J Nat Prod 55: 1170-7 (1992) SmithKline Beecham Pharmaceuticals 2D 3D TSV
1404239 8 N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase.EBI J Med Chem 35: 3581-3 (1992) Marion Merrell Dow Research Institute 2D 3D TSV
1404238 14 7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.EBI J Med Chem 35: 3578-81 (1992) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1404233 68 Renin inhibitors containing new P1-P1' dipeptide mimetics with heterocycles in P1'.EBI J Med Chem 35: 3525-36 (1992) E. Merck Darmstadt 2D 3D TSV
1404229 15 Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.EBI J Med Chem 35: 3474-82 (1992) Merck Research Laboratories 2D 3D TSV
1397049 24 NNC-112, NNC-687 and NNC-756, new selective and highly potent dopamine D1 receptor antagonists.BDB Eur J Pharmacol 219: 45-52 (1992) Novo Nordisk 2D 3D TSV
1390689 13 Inhibition of protein kinase C by cationic amphiphiles.BDB Biochemistry 31: 9025-30 (1992) McMaster University 2D 3D TSV
1388208 45 Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 2.EBI J Med Chem 35: 3402-13 (1992) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1388207 72 Non-prostanoid thromboxane A2 receptor antagonists with a dibenzoxepin ring system. 1.EBI J Med Chem 35: 3394-402 (1992) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1382133 18 Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones.EBI J Med Chem 35: 3319-24 (1992) Eli Lilly and Company 2D 3D TSV
1378901 18 The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisst.EBI J Med Chem 35: 2591-600 (1992) Pfizer Inc 2D 3D TSV
1377748 16 Synthesis of 3-[(2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl)alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators.EBI J Med Chem 35: 2407-14 (1992) Alter, S.A. 2D 3D TSV
1375965 47 Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists.EBI J Med Chem 35: 2015-25 (1992) Fujisawa Pharmaceutical Co., Ltd 2D 3D TSV
1375964 112 Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N epsilon)-amide residues.EBI J Med Chem 35: 2007-14 (1992) Abbott Laboratories 2D 3D TSV
1375963 4 Synthesis and biological evaluation of N alpha-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine.EBI J Med Chem 35: 2002-6 (1992) Medical University of South Carolina 2D 3D TSV
1375962 9 New thymidine triphosphate analogue inhibitors of human immunodeficiency virus-1 reverse transcriptase.EBI J Med Chem 35: 1938-41 (1992) University of California 2D 3D TSV
1375626 5 Anti-aids agents, 6. Salaspermic acid, an anti-HIV principle from Tripterygium wilfordii, and the structure-activity correlation with its related compounds.EBI J Nat Prod 55: 340-6 (1992) University of North Carolina 2D 3D TSV
1375293 42 Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones.BDB J Med Chem 35: 1887-97 (1992) Boehringer Ingelheim Pharmaceuticals Inc 2D 3D TSV
1373191 15 Synthesis and substance P antagonist activity of naphthimidazolium derivatives.EBI J Med Chem 35: 1273-9 (1992) Rochester 2D 3D TSV
1372359 3 Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents.EBI J Med Chem 35: 958-65 (1992) Warner-Lambert Company 2D 3D TSV
1372358 18 Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.EBI J Med Chem 35: 859-66 (1992) Institute of Cancer Research 2D 3D TSV
1370696 6 Structure-activity relationships associated with 3,4,5-triphenyl-1H-pyrazole-1-nonanoic acid, a nonprostanoid prostacyclin mimetic.EBI J Med Chem 35: 389-97 (1992) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
1370695 27 Synthesis and substance P receptor binding activity of androstano[3,2-b]pyrimido[1,2-a]benzimidazoles.EBI J Med Chem 35: 374-8 (1992) Rochester 2D 3D TSV
1362243 4 Molecular cloning and expression of a pituitary somatostatin receptor with preferential affinity for somatostatin-28.BDB Mol Pharmacol 42: 939-46 (1992) National Institute of Mental Health 2D 3D TSV
1361581 11 Computer-aided mapping of the beta-adrenoceptor. 1. Explanation for effect of para substitution on blocking activity at the beta-1-adrenoceptor.EBI J Med Chem 35: 4676-82 (1993) University of Melbourne 2D 3D TSV
1361580 25 N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors.EBI J Med Chem 35: 4638-9 (1993) Oregon State University 2D 3D TSV
1361578 99 Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.EBI J Med Chem 35: 4516-25 (1993) Bristol-Myers Squibb Co. 2D 3D TSV
1360027 16 Synthesis and pharmacological characterization of 2-(4-chloro-3-hydroxyphenyl)ethylamine and N,N-dialkyl derivatives as dopamine receptor ligands.EBI J Med Chem 35: 4408-14 (1992) University of Camerino 2D 3D TSV
1360026 350 Novel piperidine sigma receptor ligands as potential antipsychotic drugs.EBI J Med Chem 35: 4344-61 (1992) DuPont Pharmaceuticals Company 2D 3D TSV
1360025 27 Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity.EBI J Med Chem 35: 4330-3 (1992) Oregon State University 2D 3D TSV
1359142 40 Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1-pyridylalkyl)indoles. A novel conformational model to explain structure-activity relationships.EBI J Med Chem 35: 4020-6 (1992) E. Merck Darmstadt 2D 3D TSV
1359141 47 Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.EBI J Med Chem 35: 3845-57 (1992) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1356154 26 Characterization of [3H]quinpirole binding to D2-like dopamine receptors in rat brain.BDB J Pharmacol Exp Ther 262: 929-35 (1992) DuPont Pharmaceuticals Company 2D 3D TSV
1354264 19 Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.EBI J Med Chem 35: 3081-4 (1992) American Cyanamid Company 2D 3D TSV
1354263 9 Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine.EBI J Med Chem 35: 3045-9 (1992) Universit£ di Bari 2D 3D TSV
1353796 17 Synthesis and antihistaminic activity of some thiazolidin-4-ones.EBI J Med Chem 35: 2910-2 (1992) Universit£ di Napoli Federico II 2D 3D TSV
1353247 71 Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning.BDB Mol Pharmacol 42: 1-5 (1992) University of Nebraska 2D 3D TSV
1353116 10 3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.EBI J Med Chem 35: 2712-5 (1992) Hoechst-Roussel Pharmaceuticals Inc 2D 3D TSV
1352553 38 Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist.BDB J Pharmacol Exp Ther 262: 383-93 (1992) University of North Carolina 2D 3D TSV
1352351 32 Synthesis and antiulcer activity of N-substituted N'-[3-[3-(piperidinomethyl)phenoxy]propyl]ureas: histamine H2-receptor antagonists with a potent mucosal protective activity.EBI J Med Chem 35: 2446-51 (1992) Kyorin Pharmaceutical Company Ltd 2D 3D TSV
1350797 21 Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives.EBI J Med Chem 35: 2074-84 (1992) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
1348542 23 Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.EBI J Med Chem 35: 1259-66 (1992) University of Paris 2D 3D TSV
1348090 64 Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.EBI J Med Chem 35: 1092-101 (1992) H. Lundbeck A/S 2D 3D TSV
1348089 71 Dopaminergic and serotonergic activities of imidazoquinolinones and related compounds.EBI J Med Chem 35: 1076-92 (1992) Upjohn Laboratories 2D 3D TSV
1347791 35 Analgesic dipeptide derivatives. 7. 3,7-Diamino-2-hydroxyheptanoic acid (DAHHA) containing dipeptide analogues of the analgesic compound H-Lys-Trp(Nps)-OMe.EBI J Med Chem 35: 889-95 (1992) Instituto de Qu£mica M£dica 2D 3D TSV
1347569 52 Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors.BDB J Pharmacol Exp Ther 260: 1361-5 (1992) Stanford University 2D 3D TSV
1347319 15 Synthesis and alpha-adrenergic activities of 2- and 4-substituted imidazoline and imidazole analogues.EBI J Med Chem 35: 750-5 (1992) Ohio State University 2D 3D TSV
1347318 52 Synthesis, cardiac electrophysiology, and beta-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents.EBI J Med Chem 35: 743-50 (1992) Berlex Laboratories 2D 3D TSV
1346653 168 Pyrrole mannich bases as potential antipsychotic agents.EBI J Med Chem 35: 552-8 (1992) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
1346651 29 Synthesis of halogenated trimetoquinol derivatives and evaluation of their beta-agonist and thromboxane A2 (TXA2) antagonist activities.EBI J Med Chem 35: 466-79 (1992) Ohio State University 2D 3D TSV
1346637 120 Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells.BDB J Pharmacol Exp Ther 260: 576-80 (1992) Mayo Clinic 2D 3D TSV
1346276 25 Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide.EBI J Med Chem 35: 223-33 (1992) G.D. Searle and Co. 2D 3D TSV
1336055 22 Novel cAMP PDE III inhibitors: 1,6-naphthyridin-2(1H)-ones.EBI J Med Chem 35: 4858-65 (1992) Sterling Winthrop Pharmaceuticals Research Division 2D 3D TSV
1336054 63 Selective, centrally acting serotonin 5-HT2 antagonists. 2. Substituted 3-(4-fluorophenyl)-1H-indoles.EBI J Med Chem 35: 4823-31 (1993) H. Lundbeck A/S 2D 3D TSV
1336053 86 Selective, centrally acting serotonin 5-HT2 antagonists. 1. 2- and 6-substituted 1-phenyl-3-(4-piperidinyl)-1H-indoles.EBI J Med Chem 35: 4813-22 (1993) H. Lundbeck A/S 2D 3D TSV
1335080 20 Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.EBI J Med Chem 35: 4651-7 (1993) University of Ferrara 2D 3D TSV
1335078 76 O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay.EBI J Med Chem 35: 4589-94 (1993) University of Washington 2D 3D TSV
1333014 12 Incorporation of a novel conformationally restricted tyrosine analog into a cyclic, delta opioid receptor selective tetrapeptide (JOM-13) enhances delta receptor binding affinity and selectivity.EBI J Med Chem 35: 4498-500 (1992) University of Michigan 2D 3D TSV
1333013 29 Opioid agonist and antagonist activities of morphindoles related to naltrindole.EBI J Med Chem 35: 4325-9 (1992) University of Minnesota 2D 3D TSV
1333012 106 omega-[(4,6-Diphenyl-2-pyridyl)oxy]alkanoic acid derivatives: a new family of potent and orally active LTB4 antagonists.EBI J Med Chem 35: 4315-24 (1992) Centre de Recherche de Vitry-Alfortville 2D 3D TSV
1333011 29 omega-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists.EBI J Med Chem 35: 4306-14 (1992) Centre de Recherche de Vitry-Alfortville 2D 3D TSV
1331462 9 4-[2-[Methyl(2-phenethyl)amino]-2-oxoethyl]-8-(phenylmethoxy)-2- naphthalenecarboxylic acid: a high affinity, competitive, orally active leukotriene B4 receptor antagonist.EBI J Med Chem 35: 4253-5 (1992) Rhone-Poulenc Rorer Central Research 2D 3D TSV
1331461 1 L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth.EBI J Med Chem 35: 4214-20 (1992) Istituto di Genetica Biochimica ed Evoluzionistica 2D 3D TSV
1331460 54 Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.EBI J Med Chem 35: 4195-204 (1992) Glaxo Group Research 2D 3D TSV
1331459 1 The first mechanism-based inactivators for angiotensin-converting enzyme.EBI J Med Chem 35: 4175-9 (1992) Baxter Diagnostics Inc. 2D 3D TSV
1331456 3 Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists.EBI J Med Chem 35: 4092-7 (1992) Centre de Neurochimie du CNRS 2D 3D TSV
1331455 9 Delta opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives of naltrindole: evidence for delta receptor subtypes.EBI J Med Chem 35: 4086-91 (1992) University of Minnesota 2D 3D TSV
1331453 106 Effects of alkyl substitutions of xanthine skeleton on bronchodilation.EBI J Med Chem 35: 4039-44 (1992) Hokuriku University 2D 3D TSV
1331451 68 Conformationally restricted deltorphin analogues.EBI J Med Chem 35: 3956-61 (1992) Clinical Research Institute of Montreal 2D 3D TSV
1331450 21 A new class of high affinity ligands for the neurokinin A NK2 receptor: psi (CH2NR) reduced peptide bond analogues of neurokinin A4-10.EBI J Med Chem 35: 3949-55 (1992) Marion Merrell Dow Research Institute 2D 3D TSV
1331449 268 Orally active, nonpeptide oxytocin antagonists.EBI J Med Chem 35: 3919-27 (1992) Merck Research Laboratories 2D 3D TSV
1331448 101 Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product.EBI J Med Chem 35: 3905-18 (1992) Merck Research Laboratories 2D 3D TSV
1331447 32 Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionicEBI J Med Chem 35: 3832-44 (1992) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
1328199 8 Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.BDB J Biol Chem 267: 20422-8 (1992) University of Chicago 2D 3D TSV
1327769 12 Antagonistic properties are shifted back to agonistic properties by further N-terminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes.BDB Eur J Biochem 208: 815-9 (1992) Université Libre de Bruxelles 2D 3D TSV
1326635 11 3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex.EBI J Med Chem 35: 3423-5 (1992) Eli Lilly and Company 2D 3D TSV
1326634 38 Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-substituted-4-(phenylamino)quinolines.EBI J Med Chem 35: 3413-22 (1992) SmithKline Beecham Pharmaceuticals R&D 2D 3D TSV
1325033 19 Receptor occupancy and adenylate cyclase activation in AR 4-2J rat pancreatic acinar cell membranes by analogs of pituitary adenylate cyclase-activating peptides amino-terminally shortened or modified at position 1, 2, 3, 20, or 21.BDB Mol Pharmacol 42: 347-55 (1992) Universit´ Libre de Bruxelles 2D 3D TSV
1324981 3 A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase IEBI J Nat Prod 55: 401-413 (1992) TBA 2D 3D TSV
1324321 20 Design of a functional hexapeptide antagonist of endothelin.EBI J Med Chem 35: 3301-3 (1992) Warner-Lambert Company 2D 3D TSV
1324317 21 Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.EBI J Med Chem 35: 3180-3 (1992) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
1324316 22 Omega-[(omega-arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists.EBI J Med Chem 35: 3170-9 (1992) Centre de Recherche de Vitry-Alfortville 2D 3D TSV
1323682 61 Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.EBI J Med Chem 35: 3058-66 (1992) Upjohn Company 2D 3D TSV
1323680 71 Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.EBI J Med Chem 35: 2979-83 (1992) University of Massachusetts Medical School 2D 3D TSV
1323679 21 Substituted 1-(aminomethyl)-2-(arylacetyl)-1,2,3,4-tetrahydroisoquinolines: a novel class of very potent antinociceptive agents with varying degrees of selectivity for kappa and mu opioid receptors.EBI J Med Chem 35: 2970-8 (1992) Zambeletti Research Laboratories 2D 3D TSV
1323677 18 Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.EBI J Med Chem 35: 2928-38 (1992) G.D. Searle and Co. 2D 3D TSV
1322988 60 Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodoEBI J Med Chem 35: 2826-35 (1992) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
1322987 34 Enantiomeric N-substituted N-normetazocines: a comparative study of affinities at sigma, PCP, and mu opioid receptors.EBI J Med Chem 35: 2812-8 (1992) Research Triangle Institute 2D 3D TSV
1322986 13 Inhibition of collagenase by aranciamycin and aranciamycin derivatives.EBI J Med Chem 35: 2768-71 (1992) Technical University of Denmark 2D 3D TSV
1321911 59 Inhibitors of blood platelet cAMP phosphodiesterase. 3. 1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives with enhanced aqueous solubility.EBI J Med Chem 35: 2688-96 (1992) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
1321910 237 Inhibitors of blood platelet cAMP phosphodiesterase. 2. Structure-activity relationships associated with 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones substituted with functionalized side chains.EBI J Med Chem 35: 2672-87 (1992) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
1321909 8 Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives.EBI J Med Chem 35: 2652-8 (1992) ICI Pharmaceuticals Group 2D 3D TSV
1321908 44 Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.EBI J Med Chem 35: 2600-9 (1992) ICI Pharmaceuticals Group 2D 3D TSV
1321744 14 Multiple histamine receptors: properties and functional characteristics.BDB Biochem Soc Trans 20: 122-5 (1992) Queen's Medical Centre 2D 3D TSV
1321043 17 Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist.BDB Eur J Biochem 207: 239-46 (1992) Université Libre de Bruxelles 2D 3D TSV
1320692 19 Comparison of antagonist and agonist binding to the leukotriene B4 receptor intact human polymorphonuclear neutrophils (PMN).BDB J Pharmacol Exp Ther 262: 80-9 (1992) Ciba-Geigy Corporation 2D 3D TSV
1320204 1 Characterization of a novel 5-HT4 receptor antagonist of the azabicycloalkyl benzimidazolone class: DAU 6285.BDB Naunyn Schmiedebergs Arch Pharmacol 345: 264-9 (1992) Centre de pharmacologie-endocrinologie (Montpellier, France) 2D 3D TSV
1320122 55 Ring substituted and other conformationally constrained tyrosine analogues of [D-Pen2,D-Pen5]enkephalin with delta opioid receptor selectivity.EBI J Med Chem 35: 2384-91 (1992) University of Arizona 2D 3D TSV
1320121 48 Electrophilic opioid ligands. Oxygen tethered alpha-methylene-gamma-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6 beta-naltrexol.EBI J Med Chem 35: 2374-84 (1992) University of Washington 2D 3D TSV
1319495 21 Selective reversible and irreversible ligands for the kappa opioid receptor.EBI J Med Chem 35: 2243-7 (1992) National Taiwan University 2D 3D TSV
1319493 31 Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.EBI J Med Chem 35: 2221-30 (1992) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
1319490 27 Structure-activity study of hCGRP8-37, a calcitonin gene-related peptide receptor antagonist.EBI J Med Chem 35: 2163-8 (1992) Université du Québec 2D 3D TSV
1317926 9 Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications.EBI J Med Chem 35: 2139-42 (1992) TBA 2D 3D TSV
1317925 6 A novel probe for the cannabinoid receptor.EBI J Med Chem 35: 2065-9 (1992) Hebrew University 2D 3D TSV
1317924 28 Synthesis and structure-activity relationships of a series of novel benzopyran-containing platelet activating factor antagonists.EBI J Med Chem 35: 2055-61 (1992) Abbott Laboratories 2D 3D TSV
1317923 48 Spiropiperidines as high-affinity, selective sigma ligands.EBI J Med Chem 35: 2033-9 (1992) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1317922 48 Benz[f]isoquinoline analogues as high-affinity sigma ligands.EBI J Med Chem 35: 2025-33 (1992) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1317407 7 Akuammine and Dihydroakuammine, Two Indolomonoterpene Alkaloids Displaying Affinity for Opioid ReceptorsEBI J Nat Prod 55: 380-384 (1992) TBA 2D 3D TSV
1316968 21 Reversible inhibitors of the gastric (H+/K+)-ATPase. 2. 1-Arylpyrrolo[3,2-c]quinolines: effect of the 4-substituent.EBI J Med Chem 35: 1845-52 (1992) SmithKline Beecham Pharmaceuticals R&D 2D 3D TSV
1315870 39 Substitution on the Phe3 aromatic ring in cyclic delta opioid receptor-selective dermorphin/deltorphin tetrapeptide analogues: electronic and lipophilic requirements for receptor affinity.EBI J Med Chem 35: 1535-41 (1992) University of Michigan 2D 3D TSV
1315869 231 (Aminoalkoxy)chromones. Selective sigma receptor ligands.EBI J Med Chem 35: 1526-35 (1992) Nova Pharmaceutical Corporation 2D 3D TSV
1315868 44 Phenylmorphans and analogues: opioid receptor subtype selectivity and effect of conformation on activity.EBI J Med Chem 35: 1521-5 (1992) Harvard Medical School 2D 3D TSV
1315867 31 Endothelin: a new challenge.EBI J Med Chem 35: 1493-508 (1992) Warner-Lambert Company 2D 3D TSV
1315531 17 Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.BDB Biochem Biophys Res Commun 184: 752-9 (1992) Veterans Affairs Medical Center 2D 3D TSV
1315395 18 Novel naphthalenic ligands with high affinity for the melatonin receptor.EBI J Med Chem 35: 1484-6 (1992) Universite de Lille 2D 3D TSV
1313879 21 Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.EBI J Med Chem 35: 1299-318 (1992) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
1313878 36 Stereospecificity of amino acid side chains in deltorphin defines binding to opioid receptors.EBI J Med Chem 35: 1222-7 (1992) National Institute of Environmental Health Sciences 2D 3D TSV
1313110 26 (H+,K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate.EBI J Med Chem 35: 1049-57 (1992) Byk Gulden Pharmaceuticals 2D 3D TSV
1313109 40 Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.EBI J Med Chem 35: 1009-18 (1992) Universit£ di Pisa 2D 3D TSV
1312602 18 Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.EBI J Med Chem 35: 895-903 (1992) Rh£ne-Poulenc Rorer Central Research 2D 3D TSV
1312599 28 Novel inhibitors of prolyl 4-hydroxylase. 2. 5-Amide substituted pyridine-2-carboxylic acids.EBI J Med Chem 35: 804-7 (1992) ICI Pharmaceuticals Group 2D 3D TSV
1312598 18 Novel inhibitors of prolyl 4-hydroxylase.EBI J Med Chem 35: 800-4 (1992) ICI Pharmaceuticals Group 2D 3D TSV
1311765 38 Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site.EBI J Med Chem 35: 780-93 (1992) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
1311764 4 Systemic analgesic activity and delta-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin.EBI J Med Chem 35: 684-7 (1992) Searle Research and Development 2D 3D TSV
1311763 14 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase.EBI J Med Chem 35: 620-8 (1992) Syntex Research 2D 3D TSV
1310743 38 New kappa-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus.EBI J Med Chem 35: 490-501 (1992) Glaxo Group Research Ltd. 2D 3D TSV
1310742 12 2-[(2-pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K(+)-ATPase inhibitors.EBI J Med Chem 35: 438-50 (1992) Hoechst AG 2D 3D TSV
1310135 23 Pharmacological characterization of a novel muscarinic partial agonist, YM796, in transfected cells expressing the m1 or m2 muscarinic receptor gene.BDB Life Sci 50: 355-63 (1992) University of Arizona 2D 3D TSV
1310120 33 Structure-function studies of peptides inhibiting the ribonucleotide reductase activity of herpes simplex virus type I.EBI J Med Chem 35: 346-50 (1992) Notre-Dame Hospital Research 2D 3D TSV
1310118 32 Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding.EBI J Med Chem 35: 252-8 (1992) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
1310117 12 Beta-proline analogues as agonists at the strychnine-sensitive glycine receptor.EBI J Med Chem 35: 233-41 (1992) Warner-Lambert Company 2D 3D TSV
1310116 8 Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials.EBI J Med Chem 35: 94-9 (1992) Kanebo Ltd. 2D 3D TSV
1310115 11 Synthesis, antinociceptive activity, and opioid receptor profiles of substituted trans-3-(decahydro- and octahydro-4a-isoquinolinyl)phenols.EBI J Med Chem 35: 48-56 (1992) Glaxo Group Research Ltd. 2D 3D TSV
1310114 30 Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor.EBI J Med Chem 35: 38-47 (1992) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
1294695 3 Scoparic acid A, a beta-glucuronidase inhibitor from Scoparia dulcis.EBI J Nat Prod 55: 1748-55 (1992) Toyama Medical and Pharmaceutical University 2D 3D TSV
1294693 5 Phospholipase A2 inhibitors from marine organisms.EBI J Nat Prod 55: 1701-17 (1992) University of California-San Diego 2D 3D TSV
1282570 6 Discovery of a potent substance P antagonist: recognition of the key molecular determinant.EBI J Med Chem 35: 4911-3 (1993) Pfizer Inc 2D 3D TSV
1282569 54 Potential anti-AIDS naphthalenesulfonic acid derivatives. Synthesis and inhibition of HIV-1 induced cytopathogenesis and HIV-1 and HIV-2 reverse transcriptase activities.EBI J Med Chem 35: 4846-53 (1992) University of Illinois at Chicago 2D 3D TSV
1280300 7 Gonadotropin-releasing hormone antagonists with N omega-triazolylornithine, -lysine, or -p-aminophenylalanine residues at positions 5 and 6.EBI J Med Chem 35: 4270-8 (1992) Salk Institute 2D 3D TSV
1279173 72 Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one.BDB J Med Chem 35: 3792-802 (1992) Merck Research Laboratories 2D 3D TSV
1279172 22 Synthesis and evaluation of 2-pyridinone derivatives as HIV-1 specific reverse transcriptase inhibitors. 1. Phthalimidoalkyl and -alkylamino analogues.BDB J Med Chem 35: 3784-91 (1992) Merck Research Laboratories 2D 3D TSV
1271416 10 Conformationally rigid amphetamine analogs as inhibitors of monoamine uptake by brain synaptosomes.EBI J Med Chem 19: 725-7 (1976) TBA 2D 3D TSV
1271404 55 Novel bis(benzamidino) compounds with an aromatic central link. Inhibitors of thrombin, pancreatic kallikrein, trypsin, and complement.EBI J Med Chem 19: 634-9 (1976) TBA 2D 3D TSV

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