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| PMID | Data | Article Title | Citation | Organization | Data Download |
|---|---|---|---|---|---|
| 11997326 | 7 | Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT. |
Am J Physiol Renal Physiol 282: 1097-102 (2002) | Albert Einstein College of Medicine | 2D 3D TSV |
| 11992791 | 53 | Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides. |
Bioorg Med Chem Lett 12: 1429-33 (2002) | Guilford Pharmaceuticals Inc | 2D 3D TSV |
| 11992790 | 40 | Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors. |
Bioorg Med Chem Lett 12: 1421-8 (2002) | Guilford Pharmaceuticals Inc | 2D 3D TSV |
| 11992789 | 2 | Aromatic farnesyl diphosphate analogues: vinyl triflate-mediated synthesis and preliminary enzymatic evaluation. |
Bioorg Med Chem Lett 12: 1417-20 (2002) | Wayne State University | 2D 3D TSV |
| 11992787 | 37 | Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives. |
Bioorg Med Chem Lett 12: 1405-11 (2002) | GlaxoSmithKline | 2D 3D TSV |
| 11992786 | 42 | Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives. |
Bioorg Med Chem Lett 12: 1399-404 (2002) | GlaxoSmithKline | 2D 3D TSV |
| 11992783 | 78 | Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors. |
Bioorg Med Chem Lett 12: 1387-90 (2002) | Pfizer Inc | 2D 3D TSV |
| 11992782 | 6 | Syntheses and bioactivities of novel carbamates combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI). |
Bioorg Med Chem Lett 12: 1383-6 (2002) | Nikken Chemicals Co., Ltd. | 2D 3D TSV |
| 11992781 | 31 | Synthesis of highly potent and selective hetaryl ureas as integrin alpha(V)beta3-receptor antagonists. |
Bioorg Med Chem Lett 12: 1379-82 (2002) | BASF AG | 2D 3D TSV |
| 11992780 | 1 | Shikonin derivatives: synthesis and inhibition of human telomerase. |
Bioorg Med Chem Lett 12: 1375-8 (2002) | Chinese Academy of Science | 2D 3D TSV |
| 11992778 | 26 | Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain. |
Bioorg Med Chem Lett 12: 1365-9 (2002) | Roche Products Limited | 2D 3D TSV |
| 11992777 | 46 | Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck). |
Bioorg Med Chem Lett 12: 1361-4 (2002) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11992776 | 70 | Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists. |
Bioorg Med Chem Lett 12: 1357-60 (2002) | GlaxoSmithKline | 2D 3D TSV |
| 11992773 | 10 | Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). |
Bioorg Med Chem Lett 12: 1343-6 (2002) | Kingston University | 2D 3D TSV |
| 11992772 | 34 | A novel type of nonsteroidal estrone sulfatase inhibitors. |
Bioorg Med Chem Lett 12: 1339-42 (2002) | Hans-Kn�ll Institute of Natural Products Research | 2D 3D TSV |
| 11992771 | 19 | Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors. |
Bioorg Med Chem Lett 12: 1335-8 (2002) | Abbott GmbH & Co. KG | 2D 3D TSV |
| 11992770 | 19 | Structure-based optimisation of 2-aminobenzylstatine derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome. |
Bioorg Med Chem Lett 12: 1331-4 (2002) | Novartis Pharma Inc. | 2D 3D TSV |
| 11992769 | 93 | Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands. |
Bioorg Med Chem Lett 12: 1327-30 (2002) | Institute of Science and Technology | 2D 3D TSV |
| 11985477 | 20 | Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors. |
J Med Chem 45: 2101-11 (2002) | NPS Allelix Corporation | 2D 3D TSV |
| 11985476 | 35 | Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists. |
J Med Chem 45: 2090-100 (2002) | National Institute of Diabetes | 2D 3D TSV |
| 11985472 | 185 | Structure-activity relationships of a novel class of endothelin-A receptor antagonists and discovery of potent and selective receptor antagonist, 2-(benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3-carboxylic acid (S-1255). 1. Study on structure-activity relationships and bas |
J Med Chem 45: 2041-55 (2002) | Shionogi & Co., Ltd | 2D 3D TSV |
| 11985469 | 22 | Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease. |
J Med Chem 45: 2016-23 (2002) | Pfizer Inc | 2D 3D TSV |
| 11985468 | 21 | Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents. |
J Med Chem 45: 2003-15 (2002) | Washington University | 2D 3D TSV |
| 11985465 | 22 | Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B. |
J Med Chem 45: 1971-82 (2002) | Carlsberg Laboratory | 2D 3D TSV |
| 11985463 | 12 | Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. |
J Med Chem 45: 1963-6 (2002) | GlaxoSmithKline | 2D 3D TSV |
| 11985462 | 3 | Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. |
J Med Chem 45: 1959-62 (2002) | TBA | 2D 3D TSV |
| 11983514 | 17 | Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. |
Bioorg Med Chem 10: 2177-84 (2002) | Universidad de Navarra | 2D 3D TSV |
| 11983334 | 6 | Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site. |
Chem Biol 9: 455-63 (2002) | Wayne State University | 2D 3D TSV |
| 11975521 | 2 | Haploscleridamine, a novel tryptamine-derived alkaloid from a sponge of the order haplosclerida: an inhibitor of cathepsin K. |
J Nat Prod 65: 628-9 (2002) | Millennium Pharmaceuticals Inc | 2D 3D TSV |
| 11975520 | 3 | A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K. |
J Nat Prod 65: 624-7 (2002) | Millennium Pharmaceuticals Inc | 2D 3D TSV |
| 11975517 | 3 | Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma. |
J Nat Prod 65: 616-7 (2002) | Korea Research Institute of Bioscience and Biotechnology | 2D 3D TSV |
| 11975488 | 2 | Synthesis and structure-activity relationship study of lamellarin derivatives. |
J Nat Prod 65: 500-4 (2002) | Nagasaki University | 2D 3D TSV |
| 11975483 | 10 | New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea. |
J Nat Prod 65: 476-80 (2002) | The University of Mississippi | 2D 3D TSV |
| 11975475 | 1 | Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety. |
J Nat Prod 65: 433-8 (2002) | Universit£ di Milano | 2D 3D TSV |
| 11965381 | 22 | Novel diamide-based inhibitors of IMPDH. |
Bioorg Med Chem Lett 12: 1323-6 (2002) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11965379 | 94 | Enantiospecific, selective cyclooxygenase-2 inhibitors. |
Bioorg Med Chem Lett 12: 1315-8 (2002) | Vanderbilt University School of Medicine | 2D 3D TSV |
| 11965378 | 78 | Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity. |
Bioorg Med Chem Lett 12: 1311-4 (2002) | Berlex Biosciences | 2D 3D TSV |
| 11965377 | 66 | Design and synthesis of aminophenol-based factor Xa inhibitors. |
Bioorg Med Chem Lett 12: 1307-10 (2002) | Berlex Biosciences | 2D 3D TSV |
| 11965376 | 19 | Optimization of the 4-aryl group of 4-aryl-pyridine glucagon antagonists: development of an efficient, alternative synthesis. |
Bioorg Med Chem Lett 12: 1303-6 (2002) | Bayer Research Center | 2D 3D TSV |
| 11965374 | 43 | Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein. |
Bioorg Med Chem Lett 12: 1295-8 (2002) | Aventis Pharma | 2D 3D TSV |
| 11965373 | 30 | Discovery of highly potent Src SH2 binders: structure-activity studies and X-ray structures. |
Bioorg Med Chem Lett 12: 1291-4 (2002) | Aventis Pharma | 2D 3D TSV |
| 11965372 | 4 | Imidazole-based ligands of the Src SH2 protein. |
Bioorg Med Chem Lett 12: 1287-9 (2002) | Aventis Pharma | 2D 3D TSV |
| 11965371 | 4 | Synthesis of a novel fluorescent probe for estrogen receptor. |
Bioorg Med Chem Lett 12: 1283-5 (2002) | Abbott Laboratories | 2D 3D TSV |
| 11965370 | 18 | The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds. |
Bioorg Med Chem Lett 12: 1279-82 (2002) | Kingston University | 2D 3D TSV |
| 11965369 | 10 | Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues. |
Bioorg Med Chem Lett 12: 1275-8 (2002) | Sumitomo Pharmaceuticals Co., Ltd | 2D 3D TSV |
| 11965368 | 64 | Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I. |
Bioorg Med Chem Lett 12: 1269-73 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11965364 | 36 | Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter. |
Bioorg Med Chem Lett 12: 1249-52 (2002) | National Institute on Drug Abuse-Intramural Research Program | 2D 3D TSV |
| 11965363 | 11 | Structure-activity relationships for mini atrial natriuretic peptide by proline-scanning mutagenesis and shortening of peptide backbone. |
Bioorg Med Chem Lett 12: 1245-7 (2002) | Institute for Bioorganic Research | 2D 3D TSV |
| 11965361 | 1 | Synthesis of a molecular mimic of the Glc1Man9 oligoside as potential inhibitor of calnexin binding to DeltaF508 CFTR protein. |
Bioorg Med Chem Lett 12: 1237-40 (2002) | Institut Curie | 2D 3D TSV |
| 11964599 | 4 | Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. |
Anesthesiology 96: 913-20 (2002) | Vanderbilt University | 2D 3D TSV |
| 11961115 | 7 | Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. |
Mol Pharmacol 61: 982-8 (2002) | University of Tokyo | 2D 3D TSV |
| 11961113 | 36 | Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. |
Mol Pharmacol 61: 964-73 (2002) | Eli Lilly and Company | 2D 3D TSV |
| 11961071 | 4 | Agonist, antagonist, and inverse agonist characteristics of TIPP (H-Tyr-Tic-Phe-Phe-OH), a selective delta-opioid receptor ligand. |
J Pharmacol Exp Ther 301: 661-71 (2002) | University of Arkansas | 2D 3D TSV |
| 11961053 | 26 | Biochemical and behavioral characterization of novel methylphenidate analogs. |
J Pharmacol Exp Ther 301: 527-35 (2002) | Mercer University | 2D 3D TSV |
| 11960505 | 18 | Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. |
J Med Chem 45: 1949-56 (2002) | Chiba University | 2D 3D TSV |
| 11960504 | 14 | Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate. |
J Med Chem 45: 1942-8 (2002) | Duquesne University | 2D 3D TSV |
| 11960503 | 140 | Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors. |
J Med Chem 45: 1930-41 (2002) | Georgetown University Medical Center | 2D 3D TSV |
| 11960501 | 1 | Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A. |
J Med Chem 45: 1901-17 (2002) | University of Pittsburgh | 2D 3D TSV |
| 11960500 | 109 | 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels. |
J Med Chem 45: 1887-900 (2002) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 11960499 | 7 | Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics. |
J Med Chem 45: 1879-86 (2002) | University of Pennsylvania Health System | 2D 3D TSV |
| 11960497 | 36 | Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT(3). |
J Med Chem 45: 1853-9 (2002) | Institut de Chimie Pharmaceutique Albert Lespagnol | 2D 3D TSV |
| 11960496 | 50 | 5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists. |
J Med Chem 45: 1845-52 (2002) | Ghent University | 2D 3D TSV |
| 11960491 | 22 | Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II. |
J Med Chem 45: 1799-805 (2002) | Aventis Pharma Germany GmbH | 2D 3D TSV |
| 11960490 | 3 | Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity. |
J Med Chem 45: 1785-98 (2002) | Biovitrum AB | 2D 3D TSV |
| 11960489 | 10 | Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. |
J Med Chem 45: 1778-84 (2002) | Sapienza University of Rome | 2D 3D TSV |
| 11960488 | 3 | Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor. |
J Med Chem 45: 1767-77 (2002) | Uppsala University | 2D 3D TSV |
| 11960487 | 30 | Structure-based design of novel potent nonpeptide thrombin inhibitors. |
J Med Chem 45: 1757-66 (2002) | Boehringer Ingelheim Pharma KG | 2D 3D TSV |
| 11960486 | 6 | Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB(1) cannabinoid receptor ligands and potential antagonists: synthesis, lipophilicity, affinity, and molecular modeling. |
J Med Chem 45: 1748-56 (2002) | Universit£ de Lausanne | 2D 3D TSV |
| 11960485 | 18 | Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics. |
J Med Chem 45: 1741-7 (2002) | Novartis Pharmaceuticals | 2D 3D TSV |
| 11959009 | 7 | Bivalent inhibition of beta-tryptase: distance scan of neighboring subunits by dibasic inhibitors. |
Bioorg Med Chem Lett 12: 985-8 (2002) | Institut für Biochemie | 2D 3D TSV |
| 11959007 | 27 | Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase. |
Bioorg Med Chem Lett 12: 977-9 (2002) | Universit£ Lyon I | 2D 3D TSV |
| 11959006 | 10 | Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors. |
Bioorg Med Chem Lett 12: 971-5 (2002) | Lek d.d. | 2D 3D TSV |
| 11959005 | 19 | Novel N-[1-(1-substituted 4-piperidinylmethyl)-4-piperidinyl]benzamides as potent colonic prokinetic agents. |
Bioorg Med Chem Lett 12: 967-70 (2002) | Dainippon Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11958998 | 22 | Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template. |
Bioorg Med Chem Lett 12: 937-41 (2002) | The Schering Plough Research Institute | 2D 3D TSV |
| 11958997 | 53 | Oxal hydroxamic acid derivatives with inhibitory activity against matrix metalloproteinases. |
Bioorg Med Chem Lett 12: 933-6 (2002) | University of Bielefeld | 2D 3D TSV |
| 11958995 | 9 | Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety. |
Bioorg Med Chem Lett 12: 923-8 (2002) | Kyoto University | 2D 3D TSV |
| 11958994 | 31 | Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors. |
Bioorg Med Chem Lett 12: 919-22 (2002) | Aventis Pharmaceuticals, Inc. | 2D 3D TSV |
| 11958993 | 23 | Structure-activity study of L-cysteine-based N-type calcium channel blockers: optimization of N- and C-terminal substituents. |
Bioorg Med Chem Lett 12: 915-8 (2002) | Minase Research Institute | 2D 3D TSV |
| 11958992 | 10 | Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding. |
Bioorg Med Chem Lett 12: 911-3 (2002) | The University of Tokyo | 2D 3D TSV |
| 11958989 | 32 | QSAR study on adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues using the hansch approach. |
Bioorg Med Chem Lett 12: 899-902 (2002) | Jadavpur University | 2D 3D TSV |
| 11958985 | 21 | Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1). |
Bioorg Med Chem Lett 12: 883-6 (2002) | Eli Lilly and Company | 2D 3D TSV |
| 11958984 | 24 | Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity. |
Bioorg Med Chem Lett 12: 879-81 (2002) | Tohoku Pharmaceutical University | 2D 3D TSV |
| 11958981 | 25 | Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors. |
Bioorg Med Chem Lett 12: 865-8 (2002) | Bayer AG | 2D 3D TSV |
| 11958976 | 30 | Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters. |
Bioorg Med Chem Lett 12: 845-7 (2002) | State University of New York | 2D 3D TSV |
| 11934595 | 80 | Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains. |
Bioorg Med Chem Lett 12: 1233-5 (2002) | Roche Bioscience | 2D 3D TSV |
| 11934593 | 1 | A practical synthesis of (S) 3-tert-butoxycarbonylamino-2-oxo-2,3,4,5-tetrahydro-1,5-benzodiazepine-1-acetic acid methyl ester as a conformationally restricted dipeptido-mimetic for caspase-1 (ICE) inhibitors. |
Bioorg Med Chem Lett 12: 1225-7 (2002) | Vertex Pharmaceuticals Inc | 2D 3D TSV |
| 11934592 | 24 | Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. |
Bioorg Med Chem Lett 12: 1219-23 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11934589 | 57 | Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates. |
Bioorg Med Chem Lett 12: 1203-8 (2002) | Corvas International Inc | 2D 3D TSV |
| 11934588 | 69 | Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group. |
Bioorg Med Chem Lett 12: 1199-202 (2002) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11934587 | 19 | Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 1: Structure-based design of novel acetylenic P1' groups. |
Bioorg Med Chem Lett 12: 1195-8 (2002) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11934585 | 8 | Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor. |
Bioorg Med Chem Lett 12: 1189-92 (2002) | Johnson & Johnson Pharmaceutical Research and Development LLC | 2D 3D TSV |
| 11934583 | 20 | Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors. |
Bioorg Med Chem Lett 12: 1181-4 (2002) | Shire BioChem | 2D 3D TSV |
| 11934581 | 32 | Novel potent antagonists of human neuropeptide Y Y5 receptor. Part 1: 2-oxobenzothiazolin-3-acetic acid derivatives. |
Bioorg Med Chem Lett 12: 1171-5 (2002) | Fujisawa Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11934578 | 12 | Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist. |
Bioorg Med Chem Lett 12: 1159-62 (2002) | The Royal Danish School of Pharmacy | 2D 3D TSV |
| 11934576 | 85 | Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands. |
Bioorg Med Chem Lett 12: 1149-52 (2002) | Université de Lille 2 | 2D 3D TSV |
| 11934574 | 8 | Design and synthesis of lignostilbene-alpha,beta-dioxygenase inhibitors. |
Bioorg Med Chem Lett 12: 1139-42 (2002) | RIKEN | 2D 3D TSV |
| 11931626 | 124 | A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. |
J Med Chem 45: 1712-22 (2002) | Northwestern University | 2D 3D TSV |
| 11931625 | 20 | Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation. |
J Med Chem 45: 1697-711 (2002) | Abbott Laboratories | 2D 3D TSV |
| 11931624 | 6 | Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523). |
J Med Chem 45: 1690-6 (2002) | Harvard Medical School | 2D 3D TSV |
| 11931623 | 6 | Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor. |
J Med Chem 45: 1686-9 (2002) | Pfizer Inc | 2D 3D TSV |
| 11931622 | 3 | Synthesis of photoreactive phosphatidic acid analogues displaying activatory properties on cyclic AMP-phosphodiesterases. Photoaffinity labeling of an isoform of phosphodiesterase. |
J Med Chem 45: 1678-85 (2002) | INSERM U352 | 2D 3D TSV |
| 11931620 | 40 | Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units. |
J Med Chem 45: 1665-71 (2002) | Hebrew University | 2D 3D TSV |
| 11931619 | 19 | Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. |
J Med Chem 45: 1656-64 (2002) | Virginia Commonwealth University | 2D 3D TSV |
| 11931617 | 36 | Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes. |
J Med Chem 45: 1633-43 (2002) | University of Camerino | 2D 3D TSV |
| 11931615 | 46 | Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics. |
J Med Chem 45: 1607-23 (2002) | Agouron Pharmaceuticals Inc | 2D 3D TSV |
| 11931613 | 76 | Development of new hydrogen-bond descriptors and their application to comparative molecular field analyses. |
J Med Chem 45: 1585-97 (2002) | University of Marburg | 2D 3D TSV |
| 11931612 | 112 | GBR compounds and mepyramines as cocaine abuse therapeutics: chemometric studies on selectivity using grid independent descriptors (GRIND). |
J Med Chem 45: 1577-84 (2002) | Universit£ di Perugia | 2D 3D TSV |
| 11931611 | 7 | Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase. |
J Med Chem 45: 1567-76 (2002) | Sapienza University of Rome | 2D 3D TSV |
| 11931610 | 4 | Beta-C-mannosides as selectin inhibitors. |
J Med Chem 45: 1563-6 (2002) | Wyeth Research | 2D 3D TSV |
| 11931608 | 17 | Inhibition of protein-protein association by small molecules: approaches and progress. |
J Med Chem 45: 1543-58 (2002) | Pfizer Inc | 2D 3D TSV |
| 11927256 | 30 | Insight into binding of calyculin A to protein phosphatase 1: isolation of hemicalyculin a and chemical transformation of calyculin A. |
Chem Biol 9: 309-19 (2002) | The University of Tokyo | 2D 3D TSV |
| 11916147 | 11 | Evaluation of 7-hydroxy-flavones as inhibitors of oestrone and oestradiol biosynthesis. |
J Enzym Inhib 16: 417-24 (2001) | Cardiff University | 2D 3D TSV |
| 11916140 | 21 | Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds. |
J Enzym Inhib 16: 351-8 (2001) | Università degli Studi | 2D 3D TSV |
| 11914912 | 1 | P-glycoprotein inhibition by the multidrug resistance-reversing agent MS-209 enhances bioavailability and antitumor efficacy of orally administered paclitaxel. |
Cancer Chemother Pharmacol 49: 322-8 (2002) | Nihon Schering K.K. | 2D 3D TSV |
| 11909733 | 30 | Beta-carbolines as specific inhibitors of cyclin-dependent kinases. |
Bioorg Med Chem Lett 12: 1129-32 (2002) | Institute of Molecular and Cell Biology | 2D 3D TSV |
| 11909727 | 35 | Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes. |
Bioorg Med Chem Lett 12: 1103-7 (2002) | COR Therapeutics Inc | 2D 3D TSV |
| 11909726 | 36 | 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. |
Bioorg Med Chem Lett 12: 1099-102 (2002) | Novartis Pharma AG | 2D 3D TSV |
| 11909724 | 35 | Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists. |
Bioorg Med Chem Lett 12: 1087-91 (2002) | Schering-Plough Research Institute | 2D 3D TSV |
| 11909720 | 8 | Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase. |
Bioorg Med Chem Lett 12: 1071-4 (2002) | National Museum of Natural History | 2D 3D TSV |
| 11909718 | 53 | Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1. |
Bioorg Med Chem Lett 12: 1063-6 (2002) | Xenova Limited | 2D 3D TSV |
| 11909717 | 7 | New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives. |
Bioorg Med Chem Lett 12: 1059-61 (2002) | UPRES EA 1085 | 2D 3D TSV |
| 11909715 | 73 | Squaric acid derivatives as VLA-4 integrin antagonists. |
Bioorg Med Chem Lett 12: 1051-4 (2002) | Celltech R&D Ltd | 2D 3D TSV |
| 11909713 | 42 | Thalidomide and its analogues as cyclooxygenase inhibitors. |
Bioorg Med Chem Lett 12: 1043-6 (2002) | The University of Tokyo | 2D 3D TSV |
| 11909712 | 124 | N-alkylaminoacids and their derivatives interact with melanocortin receptors. |
Bioorg Med Chem Lett 12: 1039-42 (2002) | Uppsala University | 2D 3D TSV |
| 11909711 | 86 | Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors. |
Bioorg Med Chem Lett 12: 1035-8 (2002) | Uppsala University | 2D 3D TSV |
| 11909707 | 69 | Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1. |
Bioorg Med Chem Lett 12: 1017-22 (2002) | Life Science R & D, LGCI | 2D 3D TSV |
| 11909705 | 19 | Novel potent antagonists of human neuropeptide Y-Y5 receptor. Part 4: tetrahydrodiazabenzazulene derivatives. |
Bioorg Med Chem Lett 12: 1009-11 (2002) | Fujisawa Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11909704 | 43 | Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease. |
Bioorg Med Chem Lett 12: 1005-8 (2002) | Schering-Plough Research Institute | 2D 3D TSV |
| 11909701 | 35 | Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors. |
Bioorg Med Chem Lett 12: 993-5 (2002) | Georgetown University Medical Center | 2D 3D TSV |
| 11909604 | 23 | Interaction of human organic anion transporters with various cephalosporin antibiotics. |
Eur J Pharmacol 438: 137-42 (2002) | Kyorin University | 2D 3D TSV |
| 11909603 | 1 | T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist. |
Eur J Pharmacol 438: 129-35 (2002) | Takeda Chemical Industries, Ltd | 2D 3D TSV |
| 11908993 | 1 | Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis. |
J Nat Prod 65: 411-3 (2002) | The University of Tokyo | 2D 3D TSV |
| 11908961 | 3 | Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge. |
J Nat Prod 65: 259-61 (2002) | Kirin Brewery Co., Ltd | 2D 3D TSV |
| 11907190 | 4 | 4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Biochemical and pharmacological characterization. |
J Pharmacol Exp Ther 301: 322-32 (2002) | Sanofi Synthelabo | 2D 3D TSV |
| 11907155 | 384 | Elucidation of vasoactive intestinal peptide pharmacophore for VPAC(1) receptors in human, rat, and guinea pig. |
J Pharmacol Exp Ther 301: 37-50 (2002) | National Institutes of Health | 2D 3D TSV |
| 11906293 | 7 | Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. |
J Med Chem 45: 1518-34 (2002) | Takeda Chemical Industries, Ltd | 2D 3D TSV |
| 11906292 | 32 | 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1). |
J Med Chem 45: 1511-7 (2002) | Central Pharmaceutical Research Institute | 2D 3D TSV |
| 11906291 | 129 | 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. |
J Med Chem 45: 1500-10 (2002) | University of Bonn | 2D 3D TSV |
| 11906289 | 87 | Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP). |
J Med Chem 45: 1477-86 (2002) | CNRS | 2D 3D TSV |
| 11906288 | 713 | Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties. |
J Med Chem 45: 1466-76 (2002) | Universit£ degli Studi di Firenze | 2D 3D TSV |
| 11906287 | 9 | Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking. |
J Med Chem 45: 1460-5 (2002) | University of Milan | 2D 3D TSV |
| 11906286 | 34 | Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor. |
J Med Chem 45: 1447-59 (2002) | University of South Carolina | 2D 3D TSV |
| 11906282 | 6 | Molecular dynamics and free energy analyses of cathepsin D-inhibitor interactions: insight into structure-based ligand design. |
J Med Chem 45: 1412-9 (2002) | University of California | 2D 3D TSV |
| 11906281 | 22 | Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. |
J Med Chem 45: 1402-11 (2002) | Laboratorios Menarini S.A. | 2D 3D TSV |
| 11906280 | 38 | Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes. |
J Med Chem 45: 1399-401 (2002) | Novartis Pharmaceuticals | 2D 3D TSV |
| 11906279 | 2 | Design, synthesis, and evaluation of opioid analogues with non-peptidic beta-turn scaffold: enkephalin and endomorphin mimetics. |
J Med Chem 45: 1395-8 (2002) | TBA | 2D 3D TSV |
| 11896401 | 3 | Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. |
Nat Struct Biol 9: 268-72 (2002) | Boehringer Ingelheim Pharmaceuticals Inc | 2D 3D TSV |
| 11888271 | 2 | Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine. |
Biochemistry 41: 3555-64 (2002) | Weizmann Institute of Science | 2D 3D TSV |
| 11883641 | 8 | Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. |
Pharm Res 19: 147-53 (2002) | Kitasato University | 2D 3D TSV |
| 11882920 | 41 | Characterization of phospholipase C activity at h5-HT2C compared with h5-HT2B receptors: influence of novel ligands upon membrane-bound levels of [3H]phosphatidylinositols. |
Naunyn Schmiedebergs Arch Pharmacol 365: 242-52 (2002) | Institut de Recherches Servier | 2D 3D TSV |
| 11882004 | 67 | Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton. |
J Med Chem 45: 1348-62 (2002) | AstraZeneca R&D Charnwood | 2D 3D TSV |
| 11882001 | 34 | Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine. |
J Med Chem 45: 1321-9 (2002) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
| 11881999 | 123 | Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. |
J Med Chem 45: 1300-12 (2002) | AstraZeneca | 2D 3D TSV |
| 11881998 | 32 | First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. |
J Med Chem 45: 1292-9 (2002) | Instituto de Quimica Medica (CSIC) | 2D 3D TSV |
| 11881997 | 14 | Carbocyclic dinucleoside polyphosphonates: interaction with HIV reverse transcriptase and antiviral activity. |
J Med Chem 45: 1284-91 (2002) | Russian Academy of Sciences | 2D 3D TSV |
| 11881994 | 42 | Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation. |
J Med Chem 45: 1253-8 (2002) | University of Tours | 2D 3D TSV |
| 11881993 | 175 | Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum. |
J Med Chem 45: 1244-52 (2002) | National Center for Genetic Engineering and Biotechnology at Thailand | 2D 3D TSV |
| 11881991 | 21 | PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors. |
J Med Chem 45: 1221-32 (2002) | Protherics Molecular Design | 2D 3D TSV |
| 11881989 | 7 | Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters. |
J Med Chem 45: 1203-10 (2002) | University of New Orleans | 2D 3D TSV |
| 11881988 | 16 | Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues. |
J Med Chem 45: 1196-202 (2002) | Universit£ di Camerino | 2D 3D TSV |
| 11881986 | 24 | 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. |
J Med Chem 45: 1180-3 (2002) | Sapienza University of Rome | 2D 3D TSV |
| 11881985 | 48 | 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. |
J Med Chem 45: 1176-9 (2002) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 11881984 | 61 | Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. |
J Med Chem 45: 1151-75 (2002) | The University of Newcastle | 2D 3D TSV |
| 11878817 | 2 | Comparison between isopropyl unoprostone and latanoprost by prostaglandin E(2)induction, affinity to prostaglandin transporter, and intraocular metabolism. |
Exp Eye Res 74: 41-9 (2002) | Yamanashi Medical University | 2D 3D TSV |
| 11861823 | 10 | Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist. |
J Pharmacol Exp Ther 300: 1122-30 (2002) | Sanofi-Synthelabo Recherche | 2D 3D TSV |
| 11861807 | 8 | A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid. |
J Pharmacol Exp Ther 300: 984-91 (2002) | Istituto di Chimica Biomolecolare | 2D 3D TSV |
| 11861777 | 6 | Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. |
J Pharmacol Exp Ther 300: 746-53 (2002) | University of Tokyo | 2D 3D TSV |
| 11859013 | 93 | Structure-activity relationships of oxime neurokinin antagonists: oxime modifications. |
Bioorg Med Chem Lett 12: 833-6 (2002) | Schering-Plough Research Institute | 2D 3D TSV |
| 11859012 | 86 | 2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain. |
Bioorg Med Chem Lett 12: 827-32 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11859009 | 16 | Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines. |
Bioorg Med Chem Lett 12: 811-5 (2002) | Inha University | 2D 3D TSV |
| 11859006 | 15 | Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives. |
Bioorg Med Chem Lett 12: 799-802 (2002) | Fujisawa Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11859005 | 24 | Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family. |
Bioorg Med Chem Lett 12: 795-8 (2002) | Schering-Plough Research Institute | 2D 3D TSV |
| 11859004 | 18 | Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands. |
Bioorg Med Chem Lett 12: 791-4 (2002) | Schering-Plough Research Institute | 2D 3D TSV |
| 11859003 | 63 | Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines. |
Bioorg Med Chem Lett 12: 787-90 (2002) | Wyeth Research | 2D 3D TSV |
| 11859001 | 30 | Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor. |
Bioorg Med Chem Lett 12: 779-82 (2002) | Laboratoires Innothera | 2D 3D TSV |
| 11858999 | 21 | Novel agents combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI). |
Bioorg Med Chem Lett 12: 771-4 (2002) | Nikken Chemicals Co., Ltd. | 2D 3D TSV |
| 11858996 | 32 | Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 2: substituted benzo[a]cycloheptene derivatives. |
Bioorg Med Chem Lett 12: 757-61 (2002) | Fujisawa Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11858995 | 1 | Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation. |
Bioorg Med Chem Lett 12: 753-5 (2002) | Organon Laboratories Ltd | 2D 3D TSV |
| 11858994 | 7 | Synthesis of an alpha-fucosidase inhibitor, 5a-carba-beta-L-fucopyranosylamine, and fucose-type alpha- and beta-DL-valienamine unsaturated derivatives. |
Bioorg Med Chem Lett 12: 749-52 (2002) | Keio University | 2D 3D TSV |
| 11858993 | 60 | Novel, potent non-covalent thrombin inhibitors incorporating p(3)-lactam scaffolds. |
Bioorg Med Chem Lett 12: 743-8 (2002) | Corvas International Inc | 2D 3D TSV |
| 11858990 | 20 | N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists. |
Bioorg Med Chem Lett 12: 729-31 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11858756 | 25 | New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii. |
J Nat Prod 65: 198-202 (2002) | Hokuriku University | 2D 3D TSV |
| 11858749 | 32 | Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity. |
J Nat Prod 65: 163-9 (2002) | University of Illinois at Chicago | 2D 3D TSV |
| 11855993 | 91 | Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. |
J Med Chem 45: 1128-41 (2002) | Freie Universität Berlin | 2D 3D TSV |
| 11855991 | 27 | Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin analogues. |
J Med Chem 45: 1108-21 (2002) | Rutgers University | 2D 3D TSV |
| 11855989 | 51 | 6-Sulfonylchromenes as highly potent K(ATP)-channel openers. |
J Med Chem 45: 1086-97 (2002) | Heinrich-Heine-Universit£t | 2D 3D TSV |
| 11855986 | 24 | Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165. |
J Med Chem 45: 1064-72 (2002) | Institut f£r Pharmazeutische Chemie der Philipps-Universit£t Marburg | 2D 3D TSV |
| 11855984 | 102 | Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins. |
J Med Chem 45: 1045-51 (2002) | Merck KGaA | 2D 3D TSV |
| 11855983 | 18 | Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists. |
J Med Chem 45: 1035-44 (2002) | Universita' di Firenze | 2D 3D TSV |
| 11855980 | 46 | Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase. |
J Med Chem 45: 1002-18 (2002) | University of Regensburg | 2D 3D TSV |
| 11855979 | 13 | Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5). |
J Med Chem 45: 999-1001 (2002) | GlaxoSmithKline | 2D 3D TSV |
| 11844706 | 30 | Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease. |
Bioorg Med Chem Lett 12: 705-8 (2002) | IRBM, MRL Rome | 2D 3D TSV |
| 11844705 | 13 | A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease. |
Bioorg Med Chem Lett 12: 701-4 (2002) | IRBM, MRL Rome | 2D 3D TSV |
| 11844703 | 14 | Insertion of 2-carboxysuccinate and tricarballylic acid fragments into cyclic-pseudopeptides: new antagonists for the human tachykinin NK-2 receptor. |
Bioorg Med Chem Lett 12: 693-6 (2002) | Menarini Ricerche S.p.A. Laboratori di Firenze | 2D 3D TSV |
| 11844702 | 14 | Pyridazine based inhibitors of p38 MAPK. |
Bioorg Med Chem Lett 12: 689-92 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11844701 | 5 | Identification of unique VLA-4 antagonists from a combinatorial library. |
Bioorg Med Chem Lett 12: 685-8 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11844699 | 16 | CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines. |
Bioorg Med Chem Lett 12: 677-9 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11844695 | 35 | Human glucagon receptor antagonists based on alkylidene hydrazides. |
Bioorg Med Chem Lett 12: 663-6 (2002) | Pfizer Inc | 2D 3D TSV |
| 11844693 | 35 | Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors. |
Bioorg Med Chem Lett 12: 653-8 (2002) | Janssen-Cilag S.A. | 2D 3D TSV |
| 11844691 | 107 | 4-amidinobenzylamine-based inhibitors of urokinase. |
Bioorg Med Chem Lett 12: 645-8 (2002) | Universitat Jena | 2D 3D TSV |
| 11844690 | 8 | Solution and solid-phase synthesis of potent inhibitors of hepatitis C virus NS3 proteinase. |
Bioorg Med Chem Lett 12: 641-3 (2002) | Roche Discovery Welwyn | 2D 3D TSV |
| 11844689 | 51 | Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists. |
Bioorg Med Chem Lett 12: 637-40 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11844688 | 102 | Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy. |
Bioorg Med Chem Lett 12: 633-6 (2002) | Friedrich-Alexander University | 2D 3D TSV |
| 11844687 | 11 | A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor. |
Bioorg Med Chem Lett 12: 629-32 (2002) | Banyu Tsukuba Research Institute | 2D 3D TSV |
| 11844685 | 20 | A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors. |
Bioorg Med Chem Lett 12: 619-22 (2002) | Wayne State University | 2D 3D TSV |
| 11844683 | 31 | The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists. |
Bioorg Med Chem Lett 12: 611-4 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11844682 | 36 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2. |
Bioorg Med Chem Lett 12: 607-10 (2002) | Nippon Roche Research Center | 2D 3D TSV |
| 11844681 | 45 | Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase. |
Bioorg Med Chem Lett 12: 601-5 (2002) | Schering-Plough Research Institute | 2D 3D TSV |
| 11844676 | 48 | Encounter with unexpected collagenase-1 selective inhibitor: switchover of inhibitor binding pocket induced by fluorine atom. |
Bioorg Med Chem Lett 12: 581-4 (2002) | Organon K.K. | 2D 3D TSV |
| 11844675 | 114 | 2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series. |
Bioorg Med Chem Lett 12: 575-9 (2002) | GlaxoSmithKline | 2D 3D TSV |
| 11844674 | 59 | Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance. |
Bioorg Med Chem Lett 12: 571-4 (2002) | Xenova Ltd. | 2D 3D TSV |
| 11844670 | 27 | Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase. |
Bioorg Med Chem Lett 12: 551-5 (2002) | Dainippon Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11844666 | 31 | Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. |
Bioorg Med Chem Lett 12: 533-7 (2002) | Laboratorios Menarini S.A. | 2D 3D TSV |
| 11844665 | 38 | A combinatorial library of indinavir analogues and its in vitro and in vivo studies. |
Bioorg Med Chem Lett 12: 529-32 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11844664 | 35 | Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase. |
Bioorg Med Chem Lett 12: 525-8 (2002) | University of Toledo | 2D 3D TSV |
| 11844663 | 54 | Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors. |
Bioorg Med Chem Lett 12: 521-4 (2002) | Vanderbilt University School of Medicine | 2D 3D TSV |
| 11844662 | 34 | Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides. |
Bioorg Med Chem Lett 12: 517-20 (2002) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11837698 | 8 | Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. |
Pharm Res 19: 34-41 (2002) | The University of Tokyo | 2D 3D TSV |
| 11831912 | 43 | Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids. |
J Med Chem 45: 988-91 (2002) | The Royal Danish School of Pharmacy | 2D 3D TSV |
| 11831911 | 15 | Cyclohexylmethylpiperidinyltriphenylpropioamide: a selective muscarinic M(3) antagonist discriminating against the other receptor subtypes. |
J Med Chem 45: 984-7 (2002) | Banyu Tsukuba Research Institute | 2D 3D TSV |
| 11831910 | 60 | Computational studies on tetrahydropyrimidine-2-one HIV-1 protease inhibitors: improving three-dimensional quantitative structure-activity relationship comparative molecular field analysis models by inclusion of calculated inhibitor- and receptor-based properties. |
J Med Chem 45: 973-83 (2002) | University of Missouri-St. Louis | 2D 3D TSV |
| 11831909 | 4 | Novel antagonists acting at the P2Y(1) purinergic receptor: synthesis and conformational analysis using potentiometric and nuclear magnetic resonance titration techniques. |
J Med Chem 45: 962-72 (2002) | Universit£ Louis Pasteur | 2D 3D TSV |
| 11831905 | 33 | New strategy for antedrug application: development of metalloproteinase inhibitors as antipsoriatic drugs. |
J Med Chem 45: 930-6 (2002) | Organon K.K. | 2D 3D TSV |
| 11831904 | 172 | New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids. |
J Med Chem 45: 919-29 (2002) | Nippon Organon K.K. | 2D 3D TSV |
| 11831903 | 31 | Cysteine derivatives as inhibitors for carboxypeptidase A: synthesis and structure-activity relationships. |
J Med Chem 45: 911-8 (2002) | Pohang University of Science and Technology | 2D 3D TSV |
| 11831902 | 12 | Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors. |
J Med Chem 45: 902-10 (2002) | Institute of Research | 2D 3D TSV |
| 11831900 | 8 | Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV. |
J Med Chem 45: 888-93 (2002) | University of Pennsylvania | 2D 3D TSV |
| 11831896 | 8 | Structural basis of RasGRP binding to high-affinity PKC ligands. |
J Med Chem 45: 853-60 (2002) | Georgetown University Medical Center | 2D 3D TSV |
| 11831895 | 47 | CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site. |
J Med Chem 45: 841-52 (2002) | University of Tennessee Health Science Center | 2D 3D TSV |
| 11831892 | 46 | Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity. |
J Med Chem 45: 789-804 (2002) | Novo Nordisk A/S | 2D 3D TSV |
| 11831890 | 278 | Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists. |
J Med Chem 45: 770-80 (2002) | Università degli Studi di Ferrara | 2D 3D TSV |
| 11831887 | 34 | Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. |
J Med Chem 45: 753-7 (2002) | TBA | 2D 3D TSV |
| 11828475 | 5 | Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors. |
Chembiochem 2: 438-44 (2001) | Université Louis Pasteur | 2D 3D TSV |
| 11828463 | 20 | Inhibition studies of porphobilinogen synthase from Escherichia coli differentiating between the two recognition sites. |
Chembiochem 2: 343-54 (2001) | University of Neuchâtel | 2D 3D TSV |
| 11818398 | 1 | Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium. |
Invest Ophthalmol Vis Sci 43: 510-4 (2002) | University Hospital | 2D 3D TSV |
| 11817957 | 58 | Complexation and chiral recognition thermodynamics of 6-amino-6-deoxy-beta-cyclodextrin with anionic, cationic, and neutral chiral guests: counterbalance between van der Waals and coulombic interactions. |
J Am Chem Soc 124: 813-26 (2002) | Japan Science and Technology Agency | 2D 3D TSV |
| 11815391 | 5 | Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake. |
Br J Pharmacol 135: 555-63 (2002) | Tokyo Women's Medical University | 2D 3D TSV |
| 11814830 | 26 | 7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma. |
Bioorg Med Chem Lett 12: 509-12 (2002) | Celltech R&D Ltd | 2D 3D TSV |
| 11814827 | 10 | N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents. |
Bioorg Med Chem Lett 12: 497-500 (2002) | University of Maryland | 2D 3D TSV |
| 11814826 | 14 | Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors. |
Bioorg Med Chem Lett 12: 491-5 (2002) | 3-Dimensional Pharmaceuticals Inc | 2D 3D TSV |
| 11814822 | 108 | alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines. |
Bioorg Med Chem Lett 12: 471-5 (2002) | GlaxoSmithKline | 2D 3D TSV |
| 11814821 | 6 | Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent. |
Bioorg Med Chem Lett 12: 465-9 (2002) | Abbott Laboratories | 2D 3D TSV |
| 11814820 | 28 | Discovery of 5-hydroxyalkyl-4-phenylpyridines as a new class of glucagon receptor antagonists. |
Bioorg Med Chem Lett 12: 461-4 (2002) | Bayer Research Center | 2D 3D TSV |
| 11814819 | 3 | Synthesis of an alpha-aminophosphonate nucleoside as an inhibitor of S-adenosyl-L-homocysteine hydrolase. |
Bioorg Med Chem Lett 12: 457-60 (2002) | University of Waterloo | 2D 3D TSV |
| 11814816 | 30 | Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective alpha(V)beta(3) antagonists. |
Bioorg Med Chem Lett 12: 441-6 (2002) | Knoll GmbH | 2D 3D TSV |
| 11814815 | 13 | alpha(1)-Adrenoceptor antagonists. Rational design, synthesis and biological evaluation of new trazodone-like compounds. |
Bioorg Med Chem Lett 12: 437-40 (2002) | Universit£ di Pisa | 2D 3D TSV |
| 11814812 | 12 | 4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors. |
Bioorg Med Chem Lett 12: 423-5 (2002) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11814808 | 6 | [(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5. |
Bioorg Med Chem Lett 12: 407-9 (2002) | Novartis Pharma AG | 2D 3D TSV |
| 11814807 | 30 | A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists. |
Bioorg Med Chem Lett 12: 403-6 (2002) | Neurocrine Biosciences Inc | 2D 3D TSV |
| 11814806 | 39 | Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists. |
Bioorg Med Chem Lett 12: 399-402 (2002) | Neurocrine Biosciences Inc | 2D 3D TSV |
| 11814804 | 9 | The first two cantharidin analogues displaying PP1 selectivity. |
Bioorg Med Chem Lett 12: 391-3 (2002) | The University of Newcastle | 2D 3D TSV |
| 11814801 | 24 | Dihydropyridine neuropeptide Y Y(1) receptor antagonists. |
Bioorg Med Chem Lett 12: 379-82 (2002) | Pharmaceutical Research Institute | 2D 3D TSV |
| 11814800 | 14 | Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin. |
Bioorg Med Chem Lett 12: 375-8 (2002) | Organon K.K. | 2D 3D TSV |
| 11814797 | 3 | 2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase. |
Bioorg Med Chem Lett 12: 361-3 (2002) | University of St. Andrews | 2D 3D TSV |
| 11814792 | 18 | Approach to dual-acting platelet activating factor (PAF) receptor antagonist/thromboxane synthase inhibitor (TxSI) based on the link of PAF antagonists and TxSIs. |
Bioorg Med Chem Lett 12: 341-4 (2002) | Nikken Chemicals Co., Ltd. | 2D 3D TSV |
| 11814791 | 13 | Novel dihydropyrazine analogues as NPY antagonists. |
Bioorg Med Chem Lett 12: 337-40 (2002) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11814790 | 8 | Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha. |
Bioorg Med Chem Lett 12: 333-5 (2002) | Kyorin Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11814789 | 7 | Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly. |
Bioorg Med Chem Lett 12: 329-32 (2002) | University of California | 2D 3D TSV |
| 11814787 | 73 | Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1). |
Bioorg Med Chem Lett 12: 319-23 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11814784 | 53 | Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors. |
Bioorg Med Chem Lett 12: 307-10 (2002) | Wyeth-Ayerst Research Laboratories | 2D 3D TSV |
| 11814780 | 18 | Synthesis and evaluation of imidazo[1,5-a]pyrazines as corticotropin releasing hormone receptor ligands. |
Bioorg Med Chem Lett 12: 291-4 (2002) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11814779 | 8 | Biotinylated lithocholic acids for affinity chromatography of mammalian DNA polymerases alpha and beta. |
Bioorg Med Chem Lett 12: 287-90 (2002) | Tokyo University of Science | 2D 3D TSV |
| 11814775 | 35 | New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template. |
Bioorg Med Chem Lett 12: 271-4 (2002) | Wyeth-Ayerst Research Laboratories | 2D 3D TSV |
| 11814774 | 50 | Estimation of binding affinities for celecoxib analogues with COX-2 via Monte Carlo-extended linear response. |
Bioorg Med Chem Lett 12: 267-70 (2002) | Yale University | 2D 3D TSV |
| 11809867 | 38 | A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study. |
Mol Pharmacol 61: 415-24 (2002) | University of Ferrara | 2D 3D TSV |
| 11809864 | 10 | Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194). |
Mol Pharmacol 61: 391-9 (2002) | UCB Pharma SA | 2D 3D TSV |
| 11809072 | 6 | A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex. |
J Nat Prod 65: 76-8 (2002) | Kyungpook National University | 2D 3D TSV |
| 11809055 | 1 | New chlorinated diphenyl ethers from an Aspergillus species. |
J Nat Prod 65: 7-10 (2002) | University of Western Australia | 2D 3D TSV |
| 11806723 | 20 | Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties. |
J Med Chem 45: 713-20 (2002) | University of Cagliary | 2D 3D TSV |
| 11806722 | 14 | Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia. |
J Med Chem 45: 703-12 (2002) | Pharmasset Inc | 2D 3D TSV |
| 11806720 | 6 | Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase. |
J Med Chem 45: 685-95 (2002) | Department of Research & Development | 2D 3D TSV |
| 11806719 | 61 | Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis. |
J Med Chem 45: 676-84 (2002) | University of California | 2D 3D TSV |
| 11806718 | 15 | Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin. |
J Med Chem 45: 670-5 (2002) | Chugai Pharmaceutical Co. Ltd | 2D 3D TSV |
| 11806716 | 44 | Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules. |
J Med Chem 45: 654-62 (2002) | Wayne State University | 2D 3D TSV |
| 11806715 | 13 | Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry. |
J Med Chem 45: 640-53 (2002) | Centre Hospitalier Universitaire de Qu£bec and Universit£ Laval | 2D 3D TSV |
| 11806713 | 8 | Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone. |
J Med Chem 45: 623-30 (2002) | Karo Bio AB | 2D 3D TSV |
| 11806711 | 6 | Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts. |
J Med Chem 45: 590-7 (2002) | University of Nottingham | 2D 3D TSV |
| 11806709 | 63 | Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres. |
J Med Chem 45: 567-83 (2002) | GlaxoSmithKline | 2D 3D TSV |
| 11806708 | 2 | Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. |
J Med Chem 45: 563-6 (2002) | TBA | 2D 3D TSV |
| 11806706 | 7 | Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles. |
J Med Chem 45: 541-58 (2002) | University of Wisconsin-Madison | 2D 3D TSV |
| 11805207 | 8 | Preclinical pharmacology of fiduxosin, a novel alpha(1)-adrenoceptor antagonist with uroselective properties. |
J Pharmacol Exp Ther 300: 478-86 (2002) | Abbott Laboratories | 2D 3D TSV |
| 11792694 | 2 | Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates. |
Drug Metab Dispos 30: 220-3 (2002) | The University of Tokyo | 2D 3D TSV |
| 11784158 | 28 | 4'-Arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity. |
J Med Chem 45: 537-40 (2002) | University of Bristol | 2D 3D TSV |
| 11784157 | 14 | Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors. |
J Med Chem 45: 533-6 (2002) | Universit£ de Lille 2 | 2D 3D TSV |
| 11784156 | 20 | Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). |
J Med Chem 45: 529-32 (2002) | University of Utah | 2D 3D TSV |
| 11784155 | 64 | Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines. |
J Med Chem 45: 511-28 (2002) | Pfizer Inc | 2D 3D TSV |
| 11784153 | 125 | 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists. |
J Med Chem 45: 492-503 (2002) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
| 11784148 | 81 | Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. |
J Med Chem 45: 438-48 (2002) | Pharmazeutisches Institut der Universität Freiburg | 2D 3D TSV |
| 11784146 | 9 | 2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor. |
J Med Chem 45: 420-9 (2002) | Leiden/Amsterdam Center for Drug Research | 2D 3D TSV |
| 11784143 | 4 | C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump. |
J Med Chem 45: 390-8 (2002) | Georgetown University School of Medicine | 2D 3D TSV |
| 11784141 | 11 | Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity. |
J Med Chem 45: 371-81 (2002) | University of Queensland | 2D 3D TSV |
| 11784139 | 82 | Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies. |
J Med Chem 45: 344-59 (2002) | Universit£ degli Studi di Siena | 2D 3D TSV |
| 11784138 | 36 | Elucidating the inhibiting mode of AHPBA derivatives against HIV-1 protease and building predictive 3D-QSAR models. |
J Med Chem 45: 333-43 (2002) | Chinese Academy of Sciences | 2D 3D TSV |
| 11784136 | 100 | Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. |
J Med Chem 45: 312-20 (2002) | University of Namur | 2D 3D TSV |
| 11784131 | 2 | Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence. |
J Med Chem 45: 263-74 (2002) | Universidad de Granada | 2D 3D TSV |
| 11784130 | 42 | Design of substrate-based inhibitors of human beta-secretase. |
J Med Chem 45: 259-62 (2002) | TBA | 2D 3D TSV |
| 11779105 | 4 | Stable expression of a synthetic gene for the human motilin receptor: use in an aequorin-based receptor activation assay. |
Anal Biochem 300: 146-51 (2002) | Kosan Biosciences Inc | 2D 3D TSV |
| 11770010 | 3 | Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein. |
Naunyn Schmiedebergs Arch Pharmacol 364: 551-7 (2001) | Institute of Clinical Pharmacology | 2D 3D TSV |
| 11758759 | 34 | Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. |
Pharm Res 18: 1528-34 (2001) | Kyoto University Hospital | 2D 3D TSV |
| 11755395 | 5 | Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease. |
Chem Biol 8: 1161-6 (2001) | State University of New York | 2D 3D TSV |
| 11755367 | 38 | First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants. |
Bioorg Med Chem Lett 12: 261-4 (2001) | UCB Pharma SA | 2D 3D TSV |
| 11755366 | 24 | Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase. |
Bioorg Med Chem Lett 12: 255-9 (2001) | University College London | 2D 3D TSV |
| 11755365 | 113 | Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2. |
Bioorg Med Chem Lett 12: 249-53 (2001) | Janssen-Cilag S.A. | 2D 3D TSV |
| 11755364 | 104 | Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1. |
Bioorg Med Chem Lett 12: 243-8 (2001) | Janssen-Cilag S.A. | 2D 3D TSV |
| 11755362 | 24 | Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor. |
Bioorg Med Chem Lett 12: 233-5 (2001) | Novartis Pharma AG | 2D 3D TSV |
| 11755361 | 24 | N-Methylbenzanilide derivatives as a novel class of selective V(1A) receptor antagonists. |
Bioorg Med Chem Lett 12: 229-32 (2001) | Yamanouchi Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11755357 | 14 | Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity. |
Bioorg Med Chem Lett 12: 213-6 (2001) | University of Louisville | 2D 3D TSV |
| 11755355 | 32 | Biphenyls as potent vitronectin receptor antagonists. |
Bioorg Med Chem Lett 12: 205-8 (2001) | Bayer AG | 2D 3D TSV |
| 11755353 | 61 | 3-Aryl pyridone derivatives. Potent and selective kappa opioid receptor agonists. |
Bioorg Med Chem Lett 12: 197-200 (2001) | AstraZeneca R&D Mölndal | 2D 3D TSV |
| 11755352 | 40 | Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block. |
Bioorg Med Chem Lett 12: 193-6 (2001) | Organon Laboratories Ltd | 2D 3D TSV |
| 11755351 | 24 | Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands. |
Bioorg Med Chem Lett 12: 189-92 (2001) | Universidad de Alcal£ | 2D 3D TSV |
| 11755350 | 31 | Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-Substituted-5-halo-2-pyridinyl)guanidines. |
Bioorg Med Chem Lett 12: 185-7 (2001) | Pfizer Inc | 2D 3D TSV |
| 11755349 | 24 | Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines. |
Bioorg Med Chem Lett 12: 181-4 (2001) | Pfizer Inc | 2D 3D TSV |
| 11755345 | 45 | Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives. |
Bioorg Med Chem Lett 12: 165-8 (2001) | NIDDK | 2D 3D TSV |
| 11755344 | 47 | The discovery of small molecule carbamates as potent dual alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists. |
Bioorg Med Chem Lett 12: 159-63 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11755343 | 54 | Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. |
Bioorg Med Chem Lett 12: 155-8 (2001) | Virginia Commonwealth University | 2D 3D TSV |
| 11755341 | 50 | Mixed lineage kinase activity of indolocarbazole analogues. |
Bioorg Med Chem Lett 12: 147-50 (2001) | Kyowa Hakko Kogyo Co., Ltd | 2D 3D TSV |
| 11755340 | 94 | Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides. |
Bioorg Med Chem Lett 12: 141-5 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11755339 | 33 | N-acyl-L-phenylalanine derivatives as potent VLA-4 antagonists that mimic a cyclic peptide conformation. |
Bioorg Med Chem Lett 12: 137-40 (2001) | Hoffmann-La Roche Inc | 2D 3D TSV |
| 11755338 | 24 | Specific and dual antagonists of alpha(4)beta(1) and alpha(4)beta(7) integrins. |
Bioorg Med Chem Lett 12: 133-6 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11755336 | 43 | The design and synthesis of a novel series of indole derived selective ET(A) antagonists. |
Bioorg Med Chem Lett 12: 125-8 (2001) | Pfizer Inc | 2D 3D TSV |
| 11755332 | 10 | Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292. |
Bioorg Med Chem Lett 12: 109-12 (2001) | Instituto de Química Médica (CSIC) | 2D 3D TSV |
| 11754608 | 6 | Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity. |
J Nat Prod 64: 1545-7 (2001) | Osaka University of Pharmaceutical Sciences | 2D 3D TSV |
| 11754594 | 59 | Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim. |
J Med Chem 45: 233-41 (2001) | Harvard Medical School | 2D 3D TSV |
| 11754593 | 148 | Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors. |
J Med Chem 45: 219-32 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11754592 | 21 | Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors. |
J Med Chem 45: 208-18 (2001) | National Institute of Diabetes | 2D 3D TSV |
| 11754590 | 53 | Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold. |
J Med Chem 45: 177-88 (2001) | Yale University | 2D 3D TSV |
| 11754589 | 68 | Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols. |
J Med Chem 45: 165-76 (2002) | Institut de Recherches Servier | 2D 3D TSV |
| 11754588 | 39 | Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. |
J Med Chem 45: 160-4 (2001) | Seoul National University | 2D 3D TSV |
| 11754583 | 112 | 7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility. |
J Med Chem 45: 115-26 (2001) | Università degli Studi di Ferrara | 2D 3D TSV |
| 11754581 | 12 | Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition. |
J Med Chem 45: 90-8 (2001) | University of Texas | 2D 3D TSV |
| 11754579 | 82 | New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones. |
J Med Chem 45: 54-71 (2001) | Universidad de Santiago de Compostela | 2D 3D TSV |
| 11754578 | 155 | Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase. |
J Med Chem 45: 41-53 (2001) | Lindsley F. Kimball Research Institute | 2D 3D TSV |
| 11754577 | 26 | Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole. |
J Med Chem 45: 32-40 (2002) | Universit£ degli Studi di Camerino | 2D 3D TSV |
| 11754576 | 33 | Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology. |
J Med Chem 45: 19-31 (2001) | The Royal Danish School of Pharmacy | 2D 3D TSV |
| 11754575 | 51 | Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality. |
J Med Chem 45: 1-18 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11752131 | 7 | Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. |
J Pharmacol Exp Ther 300: 314-23 (2002) | GlaxoSmithKline | 2D 3D TSV |
| 11752130 | 5 | The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin. |
J Pharmacol Exp Ther 300: 305-13 (2002) | Merck Research Laboratories | 2D 3D TSV |
| 11751127 | 2 | Interaction of common azole antifungals with P glycoprotein. |
Antimicrob Agents Chemother 46: 160-5 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11750183 | 29 | Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders. |
Neuropsychopharmacology 25: 904-14 (2001) | Novartis Pharma | 2D 3D TSV |
| 11750180 | 139 | Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. |
Neuropsychopharmacology 25: 871-80 (2001) | Eli Lilly and Company | 2D 3D TSV |
| 11743742 | 6 | Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. |
Chem Res Toxicol 14: 1596-603 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11743738 | 29 | Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. |
Chem Res Toxicol 14: 1563-72 (2001) | University of California at Davis | 2D 3D TSV |
| 11741777 | 15 | Synthesis of alkenyldiarylmethane (ADAM) non-nucleoside HIV-1 reverse transcriptase inhibitors with non-identical aromatic rings. |
Bioorg Med Chem 10: 283-90 (2002) | Purdue University | 2D 3D TSV |
| 11741491 | 12 | Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening. |
J Med Chem 44: 4737-40 (2001) | Waseda University | 2D 3D TSV |
| 11741490 | 18 | Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors. |
J Med Chem 44: 4733-6 (2001) | Universitat de Barcelona | 2D 3D TSV |
| 11741489 | 45 | Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans. |
J Med Chem 44: 4716-32 (2001) | Pharmacia | 2D 3D TSV |
| 11741488 | 19 | 2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization. |
J Med Chem 44: 4704-15 (2001) | University of Minnesota | 2D 3D TSV |
| 11741485 | 99 | Diaminoindanes as microsomal triglyceride transfer protein inhibitors. |
J Med Chem 44: 4677-87 (2001) | Novartis Institute for Biomedical Reasearch | 2D 3D TSV |
| 11741480 | 41 | A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues. |
J Med Chem 44: 4628-40 (2001) | Banyu Tsukuba Research Institute | 2D 3D TSV |
| 11741479 | 28 | Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design. |
J Med Chem 44: 4615-27 (2001) | Banyu Tsukuba Research Institute | 2D 3D TSV |
| 11741477 | 37 | Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics. |
J Med Chem 44: 4584-94 (2001) | University of Waterloo | 2D 3D TSV |
| 11741475 | 56 | Design, synthesis, and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists. |
J Med Chem 44: 4563-76 (2001) | The University of Toledo | 2D 3D TSV |
| 11741473 | 37 | Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. |
J Med Chem 44: 4535-53 (2001) | University of Regensburg | 2D 3D TSV |
| 11741472 | 45 | Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design. |
J Med Chem 44: 4524-34 (2001) | Novartis Pharmaceuticals Corporation | 2D 3D TSV |
| 11741471 | 13 | Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. |
J Med Chem 44: 4509-23 (2001) | University of Texas at Austin | 2D 3D TSV |
| 11741470 | 40 | Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors. |
J Med Chem 44: 4505-8 (2001) | Universidad Complutense | 2D 3D TSV |
| 11741469 | 8 | Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. |
J Med Chem 44: 4501-4 (2001) | Universita' degli Studi di Siena | 2D 3D TSV |
| 11741468 | 10 | Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors. |
J Med Chem 44: 4497-500 (2001) | New York University | 2D 3D TSV |
| 11738604 | 13 | Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1). |
Bioorg Med Chem 10: 31-40 (2002) | Pfizer Inc | 2D 3D TSV |
| 11738583 | 45 | Potent P1' biphenylmethyl substituted aggrecanase inhibitors. |
Bioorg Med Chem Lett 12: 101-4 (2001) | Bristol-Myers Squibb Pharma Company | 2D 3D TSV |
| 11738578 | 26 | Modifications and structure-activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists. |
Bioorg Med Chem Lett 12: 81-4 (2001) | Tanabe Seiyaku Co., Ltd | 2D 3D TSV |
| 11738577 | 19 | Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators. |
Bioorg Med Chem Lett 12: 77-80 (2001) | Kyorin Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11738574 | 36 | 4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors. |
Bioorg Med Chem Lett 12: 65-8 (2001) | Central Pharmaceutical Research Institute | 2D 3D TSV |
| 11738571 | 36 | Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones. |
Bioorg Med Chem Lett 12: 51-5 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11738570 | 29 | Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. |
Bioorg Med Chem Lett 12: 45-9 (2001) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11738569 | 26 | Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues. |
Bioorg Med Chem Lett 12: 41-4 (2001) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11738567 | 16 | Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements. |
Bioorg Med Chem Lett 12: 31-4 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11738566 | 20 | Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide. |
Bioorg Med Chem Lett 12: 25-9 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11738564 | 9 | Synthesis and biological evaluation of novel thio-substituted chromanes as high-affinity partial agonists for the estrogen receptor. |
Bioorg Med Chem Lett 12: 17-9 (2002) | Novo Nordisk A/S | 2D 3D TSV |
| 11738561 | 34 | Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor. |
Bioorg Med Chem Lett 12: 5-8 (2002) | Zambon Group | 2D 3D TSV |
| 11731301 | 192 | Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets. |
Chem Biol 8: 1107-21 (2001) | Axys Pharmaceutical | 2D 3D TSV |
| 11728194 | 98 | Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines. |
J Med Chem 44: 4481-91 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11728193 | 12 | Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs. |
J Med Chem 44: 4475-80 (2001) | Purdue University | 2D 3D TSV |
| 11728190 | 10 | Novel tropane-based irreversible ligands for the dopamine transporter. |
J Med Chem 44: 4453-61 (2001) | National Institute on Drug Abuse-Intramural Research Program | 2D 3D TSV |
| 11728188 | 53 | trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines. |
J Med Chem 44: 4431-42 (2001) | Università Bari | 2D 3D TSV |
| 11728186 | 46 | Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent sigma1 receptor ligands. |
J Med Chem 44: 4404-15 (2001) | Wake Forest University School of Medicine | 2D 3D TSV |
| 11728185 | 55 | Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide. |
J Med Chem 44: 4393-403 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11728184 | 20 | Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity. |
J Med Chem 44: 4379-92 (2001) | BioCryst Pharmaceuticals Inc | 2D 3D TSV |
| 11728182 | 28 | [1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors. |
J Med Chem 44: 4359-69 (2001) | Università di Pisa | 2D 3D TSV |
| 11728181 | 188 | Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis. |
J Med Chem 44: 4339-58 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11728179 | 12 | Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. |
J Med Chem 44: 4313-24 (2001) | Georgetown University Medical Center | 2D 3D TSV |
| 11728178 | 15 | Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity. |
J Med Chem 44: 4309-12 (2001) | Seoul National University | 2D 3D TSV |
| 11720869 | 9 | Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors. |
Bioorg Med Chem Lett 11: 3179-82 (2001) | Universit£ di Perugia | 2D 3D TSV |
| 11720868 | 14 | Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives. |
Bioorg Med Chem Lett 11: 3175-8 (2001) | Université des Sciences et Technologies de Lille | 2D 3D TSV |
| 11720867 | 24 | [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter. |
Bioorg Med Chem Lett 11: 3169-73 (2001) | National Institute on Drug Abuse-Intramural Research Program | 2D 3D TSV |
| 11720866 | 19 | 1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: novel synthesis via cyclization of N-acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-releasing factor-1 (CRF(1)) receptor antagonist activities. |
Bioorg Med Chem Lett 11: 3165-8 (2001) | Neurocrine Biosciences Inc | 2D 3D TSV |
| 11720865 | 11 | Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues. |
Bioorg Med Chem Lett 11: 3161-4 (2001) | Shire BioChem Inc | 2D 3D TSV |
| 11720863 | 73 | Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers. |
Bioorg Med Chem Lett 11: 3151-5 (2001) | CeNeS Pharmaceuticals Inc. | 2D 3D TSV |
| 11720861 | 24 | Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues. |
Bioorg Med Chem Lett 11: 3143-6 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11720860 | 12 | Combinatorial synthesis of CCR5 antagonists. |
Bioorg Med Chem Lett 11: 3137-41 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11720859 | 1 | Modelling studies of the active site of human sorbitol dehydrogenase: an approach to structure-based inhibitor design of the enzyme. |
Bioorg Med Chem Lett 11: 3133-6 (2001) | Monash University (Parkville Campus) | 2D 3D TSV |
| 11720857 | 37 | 4-Aminopiperidine ureas as potent selective agonists of the human beta(3)-adrenergic receptor. |
Bioorg Med Chem Lett 11: 3123-7 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11720854 | 48 | Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight. |
Bioorg Med Chem Lett 11: 3111-3 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11720852 | 51 | Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection. |
Bioorg Med Chem Lett 11: 3103-6 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11720851 | 52 | Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection. |
Bioorg Med Chem Lett 11: 3099-102 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11720533 | 3 | A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus. |
J Nat Prod 64: 1457-9 (2001) | Chulalongkorn University | 2D 3D TSV |
| 11716514 | 103 | Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. |
Biochem Biophys Res Commun 289: 580-5 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11714898 | 21 | Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction. |
J Pharmacol Exp Ther 299: 1086-94 (2001) | Creighton University | 2D 3D TSV |
| 11714892 | 4 | N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide: a novel pre- and postsynaptic 5-hydroxytryptamine(1A) receptor antagonist active on the lower urinary tract. |
J Pharmacol Exp Ther 299: 1027-37 (2001) | Recordati S.p.A. | 2D 3D TSV |
| 11714875 | 18 | Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. |
J Pharmacol Exp Ther 299: 908-14 (2001) | Vrije Universiteit | 2D 3D TSV |
| 11714872 | 14 | The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist. |
J Pharmacol Exp Ther 299: 883-93 (2001) | AstraZeneca R&D | 2D 3D TSV |
| 11714616 | 28 | Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase. |
Bioorg Med Chem Lett 11: 3085-8 (2001) | Instituto de Química Médica (CSIC) | 2D 3D TSV |
| 11714615 | 22 | Dual neurokinin NK(1)/NK(2) antagonists: N-[(R,R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamides and 3-[N'-3,5-bis(trifluoromethyl)benzoyl-N-arylmethyl-N'-methylhydrazino]-N-[(R)-2-oxo-azepan-3-yl]propionamides. |
Bioorg Med Chem Lett 11: 3081-4 (2001) | Novartis Pharma AG | 2D 3D TSV |
| 11714614 | 11 | Synthesis and binding affinities of 2 beta-(3-iodoallyloxycarbonyl)-3 beta-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies. |
Bioorg Med Chem Lett 11: 3077-80 (2001) | Inha University | 2D 3D TSV |
| 11714612 | 19 | A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase). |
Bioorg Med Chem Lett 11: 3069-72 (2001) | LGCI | 2D 3D TSV |
| 11714608 | 30 | Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. |
Bioorg Med Chem Lett 11: 3049-53 (2001) | Alcohol and Drug Abuse Research Center | 2D 3D TSV |
| 11714606 | 31 | BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor. |
Bioorg Med Chem Lett 11: 3041-4 (2001) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11714605 | 39 | Beta 3 agonists. Part 1: evolution from inception to BMS-194449. |
Bioorg Med Chem Lett 11: 3035-9 (2001) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11714604 | 19 | 2-Aryl indole NK(1) antagonists: optimisation of the amide substituent. |
Bioorg Med Chem Lett 11: 3031-4 (2001) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 11714603 | 7 | Synthesis of antitumor dendritic imides. |
Bioorg Med Chem Lett 11: 3027-9 (2001) | University San Pablo-CEU | 2D 3D TSV |
| 11714602 | 18 | 7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors. |
Bioorg Med Chem Lett 11: 3023-6 (2001) | Universit£ di Pisa | 2D 3D TSV |
| 11714601 | 9 | Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists. |
Bioorg Med Chem Lett 11: 3019-21 (2001) | Bayer AG | 2D 3D TSV |
| 11714600 | 10 | Cyclopenta[g]quinazoline-based antifolates: the effect of the chirality at the 6-position on the inhibition of thymidylate synthase (TS). |
Bioorg Med Chem Lett 11: 3015-7 (2001) | The Institute of Cancer Research | 2D 3D TSV |
| 11714597 | 5 | Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism. |
Bioorg Med Chem Lett 11: 3001-5 (2001) | Kingston University | 2D 3D TSV |
| 11714595 | 43 | Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. |
Bioorg Med Chem Lett 11: 2993-5 (2001) | Taisho Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11714317 | 11 | Synthesis and quantitative structure-activity relationships of fluorine-containing 4,4-dihydroxylmethyl-2-aryliminooxazo(thiazo)lidines as trehalase inhibitors. |
J Agric Food Chem 49: 5279-84 (2001) | Dalian University of Technology | 2D 3D TSV |
| 11708932 | 7 | An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration. |
J Med Chem 44: 4296-9 (2001) | Merck | 2D 3D TSV |
| 11708931 | 44 | 5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors. |
J Med Chem 44: 4292-5 (2001) | Università di Firenze | 2D 3D TSV |
| 11708930 | 15 | Salicylaldoxime moiety as a phenolic "A-Ring" substitute in estrogen receptor ligands. |
J Med Chem 44: 4288-91 (2001) | Universit£ di Pisa | 2D 3D TSV |
| 11708928 | 17 | Role of hydrophilic interaction in binding of hydroxylated 3-deoxy C(19) steroids to the active site of aromatase. |
J Med Chem 44: 4277-83 (2001) | Tohoku Pharmaceutical University | 2D 3D TSV |
| 11708927 | 8 | A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. |
J Med Chem 44: 4268-76 (2001) | UMR 8525 CNRS-Université Lille II-Institut Pasteur de Lille | 2D 3D TSV |
| 11708926 | 84 | Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE). |
J Med Chem 44: 4252-67 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11708925 | 44 | Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. |
J Med Chem 44: 4230-51 (2001) | University of Illinois | 2D 3D TSV |
| 11708921 | 28 | 5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold. |
J Med Chem 44: 4196-206 (2001) | Instituto de Qu£mica M£dica (CSIC) | 2D 3D TSV |
| 11708918 | 29 | Design and pharmacological activity of phosphinic acid based NAALADase inhibitors. |
J Med Chem 44: 4170-5 (2001) | Guilford Pharmaceuticals Inc | 2D 3D TSV |
| 11708917 | 33 | Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis. |
J Med Chem 44: 4157-69 (2001) | Procter & Gamble Pharmaceuticals | 2D 3D TSV |
| 11708915 | 52 | Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. |
J Med Chem 44: 4125-36 (2001) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
| 11708914 | 4 | Novel agouti-related-protein-based melanocortin-1 receptor antagonist. |
J Med Chem 44: 4114-24 (2001) | University of Florida | 2D 3D TSV |
| 11708913 | 41 | The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors. |
J Med Chem 44: 4092-113 (2001) | Purdue University | 2D 3D TSV |
| 11708910 | 42 | Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action. |
J Med Chem 44: 4062-71 (2001) | National Institutes of Health | 2D 3D TSV |
| 11708909 | 12 | Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. |
J Med Chem 44: 4050-61 (2001) | German Cancer Research Center | 2D 3D TSV |
| 11708908 | 55 | Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. |
J Med Chem 44: 4042-9 (2001) | University of Pittsburgh | 2D 3D TSV |
| 11708906 | 15 | Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators. |
J Med Chem 44: 4035-8 (2001) | University of Bologna | 2D 3D TSV |
| 11708905 | 20 | N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy. |
J Med Chem 44: 4031-4 (2001) | Eli Lilly and Company | 2D 3D TSV |
| 11701096 | 24 | Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement. |
BMC Chem Biol 1: 3 (2001) | Kimmel Cancer Center | 2D 3D TSV |
| 11697047 | 10 | Glycosylasparaginase inhibition studies: competitive inhibitors, transition state mimics, noncompetitive inhibitors. |
J Enzym Inhib 16: 269-74 (2001) | University of North Carolina | 2D 3D TSV |
| 11689089 | 30 | Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nociceptin peptides. |
J Med Chem 44: 4015-8 (2001) | Tohoku Pharmaceutical University | 2D 3D TSV |
| 11689088 | 22 | Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil. |
J Med Chem 44: 4011-4 (2001) | Università di Bologna | 2D 3D TSV |
| 11689087 | 26 | Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. |
J Med Chem 44: 4001-10 (2001) | Neurocrine Biosciences Inc | 2D 3D TSV |
| 11689084 | 47 | Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists. |
J Med Chem 44: 3978-84 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11689083 | 41 | Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. |
J Med Chem 44: 3965-77 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11689082 | 29 | Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor. |
J Med Chem 44: 3956-64 (2001) | University of Ferrara | 2D 3D TSV |
| 11689081 | 86 | Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP). |
J Med Chem 44: 3946-55 (2001) | Universit£ di Firenze | 2D 3D TSV |
| 11689080 | 43 | Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues. |
J Med Chem 44: 3937-45 (2001) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
| 11689079 | 18 | Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents. |
J Med Chem 44: 3932-6 (2001) | University of North Carolina | 2D 3D TSV |
| 11689075 | 20 | Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation. |
J Med Chem 44: 3896-903 (2001) | University of Lausanne | 2D 3D TSV |
| 11689074 | 112 | N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands. |
J Med Chem 44: 3881-95 (2001) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 11689073 | 4 | Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily. |
J Med Chem 44: 3872-80 (2001) | University of Michigan Cancer Center | 2D 3D TSV |
| 11689072 | 49 | Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator. |
J Med Chem 44: 3856-71 (2001) | Axys Pharmaceuticals Inc | 2D 3D TSV |
| 11689071 | 40 | Three-dimensional quantitative structure-activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: applying a"divide and conquer" strategy. |
J Med Chem 44: 3849-55 (2001) | University of Missouri St. Louis | 2D 3D TSV |
| 11689069 | 18 | Synthesis and activity of novel and selective I(Ks)-channel blockers. |
J Med Chem 44: 3831-7 (2001) | Aventis Pharma Deutschland GmbH | 2D 3D TSV |
| 11689067 | 34 | Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives. |
J Med Chem 44: 3810-20 (2001) | University of Bologna | 2D 3D TSV |
| 11689065 | 27 | Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis. |
J Med Chem 44: 3786-94 (2001) | Università di Perugia | 2D 3D TSV |
| 11689063 | 28 | Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers. |
J Med Chem 44: 3764-7 (2001) | TBA | 2D 3D TSV |
| 11689062 | 8 | Novel lead generation through hypothetical pharmacophore three-dimensional database searching: discovery of isoflavonoids as nonsteroidal inhibitors of rat 5 alpha-reductase. |
J Med Chem 44: 3759-63 (2001) | TBA | 2D 3D TSV |
| 11683238 | 2 | Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. |
Pharm Res 18: 1262-9 (2001) | Kanazawa University | 2D 3D TSV |
| 11678667 | 1 | Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa. |
J Nat Prod 64: 1354-6 (2001) | Universit£ di Salerno | 2D 3D TSV |
| 11678659 | 1 | Antimalarial (+)-trans-hexahydrodibenzopyran derivatives from Machaerium multiflorum. |
J Nat Prod 64: 1322-5 (2001) | University of Mississippi | 2D 3D TSV |
| 11678654 | 3 | Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives. |
J Nat Prod 64: 1297-300 (2001) | Universidad de Murcia | 2D 3D TSV |
| 11678653 | 1 | Catalytic inhibition of topoisomerase IIalpha by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica. |
J Nat Prod 64: 1294-6 (2001) | University of Arizona | 2D 3D TSV |
| 11678652 | 16 | Aromatase inhibitors from Broussonetia papyrifera. |
J Nat Prod 64: 1286-93 (2001) | University of Illinois at Chicago | 2D 3D TSV |
| 11677140 | 4 | Fipronil-based photoaffinity probe for Drosophila and human beta 3 GABA receptors. |
Bioorg Med Chem Lett 11: 2979-81 (2001) | University of California | 2D 3D TSV |
| 11677139 | 92 | The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines. |
Bioorg Med Chem Lett 11: 2975-8 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11677136 | 13 | 3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors. |
Bioorg Med Chem Lett 11: 2963-5 (2001) | LGCI | 2D 3D TSV |
| 11677135 | 21 | Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis. |
Bioorg Med Chem Lett 11: 2959-62 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11677134 | 42 | Design and synthesis of potent and selective inhibitors of integrin VLA-4. |
Bioorg Med Chem Lett 11: 2955-8 (2001) | Novartis Institute for BioMedical Research | 2D 3D TSV |
| 11677133 | 14 | Discovery and parallel synthesis of a new class of cathepsin K inhibitors. |
Bioorg Med Chem Lett 11: 2951-4 (2001) | Bayer Research Center | 2D 3D TSV |
| 11677132 | 65 | Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors. |
Bioorg Med Chem Lett 11: 2947-50 (2001) | COR Therapeutics Inc | 2D 3D TSV |
| 11677131 | 42 | Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A. |
Bioorg Med Chem Lett 11: 2941-6 (2001) | The University of Newcastle | 2D 3D TSV |
| 11677124 | 67 | Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme. |
Bioorg Med Chem Lett 11: 2907-10 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11677121 | 4 | A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine. |
Bioorg Med Chem Lett 11: 2893-6 (2001) | University of Maryland | 2D 3D TSV |
| 11669456 | 10 | Characterization of ochratoxin A transport by human organic anion transporters. |
Life Sci 69: 2123-35 (2001) | Kyorin University | 2D 3D TSV |
| 11641438 | 4 | Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1. |
Mol Pharmacol 60: 1091-9 (2001) | University of Rochester School of Medicine and Dentistry | 2D 3D TSV |
| 11606389 | 1 | The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein. |
Cancer Res 61: 7525-9 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11606139 | 11 | Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents. |
J Med Chem 44: 3746-9 (2001) | Institute of Pharmaceutical Chemistry | 2D 3D TSV |
| 11606138 | 45 | Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. |
J Med Chem 44: 3730-45 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11606136 | 10 | Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses. |
J Med Chem 44: 3710-20 (2001) | Academia Sinica | 2D 3D TSV |
| 11606131 | 92 | Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro. |
J Med Chem 44: 3665-72 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11606129 | 4 | Design, synthesis, and evaluation of a long-acting, potent analogue of gonadotropin-releasing hormone. |
J Med Chem 44: 3645-52 (2001) | Institute of Science | 2D 3D TSV |
| 11606127 | 96 | Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily. |
J Med Chem 44: 3622-31 (2001) | Université Paris V | 2D 3D TSV |
| 11606122 | 7 | Alpha-amino acid phenolic ester derivatives: novel water-soluble general anesthetic agents which allosterically modulate GABA(A) receptors. |
J Med Chem 44: 3582-91 (2001) | Organon Research and Development Group | 2D 3D TSV |
| 11606121 | 152 | Toward the quantitative prediction of T-cell epitopes: coMFA and coMSIA studies of peptides with affinity for the class I MHC molecule HLA-A*0201. |
J Med Chem 44: 3572-81 (2001) | Edward Jenner Institute for Vaccine Research | 2D 3D TSV |
| 11602689 | 2 | Interaction of 2,3-dimercapto-1-propane sulfonate with the human organic anion transporter hOAT1. |
J Pharmacol Exp Ther 299: 741-7 (2001) | University of Arizona | 2D 3D TSV |
| 11602678 | 5 | OPC-28326, a selective femoral vasodilator, is an alpha2C-adrenoceptor-selective antagonist. |
J Pharmacol Exp Ther 299: 652-8 (2001) | Otsuka Maryland Research Institute | 2D 3D TSV |
| 11597422 | 39 | Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: variation of the delta address and its effects on affinity and selectivity for the delta opioid receptor. |
Bioorg Med Chem Lett 11: 2883-5 (2001) | NIDDK | 2D 3D TSV |
| 11597420 | 5 | Design and synthesis of Pfmrk inhibitors as potential antimalarial agents. |
Bioorg Med Chem Lett 11: 2875-8 (2001) | The Ohio State University | 2D 3D TSV |
| 11597419 | 105 | 2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides. |
Bioorg Med Chem Lett 11: 2871-4 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11597418 | 47 | Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity. |
Bioorg Med Chem Lett 11: 2867-70 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11597417 | 73 | Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding. |
Bioorg Med Chem Lett 11: 2863-6 (2001) | Friedrich-Alexander University | 2D 3D TSV |
| 11597415 | 36 | Synthesis and In vitro binding affinities of 1-azabicyclic compounds as muscarinic ligands. |
Bioorg Med Chem Lett 11: 2855-7 (2001) | Seoul National University | 2D 3D TSV |
| 11597414 | 10 | Potent, low molecular weight thrombin receptor antagonists. |
Bioorg Med Chem Lett 11: 2851-3 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11597413 | 46 | Design and synthesis of a novel class of histone deacetylase inhibitors. |
Bioorg Med Chem Lett 11: 2847-50 (2001) | MethylGene Inc | 2D 3D TSV |
| 11597412 | 116 | Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor. |
Bioorg Med Chem Lett 11: 2843-6 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11597411 | 4 | Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035). |
Bioorg Med Chem Lett 11: 2837-41 (2001) | Newcastle University | 2D 3D TSV |
| 11597408 | 12 | A designed antagonist of the thyroid hormone receptor. |
Bioorg Med Chem Lett 11: 2821-5 (2001) | University of California | 2D 3D TSV |
| 11597407 | 13 | Design, synthesis, and biological activity of diiminoisoindolines as complement component 3a antagonists. |
Bioorg Med Chem Lett 11: 2817-20 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11597405 | 24 | 3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor. |
Bioorg Med Chem Lett 11: 2807-11 (2001) | Universidad Complutense | 2D 3D TSV |
| 11597403 | 17 | Antiviral drug design: computational analyses of the effects of the L100I mutation for HIV-RT on the binding of NNRTIs. |
Bioorg Med Chem Lett 11: 2799-802 (2001) | Yale University | 2D 3D TSV |
| 11591522 | 17 | Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide. |
Bioorg Med Chem Lett 11: 2779-82 (2001) | Pfizer Inc | 2D 3D TSV |
| 11591521 | 39 | Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach. |
Bioorg Med Chem Lett 11: 2775-8 (2001) | Bayer Research Center | 2D 3D TSV |
| 11591520 | 6 | Discovery of novel, orally active dual NK1/NK2 antagonists. |
Bioorg Med Chem Lett 11: 2769-73 (2001) | AstraZeneca Pharmaceuticals LP | 2D 3D TSV |
| 11591519 | 20 | Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase. |
Bioorg Med Chem Lett 11: 2763-7 (2001) | University of Toledo | 2D 3D TSV |
| 11591515 | 42 | Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones. |
Bioorg Med Chem Lett 11: 2747-50 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11591514 | 61 | 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity. |
Bioorg Med Chem Lett 11: 2741-5 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11591513 | 87 | Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. |
Bioorg Med Chem Lett 11: 2735-40 (2001) | Harvard Medical School | 2D 3D TSV |
| 11591512 | 18 | Small molecule somatostatin receptor subtype-2 antagonists. |
Bioorg Med Chem Lett 11: 2731-4 (2001) | Pfizer Inc | 2D 3D TSV |
| 11591511 | 12 | Small molecule/nucleic acid affinity chromatography: application for the identification of telomerase inhibitors which target its key RNA/DNA heteroduplex. |
Bioorg Med Chem Lett 11: 2727-30 (2001) | University of Missouri | 2D 3D TSV |
| 11591510 | 57 | alpha-Alkyl-alpha-amino-beta-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1. |
Bioorg Med Chem Lett 11: 2723-5 (2001) | Pfizer Inc | 2D 3D TSV |
| 11591509 | 46 | alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1. |
Bioorg Med Chem Lett 11: 2719-22 (2001) | Pfizer Inc | 2D 3D TSV |
| 11591508 | 18 | Synthesis of N-propargylphenelzine and analogues as neuroprotective agents. |
Bioorg Med Chem Lett 11: 2715-7 (2001) | CV Technologies Inc. | 2D 3D TSV |
| 11591507 | 79 | The discovery of sulfonylated dipeptides as potent VLA-4 antagonists. |
Bioorg Med Chem Lett 11: 2709-13 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11591503 | 7 | Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists. |
Bioorg Med Chem Lett 11: 2691-6 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11591502 | 51 | Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors. |
Bioorg Med Chem Lett 11: 2687-90 (2001) | Rhône-Poulenc Rorer | 2D 3D TSV |
| 11590022 | 13 | Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. |
Chem Biol 8: 981-95 (2001) | University of California San Francisco | 2D 3D TSV |
| 11585456 | 8 | Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs. |
J Med Chem 44: 3523-30 (2001) | University of Paris | 2D 3D TSV |
| 11585453 | 52 | 1,2-Benzothiazine 1,1-dioxide P(2)-P(3) peptide mimetic aldehyde calpain I inhibitors. |
J Med Chem 44: 3488-503 (2001) | Cephalon Inc | 2D 3D TSV |
| 11585452 | 291 | Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. |
J Med Chem 44: 3469-87 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11585449 | 25 | Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs. |
J Med Chem 44: 3440-52 (2001) | Cardiff University | 2D 3D TSV |
| 11585448 | 12 | Statistical molecular design, parallel synthesis, and biological evaluation of a library of thrombin inhibitors. |
J Med Chem 44: 3424-39 (2001) | AstraZeneca | 2D 3D TSV |
| 11585447 | 16 | Are free energy calculations useful in practice? A comparison with rapid scoring functions for the p38 MAP kinase protein system. |
J Med Chem 44: 3417-23 (2001) | Vertex Pharmaceuticals Inc | 2D 3D TSV |
| 11585446 | 6 | Synthesis of novel, potent, diol-based HIV-1 protease inhibitors via intermolecular pinacol homocoupling of (2S)-2-benzyloxymethyl-4-phenylbutanal. |
J Med Chem 44: 3407-16 (2001) | Stockholm University | 2D 3D TSV |
| 11585445 | 10 | Synthesis of potent C(2)-symmetric, diol-based hiv-1 protease inhibitors. Investigation of thioalkyl and thioaryl P1/P1' substituents. |
J Med Chem 44: 3402-6 (2001) | Stockholm University | 2D 3D TSV |
| 11585444 | 295 | From hit to lead. Analyzing structure-profile relationships. |
J Med Chem 44: 3391-401 (2001) | Universities of Lille | 2D 3D TSV |
| 11585443 | 137 | From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands. |
J Med Chem 44: 3378-90 (2001) | Universities of Lille | 2D 3D TSV |
| 11585442 | 20 | Potent and selective ET-A antagonists. 2. Discovery and evaluation of potent and water soluble N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives. |
J Med Chem 44: 3369-77 (2001) | Tanabe Seiyaku Co., Ltd | 2D 3D TSV |
| 11585441 | 70 | Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives. |
J Med Chem 44: 3355-68 (2001) | Tanabe Seiyaku Co., Ltd | 2D 3D TSV |
| 11585440 | 76 | Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release. |
J Med Chem 44: 3351-4 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11585439 | 44 | Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors. |
J Med Chem 44: 3347-50 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11585438 | 21 | Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist. |
J Med Chem 44: 3343-6 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11585437 | 17 | Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection. |
J Med Chem 44: 3339-42 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11579444 | 23 | Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA. |
Chirality 13: 523-32 (2001) | The Royal Danish School of Pharmacy | 2D 3D TSV |
| 11572683 | 11 | Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II. |
J Am Chem Soc 123: 9620-7 (2001) | University of Pennsylvania | 2D 3D TSV |
| 11567092 | 4 | Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. |
Protein Sci 10: 2008-16 (2001) | GSK | 2D 3D TSV |
| 11563931 | 42 | Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway. |
J Med Chem 44: 3320-8 (2001) | Harvard Medical School | 2D 3D TSV |
| 11563929 | 33 | Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1. |
J Med Chem 44: 3302-10 (2001) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11563928 | 2 | Synthesis and biological evaluation of sialylmimetics as rotavirus inhibitors. |
J Med Chem 44: 3292-301 (2001) | Griffith University (Gold Coast Campus) | 2D 3D TSV |
| 11563927 | 75 | 1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT(2A) serotonin receptor affinity and antagonist character. |
J Med Chem 44: 3283-91 (2001) | Virginia Commonwealth University | 2D 3D TSV |
| 11563922 | 147 | Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. |
J Med Chem 44: 3231-43 (2001) | Universität Bielefeld | 2D 3D TSV |
| 11563921 | 305 | Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis. |
J Med Chem 44: 3223-30 (2001) | Universit£ de Lille 2 | 2D 3D TSV |
| 11563920 | 64 | Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition. |
J Med Chem 44: 3216-22 (2001) | Tohoku University | 2D 3D TSV |
| 11563919 | 20 | A structure-based design approach to the development of novel, reversible AChE inhibitors. |
J Med Chem 44: 3203-15 (2001) | Syngenta | 2D 3D TSV |
| 11561088 | 2 | Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2. |
J Pharmacol Exp Ther 299: 261-7 (2001) | Kyoto University Hospital | 2D 3D TSV |
| 11557132 | 5 | Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and trogl |
Toxicology 167: 83-98 (2001) | F. Hoffmann-La Roche Inc | 2D 3D TSV |
| 11551771 | 16 | Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine. |
Bioorg Med Chem Lett 11: 2655-7 (2001) | University of Cape Town | 2D 3D TSV |
| 11551770 | 40 | Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase. |
Bioorg Med Chem Lett 11: 2651-3 (2001) | Pharmacia | 2D 3D TSV |
| 11551769 | 2 | Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus. |
Bioorg Med Chem Lett 11: 2647-9 (2001) | The University of Tennessee Health Science Center | 2D 3D TSV |
| 11551767 | 54 | New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. |
Bioorg Med Chem Lett 11: 2637-41 (2001) | University of Pittsburgh | 2D 3D TSV |
| 11551765 | 7 | Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives. |
Bioorg Med Chem Lett 11: 2627-30 (2001) | Universit£t Wien | 2D 3D TSV |
| 11551763 | 25 | 1,2,4-triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists. |
Bioorg Med Chem Lett 11: 2619-22 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11551762 | 16 | Potent peptide alpha-ketohydroxamate inhibitors of recombinant human calpain I. |
Bioorg Med Chem Lett 11: 2615-7 (2001) | Cephalon Inc | 2D 3D TSV |
| 11551758 | 58 | Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity. |
Bioorg Med Chem Lett 11: 2597-602 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11551757 | 29 | Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists. |
Bioorg Med Chem Lett 11: 2593-6 (2001) | Pfizer Inc | 2D 3D TSV |
| 11551756 | 26 | Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1. |
Bioorg Med Chem Lett 11: 2589-92 (2001) | Xenova Limited | 2D 3D TSV |
| 11551755 | 18 | Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor. |
Bioorg Med Chem Lett 11: 2585-8 (2001) | British Biotech Pharmaceuticals Limited | 2D 3D TSV |
| 11551754 | 43 | Solid-Phase synthesis of a library constructed of aromatic phosphate, long alkyl chains and tryptophane components, and identification of potent dipeptide telomerase inhibitors. |
Bioorg Med Chem Lett 11: 2581-4 (2001) | Kyushu University | 2D 3D TSV |
| 11551751 | 18 | Novel 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A(2). |
Bioorg Med Chem Lett 11: 2569-72 (2001) | University of Münster | 2D 3D TSV |
| 11551750 | 6 | Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines. |
Bioorg Med Chem Lett 11: 2565-8 (2001) | University of Technology | 2D 3D TSV |
| 11549469 | 38 | Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase. |
Bioorg Med Chem Lett 11: 2561-4 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11549468 | 54 | New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives. |
Bioorg Med Chem Lett 11: 2555-9 (2001) | Universidad de Sevilla | 2D 3D TSV |
| 11549467 | 85 | Substituted imidazoles as glucagon receptor antagonists. |
Bioorg Med Chem Lett 11: 2549-53 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11549463 | 72 | Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179). |
Bioorg Med Chem Lett 11: 2533-6 (2001) | Friedrich-Alexander University | 2D 3D TSV |
| 11549462 | 11 | Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands. |
Bioorg Med Chem Lett 11: 2529-31 (2001) | Facoltà di Farmacia dell'Università degli Studi di Genova | 2D 3D TSV |
| 11549461 | 13 | Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). |
Bioorg Med Chem Lett 11: 2525-8 (2001) | Kingston University | 2D 3D TSV |
| 11549460 | 16 | Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha. |
Bioorg Med Chem Lett 11: 2521-4 (2001) | University of Illinois | 2D 3D TSV |
| 11549459 | 5 | Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase. |
Bioorg Med Chem Lett 11: 2515-9 (2001) | National Cancer Institute-Frederick | 2D 3D TSV |
| 11549455 | 6 | Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383. |
Bioorg Med Chem Lett 11: 2499-502 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11549453 | 77 | Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors. |
Bioorg Med Chem Lett 11: 2489-93 (2001) | Section de Chimie de l'Universit£ de Lausanne | 2D 3D TSV |
| 11549450 | 55 | Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes. |
Bioorg Med Chem Lett 11: 2475-9 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11549449 | 28 | Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes. |
Bioorg Med Chem Lett 11: 2469-73 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11549448 | 2 | Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates. |
Bioorg Med Chem Lett 11: 2465-8 (2001) | Kyoto Pharmaceutical University | 2D 3D TSV |
| 11549447 | 6 | The discovery of novel, potent and selective PDE5 inhibitors. |
Bioorg Med Chem Lett 11: 2461-4 (2001) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11549442 | 6 | Alpha-ketoester-based photobiological switches: synthesis, peptide chain extension and assay against alpha-chymotrypsin. |
Bioorg Med Chem Lett 11: 2441-4 (2001) | University of Canterbury | 2D 3D TSV |
| 11549437 | 17 | Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors. |
Bioorg Med Chem Lett 11: 2419-22 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11546835 | 55 | The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family. |
Pharmacol Rev 53: 381-415 (2001) | McGill University | 2D 3D TSV |
| 11543689 | 34 | Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase. |
J Med Chem 44: 3195-8 (2001) | Universit£ de Lausanne | 2D 3D TSV |
| 11543687 | 92 | Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype. |
J Med Chem 44: 3175-86 (2001) | National Institute on Drug Abuse-Intramural Research Program | 2D 3D TSV |
| 11543683 | 42 | Identification of alkylidene hydrazides as glucagon receptor antagonists. |
J Med Chem 44: 3141-9 (2001) | Pfizer Inc | 2D 3D TSV |
| 11543680 | 17 | Exploration of novel aryl binding sites of farnesyltransferase using molecular modeling and benzophenone-based farnesyltransferase inhibitors. |
J Med Chem 44: 3117-24 (2001) | Philipps-Universität Marburg | 2D 3D TSV |
| 11543679 | 15 | A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning. |
J Med Chem 44: 3109-16 (2001) | University of Arizona | 2D 3D TSV |
| 11543678 | 18 | Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking. |
J Med Chem 44: 3092-108 (2001) | National Institute of Diabetes | 2D 3D TSV |
| 11543677 | 20 | Design and synthesis of potent C(2)-symmetric diol-based HIV-1 protease inhibitors: effects of fluoro substitution. |
J Med Chem 44: 3083-91 (2001) | Linkoping University | 2D 3D TSV |
| 11543676 | 45 | Design and synthesis of matrix metalloproteinase inhibitors guided by molecular modeling. Picking the S(1) pocket using conformationally constrained inhibitors. |
J Med Chem 44: 3074-82 (2001) | Université de Montréal | 2D 3D TSV |
| 11543675 | 104 | N-Aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: further probing of the S(1), S(1)', and S(2)' pockets. |
J Med Chem 44: 3066-73 (2001) | Université de Montréal | 2D 3D TSV |
| 11543674 | 3 | Determination of the binding specificity of an integral membrane protein by saturation transfer difference NMR: RGD peptide ligands binding to integrin alphaIIbbeta3. |
J Med Chem 44: 3059-65 (2001) | University of Hamburg | 2D 3D TSV |
| 11543672 | 24 | [2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists. |
J Med Chem 44: 3048-53 (2001) | Clinical Research Institute of Montreal | 2D 3D TSV |
| 11527737 | 70 | Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta. |
Bioorg Med Chem Lett 11: 2385-8 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11527732 | 1 | Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist. |
Bioorg Med Chem Lett 11: 2365-7 (2001) | Organon K.K. | 2D 3D TSV |
| 11527731 | 25 | A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives. |
Bioorg Med Chem Lett 11: 2361-3 (2001) | Seoul National University | 2D 3D TSV |
| 11527730 | 27 | Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease. |
Bioorg Med Chem Lett 11: 2355-9 (2001) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11527728 | 56 | New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities. |
Bioorg Med Chem Lett 11: 2345-9 (2001) | Solvay Pharma | 2D 3D TSV |
| 11527727 | 8 | The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4. |
Bioorg Med Chem Lett 11: 2341-3 (2001) | Australian National University | 2D 3D TSV |
| 11527726 | 15 | Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter. |
Bioorg Med Chem Lett 11: 2337-40 (2001) | Wayne State University | 2D 3D TSV |
| 11527724 | 30 | Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors. |
Bioorg Med Chem Lett 11: 2325-30 (2001) | Axys Pharmaceuticals Inc | 2D 3D TSV |
| 11527723 | 32 | A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. |
Bioorg Med Chem Lett 11: 2319-23 (2001) | ARIAD Pharmaceuticals Inc | 2D 3D TSV |
| 11527721 | 12 | Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution. |
Bioorg Med Chem Lett 11: 2311-4 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11527718 | 9 | Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings. |
Bioorg Med Chem Lett 11: 2295-300 (2001) | NIDDK | 2D 3D TSV |
| 11527716 | 29 | Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity. |
Bioorg Med Chem Lett 11: 2287-90 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11527715 | 33 | Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor. |
Bioorg Med Chem Lett 11: 2283-6 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11527714 | 66 | Design and synthesis of glycolic and mandelic acid derivatives as factor Xa inhibitors. |
Bioorg Med Chem Lett 11: 2279-82 (2001) | COR Therapeutics Inc | 2D 3D TSV |
| 11527709 | 19 | Optimization of a screening lead for factor VIIa/TF. |
Bioorg Med Chem Lett 11: 2253-6 (2001) | Axys Pharmaceuticals Inc | 2D 3D TSV |
| 11527706 | 65 | Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents. |
Bioorg Med Chem Lett 11: 2241-4 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11520216 | 41 | Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. |
J Nat Prod 64: 1010-4 (2001) | University of Shizuoka | 2D 3D TSV |
| 11520213 | 12 | Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere. |
J Med Chem 44: 3039-42 (2001) | University of Alberta | 2D 3D TSV |
| 11520212 | 3 | S(+)-4-(1-Phenylethylamino)quinazolines as inhibitors of human immunoglobulin E synthesis: potency is dictated by stereochemistry and atomic point charges at N-1. |
J Med Chem 44: 3031-8 (2001) | Novartis Forschungsinstitut | 2D 3D TSV |
| 11520211 | 7 | Design, synthesis and pharmacological characterization of a potent radioiodinated and photoactivatable peptidic oxytocin antagonist. |
J Med Chem 44: 3022-30 (2001) | University of Montpellier | 2D 3D TSV |
| 11520208 | 45 | Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity. |
J Med Chem 44: 2990-3000 (2001) | Institut Henri Beaufour | 2D 3D TSV |
| 11520205 | 4 | 5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors. |
J Med Chem 44: 2966-75 (2001) | Leiden/Amsterdam Center for Drug Research | 2D 3D TSV |
| 11520202 | 130 | Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. |
J Med Chem 44: 2933-49 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11520201 | 10 | X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor. |
J Med Chem 44: 2928-32 (2001) | GSK | 2D 3D TSV |
| 11520200 | 17 | Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity. |
J Med Chem 44: 2921-7 (2001) | University of Alberta | 2D 3D TSV |
| 11520199 | 25 | Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides. |
J Med Chem 44: 2913-20 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11520198 | 54 | 2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists. |
J Med Chem 44: 2900-12 (2001) | Universit£ degli Studi di Urbino | 2D 3D TSV |
| 11520197 | 32 | Synthesis, molecular modeling, and structure-activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors. |
J Med Chem 44: 2886-99 (2001) | Philipps-Universität Marburg | 2D 3D TSV |
| 11520196 | 81 | Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity. |
J Med Chem 44: 2879-85 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11520195 | 19 | Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif. |
J Med Chem 44: 2869-78 (2001) | National Cancer Institute-Frederick | 2D 3D TSV |
| 11520194 | 13 | Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase). |
J Med Chem 44: 2865-8 (2001) | University of Illinois at Chicago | 2D 3D TSV |
| 11514173 | 4 | Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pK(a). |
Bioorg Med Chem Lett 11: 2213-6 (2001) | AstraZeneca | 2D 3D TSV |
| 11514172 | 20 | Identification of selective inhibitors of cyclin dependent kinase 4. |
Bioorg Med Chem Lett 11: 2209-11 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11514167 | 88 | The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups. |
Bioorg Med Chem Lett 11: 2189-92 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11514164 | 36 | Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists. |
Bioorg Med Chem Lett 11: 2177-80 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11514163 | 14 | Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist. |
Bioorg Med Chem Lett 11: 2173-6 (2001) | F. Hoffmann-La Roche Inc | 2D 3D TSV |
| 11514161 | 23 | N,N-dibenzyl-N'-benzylidenehydrazines: potent competitive glucose-6-phosphatase catalytic enzyme inhibitors. |
Bioorg Med Chem Lett 11: 2165-7 (2001) | Novo Nordisk A/S | 2D 3D TSV |
| 11514157 | 48 | N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: oral activity via P1' isobutyl substitution. |
Bioorg Med Chem Lett 11: 2147-51 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11514156 | 28 | Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element. |
Bioorg Med Chem Lett 11: 2143-6 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11514154 | 9 | 5-HT(3)R binding of lerisetron: an interdisciplinary approach to drug-Receptor interactions. |
Bioorg Med Chem Lett 11: 2133-6 (2001) | The University of Louisiana at Monroe | 2D 3D TSV |
| 11514153 | 45 | Discovery of thioazepinone ligands for Src SH2: from non-specific to specific binding. |
Bioorg Med Chem Lett 11: 2127-31 (2001) | Aventis | 2D 3D TSV |
| 11514150 | 42 | Stereoselective synthesis and antibacterial evaluation of 4-amido-isothiazolidinone oxides. |
Bioorg Med Chem Lett 11: 2111-5 (2001) | Procter & Gamble Pharmaceuticals | 2D 3D TSV |
| 11514149 | 86 | Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide. |
Bioorg Med Chem Lett 11: 2105-9 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11514144 | 51 | Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues. |
Bioorg Med Chem Lett 11: 2085-8 (2001) | Roche Bioscience | 2D 3D TSV |
| 11514143 | 71 | Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles. |
Bioorg Med Chem Lett 11: 2079-83 (2001) | Georgetown University Medical Center | 2D 3D TSV |
| 11514142 | 4 | Synthesis, antimalarial activity and inhibition of haem detoxification of novel bisquinolines. |
Bioorg Med Chem Lett 11: 2075-7 (2001) | La Trobe University | 2D 3D TSV |
| 11514141 | 16 | Pyridopyrimidine analogues as novel adenosine kinase inhibitors. |
Bioorg Med Chem Lett 11: 2071-4 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11514140 | 17 | Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers. |
Bioorg Med Chem Lett 11: 2067-70 (2001) | no Pharmaceutical Co., Ltd. | 2D 3D TSV |
| 11514139 | 41 | 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). |
Bioorg Med Chem Lett 11: 2061-5 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11512051 | 80 | The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor. |
Psychopharmacology (Berl) 157: 111-4 (2001) | Case Western Reserve University | 2D 3D TSV |
| 11504829 | 16 | Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists. |
J Pharmacol Exp Ther 298: 1260-8 (2001) | University of Melbourne | 2D 3D TSV |
| 11502885 | 35 | Identification of potent and selective neuropeptide Y Y(1) receptor agonists with orexigenic activity in vivo. |
Mol Pharmacol 60: 534-40 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11502595 | 26 | Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. |
Am J Physiol Renal Physiol 281: 454-68 (2001) | Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t | 2D 3D TSV |
| 11496833 | 15 | Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer. |
J Enzym Inhib 16: 35-45 (2001) | Cardiff University | 2D 3D TSV |
| 11496832 | 7 | Potential of pyrazolooxadiazinone derivatives as serine protease inhibitors. |
J Enzym Inhib 16: 15-34 (2001) | Università di Ferrara | 2D 3D TSV |
| 11495597 | 1 | Photochemical synthesis of N-arylbenzophenanthridine selective estrogen receptor modulators (serms). |
J Med Chem 44: 2857-60 (2001) | Eli Lilly and Company | 2D 3D TSV |
| 11495596 | 16 | Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. |
J Med Chem 44: 2849-56 (2001) | University of Kansas | 2D 3D TSV |
| 11495595 | 24 | Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of d-gluco- and d-xylopyranosylidene-spiro-(thio)hydantoins and N-(d-glucopyranosyl) amides. |
J Med Chem 44: 2843-8 (2001) | University of Debrecen | 2D 3D TSV |
| 11495592 | 12 | Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional studies. |
J Med Chem 44: 2814-26 (2001) | Pharmazeutisches Institut der Universit£t Freiburg | 2D 3D TSV |
| 11495587 | 198 | Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa. |
J Med Chem 44: 2753-71 (2001) | Axys Pharmaceuticals Inc | 2D 3D TSV |
| 11495586 | 3 | Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase. |
J Med Chem 44: 2743-52 (2001) | Universit£ de Reims Champagne-Ardenne | 2D 3D TSV |
| 11495585 | 16 | Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies. |
J Med Chem 44: 2735-42 (2001) | Università degli Studi di Ferrara | 2D 3D TSV |
| 11495584 | 76 | 6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity. |
J Med Chem 44: 2719-34 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11495583 | 62 | Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors. |
J Med Chem 44: 2707-18 (2001) | Universit£ Louis Pasteur | 2D 3D TSV |
| 11495581 | 4 | Sorbitol dehydrogenase inhibitors (SDIs): a new potent, enantiomeric SDI, 4-[2-1R-hydroxy-ethyl)-pyrimidin-4-yl]piperazine-1-sulfonic acid dimethylamide. |
J Med Chem 44: 2695-700 (2001) | Pfizer Inc | 2D 3D TSV |
| 11495580 | 35 | Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). |
J Med Chem 44: 2691-4 (2001) | Friedrich-Alexander University | 2D 3D TSV |
| 11495579 | 24 | Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity. |
J Med Chem 44: 2687-90 (2001) | Research Triangle Institute | 2D 3D TSV |
| 11495578 | 12 | Discovery of estrogen sulfotransferase inhibitors from a purine library screen. |
J Med Chem 44: 2683-6 (2001) | University of California | 2D 3D TSV |
| 11495577 | 16 | The first potent and selective inhibitors of the glycine transporter type 2. |
J Med Chem 44: 2679-82 (2001) | Organon Laboratories Ltd | 2D 3D TSV |
| 11485475 | 42 | Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. |
J Org Chem 66: 5504-16 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11474784 | 6 | HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. |
Pharm Res 18: 800-6 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11473415 | 21 | The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I. |
J Nat Prod 64: 874-82 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11472219 | 27 | Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase. |
J Med Chem 44: 2667-70 (2001) | Northwestern University | 2D 3D TSV |
| 11472217 | 157 | Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. |
J Med Chem 44: 2636-60 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11472216 | 89 | Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. |
J Med Chem 44: 2619-35 (2001) | Organix Inc | 2D 3D TSV |
| 11472213 | 12 | Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin. |
J Med Chem 44: 2593-600 (2001) | Southern Methodist University | 2D 3D TSV |
| 11472212 | 6 | Design and synthesis of potent and selective alpha(4)beta(7) integrin antagonists. |
J Med Chem 44: 2586-92 (2001) | Technische Universität München | 2D 3D TSV |
| 11472210 | 9 | Disabling erbB receptors with rationally designed exocyclic mimetics of antibodies: structure-function analysis. |
J Med Chem 44: 2565-74 (2001) | University of Pennsylvania School of Medicine | 2D 3D TSV |
| 11472209 | 72 | Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase. |
J Med Chem 44: 2555-64 (2001) | University of Nottingham | 2D 3D TSV |
| 11472208 | 24 | Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. |
J Med Chem 44: 2544-54 (2001) | Sapienza University of Rome | 2D 3D TSV |
| 11472206 | 72 | Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones. |
J Med Chem 44: 2523-35 (2001) | Vrije Universiteit | 2D 3D TSV |
| 11472205 | 37 | Novel selective PDE4 inhibitors. 1. Synthesis, structure-activity relationships, and molecular modeling of 4-(3,4-dimethoxyphenyl)-2H-phthalazin-1-ones and analogues. |
J Med Chem 44: 2511-22 (2001) | Vrije Universiteit | 2D 3D TSV |
| 11472204 | 6 | A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents. |
J Med Chem 44: 2507-10 (2001) | TBA | 2D 3D TSV |
| 11472202 | 143 | Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases. |
J Med Chem 44: 2499-502 (2001) | TBA | 2D 3D TSV |
| 11465411 | 25 | Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2). |
Pharm Res 18: 579-86 (2001) | University of Tokyo | 2D 3D TSV |
| 11462984 | 64 | GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6. |
J Med Chem 44: 453-67 (2001) | Ferring Research Institute Inc. | 2D 3D TSV |
| 11462983 | 50 | Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization. |
J Med Chem 44: 441-52 (2001) | Purdue University | 2D 3D TSV |
| 11462982 | 33 | Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor. |
J Med Chem 44: 429-40 (2001) | University of Auckland | 2D 3D TSV |
| 11462981 | 184 | New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
J Med Chem 44: 418-28 (2001) | Universidad de Navarra | 2D 3D TSV |
| 11462978 | 16 | Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel. |
J Med Chem 44: 372-89 (2001) | AstraZeneca Pharmaceuticals LP | 2D 3D TSV |
| 11462977 | 21 | Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes. |
J Med Chem 44: 362-71 (2001) | University of Bologna | 2D 3D TSV |
| 11462976 | 20 | Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines. |
J Med Chem 44: 350-61 (2001) | J. Uriach & Cía. S.A. | 2D 3D TSV |
| 11462975 | 50 | Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. |
J Med Chem 44: 340-9 (2001) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
| 11462973 | 47 | 3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists. |
J Med Chem 44: 316-27 (2001) | Universit£ di Pisa | 2D 3D TSV |
| 11462972 | 93 | Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent. |
J Med Chem 44: 305-15 (2001) | Universita' degli Studi di Salerno | 2D 3D TSV |
| 11462970 | 9 | Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase). |
J Med Chem 44: 298-301 (2001) | TBA | 2D 3D TSV |
| 11462969 | 7 | New dermatological agents for the treatment of psoriasis. |
J Med Chem 44: 281-97 (2001) | Allergan Inc | 2D 3D TSV |
| 11459929 | 7 | Trace amines: identification of a family of mammalian G protein-coupled receptors. |
Proc Natl Acad Sci U S A 98: 8966-71 (2001) | Synaptic Pharmaceutical Corporation | 2D 3D TSV |
| 11459670 | 30 | Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists. |
Bioorg Med Chem Lett 11: 1959-62 (2001) | Merck & Co. | 2D 3D TSV |
| 11459669 | 20 | Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics. |
Bioorg Med Chem Lett 11: 1955-7 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11459668 | 16 | Nicotinamide N-oxides as CXCR2 antagonists. |
Bioorg Med Chem Lett 11: 1951-4 (2001) | Celltech R&D Ltd | 2D 3D TSV |
| 11459667 | 13 | Selectivity enhancement induced by substitution of non-natural analogues of arginine and lysine in arginine-based thrombin inhibitors. |
Bioorg Med Chem Lett 11: 1947-50 (2001) | Medical University of South Carolina | 2D 3D TSV |
| 11459666 | 20 | Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors. |
Bioorg Med Chem Lett 11: 1943-5 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11459665 | 36 | 2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor. |
Bioorg Med Chem Lett 11: 1939-42 (2001) | Glaxo Wellcome Research and Development | 2D 3D TSV |
| 11459664 | 21 | alpha-Ketocarboxylic acid-based inhibitors of protein tyrosine phosphatases. |
Bioorg Med Chem Lett 11: 1935-8 (2001) | Brown University | 2D 3D TSV |
| 11459663 | 19 | Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. |
Bioorg Med Chem Lett 11: 1931-4 (2001) | Universit£ di Camerino | 2D 3D TSV |
| 11459662 | 41 | 1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2). |
Bioorg Med Chem Lett 11: 1925-9 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11459661 | 41 | Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors. |
Bioorg Med Chem Lett 11: 1919-24 (2001) | Georgetown University Medical Center | 2D 3D TSV |
| 11459659 | 28 | Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. |
Bioorg Med Chem Lett 11: 1911-4 (2001) | AstraZeneca | 2D 3D TSV |
| 11459658 | 18 | 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor. |
Bioorg Med Chem Lett 11: 1907-10 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11459657 | 20 | 3-Arylpiperidines as potentiators of existing antibacterial agents. |
Bioorg Med Chem Lett 11: 1903-6 (2001) | Pharmacia | 2D 3D TSV |
| 11459656 | 27 | Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. |
Bioorg Med Chem Lett 11: 1897-902 (2001) | Kyoto University | 2D 3D TSV |
| 11459654 | 4 | Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor. |
Bioorg Med Chem Lett 11: 1889-92 (2001) | National Institutes of Health | 2D 3D TSV |
| 11459653 | 31 | Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors. |
Bioorg Med Chem Lett 11: 1885-8 (2001) | Wyeth-Ayerst Research Laboratories | 2D 3D TSV |
| 11459643 | 20 | Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. |
Bioorg Med Chem Lett 11: 1839-42 (2001) | Kyoto Pharmaceutical University | 2D 3D TSV |
| 11459642 | 39 | Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1. |
Bioorg Med Chem Lett 11: 1833-7 (2001) | Nippon Roche Research Center | 2D 3D TSV |
| 11459640 | 30 | Nitrobenzene compounds inhibit expression of VCAM-1. |
Bioorg Med Chem Lett 11: 1823-7 (2001) | AtheroGenics, Inc. | 2D 3D TSV |
| 11459639 | 74 | Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase. |
Bioorg Med Chem Lett 11: 1817-21 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11459637 | 5 | Inhibition of fucosyltransferase V by a GDP-Azasugar. |
Bioorg Med Chem Lett 11: 1809-11 (2001) | Technische Universit£t Berlin | 2D 3D TSV |
| 11459636 | 16 | Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12)). |
Bioorg Med Chem Lett 11: 1805-8 (2001) | COR Therapeutics Inc | 2D 3D TSV |
| 11459634 | 94 | Development of potent and selective factor Xa inhibitors. |
Bioorg Med Chem Lett 11: 1797-800 (2001) | Axys Pharmaceuticals Inc | 2D 3D TSV |
| 11454940 | 13 | SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors. |
J Pharmacol Exp Ther 298: 753-68 (2001) | Sanofi Synthelabo | 2D 3D TSV |
| 11454918 | 90 | S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. |
J Pharmacol Exp Ther 298: 565-80 (2001) | Institut de Recherches Servier | 2D 3D TSV |
| 11454905 | 22 | [3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain. |
J Pharmacol Exp Ther 298: 453-60 (2001) | Eli Lilly and Company | 2D 3D TSV |
| 11454901 | 7 | Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751. |
J Pharmacol Exp Ther 298: 411-9 (2001) | Shionogi & Co. | 2D 3D TSV |
| 11454724 | 3 | Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein. |
Drug Metab Dispos 29: 1080-3 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11454474 | 84 | Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability. |
Bioorg Med Chem Lett 11: 2033-5 (2001) | Minase Research Institute | 2D 3D TSV |
| 11454473 | 119 | Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity. |
Bioorg Med Chem Lett 11: 2029-31 (2001) | Minase Research Institute | 2D 3D TSV |
| 11454472 | 107 | Design and synthesis of a highly selective EP2-receptor agonist. |
Bioorg Med Chem Lett 11: 2025-8 (2001) | Minase Research Institute | 2D 3D TSV |
| 11454470 | 17 | Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. |
Bioorg Med Chem Lett 11: 2017-9 (2001) | Leiden/Amsterdam Center for Drug Research | 2D 3D TSV |
| 11454469 | 95 | alpha(v)beta(3) Antagonists based on a central thiophene scaffold. |
Bioorg Med Chem Lett 11: 2011-5 (2001) | Aventis Pharma Deutschland GmbH | 2D 3D TSV |
| 11454468 | 35 | Discovery and SAR of org 24598-a selective glycine uptake inhibitor. |
Bioorg Med Chem Lett 11: 2007-9 (2001) | Organon Research and Development Group | 2D 3D TSV |
| 11454465 | 4 | Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication. |
Bioorg Med Chem Lett 11: 1993-5 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11454461 | 111 | The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold. |
Bioorg Med Chem Lett 11: 1975-9 (2001) | Procter and Gamble Pharmaceuticals | 2D 3D TSV |
| 11452702 | 1 | P-glycoprotein interactions of nefazodone and trazodone in cell culture. |
J Clin Pharmacol 41: 708-14 (2001) | Tufts University School of Medicine | 2D 3D TSV |
| 11451670 | 11 | Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis. |
Chem Biol 8: 701-11 (2001) | The Scripps Research Institute | 2D 3D TSV |
| 11448230 | 14 | Bisubstrate ketone analogues as serotonin N-acetyltransferase inhibitors. |
J Med Chem 44: 2479-85 (2001) | Johns Hopkins University School of Medicine | 2D 3D TSV |
| 11448228 | 25 | Peptide folding induces high and selective affinity of a linear and small beta-peptide to the human somatostatin receptor 4. |
J Med Chem 44: 2460-8 (2001) | ETH Zurich | 2D 3D TSV |
| 11448224 | 9 | Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain. |
J Med Chem 44: 2421-31 (2001) | Boehringer Ingelheim (Canada) Ltd | 2D 3D TSV |
| 11448223 | 70 | Volume learning algorithm artificial neural networks for 3D QSAR studies. |
J Med Chem 44: 2411-20 (2001) | Institute of Bioorganic & Petroleum Chemistry | 2D 3D TSV |
| 11448222 | 80 | Phenylpiperazinylalkylamino substituted pyridazinones as potent alpha(1) adrenoceptor antagonists. |
J Med Chem 44: 2403-10 (2001) | Istituto Chimico Farmaceutico e Tossicologico | 2D 3D TSV |
| 11448221 | 60 | Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii. |
J Med Chem 44: 2391-402 (2001) | Uppsala University | 2D 3D TSV |
| 11448220 | 93 | Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors. |
J Med Chem 44: 2387-90 (2001) | AstraZeneca R&D Montreal | 2D 3D TSV |
| 11448219 | 29 | Reversible carnitine palmitoyltransferase inhibitors with broad chemical diversity as potential antidiabetic agents. |
J Med Chem 44: 2383-6 (2001) | Sigma Tau Pharmaceutical Industries S.p.A. | 2D 3D TSV |
| 11438309 | 51 | The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. |
Eur J Pharmacol 423: 71-83 (2001) | Janssen Research Foundation | 2D 3D TSV |
| 11437380 | 2 | Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. |
Biochem Biophys Res Commun 285: 111-7 (2001) | Hungarian Academy of Sciences | 2D 3D TSV |
| 11430019 | 8 | Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program. |
J Nat Prod 64: 265-77 (2001) | National Cancer Institute | 2D 3D TSV |
| 11430001 | 72 | Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. |
J Nat Prod 64: 204-7 (2001) | Kumamoto University | 2D 3D TSV |
| 11428928 | 70 | Synthesis and structure-activity relationships of trisubstituted phenyl urea derivatives as neuropeptide Y5 receptor antagonists. |
J Med Chem 44: 2344-56 (2001) | Amgen Inc | 2D 3D TSV |
| 11428927 | 117 | A new concept for multidimensional selection of ligand conformations (MultiSelect) and multidimensional scoring (MultiScore) of protein-ligand binding affinities. |
J Med Chem 44: 2333-43 (2001) | The Royal Danish School of Pharmacy | 2D 3D TSV |
| 11428926 | 37 | 4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters. |
J Med Chem 44: 2319-32 (2001) | Pfizer Inc | 2D 3D TSV |
| 11428923 | 39 | Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
J Med Chem 44: 2298-303 (2001) | Allergan Inc | 2D 3D TSV |
| 11428922 | 21 | Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. |
J Med Chem 44: 2286-97 (2001) | Università di Pisa | 2D 3D TSV |
| 11428921 | 9 | Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist. |
J Med Chem 44: 2276-85 (2001) | Cambridge University Forvie Site | 2D 3D TSV |
| 11428920 | 6 | Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain. |
J Med Chem 44: 2270-5 (2001) | University of Pennsylvania | 2D 3D TSV |
| 11426832 | 8 | Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. |
Eur J Pharmacol 419: 113-20 (2001) | Kyorin University | 2D 3D TSV |
| 11425561 | 197 | Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties. |
Bioorg Med Chem Lett 11: 1787-91 (2001) | Universit£ degli Studi | 2D 3D TSV |
| 11425559 | 24 | Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase. |
Bioorg Med Chem Lett 11: 1779-82 (2001) | Universita degli Studi di Siena | 2D 3D TSV |
| 11425553 | 9 | Significance of hydrogen bonding at the S(1)' subsite of calpain I. |
Bioorg Med Chem Lett 11: 1753-5 (2001) | The University of Tennessee | 2D 3D TSV |
| 11425550 | 62 | Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor. |
Bioorg Med Chem Lett 11: 1741-3 (2001) | R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11425549 | 30 | Isoindolines: a new series of potent and selective endothelin-A receptor antagonists. |
Bioorg Med Chem Lett 11: 1737-40 (2001) | Novartis Institute for BioMedical Research | 2D 3D TSV |
| 11425547 | 137 | Potent nonpeptide GnRH receptor antagonists derived from substituted indole-5-carboxamides and -acetamides bearing a pyridine side-chain terminus. |
Bioorg Med Chem Lett 11: 1727-31 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11425546 | 89 | Substituted indole-5-carboxamides and -acetamides as potent nonpeptide GnRH receptor antagonists. |
Bioorg Med Chem Lett 11: 1723-6 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11425545 | 22 | 3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties. |
Bioorg Med Chem Lett 11: 1717-21 (2001) | Pharmacia | 2D 3D TSV |
| 11425544 | 14 | Biphenyls as surrogates of the steroidal backbone. Part 2: discovery of a novel family of non-steroidal 5-alpha-reductase inhibitors. |
Bioorg Med Chem Lett 11: 1713-6 (2001) | Aventis | 2D 3D TSV |
| 11425540 | 6 | Total synthesis of human chymase inhibitor methyllinderone and structure--activity relationships of its derivatives. |
Bioorg Med Chem Lett 11: 1695-7 (2001) | Shionogi & Co., Ltd | 2D 3D TSV |
| 11425539 | 23 | Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. |
Bioorg Med Chem Lett 11: 1691-4 (2001) | Shionogi & Co., Ltd | 2D 3D TSV |
| 11425538 | 29 | Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors. |
Bioorg Med Chem Lett 11: 1687-90 (2001) | Guilford Pharmaceuticals Inc | 2D 3D TSV |
| 11425534 | 5 | Novel sulfonate derivatives: potent antimitotic agents. |
Bioorg Med Chem Lett 11: 1671-3 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11425533 | 13 | Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy. |
Bioorg Med Chem Lett 11: 1665-9 (2001) | ARIAD Pharmaceuticals Inc | 2D 3D TSV |
| 11425531 | 2 | [3H]MFZ 2-12: a novel radioligand for the dopamine transporter. |
Bioorg Med Chem Lett 11: 1659-61 (2001) | National Institute on Drug Abuse-Intramural Research Program | 2D 3D TSV |
| 11425530 | 64 | Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase. |
Bioorg Med Chem Lett 11: 1655-8 (2001) | Roche Discovery Welwyn | 2D 3D TSV |
| 11425527 | 16 | Expedited discovery of second generation NK-1 antagonists: identification of a nonbasic aryloxy substituent. |
Bioorg Med Chem Lett 11: 1643-6 (2001) | Eli Lilly and Company | 2D 3D TSV |
| 11425526 | 3 | Quinoline-4-acetamides as sPLA(2) inhibitors. |
Bioorg Med Chem Lett 11: 1639-41 (2001) | Peking University | 2D 3D TSV |
| 11425524 | 62 | Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality. |
Bioorg Med Chem Lett 11: 1629-33 (2001) | Axys Pharmaceuticals Inc | 2D 3D TSV |
| 11425523 | 20 | Novel heteroaryl replacements of aromatic 3-tetrafluoroethoxy substituents in trifluoro-3-(tertiaryamino)-2-propanols as potent inhibitors of cholesteryl ester transfer protein. |
Bioorg Med Chem Lett 11: 1625-8 (2001) | Pharmacia | 2D 3D TSV |
| 11421762 | 6 | Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin. |
J Nat Prod 64: 842-4 (2001) | Tribhuvan University | 2D 3D TSV |
| 11421736 | 31 | Cox-2 inhibitory effects of naturally occurring and modified fatty acids. |
J Nat Prod 64: 745-9 (2001) | Uppsala University | 2D 3D TSV |
| 11412991 | 8 | Synthesis of derivatives of the novel cyclophilin-binding immunosuppressant sanglifehrin A with reduced numbers of polar functions. |
Bioorg Med Chem Lett 11: 1609-12 (2001) | Novartis Pharma AG | 2D 3D TSV |
| 11412990 | 2 | Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I. |
Bioorg Med Chem Lett 11: 1605-8 (2001) | Wayne State University | 2D 3D TSV |
| 11412987 | 2 | Synthesis of novel sialylmimetics as biological probes. |
Bioorg Med Chem Lett 11: 1587-90 (2001) | Monash University (Parkville Campus) | 2D 3D TSV |
| 11412986 | 3 | An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide. synthesis and preliminary biological studies. |
Bioorg Med Chem Lett 11: 1583-6 (2001) | The Ohio State University | 2D 3D TSV |
| 11412985 | 62 | Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme. |
Bioorg Med Chem Lett 11: 1579-82 (2001) | University of Kansas | 2D 3D TSV |
| 11412984 | 66 | Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors. |
Bioorg Med Chem Lett 11: 1573-7 (2001) | The Royal Danish School of Pharmacy | 2D 3D TSV |
| 11412983 | 9 | New probes of the agonist binding site of metabotropic glutamate receptors. |
Bioorg Med Chem Lett 11: 1569-72 (2001) | Universit£ Ren£ Descartes | 2D 3D TSV |
| 11412982 | 2 | Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata. |
Bioorg Med Chem Lett 11: 1565-8 (2001) | University of Illinois at Chicago | 2D 3D TSV |
| 11412980 | 48 | Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770. |
Bioorg Med Chem Lett 11: 1557-60 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11412979 | 67 | Biaryl ether retrohydroxamates as potent, long-lived, orally bioavailable MMP inhibitors. |
Bioorg Med Chem Lett 11: 1553-6 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11412977 | 23 | Amidino benzimidazole inhibitors of bacterial two-component systems. |
Bioorg Med Chem Lett 11: 1545-8 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11412972 | 13 | alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. |
Bioorg Med Chem Lett 11: 1517-20 (2001) | The Scripps Research Institute | 2D 3D TSV |
| 11412967 | 10 | Aromatic inhibitors of dehydroquinate synthase: synthesis, evaluation and implications for gallic acid biosynthesis. |
Bioorg Med Chem Lett 11: 1493-6 (2001) | Michigan State University | 2D 3D TSV |
| 11410378 | 50 | Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase. |
Chem Biol 8: 593-611 (2001) | Northwestern University | 2D 3D TSV |
| 11408610 | 18 | Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. |
Mol Pharmacol 60: 155-63 (2001) | Virginia Commonwealth University | 2D 3D TSV |
| 11408607 | 25 | The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning. |
Mol Pharmacol 60: 124-34 (2001) | U410 | 2D 3D TSV |
| 11408557 | 10 | Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. |
J Pharmacol Exp Ther 298: 316-22 (2001) | The University of Tokyo | 2D 3D TSV |
| 11408556 | 2 | Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors. |
J Pharmacol Exp Ther 298: 307-15 (2001) | AstraZeneca Pharmaceuticals | 2D 3D TSV |
| 11408545 | 55 | Rabbit alpha2-adrenoceptors: both platelets and adipocytes have alpha2A-pharmacology. |
J Pharmacol Exp Ther 298: 219-25 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11408360 | 1 | Methadone inhibits rhodamine123 transport in Caco-2 cells. |
Drug Metab Dispos 29: 954-6 (2001) | Tufts University School of Medicine | 2D 3D TSV |
| 11405662 | 100 | Protease inhibitors: synthesis of a series of bacterial collagenase inhibitors of the sulfonyl amino acyl hydroxamate type. |
J Med Chem 44: 2253-8 (2001) | The University of Western Australia | 2D 3D TSV |
| 11405661 | 61 | Characterization of melanocortin NDP-MSH agonist peptide fragments at the mouse central and peripheral melanocortin receptors. |
J Med Chem 44: 2247-52 (2001) | University of Florida | 2D 3D TSV |
| 11405660 | 155 | Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). |
J Med Chem 44: 2238-46 (2001) | Salk Institute | 2D 3D TSV |
| 11405659 | 22 | Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues. |
J Med Chem 44: 2229-37 (2001) | Research Triangle Institute | 2D 3D TSV |
| 11405658 | 12 | 5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position. |
J Med Chem 44: 2219-28 (2001) | Instituto de Qu£mica M£dica (CSIC) | 2D 3D TSV |
| 11405657 | 123 | Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives. |
J Med Chem 44: 2204-18 (2001) | Tanabe Seiyaku Co., Ltd | 2D 3D TSV |
| 11405654 | 1 | Combinatorial synthesis of cholesterol ester transfer protein-mRNA ligands and screening by nondenaturating gel-electrophoresis. |
J Med Chem 44: 2172-7 (2001) | Johann Wolfgang Goethe-Universit£t Frankfurt/Main | 2D 3D TSV |
| 11405652 | 29 | Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors. |
J Med Chem 44: 2152-63 (2001) | Novo Nordisk A/S | 2D 3D TSV |
| 11405650 | 42 | Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. |
J Med Chem 44: 2133-8 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11405649 | 118 | Synthesis, biological evaluation, and pharmacophore generation of new pyridazinone derivatives with affinity toward alpha(1)- and alpha(2)-adrenoceptors. |
J Med Chem 44: 2118-32 (2001) | Universit£ di Perugia | 2D 3D TSV |
| 11405647 | 24 | Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity. |
J Med Chem 44: 2094-107 (2001) | Ontogen Corporation | 2D 3D TSV |
| 11405646 | 95 | Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. |
J Med Chem 44: 2080-93 (2001) | University of Washington | 2D 3D TSV |
| 11405645 | 13 | Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole. |
J Med Chem 44: 2073-9 (2001) | University of Minnesota | 2D 3D TSV |
| 11405644 | 12 | 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. |
J Med Chem 44: 2069-72 (2001) | Università degli Studi di Siena | 2D 3D TSV |
| 11405642 | 33 | Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists. |
J Med Chem 44: 2061-4 (2001) | Eli Lilly and Company | 2D 3D TSV |
| 11405641 | 8 | Secretase targets for Alzheimer's disease: identification and therapeutic potential. |
J Med Chem 44: 2039-60 (2001) | Harvard Medical School | 2D 3D TSV |
| 11405287 | 7 | A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. |
Pharm Res 18: 171-6 (2001) | The University of Kansas | 2D 3D TSV |
| 11404457 | 5 | Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. |
Proc Natl Acad Sci U S A 98: 7564-9 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11392550 | 5 | Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors. |
Bioorg Med Chem Lett 11: 1339-42 (2001) | Institut für Biochemie der Technischen Universität Graz | 2D 3D TSV |
| 11392549 | 45 | Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications. |
Bioorg Med Chem Lett 11: 1333-7 (2001) | NIDDK | 2D 3D TSV |
| 11392548 | 59 | Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors. |
Bioorg Med Chem Lett 11: 1329-32 (2001) | Universit£ di Ferrara | 2D 3D TSV |
| 11392547 | 15 | Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors. |
Bioorg Med Chem Lett 11: 1325-8 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11392544 | 11 | Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic? |
Bioorg Med Chem Lett 11: 1313-6 (2001) | UCB Pharma SA | 2D 3D TSV |
| 11392542 | 25 | Structure-activity relationship investigations of a potent and selective benzodiazepine oxytocin antagonist. |
Bioorg Med Chem Lett 11: 1301-5 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11392541 | 2 | Identification of a potent and selective oxytocin antagonist, from screening a fully encoded differential release combinatorial chemical library. |
Bioorg Med Chem Lett 11: 1297-300 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11392540 | 23 | Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: design of potent antagonists containing the 3-azaspiro[5.5]undecanes. |
Bioorg Med Chem Lett 11: 1293-6 (2001) | COR Therapeutics Inc | 2D 3D TSV |
| 11392539 | 34 | Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes. |
Bioorg Med Chem Lett 11: 1289-92 (2001) | COR Therapeutics Inc | 2D 3D TSV |
| 11392538 | 2 | Synthesis and biological evaluations of condensed pyridine and condensed pyrimidine-based HMG-CoA reductase inhibitors. |
Bioorg Med Chem Lett 11: 1285-8 (2001) | Central Research Institute | 2D 3D TSV |
| 11392536 | 2 | Synthesis and evaluation of a difluoromethylene analogue of sphingomyelin as an inhibitor of sphingomyelinase. |
Bioorg Med Chem Lett 11: 1277-80 (2001) | Tokyo University of Pharmacy & Life Science | 2D 3D TSV |
| 11392535 | 12 | Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 2. |
Bioorg Med Chem Lett 11: 1273-6 (2001) | Nippon Roche Research Center | 2D 3D TSV |
| 11392531 | 79 | Diaryl ether inhibitors of farnesyl-protein transferase. |
Bioorg Med Chem Lett 11: 1257-60 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11384246 | 86 | Potent and selective nonpeptide inhibitors of caspases 3 and 7. |
J Med Chem 44: 2015-26 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11384244 | 61 | Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines. |
J Med Chem 44: 1993-2003 (2001) | Duquesne University | 2D 3D TSV |
| 11384242 | 126 | Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia. |
J Med Chem 44: 1971-85 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11384239 | 82 | Solid-phase synthesis of a nonpeptide RGD mimetic library: new selective alphavbeta3 integrin antagonists. |
J Med Chem 44: 1938-50 (2001) | Technische Universität München | 2D 3D TSV |
| 11384237 | 222 | Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity. |
J Med Chem 44: 1915-26 (2001) | Pfizer Inc | 2D 3D TSV |
| 11384236 | 26 | Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. |
J Med Chem 44: 1905-14 (2001) | University of Pennsylvania | 2D 3D TSV |
| 11384235 | 21 | An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P). |
J Med Chem 44: 1892-904 (2001) | National Cancer Institute-Frederick | 2D 3D TSV |
| 11384233 | 70 | 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1. |
J Med Chem 44: 1866-82 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11384232 | 18 | Identification of a putative binding site for [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (TSAO) derivatives at the p51-p66 interface of HIV-1 reverse transcriptase. |
J Med Chem 44: 1853-65 (2001) | Universidad de Alcal£ | 2D 3D TSV |
| 11384231 | 26 | 2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors. |
J Med Chem 44: 1847-52 (2001) | F. Hoffmann-La Roche Inc | 2D 3D TSV |
| 11378378 | 34 | Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors. |
Bioorg Med Chem Lett 11: 1465-8 (2001) | Celltech-Chiroscience Ltd | 2D 3D TSV |
| 11378377 | 11 | Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues. |
Bioorg Med Chem Lett 11: 1461-4 (2001) | Aventis Pharma | 2D 3D TSV |
| 11378374 | 39 | Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2. |
Bioorg Med Chem Lett 11: 1445-50 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11378373 | 35 | Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1. |
Bioorg Med Chem Lett 11: 1441-4 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11378372 | 10 | 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements. |
Bioorg Med Chem Lett 11: 1437-40 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11378371 | 2 | Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase. |
Bioorg Med Chem Lett 11: 1433-5 (2001) | The University of Iowa | 2D 3D TSV |
| 11378369 | 4 | Effect of zinc ion on the inhibition of carboxypeptidase A by imidazole-bearing substrate analogues. |
Bioorg Med Chem Lett 11: 1425-7 (2001) | Pohang University of Science and Technology | 2D 3D TSV |
| 11378366 | 40 | Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I. |
Bioorg Med Chem Lett 11: 1411-5 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11378365 | 52 | MEK (MAPKK) inhibitors. Part 2: structure-activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines. |
Bioorg Med Chem Lett 11: 1407-10 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11378364 | 34 | Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. |
Bioorg Med Chem Lett 11: 1401-5 (2001) | Research Biomet. Glaxo Wellcome Medicines Research Centre | 2D 3D TSV |
| 11378362 | 11 | Structure-activity relationships of phenylcyclohexene and biphenyl antitubulin compounds against plant and mammalian cells. |
Bioorg Med Chem Lett 11: 1393-6 (2001) | Rohm and Haas Company | 2D 3D TSV |
| 11378361 | 25 | 4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors. |
Bioorg Med Chem Lett 11: 1389-92 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11378359 | 57 | Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors. |
Bioorg Med Chem Lett 11: 1379-82 (2001) | 3-Dimensional Pharmaceuticals Inc | 2D 3D TSV |
| 11378358 | 254 | Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. |
Bioorg Med Chem Lett 11: 1375-7 (2001) | Columbia University College of Physicians and Surgeons | 2D 3D TSV |
| 11378357 | 55 | 5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors. |
Bioorg Med Chem Lett 11: 1371-3 (2001) | NPS Pharmaceuticals Inc | 2D 3D TSV |
| 11378353 | 14 | Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition. |
Bioorg Med Chem Lett 11: 1355-8 (2001) | Pharmacia | 2D 3D TSV |
| 11378352 | 3 | Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). |
Bioorg Med Chem Lett 11: 1351-3 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11374978 | 12 | Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships. |
J Nat Prod 64: 683-5 (2001) | Seoul National University | 2D 3D TSV |
| 11374954 | 6 | New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions. |
J Nat Prod 64: 612-5 (2001) | Università degli Studi di Napoli Federico II | 2D 3D TSV |
| 11374943 | 2 | Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha. |
J Nat Prod 64: 559-62 (2001) | University of Mississippi | 2D 3D TSV |
| 11356907 | 15 | Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization. |
J Pharmacol Exp Ther 297: 876-87 (2001) | Institut de Recherches Servier | 2D 3D TSV |
| 11356115 | 108 | Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands. |
J Med Chem 44: 1815-26 (2001) | Wake Forest University School of Medicine | 2D 3D TSV |
| 11356113 | 18 | Enantioselective syntheses of dopaminergic (R)- and (S)-benzyltetrahydroisoquinolines. |
J Med Chem 44: 1794-801 (2001) | Universidad de Valencia | 2D 3D TSV |
| 11356112 | 175 | Potent reversible inhibitors of the protein tyrosine phosphatase CD45. |
J Med Chem 44: 1777-93 (2001) | AstraZeneca Pharmaceuticals | 2D 3D TSV |
| 11356110 | 2 | Synthesis and biological evaluation of purine-containing butenolides. |
J Med Chem 44: 1749-57 (2001) | Academia Sinica | 2D 3D TSV |
| 11356108 | 3 | Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands. |
J Med Chem 44: 1729-40 (2001) | The University of Tennessee Health Science Center | 2D 3D TSV |
| 11356107 | 16 | Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis. |
J Med Chem 44: 1718-28 (2001) | Sankyo Co., Ltd | 2D 3D TSV |
| 11356104 | 29 | Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis. |
J Med Chem 44: 1690-701 (2001) | Georgetown University Medical Center | 2D 3D TSV |
| 11356103 | 61 | Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists. |
J Med Chem 44: 1675-89 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11356102 | 16 | Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE. |
J Med Chem 44: 1666-74 (2001) | De Novo Pharmaceuticals | 2D 3D TSV |
| 11356100 | 15 | Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens. |
J Med Chem 44: 1654-7 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11356099 | 20 | Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. |
J Med Chem 44: 1627-53 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11354387 | 20 | Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues. |
Bioorg Med Chem Lett 11: 1245-8 (2001) | University of Kentucky | 2D 3D TSV |
| 11354386 | 90 | Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands. |
Bioorg Med Chem Lett 11: 1241-3 (2001) | University of Mainz | 2D 3D TSV |
| 11354385 | 27 | 2-Aryl indole NK1 receptor antagonists: optimisation of the 2-aryl ring and the indole nitrogen substituent. |
Bioorg Med Chem Lett 11: 1237-40 (2001) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
| 11354384 | 27 | 2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution. |
Bioorg Med Chem Lett 11: 1233-6 (2001) | The Neuroscience Research Centre | 2D 3D TSV |
| 11354383 | 24 | Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity. |
Bioorg Med Chem Lett 11: 1229-31 (2001) | Polish Academy of Sciences | 2D 3D TSV |
| 11354382 | 42 | Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
Bioorg Med Chem Lett 11: 1225-7 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11354381 | 19 | Discovery of a novel CCR3 selective antagonist. |
Bioorg Med Chem Lett 11: 1219-23 (2001) | Banyu Tsukuba Research Institute | 2D 3D TSV |
| 11354380 | 3 | Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor alpha antagonists. |
Bioorg Med Chem Lett 11: 1215-8 (2001) | Eisai Co., Ltd | 2D 3D TSV |
| 11354379 | 37 | Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors. |
Bioorg Med Chem Lett 11: 1211-3 (2001) | Pfizer Inc | 2D 3D TSV |
| 11354377 | 8 | Convergent synthesis of potent peptide inhibitors of the Grb2-SH2 domain by palladium catalyzed coupling of a terminal alkyne. |
Bioorg Med Chem Lett 11: 1201-3 (2001) | Novartis Pharma AG | 2D 3D TSV |
| 11354366 | 81 | Quinazolines as cyclin dependent kinase inhibitors. |
Bioorg Med Chem Lett 11: 1157-60 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11354365 | 11 | Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles. |
Bioorg Med Chem Lett 11: 1153-6 (2001) | Université de Caen | 2D 3D TSV |
| 11354362 | 18 | Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands. |
Bioorg Med Chem Lett 11: 1141-4 (2001) | Sumitomo Pharmaceuticals Co., Ltd | 2D 3D TSV |
| 11354361 | 1 | Glycosidase inhibition by cyclic sulfonium compounds. |
Bioorg Med Chem Lett 11: 1137-9 (2001) | Graduate School of Bioscience and Biotechnology | 2D 3D TSV |
| 11354359 | 6 | Binding of dimeric aminoglycosides to the HIV-1 rev responsive element (RRE) RNA construct. |
Bioorg Med Chem Lett 11: 1127-31 (2001) | Purdue University | 2D 3D TSV |
| 11354358 | 53 | Phenoxypyrimidine inhibitors of p38alpha kinase: synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles. |
Bioorg Med Chem Lett 11: 1123-6 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11354357 | 61 | Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. |
Bioorg Med Chem Lett 11: 1119-21 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11354356 | 42 | Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors. |
Bioorg Med Chem Lett 11: 1113-8 (2001) | Georgetown University Medical Center | 2D 3D TSV |
| 11354355 | 6 | Design and synthesis of a new sialyl Lewis X mimetic: how selective are the selectin receptors? |
Bioorg Med Chem Lett 11: 1109-12 (2001) | Universit£ de Montr£al | 2D 3D TSV |
| 11342132 | 24 | Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors. |
Structure 9: 29-37 (2001) | Boehringer Ingelheim Pharma KG | 2D 3D TSV |
| 11341829 | 9 | Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action. |
Biochemistry 40: 5642-54 (2001) | Pharmacia Corporation | 2D 3D TSV |
| 11334572 | 3 | Combinatorial lead optimization of a neuropeptide FF antagonist. |
J Med Chem 44: 1623-6 (2001) | University of Florida | 2D 3D TSV |
| 11334571 | 79 | Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors. |
J Med Chem 44: 1615-22 (2001) | Georgetown University Medical Center | 2D 3D TSV |
| 11334570 | 103 | 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. |
J Med Chem 44: 1603-14 (2001) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
| 11334569 | 10 | Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues. |
J Med Chem 44: 1594-602 (2001) | Life Science Research Center | 2D 3D TSV |
| 11334568 | 16 | Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity. |
J Med Chem 44: 1588-93 (2001) | Universit£ Louis Pasteur | 2D 3D TSV |
| 11334563 | 5 | Computational analysis of PKA-balanol interactions. |
J Med Chem 44: 1530-9 (2001) | University of California at San Diego | 2D 3D TSV |
| 11334561 | 63 | Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites. |
J Med Chem 44: 1509-15 (2001) | State University of New York | 2D 3D TSV |
| 11334560 | 18 | Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen. |
J Med Chem 44: 1491-508 (2001) | University of Oxford | 2D 3D TSV |
| 11334558 | 42 | Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro(30), Tyr(32), Leu(34)]NPY(28-36)-NH2 (BW1911U90). |
J Med Chem 44: 1479-82 (2001) | University of Cincinnati and VA Medical Centers | 2D 3D TSV |
| 11327608 | 45 | Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors. |
Bioorg Med Chem Lett 11: 997-1000 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11327607 | 67 | Novel non-peptide ligands for the somatostatin sst3 receptor. |
Bioorg Med Chem Lett 11: 991-5 (2001) | Institut Henri Beaufour | 2D 3D TSV |
| 11327605 | 27 | New oxadiazolidinedione derivatives as potent and selective human beta3 agonists. |
Bioorg Med Chem Lett 11: 981-4 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11327603 | 31 | Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists. |
Bioorg Med Chem Lett 11: 973-6 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11327602 | 58 | Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors. |
Bioorg Med Chem Lett 11: 969-72 (2001) | Roche Research Center | 2D 3D TSV |
| 11327601 | 24 | Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. |
Bioorg Med Chem Lett 11: 965-8 (2001) | Seoul National University | 2D 3D TSV |
| 11327600 | 24 | Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. |
Bioorg Med Chem Lett 11: 961-4 (2001) | Seoul National University | 2D 3D TSV |
| 11327599 | 25 | Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth. |
Bioorg Med Chem Lett 11: 955-9 (2001) | Georgetotwn University | 2D 3D TSV |
| 11327595 | 4 | Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors. |
Bioorg Med Chem Lett 11: 1081-3 (2001) | Celltech R&D Ltd | 2D 3D TSV |
| 11327594 | 26 | Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists. |
Bioorg Med Chem Lett 11: 1077-80 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11327593 | 16 | 2-(3,5-Dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor. |
Bioorg Med Chem Lett 11: 1073-6 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11327592 | 9 | 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors. |
Bioorg Med Chem Lett 11: 1069-71 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11327591 | 1 | Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors. |
Bioorg Med Chem Lett 11: 1065-8 (2001) | INETI | 2D 3D TSV |
| 11327590 | 7 | Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors. |
Bioorg Med Chem Lett 11: 1063-4 (2001) | Technische Universität Graz | 2D 3D TSV |
| 11327589 | 11 | In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663). |
Bioorg Med Chem Lett 11: 1059-62 (2001) | Merck Frosst Centre for Therapeutic Research | 2D 3D TSV |
| 11327585 | 15 | Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands. |
Bioorg Med Chem Lett 11: 1045-7 (2001) | The University of Michigan Medical School | 2D 3D TSV |
| 11327582 | 23 | 2-Acylimino-3H-thiazoline derivatives: a novel template for platelet GPIIb/IIIa receptor antagonists. |
Bioorg Med Chem Lett 11: 1031-5 (2001) | Taisho Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11327581 | 44 | Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity. |
Bioorg Med Chem Lett 11: 1027-30 (2001) | AstraZeneca R&D Charnwood | 2D 3D TSV |
| 11327580 | 73 | 3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency. |
Bioorg Med Chem Lett 11: 1023-6 (2001) | AstraZeneca R&D Charnwood | 2D 3D TSV |
| 11327579 | 3 | Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition. |
Bioorg Med Chem Lett 11: 1019-22 (2001) | Facultés Universitaires N.D. de la Paix | 2D 3D TSV |
| 11327577 | 86 | Heterocycle-based MMP inhibitors with P2' substituents. |
Bioorg Med Chem Lett 11: 1009-13 (2001) | Procter and Gamble Pharmaceuticals | 2D 3D TSV |
| 11325241 | 2 | Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species. |
J Nat Prod 64: 525-6 (2001) | Harbor Branch Oceanographic Institution, Inc. | 2D 3D TSV |
| 11316767 | 1 | Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. |
Endocrinology 142: 2005-12 (2001) | Tohoku University School of Medicine | 2D 3D TSV |
| 11312929 | 90 | Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist. |
J Med Chem 44: 1305-11 (2001) | Tulane University Health Sciences Center | 2D 3D TSV |
| 11312928 | 62 | Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase. |
J Med Chem 44: 1297-304 (2001) | Welfide Corporation | 2D 3D TSV |
| 11312927 | 64 | Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase. |
J Med Chem 44: 1286-96 (2001) | Welfide Corporation | 2D 3D TSV |
| 11312926 | 39 | Development of orally active nonpeptidic inhibitors of human neutrophil elastase. |
J Med Chem 44: 1268-85 (2001) | Cortech, Inc. | 2D 3D TSV |
| 11312924 | 6 | Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. |
J Med Chem 44: 1249-56 (2001) | University of Kiel | 2D 3D TSV |
| 11312921 | 16 | Acyl substitution at the ortho position of anilides enhances oral bioavailability of thiophene sulfonamides: TBC3214, an ETA selective endothelin antagonist. |
J Med Chem 44: 1211-6 (2001) | Texas Biotechnology Corporation | 2D 3D TSV |
| 11312920 | 23 | Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. |
J Med Chem 44: 1202-10 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11312919 | 22 | Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores. |
J Med Chem 44: 1192-201 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11312916 | 2 | Discovery of an orally active non-peptide fibrinogen receptor antagonist based on the hydantoin scaffold. |
J Med Chem 44: 1158-76 (2001) | Aventis Pharma AG | 2D 3D TSV |
| 11312915 | 29 | Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine. |
J Med Chem 44: 1151-7 (2001) | Friedrich-Alexander University | 2D 3D TSV |
| 11312914 | 53 | Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling. |
J Med Chem 44: 1134-50 (2001) | Universit£ degli Studi Magna Graecia di Catanzaro | 2D 3D TSV |
| 11312774 | 36 | Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors. |
J Agric Food Chem 48: 6016-24 (2000) | University of California | 2D 3D TSV |
| 11311071 | 53 | Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. |
J Med Chem 44: 1471-4 (2001) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
| 11311069 | 64 | (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. |
J Med Chem 44: 1456-66 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11311067 | 38 | Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence. |
J Med Chem 44: 1436-45 (2001) | Kissei Pharmaceutical Company Ltd | 2D 3D TSV |
| 11311066 | 76 | Design, synthesis, and discovery of a novel CCR1 antagonist. |
J Med Chem 44: 1429-35 (2001) | Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories | 2D 3D TSV |
| 11311064 | 84 | N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity. |
J Med Chem 44: 1416-21 (2001) | Tulane University Health Sciences Center | 2D 3D TSV |
| 11311061 | 40 | Azepanone-based inhibitors of human and rat cathepsin K. |
J Med Chem 44: 1380-95 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11311060 | 12 | Development of potent truncated glucagon antagonists. |
J Med Chem 44: 1372-9 (2001) | University of Arizona | 2D 3D TSV |
| 11311057 | 15 | Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase. |
J Med Chem 44: 1349-55 (2001) | Georgetown University Medical Center | 2D 3D TSV |
| 11311055 | 42 | Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists. |
J Med Chem 44: 1337-40 (2001) | Uppsala University | 2D 3D TSV |
| 11311054 | 14 | Indenopyrazoles as novel cyclin dependent kinase (CDK) inhibitors. |
J Med Chem 44: 1334-6 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11309550 | 2 | The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. |
Clin Pharmacol Ther 69: 223-31 (2001) | University of Zurich | 2D 3D TSV |
| 11306701 | 5 | Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. |
Mol Pharmacol 59: 1171-80 (2001) | Queen's University | 2D 3D TSV |
| 11306690 | 7 | Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2. |
Mol Pharmacol 59: 1077-85 (2001) | The University of Tokyo | 2D 3D TSV |
| 11306677 | 6 | BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. |
Mol Pharmacol 59: 965-73 (2001) | UPR 9023 | 2D 3D TSV |
| 11305907 | 3 | The vnd/NK-2 homeodomain: thermodynamics of reversible unfolding and DNA binding for wild-type and with residue replacements H52R and H52R/T56W in helix III. |
Biochemistry 40: 4923-31 (2001) | National Institutes of Health | 2D 3D TSV |
| 11303071 | 22 | Pharmacological properties of (2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: a novel mucarinic antagonist with M(2)-sparing antagonistic activity. |
J Pharmacol Exp Ther 297: 790-7 (2001) | Banyu Pharmaceutical Co., Ltd. | 2D 3D TSV |
| 11303063 | 11 | Molecular and pharmacological characterization of muscarinic receptor subtypes in a rat parotid gland cell line: comparison with native parotid gland. |
J Pharmacol Exp Ther 297: 718-26 (2001) | Creighton University | 2D 3D TSV |
| 11303056 | 2 | Pharmacological characterization of KUR-1246, a selective uterine relaxant. |
J Pharmacol Exp Ther 297: 666-71 (2001) | Kissei Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11300881 | 45 | Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists. |
J Med Chem 44: 1003-10 (2001) | Purdue University | 2D 3D TSV |
| 11300880 | 168 | Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. |
J Med Chem 44: 988-1002 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11300879 | 77 | Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides. |
J Med Chem 44: 972-87 (2001) | Research Triangle Institute | 2D 3D TSV |
| 11300876 | 47 | Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters. |
J Med Chem 44: 937-48 (2001) | Wayne State University | 2D 3D TSV |
| 11300873 | 8 | A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor. |
J Med Chem 44: 917-22 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11300870 | 20 | Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. |
J Med Chem 44: 886-97 (2001) | Dartmouth College | 2D 3D TSV |
| 11300868 | 37 | Alpha(2) adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes. |
J Med Chem 44: 863-72 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11300867 | 32 | Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the"address" recognition locus. |
J Med Chem 44: 857-62 (2001) | University of Minnesota | 2D 3D TSV |
| 11300866 | 14 | A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors. |
J Med Chem 44: 851-6 (2001) | The Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11298663 | 8 | Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC). |
Cephalalgia 21: 46-52 (2001) | Roche Bioscience | 2D 3D TSV |
| 11297454 | 5 | Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells. |
J Med Chem 44: 1072-84 (2001) | Trinity College | 2D 3D TSV |
| 11297453 | 173 | Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines. |
J Med Chem 44: 1060-71 (2001) | Procter and Gamble Pharmaceuticals | 2D 3D TSV |
| 11297451 | 21 | Estimation of binding affinities for selective thrombin inhibitors via Monte Carlo simulations. |
J Med Chem 44: 1043-50 (2001) | Yale University | 2D 3D TSV |
| 11297449 | 3 | Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1b domain of protein kinase C-delta. |
J Med Chem 44: 1028-34 (2001) | University of Tennessee College of Medicine | 2D 3D TSV |
| 11297448 | 11 | Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. |
J Med Chem 44: 1025-7 (2001) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11297447 | 18 | Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates. |
J Med Chem 44: 1021-4 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11297446 | 3 | Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7'-(phthalaldehydecarboxamido)naltrindole (PNTI). |
J Med Chem 44: 1017-20 (2001) | University of Minnesota | 2D 3D TSV |
| 11294398 | 26 | Different antagonist binding properties of human and rat histamine H3 receptors. |
Bioorg Med Chem Lett 11: 951-4 (2001) | Freie Universität Berlin | 2D 3D TSV |
| 11294396 | 57 | Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole. |
Bioorg Med Chem Lett 11: 939-43 (2001) | University of Bristol | 2D 3D TSV |
| 11294392 | 3 | Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition. |
Bioorg Med Chem Lett 11: 923-5 (2001) | Novartis Pharma AG | 2D 3D TSV |
| 11294390 | 43 | Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors. |
Bioorg Med Chem Lett 11: 915-8 (2001) | 3-Dimensional Pharmaceuticals Inc | 2D 3D TSV |
| 11294389 | 27 | LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. |
Bioorg Med Chem Lett 11: 909-13 (2001) | Department of Molecular Oncogenesis | 2D 3D TSV |
| 11294387 | 15 | Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES). |
Bioorg Med Chem Lett 11: 899-902 (2001) | Kingston University | 2D 3D TSV |
| 11294386 | 5 | The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate. |
Bioorg Med Chem Lett 11: 895-8 (2001) | GlaxoWellcome Medicines Research Centre | 2D 3D TSV |
| 11294385 | 21 | Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists. |
Bioorg Med Chem Lett 11: 891-4 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11294383 | 16 | Cis- and trans-N-benzyl-octahydrobenzo[g]quinolines. Adrenergic and dopaminergic activity studies. |
Bioorg Med Chem Lett 11: 883-6 (2001) | University of Crete | 2D 3D TSV |
| 11294382 | 13 | Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors. |
Bioorg Med Chem Lett 11: 879-82 (2001) | Welfide Corporation | 2D 3D TSV |
| 11294380 | 9 | Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents. |
Bioorg Med Chem Lett 11: 871-4 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11294379 | 63 | 2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase. |
Bioorg Med Chem Lett 11: 865-9 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11292354 | 48 | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. |
J Mol Biol 307: 1451-86 (2001) | Axys Pharmaceuticals Corporation | 2D 3D TSV |
| 11284702 | 3 | A novel inhibitor of the mammalian peptide transporter PEPT1. |
Biochemistry 40: 4454-8 (2001) | Martin-Luther-University Halle-Wittenberg | 2D 3D TSV |
| 11278508 | 2 | Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. |
J Biol Chem 276: 17221-8 (2001) | Kyorin University | 2D 3D TSV |
| 11277743 | 8 | Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia. |
J Nat Prod 64: 300-3 (2001) | AstraZeneca R&D Griffith University | 2D 3D TSV |
| 11277536 | 130 | 7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src. |
Bioorg Med Chem Lett 11: 853-6 (2001) | Novartis Pharma Research | 2D 3D TSV |
| 11277535 | 80 | 7-Alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src. |
Bioorg Med Chem Lett 11: 849-52 (2001) | Novartis Pharma Research | 2D 3D TSV |
| 11277534 | 3 | N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase. |
Bioorg Med Chem Lett 11: 845-8 (2001) | Université de Lille 2 | 2D 3D TSV |
| 11277533 | 13 | Novel inhibitors of the enzyme estrone sulfatase (ES). |
Bioorg Med Chem Lett 11: 841-4 (2001) | Kingston University | 2D 3D TSV |
| 11277529 | 14 | Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter. |
Bioorg Med Chem Lett 11: 823-7 (2001) | Universit£ di Ferrara | 2D 3D TSV |
| 11277528 | 7 | Spatial requirements of the antagonist binding site of the NK2 receptor. |
Bioorg Med Chem Lett 11: 819-22 (2001) | University of Leeds | 2D 3D TSV |
| 11277527 | 2 | Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'receptor knock-down' tool. |
Bioorg Med Chem Lett 11: 815-8 (2001) | Vrije Universiteit | 2D 3D TSV |
| 11277524 | 14 | Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. |
Bioorg Med Chem Lett 11: 803-7 (2001) | Pfizer Inc | 2D 3D TSV |
| 11277522 | 7 | A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties. |
Bioorg Med Chem Lett 11: 793-5 (2001) | Purdue University | 2D 3D TSV |
| 11277515 | 51 | Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity. |
Bioorg Med Chem Lett 11: 765-8 (2001) | Allergan Inc | 2D 3D TSV |
| 11277514 | 23 | Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. |
Bioorg Med Chem Lett 11: 761-4 (2001) | Yale University | 2D 3D TSV |
| 11277513 | 25 | 2,4-Thiazolidinediones as potent and selective human beta3 agonists. |
Bioorg Med Chem Lett 11: 757-60 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11275272 | 4 | A robust GTP-induced shift in alpha(2)-adrenoceptor agonist affinity in tissue sections from rat brain. |
J Neurosci Methods 105: 159-66 (2001) | University of Nebraska | 2D 3D TSV |
| 11270320 | 11 | Dynorphin A analogs containing a conformationally constrained phenylalanine derivative in position 4: reversal of preferred stereochemistry for opioid receptor affinity and discrimination of kappa vs. delta receptors. |
Chirality 13: 125-9 (2001) | University of Maryland | 2D 3D TSV |
| 11266183 | 32 | Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry. |
Bioorg Med Chem Lett 11: 747-9 (2001) | Merck Frosst Canada & Co. | 2D 3D TSV |
| 11266182 | 53 | Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5. |
Bioorg Med Chem Lett 11: 741-5 (2001) | Institut Henri Beaufour | 2D 3D TSV |
| 11266181 | 3 | Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor. |
Bioorg Med Chem Lett 11: 737-40 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11266180 | 74 | The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa. |
Bioorg Med Chem Lett 11: 733-6 (2001) | Prosthetics Molecular Design | 2D 3D TSV |
| 11266178 | 39 | The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities. |
Bioorg Med Chem Lett 11: 723-8 (2001) | Kyoto University | 2D 3D TSV |
| 11266177 | 26 | The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding. |
Bioorg Med Chem Lett 11: 719-22 (2001) | Kyoto University | 2D 3D TSV |
| 11266176 | 5 | Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383. |
Bioorg Med Chem Lett 11: 715-8 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11266175 | 4 | Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase. |
Bioorg Med Chem Lett 11: 711-4 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11266174 | 51 | Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold. |
Bioorg Med Chem Lett 11: 705-9 (2001) | Novartis Institute for Medical Sciences | 2D 3D TSV |
| 11266173 | 1 | The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2. |
Bioorg Med Chem Lett 11: 701-4 (2001) | GlaxoSmithKline | 2D 3D TSV |
| 11266171 | 4 | RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. |
Bioorg Med Chem Lett 11: 693-6 (2001) | Aventis Pharma | 2D 3D TSV |
| 11266169 | 27 | Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor. |
Bioorg Med Chem Lett 11: 685-8 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11266168 | 14 | Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. |
Bioorg Med Chem Lett 11: 681-4 (2001) | Universidad de Valencia | 2D 3D TSV |
| 11266166 | 36 | Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides. |
Bioorg Med Chem Lett 11: 669-73 (2001) | GlaxoWellcome Medicines Research Centre | 2D 3D TSV |
| 11266164 | 3 | Synthesis, modelling and NK1 antagonist evaluation of a non-rigid cyclopropane-containing analogue of CP-99,994. |
Bioorg Med Chem Lett 11: 659-61 (2001) | Laboratoire de Chimie Thérapeutique associé au CNRS et à l'Université René Descartes (UMR 8638) | 2D 3D TSV |
| 11266163 | 26 | Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. |
Bioorg Med Chem Lett 11: 655-8 (2001) | Virginia Commonwealth University | 2D 3D TSV |
| 11266161 | 6 | Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A. |
Bioorg Med Chem Lett 11: 647-9 (2001) | University of Minnesota | 2D 3D TSV |
| 11266160 | 57 | Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core. |
Bioorg Med Chem Lett 11: 641-5 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11266159 | 63 | 3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3). |
Bioorg Med Chem Lett 11: 635-9 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11266158 | 29 | Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3. |
Bioorg Med Chem Lett 11: 631-3 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11266157 | 12 | Chemoenzymatic synthesis of functionalized cyclohexylglycines and alpha-methylcyclohexylglycines via Kazmaier-Claisen rearrangement. |
Bioorg Med Chem Lett 11: 627-9 (2001) | University of Florida | 2D 3D TSV |
| 11266156 | 42 | 8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines. |
Bioorg Med Chem Lett 11: 623-6 (2001) | Rensselaer Polytechnic Institute | 2D 3D TSV |
| 11266155 | 7 | Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz. |
Bioorg Med Chem Lett 11: 619-22 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11266153 | 32 | Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors. |
Bioorg Med Chem Lett 11: 611-4 (2001) | Korea Institute of Science and Technology | 2D 3D TSV |
| 11262093 | 36 | Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase. |
J Med Chem 44: 834-48 (2001) | Georgia Institute of Technology | 2D 3D TSV |
| 11262092 | 31 | Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles. |
J Med Chem 44: 822-33 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11262089 | 213 | Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties. |
J Med Chem 44: 787-805 (2001) | Institut de Recherches Servier | 2D 3D TSV |
| 11262085 | 92 | Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists. |
J Med Chem 44: 749-62 (2001) | Vrije Universiteit | 2D 3D TSV |
| 11262083 | 56 | Cyclic ketone inhibitors of the cysteine protease cathepsin K. |
J Med Chem 44: 725-36 (2001) | GSK | 2D 3D TSV |
| 11262081 | 19 | Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores. |
J Med Chem 44: 703-14 (2001) | Purdue University | 2D 3D TSV |
| 11262079 | 57 | Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. |
J Med Chem 44: 681-93 (2001) | GlaxoWellcome | 2D 3D TSV |
| 11262078 | 19 | A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. |
J Med Chem 44: 672-80 (2001) | University of Bologna | 2D 3D TSV |
| 11262076 | 4 | X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor. |
J Med Chem 44: 660-3 (2001) | ARIAD Pharmaceuticals Inc | 2D 3D TSV |
| 11262075 | 3 | Perspectives in animal health: old targets and new opportunities. |
J Med Chem 44: 641-59 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11259544 | 7 | Zebra finch CB1 cannabinoid receptor: pharmacology and in vivo and in vitro effects of activation. |
J Pharmacol Exp Ther 297: 189-97 (2001) | Florida State University | 2D 3D TSV |
| 11259322 | 1 | Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats. |
Drug Metab Dispos 29: 394-400 (2001) | University of Tokyo | 2D 3D TSV |
| 11248200 | 4 | Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. |
Biochim Biophys Acta 1511: 7-16 (2001) | The University of Tokyo | 2D 3D TSV |
| 11231118 | 8 | Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport. |
Eur J Pharm Sci 12: 505-13 (2001) | Kanazawa University | 2D 3D TSV |
| 11229779 | 11 | New 5-HT1A receptor agonists possessing 1,4-benzoxazepine scaffold exhibit highly potent anti-ischemic effects. |
Bioorg Med Chem Lett 11: 595-8 (2001) | Suntory Biomedical Research Limited | 2D 3D TSV |
| 11229778 | 14 | Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. |
Bioorg Med Chem Lett 11: 591-4 (2001) | Graduate School of Bioscience and Biotechnology | 2D 3D TSV |
| 11229777 | 5 | Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. |
Bioorg Med Chem Lett 11: 587-90 (2001) | Shionogi & Co., Ltd | 2D 3D TSV |
| 11229776 | 24 | Development of novel telomerase inhibitors based on a bisindole unit. |
Bioorg Med Chem Lett 11: 583-5 (2001) | Kyushu University | 2D 3D TSV |
| 11229775 | 204 | Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties. |
Bioorg Med Chem Lett 11: 575-82 (2001) | Universit£ degli Studi | 2D 3D TSV |
| 11229774 | 40 | Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). |
Bioorg Med Chem Lett 11: 571-4 (2001) | Pfizer Inc | 2D 3D TSV |
| 11229773 | 73 | Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality. |
Bioorg Med Chem Lett 11: 567-70 (2001) | Pfizer Inc | 2D 3D TSV |
| 11229772 | 16 | Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor. |
Bioorg Med Chem Lett 11: 563-6 (2001) | Virginia Commonwealth University | 2D 3D TSV |
| 11229771 | 38 | Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship. |
Bioorg Med Chem Lett 11: 559-62 (2001) | Seoul National University | 2D 3D TSV |
| 11229770 | 28 | Peptoids as endothelin receptor antagonists. |
Bioorg Med Chem Lett 11: 555-7 (2001) | Ranbaxy Laboratories Limited | 2D 3D TSV |
| 11229766 | 65 | A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase. |
Bioorg Med Chem Lett 11: 541-4 (2001) | Cubist Pharmaceuticals Inc | 2D 3D TSV |
| 11229765 | 16 | Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase. |
Bioorg Med Chem Lett 11: 537-40 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11229763 | 14 | Synthesis of analogues of the O-beta-D-ribofuranosyl nucleoside moiety of liposidomycins. Part 1: contribution of the amino group and the uracil moiety upon the inhibition of MraY. |
Bioorg Med Chem Lett 11: 529-31 (2001) | Aventis Pharma | 2D 3D TSV |
| 11229762 | 25 | Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds. |
Bioorg Med Chem Lett 11: 523-8 (2001) | Institute | 2D 3D TSV |
| 11229760 | 20 | SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists. |
Bioorg Med Chem Lett 11: 515-7 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11229759 | 40 | Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles. |
Bioorg Med Chem Lett 11: 509-13 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11229757 | 5 | Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788. |
Bioorg Med Chem Lett 11: 501-4 (2001) | Cambridge NeuroScience Inc | 2D 3D TSV |
| 11229755 | 66 | Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors. |
Bioorg Med Chem Lett 11: 491-4 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11229754 | 28 | Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl. |
Bioorg Med Chem Lett 11: 487-9 (2001) | State University of New York | 2D 3D TSV |
| 11229749 | 1 | Beta-D-glycosylamidines: potent, selective, and easily accessible 1-glycosidase inhibitors. |
Bioorg Med Chem Lett 11: 467-70 (2001) | Kyoto University | 2D 3D TSV |
| 11229747 | 10 | Synthesis of sialyl Lewis(x) mimics. Modifications of the 6-position of galactose. |
Bioorg Med Chem Lett 11: 459-62 (2001) | Novartis Pharma AG | 2D 3D TSV |
| 11229746 | 6 | First tricyclic oximino derivatives as 5-HT3 ligands. |
Bioorg Med Chem Lett 11: 453-7 (2001) | Universit£ de Caen | 2D 3D TSV |
| 11229744 | 7 | Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine. |
Bioorg Med Chem Lett 11: 447-9 (2001) | Institute of Bioorganic Chemistry RAS | 2D 3D TSV |
| 11218067 | 19 | 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. |
Naunyn Schmiedebergs Arch Pharmacol 363: 146-60 (2001) | University of Oslo | 2D 3D TSV |
| 11212127 | 7 | Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1. |
Bioorg Med Chem Lett 11: 425-7 (2001) | Philipps-Universität Marburg | 2D 3D TSV |
| 11212124 | 41 | Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists. |
Bioorg Med Chem Lett 11: 415-7 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11212119 | 12 | Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1. |
Bioorg Med Chem Lett 11: 395-8 (2001) | Nippon Roche Research Center | 2D 3D TSV |
| 11212115 | 72 | Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties. |
Bioorg Med Chem Lett 11: 379-82 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11212114 | 16 | Synthesis and biological activity of novel potent endothelin-converting enzyme-1 inhibitors. |
Bioorg Med Chem Lett 11: 375-8 (2001) | Novartis Institute for BioMedical Research | 2D 3D TSV |
| 11212112 | 24 | Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives. |
Bioorg Med Chem Lett 11: 367-70 (2001) | Uppsala University | 2D 3D TSV |
| 11212110 | 1 | Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity. |
Bioorg Med Chem Lett 11: 359-62 (2001) | Kyoto University | 2D 3D TSV |
| 11212109 | 14 | The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase. |
Bioorg Med Chem Lett 11: 355-7 (2001) | Roche Discover Welwyn | 2D 3D TSV |
| 11212103 | 4 | The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type. |
Bioorg Med Chem Lett 11: 331-3 (2001) | NIDDK | 2D 3D TSV |
| 11212102 | 24 | Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4. |
Bioorg Med Chem Lett 11: 327-9 (2001) | Tohoku Pharmaceutical University | 2D 3D TSV |
| 11212101 | 8 | Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide. |
Bioorg Med Chem Lett 11: 323-5 (2001) | Clinical Research Institute of Montreal | 2D 3D TSV |
| 11212100 | 27 | The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist. |
Bioorg Med Chem Lett 11: 319-21 (2001) | AstraZeneca | 2D 3D TSV |
| 11212099 | 107 | Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases. |
Bioorg Med Chem Lett 11: 313-7 (2001) | University of Pittsburgh | 2D 3D TSV |
| 11212098 | 25 | Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase. |
Bioorg Med Chem Lett 11: 309-12 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11212095 | 65 | General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors. |
Bioorg Med Chem Lett 11: 295-9 (2001) | Institut de Recherches Servier | 2D 3D TSV |
| 11212093 | 21 | Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors. |
Bioorg Med Chem Lett 11: 287-90 (2001) | BioChem Pharma Inc. | 2D 3D TSV |
| 11212092 | 1 | Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation. |
Bioorg Med Chem Lett 11: 283-6 (2001) | Universidade Federal do Rio de Janeiro | 2D 3D TSV |
| 11206480 | 6 | Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C. |
Bioorg Med Chem Lett 11: 99-101 (2001) | Institute of Organic Chemistry | 2D 3D TSV |
| 11206479 | 14 | A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. |
Bioorg Med Chem Lett 11: 95-8 (2001) | University of Washington | 2D 3D TSV |
| 11206478 | 18 | Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor. |
Bioorg Med Chem Lett 11: 91-4 (2001) | Institute of Molecular and Cell Biology | 2D 3D TSV |
| 11206474 | 51 | Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes. |
Bioorg Med Chem Lett 11: 265-70 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11206473 | 36 | Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes. |
Bioorg Med Chem Lett 11: 259-64 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11206471 | 11 | Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents. |
Bioorg Med Chem Lett 11: 251-4 (2001) | Indiana State University | 2D 3D TSV |
| 11206469 | 14 | Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams. |
Bioorg Med Chem Lett 11: 243-6 (2001) | GlaxoWellcome Medicines Research Centre | 2D 3D TSV |
| 11206468 | 24 | Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases. |
Bioorg Med Chem Lett 11: 239-42 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11206467 | 44 | The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position. |
Bioorg Med Chem Lett 11: 235-8 (2001) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11206465 | 13 | Solid-phase optimisation of achiral amidinobenzyl indoles as potent and selective factor Xa inhibitors. |
Bioorg Med Chem Lett 11: 227-30 (2001) | Aventis Pharma | 2D 3D TSV |
| 11206464 | 6 | Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand. |
Bioorg Med Chem Lett 11: 223-6 (2001) | Universit£ di Pisa | 2D 3D TSV |
| 11206463 | 44 | Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3' residue. |
Bioorg Med Chem Lett 11: 219-22 (2001) | The Scripps Research Institute | 2D 3D TSV |
| 11206461 | 10 | 3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors. |
Bioorg Med Chem Lett 11: 211-4 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11206459 | 29 | Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. |
Bioorg Med Chem Lett 11: 203-6 (2001) | Uppsala University | 2D 3D TSV |
| 11206458 | 14 | Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K. |
Bioorg Med Chem Lett 11: 199-202 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11206457 | 29 | Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K. |
Bioorg Med Chem Lett 11: 195-8 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11206456 | 7 | High-pressure synthesis of enantiomerically pure C-6 substituted pyrazol. |
Bioorg Med Chem Lett 11: 191-3 (2001) | AstraZeneca R&D Griffith University | 2D 3D TSV |
| 11206452 | 14 | 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth. |
Bioorg Med Chem Lett 11: 173-6 (2001) | Georgetown University Medical Center | 2D 3D TSV |
| 11206450 | 36 | 2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors. |
Bioorg Med Chem Lett 11: 165-8 (2001) | Pacific Corporation R & D Center | 2D 3D TSV |
| 11206448 | 21 | Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates. |
Bioorg Med Chem Lett 11: 157-60 (2001) | Inspire Pharmaceuticals, Inc. | 2D 3D TSV |
| 11206447 | 12 | Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors. |
Bioorg Med Chem Lett 11: 151-5 (2001) | Wyeth Research | 2D 3D TSV |
| 11206439 | 51 | Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2. |
Bioorg Med Chem Lett 11: 113-7 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11206438 | 48 | Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1. |
Bioorg Med Chem Lett 11: 107-11 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11196150 | 3 | Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. |
Cancer Res 61: 131-7 (2001) | Janssen Research Foundation | 2D 3D TSV |
| 11191840 | 25 | Cloning of a chick A3 adenosine receptor: characterization of ligand binding and receptor-effector coupling of chick A1 and A3 adenosine receptors. |
Naunyn Schmiedebergs Arch Pharmacol 363: 81-6 (2001) | University of Illinois at Chicago | 2D 3D TSV |
| 11191835 | 3 | Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters. |
Naunyn Schmiedebergs Arch Pharmacol 363: 40-9 (2001) | Universidade do Porto | 2D 3D TSV |
| 11191833 | 15 | Characterisation and comparison of novel ligands for the nociceptin/orphanin FQ receptor. |
Naunyn Schmiedebergs Arch Pharmacol 363: 28-33 (2001) | Leicester Royal Infirmary | 2D 3D TSV |
| 11182316 | 22 | Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases. |
Chem Biol 8: 17-31 (2001) | Northwestern University | 2D 3D TSV |
| 11179436 | 9 | Cloning, expression, and pharmacological characterization of a novel human histamine receptor. |
Mol Pharmacol 59: 434-41 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11179435 | 15 | Discovery of a novel member of the histamine receptor family. |
Mol Pharmacol 59: 427-33 (2001) | The Centre for Addiction and Mental Health | 2D 3D TSV |
| 11179434 | 31 | Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. |
Mol Pharmacol 59: 420-6 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11171942 | 32 | Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects. |
Pharmacol Rev 53: 119-33 (2001) | University of Reading | 2D 3D TSV |
| 11170689 | 6 | Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures. |
J Nat Prod 64: 136-8 (2001) | University of Illinois at Chicago | 2D 3D TSV |
| 11170677 | 1 | Synthesis of a novel lysophosphatidylcholine. |
J Nat Prod 64: 98-9 (2001) | Graduate School of Okayama University | 2D 3D TSV |
| 11170666 | 6 | Isolation and structure determination of nostocyclopeptides A1 and A2 from the terrestrial cyanobacterium Nostoc sp. ATCC53789. |
J Nat Prod 64: 54-9 (2001) | University of Hawaii at Manoa | 2D 3D TSV |
| 11170654 | 72 | Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes. |
J Med Chem 44: 633-40 (2001) | National Institute on Drug Abuse-Intramural Research Program | 2D 3D TSV |
| 11170652 | 19 | seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties. |
J Med Chem 44: 619-26 (2001) | Bayer AG | 2D 3D TSV |
| 11170651 | 47 | AMP deaminase inhibitors. 5. Design, synthesis, and SAR of a highly potent inhibitor series. |
J Med Chem 44: 613-8 (2001) | Metabasis Therapeutics Inc | 2D 3D TSV |
| 11170650 | 4 | Novel glucocorticoid antedrugs possessing a 17beta-(gamma-lactone) ring. |
J Med Chem 44: 602-12 (2001) | Glaxo Wellcome Research and Development | 2D 3D TSV |
| 11170646 | 106 | Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa. |
J Med Chem 44: 566-78 (2001) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11170645 | 77 | 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity. |
J Med Chem 44: 548-65 (2001) | UMR 8525 CNRS - Université Lille II | 2D 3D TSV |
| 11170644 | 18 | Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. |
J Med Chem 44: 540-7 (2001) | Yamanouchi Pharmaceutical Company, Ltd | 2D 3D TSV |
| 11170643 | 171 | Design, synthesis, and evaluation of novel A2A adenosine receptor agonists. |
J Med Chem 44: 531-9 (2001) | University of Virginia | 2D 3D TSV |
| 11170642 | 12 | Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717. |
J Med Chem 44: 524-30 (2001) | Lawrence Berkeley National Laboratory | 2D 3D TSV |
| 11170639 | 73 | Current and novel approaches to the drug treatment of schizophrenia. |
J Med Chem 44: 477-501 (2001) | Merck Sharp and Dohme Research Laboratories | 2D 3D TSV |
| 11170630 | 46 | Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins. |
J Med Chem 44: 208-14 (2001) | Hokkaido University | 2D 3D TSV |
| 11170629 | 35 | Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition. |
J Med Chem 44: 198-207 (2001) | Universidad Complutense | 2D 3D TSV |
| 11170628 | 37 | Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2) antagonist properties. |
J Med Chem 44: 186-97 (2001) | Universidad Complutense | 2D 3D TSV |
| 11170626 | 55 | 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
J Med Chem 44: 170-9 (2001) | Eisai Company, Ltd | 2D 3D TSV |
| 11170625 | 25 | Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors. |
J Med Chem 44: 155-69 (2001) | Uppsala University | 2D 3D TSV |
| 11170624 | 40 | Estimation of binding affinities for HEPT and nevirapine analogues with HIV-1 reverse transcriptase via Monte Carlo simulations. |
J Med Chem 44: 145-54 (2001) | Yale University | 2D 3D TSV |
| 11164381 | 20 | Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist. |
Eur J Pharmacol 411: 245-53 (2001) | The Royal Danish School of Pharmacy | 2D 3D TSV |
| 11160654 | 10 | Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea. |
J Pharmacol Exp Ther 296: 650-8 (2001) | Kitasato University | 2D 3D TSV |
| 11160644 | 46 | Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. |
J Pharmacol Exp Ther 296: 558-66 (2001) | Merck Frosst Centre for Therapeutic Research | 2D 3D TSV |
| 11160626 | 23 | In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. |
J Pharmacol Exp Ther 296: 420-5 (2001) | Japan Tobacco Inc | 2D 3D TSV |
| 11150177 | 43 | Extended TIP(P) analogues as precursors for labeled delta-opioid receptor ligands. |
J Med Chem 43: 5050-4 (2001) | University of Maryland | 2D 3D TSV |
| 11150176 | 9 | Synthesis and evaluation of isothiocyanate-containing derivatives of the delta-opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP) as potential affinity labels for delta-opioid receptors. |
J Med Chem 43: 5044-9 (2001) | University of Maryland | 2D 3D TSV |
| 11150175 | 17 | Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors. |
J Med Chem 43: 5037-43 (2001) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11150174 | 84 | Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. |
J Med Chem 43: 5030-6 (2001) | Virginia Commonwealth University | 2D 3D TSV |
| 11150173 | 120 | A potent, long-acting, orally active (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: novel muscarinic M(3) receptor antagonist with high selectivity for M(3) over M(2) receptors. |
J Med Chem 43: 5017-29 (2001) | Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories | 2D 3D TSV |
| 11150172 | 8 | Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. |
J Med Chem 43: 5010-6 (2001) | Schering AG | 2D 3D TSV |
| 11150171 | 2 | 5-Azidoimidacloprid and an acyclic analogue as candidate photoaffinity probes for mammalian and insect nicotinic acetylcholine receptors. |
J Med Chem 43: 5003-9 (2001) | University of California | 2D 3D TSV |
| 11150170 | 30 | D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. |
J Med Chem 43: 4998-5002 (2001) | University of Arizona | 2D 3D TSV |
| 11150168 | 165 | Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse. |
J Med Chem 43: 4981-92 (2001) | Pharm-Eco Laboratories | 2D 3D TSV |
| 11150167 | 28 | Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor. |
J Med Chem 43: 4973-80 (2001) | Deakin University | 2D 3D TSV |
| 11150166 | 12 | A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase. |
J Med Chem 43: 4964-72 (2001) | AstraZeneca | 2D 3D TSV |
| 11150165 | 228 | Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines. |
J Med Chem 43: 4948-63 (2001) | Procter and Gamble Pharmaceuticals | 2D 3D TSV |
| 11150162 | 15 | Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase. |
J Med Chem 43: 4927-9 (2001) | Colorado State University | 2D 3D TSV |
| 11150161 | 19 | 4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells. |
J Med Chem 43: 4923-6 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11148027 | 15 | Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53. |
Biochemistry 40: 336-44 (2001) | Max Planck Institute | 2D 3D TSV |
| 11145223 | 7 | Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4. |
Pharm Res 17: 1189-97 (2000) | Kanazawa University | 2D 3D TSV |
| 11141112 | 2 | Three new arylobenzofurans from Onobrychis ebenoides and evaluation of their binding affinity for the estrogen receptor. |
J Nat Prod 63: 1672-4 (2001) | University of Athens | 2D 3D TSV |
| 11141102 | 1 | Guaiane dimers and germacranolide from Artemisia caruifolia. |
J Nat Prod 63: 1626-9 (2000) | Toyama Medical and Pharmaceutical University | 2D 3D TSV |
| 11141093 | 20 | Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors. |
J Med Chem 44: 105-9 (2001) | University of Bologna | 2D 3D TSV |
| 11141092 | 85 | Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L. |
J Med Chem 44: 94-104 (2001) | Merck Frosst Centre for Therapeutic Research | 2D 3D TSV |
| 11141084 | 7 | Terminally alkylated polyamine analogues as chemotherapeutic agents. |
J Med Chem 44: 1-26 (2001) | Wayne State University | 2D 3D TSV |
| 11140741 | 43 | p38 kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas. |
Bioorg Med Chem Lett 11: 9-12 (2001) | Bayer Research Center | 2D 3D TSV |
| 11140740 | 65 | Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors. |
Bioorg Med Chem Lett 11: 83-6 (2001) | Abbott Laboratories | 2D 3D TSV |
| 11140738 | 8 | B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance. |
Bioorg Med Chem Lett 11: 75-7 (2001) | Département de Pharmacochimie Moléculaire UMR-CNRS 5063 | 2D 3D TSV |
| 11140734 | 8 | Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds. |
Bioorg Med Chem Lett 11: 59-62 (2001) | National Cancer Istitute-Frederick Cancer Research and Development Center | 2D 3D TSV |
| 11140733 | 92 | Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134). |
Bioorg Med Chem Lett 11: 55-8 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11140732 | 10 | Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers. |
Bioorg Med Chem Lett 11: 51-4 (2001) | The University of Manchester | 2D 3D TSV |
| 11140727 | 31 | Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives. |
Bioorg Med Chem Lett 11: 33-7 (2001) | Zambon Group | 2D 3D TSV |
| 11140724 | 53 | Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines. |
Bioorg Med Chem Lett 11: 17-21 (2001) | Pfizer Inc | 2D 3D TSV |
| 11140722 | 24 | Imide and lactam derivatives of N-benzylpyroglutamyl-L-phenylalanine as VCAM/VLA-4 antagonists. |
Bioorg Med Chem Lett 11: 1-4 (2001) | Hoffmann-La Roche Inc | 2D 3D TSV |
| 11133101 | 29 | Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors. |
Bioorg Med Chem Lett 10: 2825-8 (2000) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11133099 | 43 | Synthesis and activity of selective MMP inhibitors with an aryl backbone. |
Bioorg Med Chem Lett 10: 2815-7 (2000) | Pharmacia | 2D 3D TSV |
| 11133092 | 2 | A novel pyridazinone derivative as a nonprostanoid PGI2 agonist. |
Bioorg Med Chem Lett 10: 2787-90 (2000) | Fujisawa Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11133090 | 2 | Evaluation of new L-thiocitrulline derivatives as inhibitors of nitric oxide synthase. |
Bioorg Med Chem Lett 10: 2779-81 (2000) | Wake Forest University | 2D 3D TSV |
| 11133089 | 28 | Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1. |
Bioorg Med Chem Lett 10: 2775-8 (2000) | LG Chemical Ltd | 2D 3D TSV |
| 11133088 | 46 | 1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase. |
Bioorg Med Chem Lett 10: 2771-4 (2000) | Northwestern University | 2D 3D TSV |
| 11133084 | 14 | Synthesis and binding activity of endomorphin-1 analogues containing beta-amino acids. |
Bioorg Med Chem Lett 10: 2755-8 (2000) | Universit£ di Bologna | 2D 3D TSV |
| 11133082 | 32 | Assessment of substitution in the second pharmacophore of Dmt-Tic analogues. |
Bioorg Med Chem Lett 10: 2745-8 (2000) | University of Naples | 2D 3D TSV |
| 11133081 | 33 | A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents. |
Bioorg Med Chem Lett 10: 2741-3 (2000) | Georgetown University Medical Center | 2D 3D TSV |
| 11133079 | 10 | Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation. |
Bioorg Med Chem Lett 10: 2731-3 (2000) | University of California | 2D 3D TSV |
| 11133078 | 20 | Benzylidene ketal derivatives as M2 muscarinic receptor antagonists. |
Bioorg Med Chem Lett 10: 2727-30 (2000) | Schering-Plough Research Institute | 2D 3D TSV |
| 11133073 | 12 | Determination of the relative and absolute stereochemistry of a potent and alpha1A-selective adrenoceptor antagonist. |
Bioorg Med Chem Lett 10: 2705-7 (2000) | Synaptic Pharmaceutical Corporation | 2D 3D TSV |
| 11133072 | 11 | 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. |
Bioorg Med Chem Lett 10: 2701-3 (2000) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 11133071 | 60 | 2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor. |
Bioorg Med Chem Lett 10: 2697-9 (2000) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 11133070 | 4 | Solid-phase synthesis of 2,3-disubstituted indoles: discovery of a novel, high-affinity, selective h5-HT2A antagonist. |
Bioorg Med Chem Lett 10: 2693-6 (2000) | Merck Sharp & Dohme Research Laboratories | 2D 3D TSV |
| 11132243 | 125 | Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. |
Life Sci 68: 29-39 (2000) | Mayo Foundation | 2D 3D TSV |
| 11128651 | 18 | Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx). |
Bioorg Med Chem Lett 10: 2683-6 (2000) | Merck Frosst Centre for Therapeutic Research | 2D 3D TSV |
| 11128646 | 69 | Synthesis and biological evaluation of 2,5-dihydropyrazol. |
Bioorg Med Chem Lett 10: 2661-4 (2000) | Rhône-Poulenc Rorer | 2D 3D TSV |
| 11128645 | 16 | Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2. |
Bioorg Med Chem Lett 10: 2657-60 (2000) | Taisho Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11128643 | 4 | (S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors. |
Bioorg Med Chem Lett 10: 2647-51 (2000) | University of Würzburg | 2D 3D TSV |
| 11128642 | 5 | Serotonin transporter inhibitors: synthesis and binding potency of 2'-methyl- and 3'-methyl-6-nitroquipazine. |
Bioorg Med Chem Lett 10: 2643-6 (2000) | Central Washington University | 2D 3D TSV |
| 11128640 | 22 | Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes. |
Bioorg Med Chem Lett 10: 2633-7 (2000) | Kyoto University | 2D 3D TSV |
| 11128638 | 7 | 6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors. |
Bioorg Med Chem Lett 10: 2625-7 (2000) | Institute of Science & Technology | 2D 3D TSV |
| 11124001 | 5 | Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents. |
J Med Chem 43: 4919-22 (2000) | Merck Research Laboratories | 2D 3D TSV |
| 11123999 | 42 | Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists. |
J Med Chem 43: 4893-909 (2000) | Taisho Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11123998 | 141 | Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects. |
J Med Chem 43: 4884-92 (2000) | Universit£ degli Studi di Firenze | 2D 3D TSV |
| 11123996 | 21 | Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. |
J Med Chem 43: 4868-76 (2000) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
| 11123995 | 113 | Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors. |
J Med Chem 43: 4850-67 (2000) | Pfizer Inc. | 2D 3D TSV |
| 11123994 | 72 | Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909). |
J Med Chem 43: 4840-9 (2000) | National Institute of Diabetes and Digestive and Kidney Diseases | 2D 3D TSV |
| 11123988 | 23 | Semisynthesis of antitumoral acetogenins: SAR of functionalized alkyl-chain bis-tetrahydrofuranic acetogenins, specific inhibitors of mitochondrial complex I. |
J Med Chem 43: 4793-800 (2000) | Universidad de Valencia | 2D 3D TSV |
| 11123986 | 5 | Design of adenosine kinase inhibitors from the NMR-based screening of fragments. |
J Med Chem 43: 4781-6 (2000) | Abbott Laboratories | 2D 3D TSV |
| 11123985 | 176 | Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen. |
J Med Chem 43: 4768-80 (2000) | Università degli Studi di Ferrara | 2D 3D TSV |
| 11123983 | 112 | Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs. |
J Med Chem 43: 4747-58 (2000) | Universit£ de Lausanne | 2D 3D TSV |
| 11121615 | 32 | Synthesis and in vitro opioid activity profiles of DALDA analogues. |
Eur J Med Chem 35: 895-901 (2000) | Clinical Research Institute of Montreal | 2D 3D TSV |
| 11114395 | 7 | Pharmacological profiles of the metabotropic glutamate receptor ligands. |
Neuropharmacology 40: 170-7 (2001) | University of Toronto | 2D 3D TSV |
| 11112523 | 7 | Estimation of the hydrophobic effect in an antigen-antibody protein-protein interface. |
Biochemistry 39: 15375-87 (2000) | University of Maryland Biotechnology Institute | 2D 3D TSV |
| 11111828 | 16 | Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications. |
Naunyn Schmiedebergs Arch Pharmacol 362: 340-50 (2000) | Biocentre Niederursel | 2D 3D TSV |
| 11104741 | 44 | Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. |
Circulation 102: 2836-41 (2000) | NIH | 2D 3D TSV |
| 11102445 | 2 | Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. |
J Biol Chem 276: 6404-11 (2001) | Queen's University | 2D 3D TSV |
| 11101640 | 4 | Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. |
J Physiol (Lond) 529: 285-93 (2000) | University of Bristol | 2D 3D TSV |
| 11101361 | 37 | Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. |
J Med Chem 43: 4701-10 (2001) | Purdue University | 2D 3D TSV |
| 11101360 | 14 | Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R-nonyl)adenine [(+)-EHNA]. |
J Med Chem 43: 4694-700 (2001) | University of Rhode Island | 2D 3D TSV |
| 11101359 | 9 | Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics. |
J Med Chem 43: 4678-93 (2001) | Universidad de Santiago | 2D 3D TSV |
| 11101358 | 24 | 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. |
J Med Chem 43: 4667-77 (2001) | Central Pharmaceutical Research Institute | 2D 3D TSV |
| 11101357 | 84 | New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. |
J Med Chem 43: 4657-66 (2001) | Universitat de Barcelona | 2D 3D TSV |
| 11101356 | 23 | 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
J Med Chem 43: 4647-56 (2001) | Polish Academy of Sciences | 2D 3D TSV |
| 11101355 | 26 | 7-Deazaadenines bearing polar substituents: structure-activity relationships of new A(1) and A(3) adenosine receptor antagonists. |
J Med Chem 43: 4636-46 (2001) | University of Leipzig | 2D 3D TSV |
| 11101354 | 18 | Chiral derivatives of 2-cyclohexylideneperhydro-4,7-methanoindenes, a novel class of nonsteroidal androgen receptor ligand: synthesis, X-ray analysis, and biological activity. |
J Med Chem 43: 4629-35 (2001) | The University of Sydney | 2D 3D TSV |
| 11101352 | 88 | Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. |
J Med Chem 43: 4606-16 (2000) | Parke-Davis Pharmaceutical Research | 2D 3D TSV |
| 11101350 | 72 | 1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite. |
J Med Chem 43: 4582-93 (2001) | Institut de Recherche Servier | 2D 3D TSV |
| 11101348 | 22 | Discovery of chiral N,N-disubstituted trifluoro-3-amino-2-propanols as potent inhibitors of cholesteryl ester transfer protein. |
J Med Chem 43: 4575-8 (2001) | Pfizer Inc | 2D 3D TSV |
| 11099697 | 4 | Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. |
Eur J Pharmacol 409: 31-6 (2001) | Kyoto University Hospital | 2D 3D TSV |
| 11095748 | 54 | SST3-selective potent peptidic somatostatin receptor antagonists. |
Proc Natl Acad Sci U S A 97: 13973-8 (2000) | University of Berne | 2D 3D TSV |
| 11093801 | 7 | Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. |
Mol Pharmacol 58: 1601-8 (2000) | University of California Irvine | 2D 3D TSV |
| 11093791 | 20 | Synthetic modification of prostaglandin f(2alpha) indicates different structural determinants for binding to the prostaglandin F receptor versus the prostaglandin transporter. |
Mol Pharmacol 58: 1511-6 (2000) | Albert Einstein College of Medicine | 2D 3D TSV |
| 11093776 | 5 | Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists. |
Mol Pharmacol 58: 1375-80 (2000) | University of Alabama at Birmingham | 2D 3D TSV |
| 11093768 | 5 | Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists. |
Mol Pharmacol 58: 1310-7 (2000) | Pfizer Inc | 2D 3D TSV |
| 11090628 | 5 | Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. |
Mol Cell 6: 909-19 (2000) | MRC | 2D 3D TSV |
| 11087581 | 72 | Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments. |
J Med Chem 43: 4563-9 (2000) | Friedrich-Alexander University | 2D 3D TSV |
| 11087580 | 31 | Synthesis, (18)F-labeling, and biological evaluation of piperidyl and pyrrolidyl benzilates as in vivo ligands for muscarinic acetylcholine receptors. |
J Med Chem 43: 4552-62 (2000) | University of Michigan Medical School | 2D 3D TSV |
| 11087579 | 465 | Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action. |
J Med Chem 43: 4542-51 (2000) | Universit£ degli Studi di Firenze | 2D 3D TSV |
| 11087577 | 34 | Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues. |
J Med Chem 43: 4526-33 (2000) | The Royal Danish School of Pharmacy | 2D 3D TSV |
| 11087576 | 33 | Syntheses of 4'-C-ethynyl-beta-D-arabino- and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosylpyrimidines and -purines and evaluation of their anti-HIV activity. |
J Med Chem 43: 4516-25 (2000) | Tohoku University | 2D 3D TSV |
| 11087572 | 31 | 6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. |
J Med Chem 43: 4479-87 (2000) | China Medical College | 2D 3D TSV |
| 11087571 | 35 | Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase. |
J Med Chem 43: 4465-78 (2000) | Laval University | 2D 3D TSV |
| 11087570 | 14 | Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template. |
J Med Chem 43: 4452-64 (2000) | Glaxo Wellcome Research and Development | 2D 3D TSV |
| 11087569 | 37 | Computational studies on HIV-1 protease inhibitors: influence of calculated inhibitor-enzyme binding affinities on the statistical quality of 3D-QSAR CoMFA models. |
J Med Chem 43: 4446-51 (2000) | University of Missouri St. Louis | 2D 3D TSV |
| 11087568 | 55 | Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17). |
J Med Chem 43: 4437-45 (2000) | University of the Saarland | 2D 3D TSV |
| 11087567 | 6 | Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester. |
J Med Chem 43: 4428-36 (2000) | Novartis Pharma AG | 2D 3D TSV |
| 11087566 | 69 | Multiple-conformation and protonation-state representation in 4D-QSAR: the neurokinin-1 receptor system. |
J Med Chem 43: 4416-27 (2000) | Biographics Laboratory 3R | 2D 3D TSV |
| 11087565 | 86 | Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors. |
J Med Chem 43: 4398-415 (2000) | DuPont Pharmaceuticals Company | 2D 3D TSV |
| 11087564 | 30 | Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template. |
J Med Chem 43: 4388-97 (2000) | Otsuka Pharmaceutical Co., Ltd | 2D 3D TSV |
| 11087562 | 27 | Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. |
J Med Chem 43: 4370-6 (2000) | Merck Research Laboratories | 2D 3D TSV |
| 11087559 | 7 | Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography. |
J Med Chem 43: 4359-62 (2000) | University of Milano-Bicocca | 2D 3D TSV |
| 11087558 | 29 | Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors. |
J Med Chem 43: 4354-8 (2000) | NPS Allelix Corporation | 2D 3D TSV |
| 11086733 | 56 | Potent nonpeptide endothelin antagonists: synthesis and structure-activity relationships of pyrazole-5-carboxylic acids. |
Bioorg Med Chem Lett 10: 2575-8 (2001) | Hoechst Marion Roussel Inc | 2D 3D TSV |
| 11086732 | 10 | Synthesis of the novel analogues of dysidiolide and their structure-activity relationship. |
Bioorg Med Chem Lett 10: 2571-4 (2001) | The University of Tokyo | 2D 3D TSV |
| 11086731 | 16 | Arylacetamides as peripherally restricted kappa opioid receptor agonists. |
Bioorg Med Chem Lett 10: 2567-70 (2001) | Adolor Corporation | 2D 3D TSV |
| 11086729 | 51 | N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2. |
Bioorg Med Chem Lett 10: 2557-61 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11086728 | 30 | Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor. |
Bioorg Med Chem Lett 10: 2553-5 (2000) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11086723 | 12 | Androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase. |
Bioorg Med Chem Lett 10: 2533-6 (2001) | Laval University | 2D 3D TSV |
| 11086722 | 12 | Bisquaternary caracurine V derivatives as allosteric modulators of ligand binding to M2 acetylcholine receptors. |
Bioorg Med Chem Lett 10: 2529-32 (2001) | University of Würzburg | 2D 3D TSV |
| 11086721 | 10 | Inhibition of vertebrate squalene epoxidase by isoprenyl gallates and phenylalkyl gallates. |
Bioorg Med Chem Lett 10: 2525-8 (2001) | University of Shizuoka | 2D 3D TSV |
| 11086718 | 65 | Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase. |
Bioorg Med Chem Lett 10: 2513-6 (2001) | Roche Bioscience | 2D 3D TSV |
| 11086714 | 10 | Synthesis and calpain inhibitory activity of alpha-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position. |
Bioorg Med Chem Lett 10: 2497-500 (2001) | The University of Tennessee Health Science Center | 2D 3D TSV |
| 11082457 | 63 | S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine. |
J Pharmacol Exp Ther 295: 1192-205 (2000) | Centre de Recherches de Croissy | 2D 3D TSV |
| 11082453 | 77 | ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse. |
J Pharmacol Exp Ther 295: 1156-64 (2000) | Abbott Laboratories | 2D 3D TSV |
| 11080213 | 35 | Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. |
J Neurochem 75: 2590-601 (2000) | F. Hoffmann-La Roche Inc | 2D 3D TSV |
| 11078204 | 19 | Inhibitors of src tyrosine kinase: the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines. |
Bioorg Med Chem Lett 10: 2477-80 (2000) | Wyeth-Ayerst Research | 2D 3D TSV |
| 11078202 | 4 | Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A. |
Bioorg Med Chem Lett 10: 2467-9 (2001) | Georgetown University Medical Center | 2D 3D TSV |
| 11078200 | 61 | N-[1-(2-Phenylethyl)pyrrolidin-3-yl]-1-adamantanecarboxamides as novel 5-HT2 receptor antagonists. |
Bioorg Med Chem Lett 10: 2457-61 (2001) | Welfide Corporation | 2D 3D TSV |
| 11078198 | 12 | N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. |
Bioorg Med Chem Lett 10: 2449-51 (2001) | University of Maryland | 2D 3D TSV |
| 11078197 | 65 | 3alpha-(4-Substituted phenyl)nortropane-2beta-carboxylic acid methyl esters show selective binding at the norepinephrine transporter. |
Bioorg Med Chem Lett 10: 2445-7 (2001) | Research Triangle Institute | 2D 3D TSV |
| 11078196 | 4 | Synthesis of glutaminyl adenylate analogues that are inhibitors of glutaminyl-tRNA synthetase. |
Bioorg Med Chem Lett 10: 2441-4 (2001) | Universit£ Laval | 2D 3D TSV |
| 11078195 | 4 | Multistep solution-phase parallel synthesis of spiperone analogues. |
Bioorg Med Chem Lett 10: 2435-9 (2001) | ACADIA Pharmaceuticals A/S | 2D 3D TSV |
| 11078192 | 18 | Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor. |
Bioorg Med Chem Lett 10: 2421-5 (2001) | Roche Bioscience | 2D 3D TSV |
| 11078189 | 24 | Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. |
Bioorg Med Chem Lett 10: 2407-10 (2001) | Institute for Bioorganic Research | 2D 3D TSV |
| 11078188 | 20 | 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma. |
Bioorg Med Chem Lett 10: 2403-6 (2001) | Shionogi & Co., Ltd | 2D 3D TSV |
| 11078187 | 36 | Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors. |
Bioorg Med Chem Lett 10: 2397-401 (2001) | Shionogi & Co., Ltd | 2D 3D TSV |
| 11076551 | 6 | A new 7,8-euphadien-type triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that inhibits DNA polymerase beta. |
J Nat Prod 63: 1356-60 (2000) | University of Virginia | 2D 3D TSV |
| 11071707 | 71 | Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. |
Synapse 39: 32-41 (2001) | NIH | 2D 3D TSV |
| 11063624 | 95 | Structure-activity relationships of a series of pyrrolo[3,2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists. |
J Med Chem 43: 4288-312 (2000) | Amgen Inc | 2D 3D TSV |
| 11063622 | 60 | Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2. |
J Med Chem 43: 4266-77 (2000) | University of the Saarland | 2D 3D TSV |
| 11063616 | 45 | 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamines and related 2-urea derivatives are potent and selective inhibitors of the FGF receptor-1 tyrosine kinase. |
J Med Chem 43: 4200-11 (2000) | University of Auckland | 2D 3D TSV |
| 11063613 | 13 | The mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway: a potential site of action of daidzin. |
J Med Chem 43: 4169-79 (2000) | Harvard Medical School | 2D 3D TSV |
| 11063611 | 70 | 2D QSAR modeling and preliminary database searching for dopamine transporter inhibitors using genetic algorithm variable selection of Molconn Z descriptors. |
J Med Chem 43: 4151-9 (2000) | National Institute on Drug Abuse-Intramural Research Program | 2D 3D TSV |
| 11063610 | 69 | Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. |
J Med Chem 43: 4135-50 (2000) | University of Washington | 2D 3D TSV |
| 11063609 | 36 | Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. |
J Med Chem 43: 4126-34 (2000) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11063607 | 1 | Active site binding modes of HIV-1 integrase inhibitors. |
J Med Chem 43: 4109-17 (2000) | University of California | 2D 3D TSV |
| 11063606 | 137 | 3D-QSAR CoMFA on cyclin-dependent kinase inhibitors. |
J Med Chem 43: 4098-108 (2000) | Institut Curie | 2D 3D TSV |
| 11063605 | 36 | Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase. |
J Med Chem 43: 4084-97 (2000) | Newcastle University | 2D 3D TSV |
| 11063604 | 49 | Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine. |
J Med Chem 43: 4071-83 (2000) | Newcastle University | 2D 3D TSV |
| 11063603 | 53 | Rational design, synthesis, and biological activity of benzoxazinones as novel factor Xa inhibitors. |
J Med Chem 43: 4063-70 (2000) | Pfizer Inc | 2D 3D TSV |
| 11063602 | 84 | Synthesis of phenalene and acenaphthene derivatives as new conformationally restricted ligands for melatonin receptors. |
J Med Chem 43: 4051-62 (2000) | Paris-Sud University | 2D 3D TSV |
| 11063601 | 29 | (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. |
J Med Chem 43: 4045-50 (2000) | AstraZeneca R&D Boston | 2D 3D TSV |
| 11063600 | 32 | Discovery of potent cyclic pseudopeptide human tachykinin NK-2 receptor antagonists. |
J Med Chem 43: 4041-4 (2000) | Menarini Ricerche S.p.A. | 2D 3D TSV |
| 11055361 | 17 | Synthesis and estrogen receptor binding affinities of novel pyrrolo[2,1,5-cd]indolizine derivatives. |
Bioorg Med Chem Lett 10: 2383-6 (2000) | Novo Nordisk A/S | 2D 3D TSV |
| 11055360 | 13 | Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists. |
Bioorg Med Chem Lett 10: 2379-82 (2001) | Freie Universität Berlin | 2D 3D TSV |
| 11055359 | 18 | Novel heterocycles as selective alpha1-adrenergic receptor antagonists. |
Bioorg Med Chem Lett 10: 2375-7 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11055357 | 10 | Optimising inhibitors of trypanothione reductase using solid-phase chemistry. |
Bioorg Med Chem Lett 10: 2367-9 (2001) | University of Southamton | 2D 3D TSV |
| 11055356 | 236 | Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity. |
Bioorg Med Chem Lett 10: 2361-6 (2001) | Axys Pharmaceuticals Inc | 2D 3D TSV |
| 11055355 | 72 | Dibasic inhibitors of human mast cell tryptase. Part 1: synthesis and optimization of a novel class of inhibitors. |
Bioorg Med Chem Lett 10: 2357-60 (2001) | Axys Pharmaceuticals Inc | 2D 3D TSV |
| 11055351 | 6 | Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1. |
Bioorg Med Chem Lett 10: 2337-41 (2001) | Novartis Pharmaceuticals | 2D 3D TSV |
| 11055350 | 58 | Synthesis and NK1/NK2 receptor activity of substituted-4(Z)-(methoxyimino)pentyl-1-piperazines. |
Bioorg Med Chem Lett 10: 2333-5 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11055349 | 19 | The design and synthesis of novel NK1/NK2 dual antagonists. |
Bioorg Med Chem Lett 10: 2329-32 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11055344 | 37 | Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties. |
Bioorg Med Chem Lett 10: 2305-9 (2001) | Corvas International Inc | 2D 3D TSV |
| 11055342 | 21 | N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists. |
Bioorg Med Chem Lett 10: 2295-9 (2001) | Virginia Commonwealth University | 2D 3D TSV |
| 11055339 | 59 | Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists. |
Bioorg Med Chem Lett 10: 2283-6 (2001) | Merck Research Laboratories | 2D 3D TSV |
| 11055338 | 8 | Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease. |
Bioorg Med Chem Lett 10: 2279-82 (2001) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11055336 | 2 | NMR line-broadening and transferred NOESY as a medicinal chemistry tool for studying inhibitors of the hepatitis C virus NS3 protease domain. |
Bioorg Med Chem Lett 10: 2271-4 (2001) | Boehringer Ingelheim Pharmaceuticals Inc | 2D 3D TSV |
| 11055335 | 27 | Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors. |
Bioorg Med Chem Lett 10: 2267-70 (2001) | Boehringer Ingelheim Pharmaceuticals Inc | 2D 3D TSV |
| 11055334 | 22 | Analogues of SB-203207 as inhibitors of tRNA synthetases. |
Bioorg Med Chem Lett 10: 2263-6 (2001) | Australian National University | 2D 3D TSV |
| 11055333 | 21 | Selective kappa-opioid antagonists related to naltrindole. Effect of side-chain spacer in the 5'-amidinoalkyl series. |
Bioorg Med Chem Lett 10: 2259-61 (2001) | University of Bristol | 2D 3D TSV |
| 11055332 | 42 | Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor. |
Bioorg Med Chem Lett 10: 2255-7 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11055331 | 6 | Differential antibacterial activity of moenomycin analogues on gram-positive bacteria. |
Bioorg Med Chem Lett 10: 2251-4 (2000) | Advanced Medicine, Inc. | 2D 3D TSV |
| 11055330 | 30 | Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists. |
Bioorg Med Chem Lett 10: 2247-50 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11052808 | 75 | Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. |
J Med Chem 43: 4025-40 (2000) | Abbott Laboratories | 2D 3D TSV |
| 11052805 | 24 | Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide]. |
J Med Chem 43: 3995-4004 (2000) | Signal Pharmaceuticals, Inc. | 2D 3D TSV |
| 11052804 | 41 | Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. |
J Med Chem 43: 3987-94 (2000) | Freie Universit£t Berlin | 2D 3D TSV |
| 11052803 | 19 | Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. |
J Med Chem 43: 3981-6 (2000) | University of Maryland | 2D 3D TSV |
| 11052800 | 7 | Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors. |
J Med Chem 43: 3949-62 (2000) | Institut Curie | 2D 3D TSV |
| 11052799 | 10 | Synthesis and evaluation of N,N-dialkyl enkephalin-based affinity labels for delta opioid receptors. |
J Med Chem 43: 3941-8 (2000) | University of Maryland | 2D 3D TSV |
| 11052797 | 68 | trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents. |
J Med Chem 43: 3923-32 (2000) | Neurogen Corporation | 2D 3D TSV |
| 11052796 | 16 | Radioiodinated N-(2-diethylaminoethyl)benzamide derivatives with high melanoma uptake: structure-affinity relationships, metabolic fate, and intracellular localization. |
J Med Chem 43: 3913-22 (2000) | University of Heidelberg | 2D 3D TSV |
| 11052794 | 103 | N,N-Diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: a novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues. |
J Med Chem 43: 3895-905 (2000) | AstraZeneca R&D Montreal | 2D 3D TSV |
| 11052793 | 115 | New diarylmethylpiperazines as potent and selective nonpeptidic delta opioid receptor agonists with increased In vitro metabolic stability. |
J Med Chem 43: 3878-94 (2000) | AstraZeneca R&D Montreal | 2D 3D TSV |
| 11052791 | 6 | Identification of novel inhibitors of urokinase via NMR-based screening. |
J Med Chem 43: 3862-6 (2000) | Abbott Laboratories | 2D 3D TSV |
| 11052790 | 5 | Computational predictions of binding affinities to dihydrofolate reductase: synthesis and biological evaluation of methotrexate analogues. |
J Med Chem 43: 3852-61 (2000) | Uppsala University | 2D 3D TSV |
| 11052789 | 49 | Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. |
J Med Chem 43: 3837-51 (2000) | Duquesne University | 2D 3D TSV |
| 11052788 | 33 | Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide. |
J Med Chem 43: 3832-6 (2000) | Merck Research Laboratories | 2D 3D TSV |
| 11052787 | 24 | Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry. |
J Med Chem 43: 3827-31 (2000) | University of Pennsylvania | 2D 3D TSV |
| 11052785 | 14 | Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ). |
J Med Chem 43: 3820-3 (2000) | Merck Frosst Centre for Therapeutic Research | 2D 3D TSV |
| 11052784 | 7 | Structure-based design of novel bicyclic nonpeptide inhibitors for the src SH2 domain. |
J Med Chem 43: 3815-9 (2000) | ARIAD Pharmaceuticals, Inc. | 2D 3D TSV |
| 11052723 | 18 | Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae). |
J Agric Food Chem 48: 4717-22 (2000) | Kansas State University | 2D 3D TSV |
| 11044891 | 15 | Characterization of (125)I-IABN, a novel azabicyclononane benzamide selective for D2-like dopamine receptors. |
Synapse 38: 438-49 (2000) | University of North Texas | 2D 3D TSV |
| 11033082 | 16 | Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. |
Chem Biol 7: 793-803 (2000) | SmithKline Beecham Pharmaceuticals Ltd | 2D 3D TSV |
| 11027568 | 1 | Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. |
Biochem Biophys Res Commun 276: 909-16 (2000) | Schering-Plough Research Institute | 2D 3D TSV |
| 11027132 | 6 | Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa. |
Biochemistry 39: 12534-42 (2000) | Berlex | 2D 3D TSV |
| 11020293 | 42 | Novel cannabinol probes for CB1 and CB2 cannabinoid receptors. |
J Med Chem 43: 3778-85 (2000) | Organix Inc | 2D 3D TSV |
| 11020292 | 34 | beta-Turned dipeptoids as potent and selective CCK(1) receptor antagonists. |
J Med Chem 43: 3770-7 (2000) | Instituto de Qu£mica M£dica (CSIC) | 2D 3D TSV |
| 11020291 | 45 | New arylpiperazine derivatives as antagonists of the human cloned 5-HT(4) receptor isoforms. |
J Med Chem 43: 3761-9 (2000) | Paris-Sud University | 2D 3D TSV |
| 11020289 | 9 | Synthesis and opioid receptor affinity of a series of 2, 4-diaryl-substituted 3,7-diazabicylononanones. |
J Med Chem 43: 3746-51 (2000) | University of Würzburg | 2D 3D TSV |
| 11020288 | 13 | Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist. |
J Med Chem 43: 3736-45 (2000) | Merck Research Laboratories | 2D 3D TSV |
| 11020287 | 32 | Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. |
J Med Chem 43: 3718-35 (2000) | Universit£ di Firenze | 2D 3D TSV |
| 11020282 | 512 | Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. |
J Med Chem 43: 3677-87 (2000) | Universita degli Studi | 2D 3D TSV |
| 11020279 | 42 | New substituted 1-(2,3-dihydrobenzo[1, 4]dioxin-2-ylmethyl)piperidin-4-yl derivatives with alpha(2)-adrenoceptor antagonist activity. |
J Med Chem 43: 3653-64 (2000) | Centre de Recherche Pierre Fabre | 2D 3D TSV |
| 11020275 | 75 | Replacement of glycine with dicarbonyl and related moieties in analogues of the C-terminal pentapeptide of cholecystokinin: CCK(2) agonists displaying a novel binding mode. |
J Med Chem 43: 3614-23 (2000) | University of Paris | 2D 3D TSV |
| 11020274 | 142 | Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists. |
J Med Chem 43: 3596-613 (2000) | Glaxo Wellcome Medicines Research Centre | 2D 3D TSV |
| 11020273 | 33 | Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity. |
J Med Chem 43: 3587-95 (2000) | Bristol-Myers Squibb Pharmaceutical Research Institute | 2D 3D TSV |
| 11012037 | 25 | The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I. |
Bioorg Med Chem Lett 10: 2235-8 (2000) | Zambon Group | 2D 3D TSV |
| 11012033 | 8 | Development of plasmin and plasma kallikrein selective inhibitors and their effect on M1 (melanoma) and HT29 cell lines. |
Bioorg Med Chem Lett 10: 2217-21 (2001) | Kobe Gakuin University | 2D 3D TSV |
| 11012031 | 57 | Diphenylsulfone muscarinic antagonists: piperidine derivatives with high M2 selectivity and improved potency. |
Bioorg Med Chem Lett 10: 2209-12 (2001) | Schering-Plough Research Institute | 2D 3D TSV |
| 11012026 | 18 | Synthesis and biological evaluation of novel piperidine carboxamide derived calpain inhibitors. |
Bioorg Med Chem Lett 10: 2187-91 (2001) | KNOLL AG | 2D 3D TSV |
| 11012024 | 44 | The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors. |
Bioorg Med Chem Lett 10: 2179-82 (2001) | The R. W. Johnson Pharmaceutical Research Institute | 2D 3D TSV |
| 11012022 | 102 | Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck II. |
Bioorg Med Chem Lett 10: 2171-4 (2001) | BASF Bioresearch Corporation | 2D 3D TSV |
| 11012021 | 69 | Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I. |
Bioorg Med Chem Lett 10: 2167-70 (2001) | BASF Bioresearch Corporation | 2D 3D TSV |
| 11009599 | 8 | Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant. |
Biochemistry 39: 11876-83 (2000) | The Johns Hopkins University | 2D 3D TSV |
| 11007306 | 54 | Structural requirements for determining the substrate affinity of peptide transporters PEPT1 and PEPT2. |
Pflugers Arch 440: 679-84 (2000) | Kyoto University Hospital | 2D 3D TSV |
| 11006272 | 59 | A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. |
J Biol Chem 275: 40686-94 (2000) | Schering-Plough Research Institute | 2D 3D TSV |
| 11000046 | 1 | 8-O-Methylsclerotiorinamine, antagonist of the Grb2-SH2 domain, isolated from Penicillium multicolor. |
J Nat Prod 63: 1303-5 (2000) | Korea Research Institute of Bioscience & Biotechnology | 2D 3D TSV |
| 11000037 | 5 | New anabaenopeptins, potent carboxypeptidase-A inhibitors from the cyanobacterium Aphanizomenon flos-aquae. |
J Nat Prod 63: 1280-2 (2000) | The University of Tokyo | 2D 3D TSV |
| 11000011 | 28 | bis(2-(Acylamino)phenyl) disulfides, 2-(acylamino)benzenethiols, and S-(2-(acylamino)phenyl) alkanethioates as novel inhibitors of cholesteryl ester transfer protein. |
J Med Chem 43: 3566-72 (2000) | Research Triangle Institute | 2D 3D TSV |
| 11000010 | 27 | Selective protection and functionalization of morphine: synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives. |
J Med Chem 43: 3558-65 (2000) | Rensselaer Polytechnic Institute | 2D 3D TSV |
| 11000009 | 23 | Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists. |
J Med Chem 43: 3549-57 (2000) | University of Maastricht | 2D 3D TSV |
| 11000006 | 28 | 2,7-Dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine as a new template for the design of CCK(2) receptor antagonists. |
J Med Chem 43: 3518-29 (2000) | James Black Foundation | 2D 3D TSV |
| 11000005 | 16 | Development of peptide 3D structure mimetics: rational design of novel peptoid cholecystokinin receptor antagonists. |
J Med Chem 43: 3505-17 (2000) | James Black Foundation | 2D 3D TSV |
| 11000004 | 16 | Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. |
J Med Chem 43: 3495-504 (2000) | The University of Queensland | 2D 3D TSV |
| 11000003 | 8 | Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor. |
J Med Chem 43: 3487-94 (2000) | Merck Research Laboratories | 2D 3D TSV |
| 11000002 | 10 | BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. |
J Med Chem 43: 3482-6 (2000) | BioCryst Pharmaceuticals Inc | 2D 3D TSV |
| 11000000 | 1 | (S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain. |
J Med Chem 43: 3474-7 (2000) | Pfizer Inc | 2D 3D TSV |
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