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8997630 77 Iloperidone binding to human and rat dopamine and 5-HT receptors.BDB Eur J Pharmacol 317: 417-23 (1996) Hoechst Marion Roussel Inc 2D 3D TSV
8996189 24 Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors.BDB J Pharmacol Exp Ther 280: 122-8 (1997) Pfizer Inc 2D 3D TSV
8996185 121 Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.BDB J Pharmacol Exp Ther 280: 83-97 (1997) Synthélabo Recherche 2D 3D TSV
8988595 5 Bastadin 20 and bastadin O-sulfate esters from Ianthella basta: novel modulators of the Ry1R FKBP12 receptor complex.EBI J Nat Prod 59: 1121-7 (1997) University of California 2D 3D TSV
8984162 3 Two fungal lanostane derivatives as phospholipase A2 inhibitors.EBI J Nat Prod 59: 977-9 (1997) Universitat de Val£ncia 2D 3D TSV
8978857 17 Structure-activity relationships of phomactin derivatives as platelet activating factor antagonists.EBI J Med Chem 39: 5281-4 (1997) Sankyo Co., Ltd 2D 3D TSV
8978855 16 Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs.EBI J Med Chem 39: 5267-75 (1997) Pharmacia & Upjohn 2D 3D TSV
8978853 57 Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors.EBI J Med Chem 39: 5246-56 (1997) Harvard University 2D 3D TSV
8978852 10 Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity (II): Optimization of the C3 amino substituent.EBI J Med Chem 39: 5236-45 (1997) Glaxo Wellcome Research and Development 2D 3D TSV
8978850 205 Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.BDB J Med Chem 39: 5215-27 (1996) Sphinx Laboratories 2D 3D TSV
8978846 68 Synthesis and phospholipase A2 inhibitory activity of thielocin B3 derivatives.EBI J Med Chem 39: 5183-91 (1997) Shionogi & Co., Ltd 2D 3D TSV
8978844 86 Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides.EBI J Med Chem 39: 5159-75 (1997) Eli Lilly and Company 2D 3D TSV
8978843 119 Indole inhibitors of human nonpancreatic secretory phospholipase A2. 2. Indole-3-acetamides with additional functionality.EBI J Med Chem 39: 5137-58 (1997) Eli Lilly and Company 2D 3D TSV
8978842 9 Synthesis and evaluation of two positron-labeled nitric oxide synthase inhibitors, S-[11C]methylisothiourea and S-(2-[18F]fluoroethyl)isothiourea, as potential positron emission tomography tracers.EBI J Med Chem 39: 5110-8 (1997) Washington University 2D 3D TSV
8978840 12 Synthesis and bioevaluation of delta 7-5-desaturase inhibitors, an enzyme late in the biosynthesis of the fungal sterol ergosterol.EBI J Med Chem 39: 5092-9 (1997) Institute 2D 3D TSV
8978838 24 Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease.EBI J Med Chem 39: 5072-82 (1997) Agouron Pharmaceuticals Inc 2D 3D TSV
8978837 60 Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.EBI J Med Chem 39: 5064-71 (1997) University of North Carolina 2D 3D TSV
8978835 18 Indole derivatives as a new class of steroid 5 alpha-reductase inhibitors.EBI J Med Chem 39: 5047-52 (1997) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
8978834 33 Bicyclic N-hydroxyurea inhibitors of 5-lipoxygenase: pharmacodynamic, pharmacokinetic, and in vitro metabolic studies characterizing N-hydroxy-N-(2,3-dihydro-6-(phenylmethoxy)-3-benzofuranyl)urea.EBI J Med Chem 39: 5035-46 (1997) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8978832 18 Identification of retinoic acid receptor beta subtype specific agonists.EBI J Med Chem 39: 5027-30 (1997) Allergan Inc 2D 3D TSV
8968364 10 Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist.BDB J Pharmacol Exp Ther 279: 1392-403 (1996) Pharmacia and Upjohn, Inc. 2D 3D TSV
8968358 12 The interaction of the enantiomers of aceclidine with subtypes of the muscarinic receptor.BDB J Pharmacol Exp Ther 279: 1335-44 (1996) University of California 2D 3D TSV
8960563 12 Quantitative structure-activity relationship study of fibrinogen inhibitors, [[4-(4-amidinophenoxy)butanoyl]aspartyl]valine (FK633) derivatives, using a novel hydrophobic descriptor.EBI J Med Chem 39: 5017-20 (1997) Fujisawa Pharmaceutical Company, Ltd 2D 3D TSV
8960557 27 Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists.EBI J Med Chem 39: 4966-77 (1997) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8960555 13 Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemotherapy.EBI J Med Chem 39: 4952-7 (1996) Universit£ di Perugia 2D 3D TSV
8960554 30 Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 4. Potent, orally active analgesics.EBI J Med Chem 39: 4942-51 (1996) Sandoz Institute for Medical Research 2D 3D TSV
8960553 60 Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.EBI J Med Chem 39: 4935-41 (1997) Drew University 2D 3D TSV
8960552 58 Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.EBI J Med Chem 39: 4928-34 (1997) Universit£ di Bari 2D 3D TSV
8960551 74 Serotonin dimers: application of the bivalent ligand approach to the design of new potent and selective 5-HT(1B/1D) agonists.EBI J Med Chem 39: 4920-7 (1997) Centre de Recherche Pierre Fabre 2D 3D TSV
8960550 5 Conformationally constrained analogues of diacylglycerol. 13. Protein kinase C ligands based on templates derived from 2,3-dideoxy-L-erythro(threo)-hexono-1,4-lactone and 2-deoxyapiolactone.EBI J Med Chem 39: 4912-9 (1997) National Cancer Institute-Bethesda 2D 3D TSV
8960549 19 Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro.BDB J Med Chem 39: 4905-11 (1996) Hebrew University of Jerusalem 2D 3D TSV
8960547 19 Anti-inflammatory 17beta-thioalkyl-16alpha,17alpha-ketal and -acetal androstanes: a new class of airway selective steroids for the treatment of asthma.EBI J Med Chem 39: 4888-96 (1997) Rh£ne-Poulenc Rorer Central Research 2D 3D TSV
8960546 160 Development of potent thrombin receptor antagonist peptides.EBI J Med Chem 39: 4879-87 (1997) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8960545 21 (Carboxyalkyl)benzyl propargyl ethers as selective inhibitors of leukocyte-type 12-lipoxygenases.EBI J Med Chem 39: 4871-8 (1997) Wayne State University 2D 3D TSV
8960544 10 Potent, selective, orally active 3-oxo-1,4-benzodiazepine GPIIb/IIIa integrin antagonists.EBI J Med Chem 39: 4867-70 (1997) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8960059 1 Reversal of P-glycoprotein-associated multidrug resistance by ivermectin.EBI Biochem Pharmacol 53: 17-25 (1997) Institute of Parasitology of McGill University 2D 3D TSV
8956326 4 Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells.EBI Pharm Res 13: 1631-4 (1996) University of California San Francisco 2D 3D TSV
8955089 4 Role of salt bridge formation in antigen-antibody interaction. Entropic contribution to the complex between hen egg white lysozyme and its monoclonal antibody HyHEL10.BDB J Biol Chem 271: 32612-6 (1996) Tohoku University 2D 3D TSV
8946946 32 Cloning, expression and pharmacology of the mouse 5-HT(4L) receptor.BDB FEBS Lett 398: 19-25 (1996) CNRS UPR 9023 2D 3D TSV
8946748 2 Six lignans from Phyllanthus myrtifolius.EBI J Nat Prod 59: 1061-5 (1996) National Taiwan University 2D 3D TSV
8941400 12 Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding.EBI J Med Chem 39: 4860-6 (1997) School of Pharmacy and Pharmacology 2D 3D TSV
8941399 7 Estrogenic triarylethylene acetic acids: effect of structural variation on estrogen receptor affinity and estrogenic potency and efficacy in MCF-7 cells.EBI J Med Chem 39: 4853-9 (1996) University of Georgia 2D 3D TSV
8941398 17 Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.EBI J Med Chem 39: 4844-52 (1997) Hokkaido University 2D 3D TSV
8941396 20 Solution of the conformation and alignment tensors for the binding of trimethoprim and its analogs to dihydrofolate reductase: 3D-quantitative structure-activity relationship study using molecular shape analysis, 3-way partial least-squares regression, and 3-way factor analysis.EBI J Med Chem 39: 4825-32 (1996) University of Illinois at Chicago 60612 2D 3D TSV
8941387 10 Synthesis and dopamine transporter affinity of 2-(methoxycarbonyl)-9-methyl-3-phenyl-9-azabicyclo[3.3.1]nonane derivatives.EBI J Med Chem 39: 4744-9 (1997) University of New Orleans 2D 3D TSV
8941385 18 Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.EBI J Med Chem 39: 4727-37 (1997) Katholieke Universiteit Leuven 2D 3D TSV
8941384 51 5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates.EBI J Med Chem 39: 4717-26 (1997) University of Groningen 2D 3D TSV
8941383 146 Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).EBI J Med Chem 39: 4704-16 (1997) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8941382 40 Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents.EBI J Med Chem 39: 4692-703 (1997) Glaxo Wellcome Inc. 2D 3D TSV
8935801 586 Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.BDB Psychopharmacology (Berl) 124: 57-73 (1996) Janssen Research Foundation 2D 3D TSV
8930187 5 Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect.BDB J Pharmacol Exp Ther 279: 803-12 (1996) Leiden University 2D 3D TSV
8917655 72 6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists.EBI J Med Chem 39: 4667-75 (1996) National Institute of Diabetes 2D 3D TSV
8917654 7 High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines.EBI J Med Chem 39: 4654-66 (1996) Upjohn Laboratories 2D 3D TSV
8917652 23 Structure-based design of HIV protease inhibitors: 5,6-dihydro-4-hydroxy-2-pyrones as effective, nonpeptidic inhibitors.EBI J Med Chem 39: 4630-42 (1996) Pharmacia & Upjohn 2D 3D TSV
8917650 140 Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds.EBI J Med Chem 39: 4608-21 (1996) Hoechst Marion Roussel Inc 2D 3D TSV
8917649 60 Synthesis and biological profile of the enantiomers of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin- 1-yl]furan-2-ylmethanone (cyclazosin), a potent competitive alpha 1B- adrenoceptor antagonist.EBI J Med Chem 39: 4602-7 (1996) University of Camerino 2D 3D TSV
8917645 20 Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.EBI J Med Chem 39: 4569-75 (1996) University of Minnesota 2D 3D TSV
8917644 49 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.EBI J Med Chem 39: 4563-8 (1996) Duquesne University 2D 3D TSV
8917642 4 Studies on selectin blocker. 3. Investigation of the carbohydrate ligand sialyl Lewis X recognition site of P-selectin.EBI J Med Chem 39: 4547-53 (1996) Kanebo Ltd. 2D 3D TSV
8917639 50 Design, synthesis, and evolution of a novel, selective, and orally bioavailable class of thrombin inhibitors: P1-argininal derivatives incorporating P3-P4 lactam sulfonamide moieties.EBI J Med Chem 39: 4531-6 (1996) Corvas International Inc 2D 3D TSV
8917638 26 Potent and selective thrombin inhibitors incorporating the constrained arginine mimic l-3-piperidyl(N-guanidino)alanine at P1.EBI J Med Chem 39: 4527-30 (1996) Corvas International Inc 2D 3D TSV
8910390 13 Molecular and pharmacological characterization of native cortical gamma-aminobutyric acidA receptors containing both alpha1 and alpha3 subunits.BDB J Biol Chem 271: 27902-11 (1996) Universidad de Sevilla 2D 3D TSV
8910290 5 Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species.BDB J Biol Chem 271: 27217-20 (1996) Yamanouchi Pharmaceutical Co., Ltd 2D 3D TSV
8904845 3 Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus.EBI J Nat Prod 59: 962-4 (1997) Searle Research and Development 2D 3D TSV
8903934 7 Pharmacological and functional characterisation of the wild-type and site-directed mutants of the human H1 histamine receptor stably expressed in CHO cells.BDB J Recept Signal Transduct Res 15: 91-102 (1995) Universite Libre de Bruxelles 2D 3D TSV
8903510 9 Peripheral 5-HT4 receptors.BDB FASEB J 10: 1398-407 (1996) Roche Bioscience 2D 3D TSV
8894098 20 Discovery and optimization of nonpeptide HIV-1 protease inhibitors.BDB Bioorg Med Chem 4: 1401-10 (1996) Parke-Davis Pharmaceutical Research 2D 3D TSV
8893849 10 Synthesis and solution conformation of cyclo[RGDRGD]: a cyclic peptide with selectivity for the alpha V beta 3 receptor.EBI J Med Chem 39: 4520-6 (1996) Texas A&M University 2D 3D TSV
8893848 21 Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.EBI J Med Chem 39: 4515-9 (1996) University of Connecticut 2D 3D TSV
8893842 6 Aspartic acid conjugates of 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1(3-aminophenyl)-2-(1-pyrrolidi nyl) ethyl]acetamide: kappa opioid receptor agonists with limited access to the central nervous system.EBI J Med Chem 39: 4478-82 (1996) University of Minnesota 2D 3D TSV
8893841 23 Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.EBI J Med Chem 39: 4471-7 (1996) Université Blaise Pascal 2D 3D TSV
8893840 12 The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses.EBI J Med Chem 39: 4460-70 (1996) Eisai Co., Ltd 2D 3D TSV
8893838 106 Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1, 3-dioxoperhydroimidazo[1,5-alpha]pyridine: a selective 5-HT1A receptor agonist.EBI J Med Chem 39: 4439-50 (1996) Universidad Complutense 2D 3D TSV
8893836 50 Novel (R)-2-amino-5-fluorotetralins: dopaminergic antagonists and inverse agonists.EBI J Med Chem 39: 4421-9 (1996) Uppsala University 2D 3D TSV
8893834 30 Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors.EBI J Med Chem 39: 4396-405 (1996) TBA 2D 3D TSV
8893833 42 Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents.EBI J Med Chem 39: 4382-95 (1996) Warner-Lambert Company 2D 3D TSV
8893829 13 Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists.EBI J Med Chem 39: 4358-60 (1996) Neurocrine Biosciences Inc 2D 3D TSV
8893828 28 Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: application to the synthesis and optimization of corticotropin-releasing factor1 receptor antagonists.EBI J Med Chem 39: 4354-7 (1996) Neurocrine Biosciences Inc 2D 3D TSV
8893827 17 Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.BDB J Med Chem 39: 4349-53 (1996) Upjohn 2D 3D TSV
8891613 25 Characterisation of the specific binding of the histamine H3 receptor antagonist radioligand [3H]GR168320.BDB Eur J Pharmacol 311: 305-10 (1996) Glaxo Research & Development Ltd. 2D 3D TSV
8889190 55 Thermodynamics of hydrogen bond and hydrophobic interactions in cyclodextrin complexes.BDB Biophys J 71: 2144-54 (1996) NIH 2D 3D TSV
8887981 72 A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.BDB Neuropharmacology 35: 725-34 (1996) Abbott Laboratories 2D 3D TSV
8884876 47 Characterisation of the melanocortin 4 receptor by radioligand binding.BDB Pharmacol Toxicol 79: 161-5 (1996) Uppsala University 2D 3D TSV
8882431 4 Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18.EBI J Nat Prod 59: 286-9 (1997) Arizona State University 2D 3D TSV
8879560 22 Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA--II. Modification of pyrrolidine ring at P1' proline.BDB Bioorg Med Chem 4: 1365-77 (1996) Sankyo Co., Ltd 2D 3D TSV
8879541 35 Tyrphostins IV--highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines.BDB Bioorg Med Chem 4: 1203-7 (1996) Hebrew University of Jerusalem 2D 3D TSV
8878062 8 Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1.EBI Naunyn Schmiedebergs Arch Pharmacol 354: 320-6 (1997) University of Heidelberg 2D 3D TSV
8876023 52 Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor.BDB Psychopharmacology (Berl) 126: 234-40 (1996) University of Turku 2D 3D TSV
8867105 49 Pharmacological comparison between [3H]GR 113808 binding sites and functional 5-HT4 receptors in neurons.BDB Eur J Pharmacol 298: 165-74 (1996) CNRS UPR 9023 2D 3D TSV
8864237 4 Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.EBI J Nat Prod 59: 839-42 (1997) Chulalongkorn University 2D 3D TSV
8863838 28 Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.BDB Mol Pharmacol 50: 923-30 (1996) UPR Centre 2D 3D TSV
8863817 4 Structural determinants of substrates for the prostaglandin transporter PGT.EBI Mol Pharmacol 50: 738-42 (1996) Albert Einstein College of Medicine 2D 3D TSV
8863814 21 Identification and characterization of novel somatostatin antagonists.BDB Mol Pharmacol 50: 709-15 (1996) Cyenamid Agricultural Research Center 2D 3D TSV
8863812 8 Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors.EBI J Med Chem 39: 4340-4 (1996) State University of New York 2D 3D TSV
8863811 56 Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase.EBI J Med Chem 39: 4335-9 (1996) University of Maryland 2D 3D TSV
8863807 71 HIV protease inhibitory bis-benzamide cyclic ureas: a quantitative structure-activity relationship analysis.EBI J Med Chem 39: 4299-312 (1996) DuPont Pharmaceuticals Company 2D 3D TSV
8863806 68 3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]EBI J Med Chem 39: 4285-98 (1996) Université d'Orléans 2D 3D TSV
8863805 35 Molecular basis of peripheral vs central benzodiazepine receptor selectivity in a new class of peripheral benzodiazepine receptor ligands related to alpidem.EBI J Med Chem 39: 4275-84 (1996) Università di Siena 2D 3D TSV
8863804 141 Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs.BDB J Med Chem 39: 4261-74 (1996) Eli Lilly and Company 2D 3D TSV
8863803 22 Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives.EBI J Med Chem 39: 4255-60 (1996) Universit£ di Bari 2D 3D TSV
8863801 40 Synthesis, resolution, and preliminary evaluation of trans-2-amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes and related derivatives as dopamine receptors ligands.EBI J Med Chem 39: 4238-46 (1996) Universit£ di Camerino 2D 3D TSV
8863800 115 Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.EBI J Med Chem 39: 4233-7 (1996) University of Groningen 2D 3D TSV
8863798 52 2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors.EBI J Med Chem 39: 4211-7 (1996) Universit£ di Camerino 2D 3D TSV
8863797 9 Hydroxamic acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase.EBI J Med Chem 39: 4197-210 (1996) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8863796 65 Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase by nuclear variants of mycophenolic acid.EBI J Med Chem 39: 4181-96 (1996) Syntex Research 2D 3D TSV
8863795 24 Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity.EBI J Med Chem 39: 4173-80 (1996) Bio-M£ga/Boehringer Ingelheim Research Inc. 2D 3D TSV
8863793 14 Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid.EBI J Med Chem 39: 4162-6 (1996) Brigham Young University 2D 3D TSV
8863792 22 Synthesis and structure-activity relationship of pyrazolo[3,4-d]pyrimidines: potent and selective adenosine A1 receptor antagonists.EBI J Med Chem 39: 4156-61 (1996) Griffith University 2D 3D TSV
8863790 55 Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.EBI J Med Chem 39: 4142-8 (1996) National Institute of Diabetes 2D 3D TSV
8863789 31 3 alpha-(4'-substituted phenyl)tropane-2 beta-carboxylic acid methyl esters: novel ligands with high affinity and selectivity at the dopamine transporter.EBI J Med Chem 39: 4139-41 (1996) Research Triangle Institute 2D 3D TSV
8862725 8 Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay.EBI Anticancer Drugs 7: 568-78 (1997) Strasbourg 1 University 2D 3D TSV
8845011 25 A novel class of 5-HT2A receptor antagonists: aryl aminoguanidines.BDB Life Sci 59: 1259-68 (1996) Eli Lilly and Company 2D 3D TSV
8831779 22 Cycloalkylpyranones and cycloalkyldihydropyrones as HIV protease inhibitors: exploring the impact of ring size on structure-activity relationships.EBI J Med Chem 39: 4125-30 (1996) Pharmacia and Upjohn, Inc. 2D 3D TSV
8831778 22 The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptoEBI J Med Chem 39: 4120-4 (1996) University of Arizona 2D 3D TSV
8831777 48 Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist.EBI J Med Chem 39: 4116-9 (1996) Abbott Laboratories 2D 3D TSV
8831775 34 New purines and purine analogs as modulators of multidrug resistance.EBI J Med Chem 39: 4099-108 (1996) Institut de Recherches Servier 2D 3D TSV
8831774 261 Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases.EBI J Med Chem 39: 4089-98 (1996) Georgia Institute of Technology 2D 3D TSV
8831772 18 Principal components describing biological activities and molecular diversity of heterocyclic aromatic ring fragments.EBI J Med Chem 39: 4065-72 (1996) Organon Research and Development Group 2D 3D TSV
8831771 64 On the bioisosteric potential of diazines: diazine analogues of the combined thromboxane A2 receptor antagonist and synthetase inhibitor Ridogrel.EBI J Med Chem 39: 4058-64 (1996) University of Innsbruck 2D 3D TSV
8831770 136 Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.EBI J Med Chem 39: 4044-57 (1996) Hoechst Marion Roussel Inc 2D 3D TSV
8831769 42 Derivatives of (R)- and (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: synthesis and interactions with 5-HT1A receptors.EBI J Med Chem 39: 4036-43 (1996) Uppsala University 2D 3D TSV
8831768 65 Synthesis and transporter binding properties of 3 beta-(4'-alkyl-, 4'-alkenyl-, and 4'-alkynylphenyl)nortropane-2 beta-carboxylic acid methyl esters: serotonin transporter selective analogs.EBI J Med Chem 39: 4027-35 (1996) Research Triangle Institute 2D 3D TSV
8831767 60 Structure-activity relationships for the binding of arylpiperazines and arylbiguanides at 5-HT3 serotonin receptors.EBI J Med Chem 39: 4017-26 (1996) Virginia Commonwealth University 2D 3D TSV
8831765 9 Homology modeling of metabotropic glutamate receptors. (mGluRs) structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists.EBI J Med Chem 39: 3998-4006 (1996) Università di Perugia 2D 3D TSV
8831762 3 Novel AMPA receptor antagonists: synthesis and structure-activity relationships of 1-hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and related compounds.EBI J Med Chem 39: 3971-9 (1996) Yamanouchi Pharmaceutical Company Limited 2D 3D TSV
8831761 53 Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.EBI J Med Chem 39: 3951-70 (1996) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
8831760 108 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.EBI J Med Chem 39: 3938-50 (1996) Abbott Laboratories 2D 3D TSV
8831759 16 1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.EBI J Med Chem 39: 3929-37 (1996) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8831757 16 Heterocyclic amides: inhibitors of acyl-CoA:cholesterol O-acyl transferase with hypocholesterolemic activity in several species and antiatherosclerotic activity in the rabbit.EBI J Med Chem 39: 3908-19 (1996) Warner-Lambert Company 2D 3D TSV
8831752 9 Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor.EBI J Med Chem 39: 3875-7 (1996) Clemson University 2D 3D TSV
8824284 43 Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior.BDB J Biol Chem 271: 26315-9 (1996) Bayer Corporation 2D 3D TSV
8824261 8 Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.EBI J Biol Chem 271: 26157-64 (1996) Institute for Biochemistry 2D 3D TSV
8822531 111 Radioreceptor binding profile of the atypical antipsychotic olanzapine.BDB Neuropsychopharmacology 14: 87-96 (1996) Eli Lilly and Company 2D 3D TSV
8821530 16 In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties.BDB Br J Pharmacol 117: 427-434 (1996) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8818233 18 5H-pyrrolo[1,2-b] [1,2,5]benzothiadiazepines (PBTDs): a novel class of non-nucleoside reverse transcriptase inhibitors.BDB Bioorg Med Chem 4: 837-50 (1996) Sapienza University of Rome 2D 3D TSV
8813606 15 [3H]5-hydroxytryptamine labels the agonist high affinity state of the cloned rat 5-HT4 receptor.BDB Eur J Pharmacol 304: 231-5 (1996) Synaptic Pharmaceutical Corporation 2D 3D TSV
8813598 34 Affinity of various ligands for GABAA receptors containing alpha 4 beta 3 gamma 2, alpha 4 gamma 2, or alpha 1 beta 3 gamma 2 subunits.BDB Eur J Pharmacol 304: 155-62 (1996) University Clinic for Psychiatry 2D 3D TSV
8809171 13 (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity.EBI J Med Chem 39: 3837-41 (1996) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8809168 31 A novel series of (phenoxyalkyl)imidazoles as potent H3-receptor histamine antagonists.EBI J Med Chem 39: 3806-13 (1996) University College London 2D 3D TSV
8809166 10 Unsaturated side chain beta-11-hydroxyhexahydrocannabinol analogs.EBI J Med Chem 39: 3790-6 (1996) University of Hawaii 2D 3D TSV
8809165 120 Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.BDB J Med Chem 39: 3769-89 (1996) Upjohn 2D 3D TSV
8809164 5 Structure-activity relationships study of two series of leukotriene B4 antagonists: novel indolyl and naphthyl compounds substituted with a 2-[methyl(2-phenethyl)amino]-2-oxoethyl side chain.EBI J Med Chem 39: 3756-68 (1996) Rhône-Poulenc Rorer 2D 3D TSV
8809163 3 A novel series of [2-[methyl(2-phenethyl)amino]-2-oxoethyl] benzene-containing leukotriene B4 antagonists: initial structure-activity relationships.EBI J Med Chem 39: 3748-55 (1996) Rhone-Poulenc Rorer Central Research 2D 3D TSV
8809161 90 Serotonin 5-HT2 receptor, dopamine D2 receptor, and alpha 1 adrenoceptor antagonists. Conformationally flexible analogues of the atypical antipsychotic sertindole.EBI J Med Chem 39: 3723-38 (1996) H. Lundbeck A/S 2D 3D TSV
8809160 132 Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.EBI J Med Chem 39: 3712-22 (1996) F. Hoffmann-La Roche Inc 2D 3D TSV
8809159 26 Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands.EBI J Med Chem 39: 3701-11 (1996) University of Tennessee-Memphis 2D 3D TSV
8809156 2 Synthesis and cardiotonic activity of novel pyrimidine derivatives: crystallographic and quantum chemical studies.EBI J Med Chem 39: 3671-83 (1996) Università di Padova 2D 3D TSV
8809154 120 Potent inhibitors of secretory phospholipase A2: synthesis and inhibitory activities of indolizine and indene derivatives.EBI J Med Chem 39: 3636-58 (1996) Shionogi & Co., Ltd 2D 3D TSV
8809153 60 Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.EBI J Med Chem 39: 3625-35 (1996) University of Alabama at Birmingham 2D 3D TSV
8809152 65 Synthesis of a series of aryl kainic acid analogs and evaluation in cells stably expressing the kainate receptor humGluR6.EBI J Med Chem 39: 3617-24 (1996) Eli Lilly and Company 2D 3D TSV
8798583 19 Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.BDB J Biol Chem 271: 23646-9 (1996) Mayo Foundation 2D 3D TSV
8788495 7 GR127935: a potent and selective 5-HT1D receptor antagonist.BDB Behav Brain Res 73: 157-61 (1996) Glaxo Research and Development Ltd. 2D 3D TSV
8788493 64 Novel discriminatory ligands for 5-HT2B receptors.BDB Behav Brain Res 73: 149-52 (1996) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8784459 10 The chemistry of pseudomonic acid. 17. Dual-action C-1 oxazole derivatives of pseudomonic acid having an extended spectrum of antibacterial activity.EBI J Med Chem 39: 3596-600 (1996) SmithKline Beecham Pharmaceuticals 2D 3D TSV
8784456 55 ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme.EBI J Med Chem 39: 3569-84 (1996) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8784455 15 Synthesis and evaluation of aryl-substituted N-(arylethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamines and corresponding arylacetamides for sigma receptor affinity.EBI J Med Chem 39: 3564-8 (1996) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8784454 76 Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.EBI J Med Chem 39: 3556-63 (1996) Allergan Inc 2D 3D TSV
8784453 134 Orally active, nonpeptide vasopressin V2 receptor antagonists: a novel series of 1-[4-(benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepines and related compounds.EBI J Med Chem 39: 3547-55 (1996) Otsuka Pharmaceutical Co., Ltd 2D 3D TSV
8784452 11 Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.EBI J Med Chem 39: 3539-46 (1996) University of Kansas 2D 3D TSV
8784451 15 Synthesis and evaluation of 2-[(5-methylbenz-1-ox-4-azin-6-yl)imino]imidazoline, a potent, peripherally acting alpha 2 adrenoceptor agonist.EBI J Med Chem 39: 3533-8 (1996) Allergan Inc 2D 3D TSV
8784450 73 Nonlinear quantitative structure-activity relationship for the inhibition of dihydrofolate reductase by pyrimidines.EBI J Med Chem 39: 3526-32 (1996) Scripps Research Institute 2D 3D TSV
8784449 203 Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.BDB J Med Chem 39: 3514-25 (1996) DuPont Pharmaceuticals Company 2D 3D TSV
8784448 63 11-substituted (R)-aporphines: synthesis, pharmacology, and modeling of D2A and 5-HT1A receptor interactions.EBI J Med Chem 39: 3503-13 (1996) Uppsala University 2D 3D TSV
8784447 63 10-substituted 11-oxygenated (R)-aporphines: synthesis, pharmacology, and modeling of 5-HT1A receptor interactions.EBI J Med Chem 39: 3491-502 (1996) Uppsala University 2D 3D TSV
8784443 17 Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer.EBI J Med Chem 39: 3461-9 (1996) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
8784441 66 Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific"peripheral-type" benzodiazepine receptor ligands.EBI J Med Chem 39: 3435-50 (1996) Universit£ di Siena 2D 3D TSV
8784440 3 New series of potent, orally bioavailable, non-peptidic cyclic sulfones as HIV-1 protease inhibitors.EBI J Med Chem 39: 3431-4 (1996) Gilead Sciences Inc 2D 3D TSV
8779894 15 Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter.EBI Am J Physiol 270: 326-31 (1996) Albert Einstein College of Medicine 2D 3D TSV
8778243 1 Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase.EBI J Nat Prod 59: 525-7 (1996) Chinese Academy of Sciences 2D 3D TSV
8778237 2 HIV inhibitory natural products. 26. Quinoline alkaloids from Euodia roxburghiana.EBI J Nat Prod 59: 469-71 (1996) National Cancer Institute 2D 3D TSV
8770901 16 Structure-function relationship of the inhibition of the 3,5,3'-triiodothyronine binding to the alpha1- and beta1-thyroid hormone receptor by amiodarone analogs.BDB Endocrinology 137: 2807-14 (1996) University of Amsterdam 2D 3D TSV
8769372 74 Binding properties of somatostatin receptor subtypes.BDB Metab Clin Exp 45: 17-20 (1996) Sandoz Pharma Ltd 2D 3D TSV
8765528 16 (+/-)-3-[4'-(N,N-dimethylamino)cinnamyl]benzazepine analogs: novel dopamine D1 receptor antagonists.EBI J Med Chem 39: 3423-8 (1996) National Institutes of Health 2D 3D TSV
8765520 3 Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates.EBI J Med Chem 39: 3367-74 (1996) Purdue University 2D 3D TSV
8765519 6 Mechanistic studies on the inactivation of papain by epoxysuccinyl inhibitors.EBI J Med Chem 39: 3357-66 (1996) University of Wisconsin 2D 3D TSV
8765518 17 New low-density lipoprotein receptor upregulators acting via a novel mechanism.EBI J Med Chem 39: 3343-56 (1996) Rhône-Poulenc Rorer 2D 3D TSV
8765515 37 3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer.EBI J Med Chem 39: 3319-23 (1996) Cancer Research Campaign Centre for Cancer Therapeutics 2D 3D TSV
8765512 25 Paracyclophanes: a novel class of water-soluble inhibitors of HIV proteinase.BDB J Med Chem 39: 3291-9 (1996) Sandoz Research Institute 2D 3D TSV
8765511 14 Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation.BDB J Med Chem 39: 3278-90 (1996) University of Illinois at Chicago 2D 3D TSV
8765510 100 3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: novel muscarinic antagonists.EBI J Med Chem 39: 3269-77 (1996) Uppsala University 2D 3D TSV
8765507 20 Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.EBI J Med Chem 39: 3248-55 (1996) CoCensys Inc 2D 3D TSV
8765505 26 Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity.EBI J Med Chem 39: 3238-40 (1996) Celgene Corporation 2D 3D TSV
8765504 34 (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.EBI J Med Chem 39: 3235-7 (1996) SIBIA Neurosciences Inc 2D 3D TSV
8765503 39 Identification of the first retinoid X, receptor homodimer antagonist.EBI J Med Chem 39: 3229-34 (1996) Ligand Pharmaceuticals Inc 2D 3D TSV
8759643 17 Aza-peptide analogs as potent human immunodeficiency virus type-1 protease inhibitors with oral bioavailability.BDB J Med Chem 39: 3203-16 (1996) Ciba-Geigy Ltd 2D 3D TSV
8759642 53 1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.EBI J Med Chem 39: 3195-202 (1996) Universit£ di Bari 2D 3D TSV
8759641 48 A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.EBI J Med Chem 39: 3188-94 (1996) Royal Danish School of Pharmacy 2D 3D TSV
8759640 61 Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.EBI J Med Chem 39: 3179-87 (1996) Warner-Lambert Company 2D 3D TSV
8759639 33 Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P.EBI J Med Chem 39: 3174-8 (1996) Hebrew University of Jerusalem 2D 3D TSV
8759638 6 Synthesis and characterization of pseudopeptide bradykinin B2 receptor antagonists containing the 1,3,8-triazaspiro[4.5]decan-4-one ring system.EBI J Med Chem 39: 3169-73 (1996) Scios Nova Inc 2D 3D TSV
8759636 1 Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase.EBI J Med Chem 39: 3148-57 (1996) Eisai Company, Ltd 2D 3D TSV
8759635 16 Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.EBI J Med Chem 39: 3139-47 (1996) F. Hoffmann-La Roche Inc 2D 3D TSV
8759634 54 Antipsoriatic anthrones with modulated redox properties. 3. 10-thio-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of keratinocyte growth, 5-lipoxygenase, and the formation of 12(S)-HETE in mouse epidermis.EBI J Med Chem 39: 3132-8 (1996) Universität Regensburg 2D 3D TSV
8759633 20 Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity.EBI J Med Chem 39: 3123-31 (1996) Institute 2D 3D TSV
8759629 11 Synthesis of 2-amido-2,3-dihydro-1H-phenalene derivatives as new conformationally restricted ligands for melatonin receptors.EBI J Med Chem 39: 3089-95 (1996) CNRS-BIOCIS 2D 3D TSV
8759625 1 Mechanism-based inhibition of L-pipecolate oxidase by 4,5-dehydro-L-pipecolic acid.EBI J Med Chem 39: 3046-8 (1996) Oregon State University 2D 3D TSV
8759624 1 Potent inhibition of tumor necrosis factor-alpha production by tetrafluorothalidomide and tetrafluorophthalimides.EBI J Med Chem 39: 3044-5 (1996) Institute of Technology 2D 3D TSV
8759623 31 Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group.EBI J Med Chem 39: 3039-43 (1996) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
8759622 15 Identification of a retinoic acid receptor alpha subtype specific agonist.EBI J Med Chem 39: 3035-8 (1996) Allergan Inc 2D 3D TSV
8759171 4 Lycaconitine revisited: partial synthesis and neuronal nicotinic acetylcholine receptor affinities.EBI J Nat Prod 59: 707-9 (1996) Ohio Northern University 2D 3D TSV
8730754 7 Pharmacological profile of TP-680, a new cholecystokininA receptor antagonist.BDB Br J Pharmacol 117: 1558-64 (1996) University of Occupational and Environmental Health 2D 3D TSV
8730737 23 Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety.BDB Br J Pharmacol 117: 1443-8 (1996) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8723491 8 Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors.EBI Antimicrob Agents Chemother 40: 1304-7 (1996) Merck Research Laboratories 2D 3D TSV
8719416 17 Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site.BDB Eur J Pharmacol 291: 319-25 (1995) CoCensys Inc 2D 3D TSV
8709137 14 3-[2-(N-phenylacetamide)]-1,5-benzodiazepines: orally active, binding selective CCK-A agonists.EBI J Med Chem 39: 3030-4 (1996) Glaxo Wellcome Research and Development 2D 3D TSV
8709135 20 Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.EBI J Med Chem 39: 3014-8 (1996) Warner-Lambert Company 2D 3D TSV
8709134 26 Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine.EBI J Med Chem 39: 3001-13 (1996) Ohio State University 2D 3D TSV
8709132 92 Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.EBI J Med Chem 39: 2980-9 (1996) National Institute of Diabetes 2D 3D TSV
8709131 42 Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.EBI J Med Chem 39: 2971-9 (1996) Zeneca Pharmaceuticals 2D 3D TSV
8709129 18 Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.EBI J Med Chem 39: 2953-61 (1996) Purdue University 2D 3D TSV
8709128 11 Similarities and differences in the structure-activity relationships of capsaicin and resiniferatoxin analogues.EBI J Med Chem 39: 2939-52 (1996) Institute for Medical Research 2D 3D TSV
8709127 29 Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers.EBI J Med Chem 39: 2922-38 (1996) Universit£ di Siena 2D 3D TSV
8709125 11 N-heteroaryl-2-phenyl-3-(benzyloxy)piperidines: a novel class of potent orally active human NK1 antagonists.EBI J Med Chem 39: 2907-14 (1996) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
8709120 17 (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist.EBI J Med Chem 39: 2874-6 (1996) Università di Perugia 2D 3D TSV
8709117 7 New steroidal diazo ketones as potential photoaffinity labeling reagents for the mineralocorticoid receptor: synthesis and biological activities.EBI J Med Chem 39: 2860-4 (1996) Université P. et M. Curie 2D 3D TSV
8709110 27 Bis tertiary amide inhibitors of the HIV-1 protease generated via protein structure-based iterative design.BDB J Med Chem 39: 2795-811 (1996) Agouron Pharmaceuticals Inc 2D 3D TSV
8709109 18 Structure-based design and synthesis of substituted 2-butanols as nonpeptidic inhibitors of HIV protease: secondary amide series.BDB J Med Chem 39: 2781-94 (1996) Agouron Pharmaceuticals Inc 2D 3D TSV
8709108 28 Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus.EBI J Med Chem 39: 2773-80 (1996) Eli Lilly and Company 2D 3D TSV
8709107 99 Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.EBI J Med Chem 39: 2764-72 (1996) Yamanouchi Pharmaceutical Company Limited 2D 3D TSV
8709106 89 Synthesis, ligand binding, and quantitative structure-activity relationship study of 3 beta-(4'-substituted phenyl)-2 beta-heterocyclic tropanes: evidence for an electrostatic interaction at the 2 beta-position.EBI J Med Chem 39: 2753-63 (1996) Research Triangle Institute 2D 3D TSV
8709105 134 Forskolin carbamates: binding and activation studies with type I adenylyl cyclase.EBI J Med Chem 39: 2745-52 (1996) Food and Drug Administration 2D 3D TSV
8709104 10 Novel cyclic analogs of angiotensin II with cyclization between positions 5 and 7: conformational and biological implications.EBI J Med Chem 39: 2738-44 (1996) Washington University 2D 3D TSV
8709099 20 Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans.EBI J Med Chem 39: 2696-704 (1996) Tan£be Seiyaku Company, Ltd. 2D 3D TSV
8709096 26 Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.EBI J Med Chem 39: 2672-80 (1996) Universitá di Siena 2D 3D TSV
8709095 87 (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.EBI J Med Chem 39: 2664-71 (1996) Eli Lilly and Company 2D 3D TSV
8709094 41 Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.EBI J Med Chem 39: 2659-63 (1996) Ligand Pharmaceuticals Inc 2D 3D TSV
8709093 21 3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A agonists that demonstrate oral activity as satiety agents.EBI J Med Chem 39: 2655-8 (1996) Glaxo Wellcome Research and Development 2D 3D TSV
8709092 21 Modulators of leukotriene biosynthesis and receptor activation.EBI J Med Chem 39: 2629-54 (1996) Abbott Laboratories 2D 3D TSV
8699190 9 Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes.EBI J Nat Prod 59: 443-5 (1996) Fukuyama University 2D 3D TSV
8699182 1 Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.EBI J Nat Prod 59: 374-8 (1996) National Research Instituter of Chinese Medicine 2D 3D TSV
8691489 12 Synthesis and ligand binding of eta(6)-(2beta-carbomethoxy-3beta-phenyltropane) transition metal complexes.EBI J Med Chem 39: 1560-3 (1996) University of New Orleans 2D 3D TSV
8691487 21 Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies.EBI J Med Chem 39: 1549-54 (1996) Institut für Biochemie II der Universität 2D 3D TSV
8691482 25 A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers.EBI J Med Chem 39: 1514-20 (1996) Warner-Lambert Company 2D 3D TSV
8691479 24 trans-2-Aryl-N,N-dipropylcyclopropylamines: synthesis and interactions with 5-HT(1A) receptors.EBI J Med Chem 39: 1485-93 (1996) Uppsala University 2D 3D TSV
8691478 25 Bradykinin receptor antagonists containing N-substituted amino acids: in vitro and in vivo B(2) and B(1) receptor antagonist activity.EBI J Med Chem 39: 1472-84 (1996) Cortech, Inc. 2D 3D TSV
8691477 28 N6,C8-distributed adenosine derivatives as partial agonists for adenosine A1 receptors.EBI J Med Chem 39: 1463-71 (1996) Leiden/Amsterdam Center for Drug Research 2D 3D TSV
8691474 111 2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.EBI J Med Chem 39: 1438-46 (1996) Duquesne University 2D 3D TSV
8691472 49 Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT.EBI J Med Chem 39: 1423-32 (1996) Rhône-Poulenc Rorer 2D 3D TSV
8691471 16 The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C3-modified analogues.EBI J Med Chem 39: 1413-22 (1996) Glaxo Wellcome Research and Development 2D 3D TSV
8691465 4 Ligand interactions with E-selectin. Identification of a new binding site for recognition of N-acyl aromatic glucosamine substituents of sialyl Lewis X.EBI J Med Chem 39: 1357-60 (1996) Cytel Corporation 2D 3D TSV
8691464 9 Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins.EBI J Med Chem 39: 1352-6 (1996) Università di Pisa 2D 3D TSV
8691463 3 Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates.EBI J Med Chem 39: 1349-51 (1996) University of Bath 2D 3D TSV
8691462 14 2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.EBI J Med Chem 39: 1345-8 (1996) Merck Research Laboratories 2D 3D TSV
8691459 24 Alkyl and alkoxyethyl antineoplastic phospholipids.EBI J Med Chem 39: 2609-14 (1996) National Hellenic Research Foundation 2D 3D TSV
8691458 60 Design of orally active dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme with long duration of action.EBI J Med Chem 39: 2594-608 (1996) University of Paris 2D 3D TSV
8691457 12 Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.EBI J Med Chem 39: 2586-93 (1996) Yale University 2D 3D TSV
8691456 7 Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of alpha-chymotrypsin: significance of the"aromatic" nature of the novel ester-type coumarin for strong inhibitory activity.EBI J Med Chem 39: 2579-85 (1996) Université de Liège 2D 3D TSV
8691453 42 Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site.EBI J Med Chem 39: 2554-8 (1996) State University of New York 2D 3D TSV
8691452 1 Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C.EBI J Med Chem 39: 2541-53 (1996) National Cancer Institute-Bethesda 2D 3D TSV
8691451 7 Synthesis and biological evaluation of N alpha-(4-amino-4-deoxy-10-methylpteroyl)-DL-4,4-difluoroornithine.EBI J Med Chem 39: 2536-40 (1996) University of Michigan 2D 3D TSV
8691450 49 Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase.EBI J Med Chem 39: 2529-35 (1996) Università di Modena 2D 3D TSV
8691445 70 Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists.EBI J Med Chem 39: 2482-91 (1996) Julius-Maximilians-Universität Würzburg 2D 3D TSV
8691444 105 Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.EBI J Med Chem 39: 2472-81 (1996) National Cancer Institute-Bethesda 2D 3D TSV
8691442 52 Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.EBI J Med Chem 39: 2456-60 (1996) University of Arizona 2D 3D TSV
8691441 19 Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences.EBI J Med Chem 39: 2449-55 (1996) University of Arizona 2D 3D TSV
8691440 22 Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic.EBI J Med Chem 39: 2441-8 (1996) University of Pennsylvania 2D 3D TSV
8691438 48 (S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.EBI J Med Chem 39: 2435-7 (1996) Pharmacia & Upjohn 2D 3D TSV
8691435 33 Retinoic acid receptor beta,gamma-selective ligands: synthesis and biological activity of 6-substituted 2-naphthoic acid retinoids.EBI J Med Chem 39: 2411-21 (1996) Pharmaceutical Research Institute 2D 3D TSV
8691434 25 Structure-based design of novel HIV protease inhibitors: sulfonamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent non-peptidic inhibitors.BDB J Med Chem 39: 2400-10 (1996) Upjohn 2D 3D TSV
8691433 2 New neplanocin analogues. 6. Synthesis and potent antiviral activity of 6'-homoneplanocin A1.EBI J Med Chem 39: 2392-9 (1996) Hokkaido University 2D 3D TSV
8691432 79 New prolyl endopeptidase inhibitors: in vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives.EBI J Med Chem 39: 2379-91 (1996) Institut de Recherche Servier 2D 3D TSV
8691430 42 Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives.EBI J Med Chem 39: 2354-66 (1996) Warner-Lambert Company 2D 3D TSV
8691429 4 Aristeromycin-5'-carboxaldehyde: a potent inhibitor of S-adenosyl-L-homocysteine hydrolase.EBI J Med Chem 39: 2347-53 (1996) University of Kansas 2D 3D TSV
8691428 1 Ryanodine action at calcium release channels. 2. relation to substituents of the cyclohexane ring.EBI J Med Chem 39: 2339-46 (1996) University of California 2D 3D TSV
8691427 3 Ryanodine action at calcium release channels. 1. importance of hydroxyl substituents.EBI J Med Chem 39: 2331-8 (1996) University of California 2D 3D TSV
8691426 114 Synthesis and structure-activity relationships of 2-substituted D-tryptophan-containing peptidic endothelin receptor antagonists: importance of the C-2 substituent of the D-tryptophan residue for endothelin A and B receptor subtype selectivity.EBI J Med Chem 39: 2313-30 (1996) Tsukuba Research Institute 2D 3D TSV
8691425 23 Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives.EBI J Med Chem 39: 2302-12 (1996) Laboratoires Fournier SCA 2D 3D TSV
8691424 61 Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.EBI J Med Chem 39: 2293-301 (1996) National Institute of Diabetes 2D 3D TSV
8691423 89 4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase.EBI J Med Chem 39: 2285-92 (1996) CIBA Pharmaceuticals 2D 3D TSV
8691422 25 2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor.EBI J Med Chem 39: 2281-4 (1996) SmithKline Beecham S.p.A. 2D 3D TSV
8676355 90 Structure-activity relationships of a series of substituted benzamides: potent D2/5-HT2 antagonists and 5-HT1a agonists as neuroleptic agents.EBI J Med Chem 39: 1172-88 (1996) Glaxo Wellcome Inc. 2D 3D TSV
8676354 42 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists.EBI J Med Chem 39: 1164-71 (1996) Università degli Studi di Ferrara 2D 3D TSV
8676353 140 Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity.EBI J Med Chem 39: 1157-63 (1996) Freie Universität Berlin 2D 3D TSV
8676350 39 Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.EBI J Med Chem 39: 1136-41 (1996) University of Arizona 2D 3D TSV
8676348 10 8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as buspirone.EBI J Med Chem 39: 1125-9 (1996) Polish Academy of Sciences 2D 3D TSV
8676347 39 Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones.EBI J Med Chem 39: 1112-24 (1996) Zeneca Pharmaceuticals 2D 3D TSV
8676339 143 2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722.EBI J Med Chem 39: 1039-48 (1996) Abbott Laboratories 2D 3D TSV
8676338 16 Time-dependent inactivation of aromatase by 6-alkylandrosta-1,4-diene-3,17-diones. Effects of length and configuration of 6-alkyl group.BDB J Med Chem 39: 1033-8 (1996) Tohoku College of Pharmacy 2D 3D TSV
8676336 2 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides.EBI J Med Chem 39: 1021-7 (1996) National Cancer Institute-Bethesda 2D 3D TSV
8676335 2 Carbohydrates in an acidic multivalent assembly: nanomolar P-selectin inhibitors.EBI J Med Chem 39: 1018-20 (1996) Lawrence Berkeley National Laboratories 2D 3D TSV
8676334 9 Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.EBI J Med Chem 39: 1016-7 (1996) University of North Carolina at Chapel Hill 2D 3D TSV
8676333 46 N-terminus urea-substituted chemotactic peptides: new potent agonists and antagonists toward the neutrophil fMLF receptor.EBI J Med Chem 39: 1013-5 (1996) Johnson Matthey Biomedical Research 2D 3D TSV
8676127 40 Effects of Various Isoquinoline Alkaloids on In Vitro 3H-Dopamine Uptake by Rat Striatal SynaptosomesEBI J Nat Prod 58: 1475-1484 (1995) TBA 2D 3D TSV
8670053 3 ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.EBI Biochem J 314: 433-7 (1996) Deutsches Krebsforschungszentrum 2D 3D TSV
8667369 121 Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist.EBI J Med Chem 39: 2259-69 (1996) Università di Perugia 2D 3D TSV
8667368 42 Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist.EBI J Med Chem 39: 2253-8 (1996) University of Camerino 2D 3D TSV
8667367 28 Synthesis and structure-activity relationships of 6-substituted androst-4-ene analogs as aromatase inhibitors.BDB J Med Chem 39: 2245-52 (1996) Tohoku College of Pharmacy 2D 3D TSV
8667363 1 Diphenylpropionic acids as new AT1 selective angiotensin II antagonists.EBI J Med Chem 39: 2197-206 (1996) J. Uriach & Cia SA 2D 3D TSV
8667361 23 Ureido-based peptidomimetic inhibitor of herpes simplex virus ribonucleotide reductase: an investigation of inhibitor bioactive conformation.EBI J Med Chem 39: 2178-87 (1996) Bio-Méga/Boehringer Ingelheim Research Inc. 2D 3D TSV
8667360 46 Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins.BDB J Med Chem 39: 2170-7 (1996) Hebrew University of Jerusalem 2D 3D TSV
8667359 36 Preparation and structure-activity relationship of novel P1/P1'-substituted cyclic urea-based human immunodeficiency virus type-1 protease inhibitors.BDB J Med Chem 39: 2156-69 (1996) DuPont Pharmaceuticals Company 2D 3D TSV
8667357 33 Comparative molecular moment analysis (CoMMA): 3D-QSAR without molecular superposition.EBI J Med Chem 39: 2129-40 (1996) IBM Thomas J. Watson Research Center 2D 3D TSV
8667356 50 Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists.EBI J Med Chem 39: 2123-8 (1996) BASF AG 2D 3D TSV
8667355 2 Discovery of an orally active non-peptide fibrinogen receptor antagonist.EBI J Med Chem 39: 2118-22 (1996) Hoechst AG 2D 3D TSV
8667026 14 The C-terminal domain of the mGluR1 metabotropic glutamate receptor affects sensitivity to agonists.BDB J Neurochem 67: 58-63 (1996) CNS Research 2D 3D TSV
8666985 12 Similarity between rat brain nicotinic alpha-bungarotoxin receptors and stably expressed alpha-bungarotoxin binding sites.BDB J Neurochem 67: 145-54 (1996) McGill University 2D 3D TSV
8663568 17 Cloning and expression of a novel neuropeptide Y receptor.BDB J Biol Chem 271: 16435-8 (1996) Merck Research Laboratories 2D 3D TSV
8648612 30 Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells.EBI J Med Chem 39: 1729-35 (1996) University of Minnesota 2D 3D TSV
8648610 35 Inhibitors of acyl CoA:cholesterol acyltransferase.EBI J Med Chem 39: 1704-19 (1996) Schering-Plough Research Institute 2D 3D TSV
8648609 15 Design, synthesis, and biochemical evaluation of N-substituted maleimides as inhibitors of prostaglandin endoperoxide synthases.EBI J Med Chem 39: 1692-703 (1996) Vanderbilt University School of Medicine 2D 3D TSV
8648606 72 Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.EBI J Med Chem 39: 1664-75 (1996) Cambridge University Forvie Site 2D 3D TSV
8648604 15 All-atom models for the non-nucleoside binding site of HIV-1 reverse transcriptase complexed with inhibitors: a 3D QSAR approach.EBI J Med Chem 39: 1645-50 (1996) National Cancer Institute-Frederick 2D 3D TSV
8648603 101 Synthesis and cyclic GMP phosphodiesterase inhibitory activity of a series of 6-phenylpyrazolo[3,4-d]pyrimidones.EBI J Med Chem 39: 1635-44 (1996) Laboratories Glaxo Wellcome Centre de Recherches 2D 3D TSV
8648598 3 Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.EBI J Med Chem 39: 1589-600 (1996) Oxford University 2D 3D TSV
8648595 7 Conformationally restricted TRH analogs: a probe for the pyroglutamate region.EBI J Med Chem 39: 1571-4 (1996) Washington University 2D 3D TSV
8643460 10 Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.BDB Proc Natl Acad Sci U S A 93: 4661-5 (1996) Amgen Inc 2D 3D TSV
8642569 23 Design and synthesis of new linear and cyclic bradykinin antagonists.EBI J Med Chem 39: 2095-101 (1996) Institute de Recherches Servier 2D 3D TSV
8642568 28 Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides.EBI J Med Chem 39: 2087-94 (1996) Boehringer Ingelheim Pharmaceuticals Inc 2D 3D TSV
8642567 64 Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.EBI J Med Chem 39: 2081-6 (1996) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8642566 277 Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.EBI J Med Chem 39: 2068-80 (1996) Universit£ de Caen 2D 3D TSV
8642565 36 Inhibitors of human immunodeficiency virus type 1 protease containing 2-aminobenzyl-substituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, activity, and oral bioavailability.BDB J Med Chem 39: 2060-7 (1996) Sandoz Research Institute 2D 3D TSV
8642564 12 Studies on selectin blockers. 2. Novel selectin blocker as potential therapeutics for inflammatory disorders.EBI J Med Chem 39: 2055-9 (1996) New Drug Research Laboratory 2D 3D TSV
8642563 18 Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching.BDB J Med Chem 39: 2047-54 (1996) National Institutes of Health 2D 3D TSV
8642558 30 Aminodiol HIV protease inhibitors. Synthesis and structure-activity relationships of P1/P1' compounds: correlation between lipophilicity and cytotoxicity.BDB J Med Chem 39: 1991-2007 (1996) Bristol-Myers Squibb Co. 2D 3D TSV
8642556 1 Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones.EBI J Med Chem 39: 1975-80 (1996) University of North Carolina 2D 3D TSV
8642555 11 (Aminoalkyl)indole isothiocyanates as potential electrophilic affinity ligands for the brain cannabinoid receptor.EBI J Med Chem 39: 1967-74 (1996) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8642554 42 Asymmetric syntheses, opioid receptor affinities, and antinociceptive effects of 8-amino-5,9-methanobenzocyclooctenes, a new class of structural analogues of the morphine alkaloids.EBI J Med Chem 39: 1956-66 (1996) Institute 2D 3D TSV
8642552 20 Design and synthesis of 2-naphthoate esters as selective dopamine D4 antagonists.EBI J Med Chem 39: 1946-8 (1996) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8642551 27 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.EBI J Med Chem 39: 1943-5 (1996) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
8642550 30 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.EBI J Med Chem 39: 1941-2 (1996) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
8640791 1 Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.EBI Cancer Res 56: 988-94 (1996) Deutsches Krebsforschungszentrum 2D 3D TSV
8632757 19 Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.BDB Mol Pharmacol 49: 253-9 (1996) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
8632441 24 Studies on selectin blocker. 1. Structure-activity relationships of sialyl Lewis X analogs.EBI J Med Chem 39: 1339-43 (1996) Institute of Cancer Research 2D 3D TSV
8632440 2 Novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonists: synthesis and structure-activity relationships of 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and related compounds.EBI J Med Chem 39: 1331-8 (1996) Yamanouchi Pharmaceutical Company Limited 2D 3D TSV
8632437 8 Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers.EBI J Med Chem 39: 1303-13 (1996) MediChem Research, Inc. 2D 3D TSV
8632434 198 Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.EBI J Med Chem 39: 1271-80 (1996) Southern Research Institute 2D 3D TSV
8632433 36 Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides.EBI J Med Chem 39: 1262-70 (1996) Institute for Bio-Medical Research 2D 3D TSV
8632431 167 Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 17. Structure-activity relationships of several series of compounds derived from N-chlorosulfonyl isocyanate.EBI J Med Chem 39: 1243-52 (1996) Warner-Lambert Company 2D 3D TSV
8632428 63 [125I]iodoproxyfan and related compounds: a reversible radioligand and novel classes of antagonists with high affinity and selectivity for the histamine H3 receptor.EBI J Med Chem 39: 1220-6 (1996) Freie Universität Berlin 2D 3D TSV
8632427 80 Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors.EBI J Med Chem 39: 1210-9 (1996) University of Paris 2D 3D TSV
8632426 62 Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs.EBI J Med Chem 39: 1201-9 (1996) Georgia Institute of Technology 2D 3D TSV
8632424 16 Synthesis and pharmacologic evaluation of 2-endo-amino-3-exo-isopropylbicyclo[2.2.1]heptane: a potent imidazoline1 receptor specific agent.EBI J Med Chem 39: 1193-5 (1996) Allergan Inc 2D 3D TSV
8632423 16 Homologs of idoxifene: variation of estrogen receptor binding and calmodulin antagonism with chain length.EBI J Med Chem 39: 999-1004 (1996) Institute of Cancer Research 2D 3D TSV
8632421 32 Azole endothelin antagonists. 3. Using delta log P as a tool to improve absorption.EBI J Med Chem 39: 982-91 (1996) Abbott Laboratories 2D 3D TSV
8632420 112 Azole endothelin antagonists. 2. Structure-activity studies.EBI J Med Chem 39: 968-81 (1996) Abbott Laboratories 2D 3D TSV
8632419 50 Azole endothelin antagonists. 1. A receptor model explains an unusual structure-activity profile.EBI J Med Chem 39: 957-67 (1996) Abbott Laboratories 2D 3D TSV
8632418 21 Guanine, pyrazolo[3,4-d]pyrimidine, and triazolo[4,5-d]pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase.EBI J Med Chem 39: 949-56 (1996) Burroughs Wellcome Co. 2D 3D TSV
8632415 17 Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.BDB J Med Chem 39: 918-28 (1996) University of Auckland 2D 3D TSV
8632413 38 High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.EBI J Med Chem 39: 892-903 (1996) Wellcome Research Laboratories 2D 3D TSV
8632410 33 Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors.EBI J Med Chem 39: 860-72 (1996) Universitá di Siena 2D 3D TSV
8632409 15 Comparative molecular field analysis-based prediction of drug affinities at recombinant D1A dopamine receptors.EBI J Med Chem 39: 850-9 (1996) VA Medical Center 2D 3D TSV
8632408 24 Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.EBI J Med Chem 39: 842-9 (1996) Neuroscience Research Centre 2D 3D TSV
8632407 43 Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.EBI J Med Chem 39: 834-41 (1996) Universität de Saarlandes 2D 3D TSV
8632404 3 (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase.EBI J Med Chem 39: 814-6 (1996) Centre de Neurochimie du CNRS 2D 3D TSV
8632403 14 Bis(31/31') ([CYS(31), Trp(32), Nva(34)] NPY-(31-36)): a specific NPY Y-1 receptor antagonist.EBI J Med Chem 39: 811-3 (1996) University of Cincinnati Medical Center 2D 3D TSV
8632342 110 Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: evidence for species differences.BDB J Pharmacol Exp Ther 276: 720-7 (1996) Eli Lilly and Company 2D 3D TSV
8627617 47 Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors.EBI J Med Chem 39: 1928-34 (1996) University of Wisconsin-Milwaukee 2D 3D TSV
8627616 12 Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids.EBI J Med Chem 39: 1924-7 (1996) Nippon Zoki Pharmaceutical Company Ltd 2D 3D TSV
8627615 16 2-(Hydroxyalkyl)estradiols: synthesis and biological evaluation.EBI J Med Chem 39: 1917-23 (1996) Ohio State University 2D 3D TSV
8627611 17 Structure-based design of novel, urea-containing FKBP12 inhibitors.EBI J Med Chem 39: 1872-84 (1996) Agouron Pharmaceuticals Inc 2D 3D TSV
8627609 51 Selective inhibitors of monoamine oxidase. 3. Structure-activity relationship of tricyclics bearing imidazoline, oxadiazole, or tetrazole groups.EBI J Med Chem 39: 1857-63 (1996) Wellcome Research Laboratories 2D 3D TSV
8627608 100 Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.EBI J Med Chem 39: 1846-56 (1996) Searle Research and Development 2D 3D TSV
8627607 147 Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii.EBI J Med Chem 39: 1836-45 (1996) Duquesne University 2D 3D TSV
8627606 47 Tyrosine Kinase Inhibitors. 10. Isomeric 4-[(3-Bromophenyl)amino]pyrido[d]- pyrimidines Are Potent ATP Binding Site Inhibitors of the Tyrosine Kinase Function of the Epidermal Growth Factor ReceptorBDB J Med Chem 39: 1823-35 (1996) University of Auckland 2D 3D TSV
8627605 10 Opioid antagonist activity of naltrexone-derived bivalent ligands: importance of a properly oriented molecular scaffold to guide"address" recognition at kappa opioid receptors.EBI J Med Chem 39: 1816-22 (1996) University of Minnesota 2D 3D TSV
8627604 38 Non-peptide cholecystokinin-B/gastrin receptor antagonists based on bicyclic, heteroaromatic skeletons.EBI J Med Chem 39: 1806-15 (1996) James Black Foundation 2D 3D TSV
8627603 58 Mapping the melatonin receptor. 4. Comparison of the binding affinities of a series of substituted phenylalkyl amides.EBI J Med Chem 39: 1797-805 (1996) University College London 2D 3D TSV
8627601 169 Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.EBI J Med Chem 39: 1778-89 (1996) Ligand Pharmaceuticals Inc 2D 3D TSV
8627599 4 Development of a high specific activity sulfur-35-labeled sulfonamide radioligand that allowed the identification of a new growth hormone secretagogue receptor.EBI J Med Chem 39: 1767-70 (1996) Merck Research Laboratories 2D 3D TSV
8627597 17 2(S)-((3,5-bis(trifluoromethyl)benzyl)-oxy)-3(S)-phenyl-4- ((3-oxo-1,2,4-triazol-5-yl)methyl)morpholine (1): a potent, orally active, morpholine-based human neurokinin-1 receptor antagonist.EBI J Med Chem 39: 1760-2 (1996) Merck Research Laboratories 2D 3D TSV
8627580 8 Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.BDB J Pharmacol Exp Ther 277: 968-81 (1996) Hoechst Marion Roussel Inc 2D 3D TSV
8627566 53 In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.BDB J Pharmacol Exp Ther 277: 840-51 (1996) Hoechst Marion Roussel Inc 2D 3D TSV
8627565 2 Transport characteristics of differently charged cephalosporin antibiotics in oocytes expressing the cloned intestinal peptide transporter PepT1 and in human intestinal Caco-2 cells.EBI J Pharmacol Exp Ther 277: 831-9 (1996) University of Giessen 2D 3D TSV
8621644 9 ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids.EBI J Biol Chem 271: 9683-9 (1996) Queen's University 2D 3D TSV
8584042 40 BIMT 17, a 5-HT2A receptor antagonist and 5-HT1A receptor full agonist in rat cerebral cortex.BDB Naunyn Schmiedebergs Arch Pharmacol 352: 276-82 (1995) Boehringer Ingelheim Italia 2D 3D TSV
8576924 69 Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors.EBI J Med Chem 39: 802-6 (1996) Universit£ di Ferrara 2D 3D TSV
8576921 63 Interactions of flavonoids and other phytochemicals with adenosine receptors.EBI J Med Chem 39: 781-8 (1996) National Institute of Diabetes 2D 3D TSV
8576920 34 Design and synthesis of 1-aminocycloalkane-1-carboxylic acid-substituted deltorphin analogues: unique delta and mu opioid activity in modified peptides.EBI J Med Chem 39: 773-80 (1996) University of Ferrara 2D 3D TSV
8576919 30 Structure-activity relationships of a new family of steroidal aromatase inhibitors. 1. Synthesis and evaluation of a series of analogs related to 19-[(methylthio)methyl]androstenedione (RU54115).BDB J Med Chem 39: 757-72 (1996) Centre de Recherche de Roussel Uclaf 2D 3D TSV
8576918 38 Structure-activity relationship studies of novel 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(3-phenylpropyl)piperidine analogs: synthesis and biological evaluation at the dopamine and serotonin transporter sites.EBI J Med Chem 39: 749-56 (1996) Organix Inc 2D 3D TSV
8576917 79 3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists.EBI J Med Chem 39: 736-48 (1996) Eli Lilly and Company 2D 3D TSV
8576914 14 Water soluble inhibitors of topoisomerase I: quaternary salt derivatives of camptothecin.EBI J Med Chem 39: 713-9 (1996) Glaxo Wellcome Research Institute 2D 3D TSV
8576912 34 Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.EBI J Med Chem 39: 695-704 (1996) Zeneca Pharma 2D 3D TSV
8576911 4 Slow-binding inhibition of gamma-aminobutyric acid aminotransferase by hydrazine analogues.EBI J Med Chem 39: 686-94 (1996) Northwestern University 2D 3D TSV
8576908 33 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.EBI J Med Chem 39: 669-72 (1996) G. D. Searle Research and Development 2D 3D TSV
8576907 13 The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.EBI J Med Chem 39: 665-8 (1996) Glaxo Wellcome Research and Development 2D 3D TSV
8576905 25 alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.EBI J Med Chem 39: 657-60 (1996) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8576904 78 Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.EBI J Med Chem 39: 625-56 (1996) DuPont Pharmaceuticals Company 2D 3D TSV
8568831 42 Potent human immunodeficiency virus type 1 protease inhibitors that utilize noncoded D-amino acids as P2/P3 ligands.BDB J Med Chem 39: 96-108 (1996) Eli Lilly and Company 2D 3D TSV
8568830 2 (-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.EBI J Med Chem 39: 86-95 (1996) Freie Universität Berlin 2D 3D TSV
8568829 22 Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).EBI J Med Chem 39: 73-85 (1996) Institute of Cancer Research 2D 3D TSV
8568828 2 Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-gamma,gamma-difluoromethotrexate.EBI J Med Chem 39: 66-72 (1996) University of Michigan 2D 3D TSV
8568827 6 Synthesis and biological activity of folic acid and methotrexate analogues containing L-threo-(2S,4S)-4-fluoroglutamic acid and DL-3,3-difluoroglutamic acid.EBI J Med Chem 39: 56-65 (1996) University of Michigan 2D 3D TSV
8568825 13 Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template.EBI J Med Chem 39: 36-45 (1996) National Cancer Institute-Bethesda 2D 3D TSV
8568823 36 Nonpeptide angiotensin II receptor antagonists: synthesis, biological activities, and structure-activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds.EBI J Med Chem 39: 323-38 (1996) Sankyo Company Ltd 2D 3D TSV
8568822 80 Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors.EBI J Med Chem 39: 314-22 (1996) Virginia Commonwealth University 2D 3D TSV
8568820 10 Studies of cardiotonic agents. 8. Synthesis and biological activities of optically active 6-(4-(benzylamino)-7-quinazolinyl)-4,5-dihydro-5-methyl-3(2H)- pyridazinone (KF15232).EBI J Med Chem 39: 297-303 (1996) Kyowa Hakka Co., Ltd. 2D 3D TSV
8568819 6 Conformationally constrained analogues of diacylglycerol. 11. Ultrapotent protein kinase C ligands based on a chiral 5-disubstituted tetrahydro-2-furanone template.EBI J Med Chem 39: 29-35 (1996) National Cancer Institute-Bethesda 2D 3D TSV
8568818 12 Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping.EBI J Med Chem 39: 285-96 (1996) University of North Carolina 2D 3D TSV
8568817 2 Theoretical study of inhibition of adenosine deaminase by (8R)-coformycin and (8R)-deoxycoformycin.EBI J Med Chem 39: 277-84 (1996) University of California 2D 3D TSV
8568816 69 Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure-Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor ReceptorBDB J Med Chem 39: 267-76 (1996) Parke-Davis Pharmaceutical Research 2D 3D TSV
8568815 70 Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships.EBI J Med Chem 39: 253-66 (1996) Searle Research and Development 2D 3D TSV
8568814 23 Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.EBI J Med Chem 39: 246-52 (1996) Hoechst-Roussel Pharmaceuticals Inc 2D 3D TSV
8568812 36 Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity.EBI J Med Chem 39: 224-36 (1996) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8568811 22 Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.EBI J Med Chem 39: 217-23 (1996) University of Pittsburgh 2D 3D TSV
8568809 34 Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.EBI J Med Chem 39: 2-9 (1996) University of California 2D 3D TSV
8568807 7 In vitro and in vivo studies of benzisoquinoline ligands for the brain synaptic vesicle monoamine transporter.EBI J Med Chem 39: 191-6 (1996) University of Michigan Medical School 2D 3D TSV
8568806 9 Conformationally constrained analogues of diacylglycerol. 10. Ultrapotent protein kinase C ligands based on a racemic 5-disubstituted tetrahydro-2-furanone template.EBI J Med Chem 39: 19-28 (1996) National Cancer Institute-Bethesda 2D 3D TSV
8568804 42 New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives.EBI J Med Chem 39: 176-82 (1996) Universit£ di Bari 2D 3D TSV
8568803 27 High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex.EBI J Med Chem 39: 158-75 (1996) Upjohn Laboratories 2D 3D TSV
8568802 42 Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives.EBI J Med Chem 39: 149-57 (1996) Glaxo Wellcome Inc. 2D 3D TSV
8568801 13 3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.EBI J Med Chem 39: 143-8 (1996) Pfizer Inc 2D 3D TSV
8568800 155 Structure-antigastrin activity relationships of new spiroglumide amido acid derivatives.EBI J Med Chem 39: 135-42 (1996) Rotta Research Laboratorium 2D 3D TSV
8568799 281 Binding of arylpiperazines, (aryloxy)propanolamines, and tetrahydropyridylindoles to the 5-HT1A receptor: contribution of the molecular lipophilicity potential to three-dimensional quantitative structure-affinity relationship models.EBI J Med Chem 39: 126-34 (1996) Universit£ de Lausanne 2D 3D TSV
8568798 29 Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.EBI J Med Chem 39: 120-5 (1996) Pfizer Inc. 2D 3D TSV
8566176 79 Deriving the therapeutic concentrations for clozapine and haloperidol: the apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand.BDB Eur J Pharmacol 291: 59-66 (1995) University of Toronto 2D 3D TSV
8564266 77 Evaluation of the receptor selectivity of the H3 receptor antagonists, iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed.BDB Br J Pharmacol 116: 2315-21 (1995) Vrije Universiteit 2D 3D TSV
8564196 35 Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo.BDB Br J Pharmacol 115: 1387-92 (1995) Syntex Discovery Research 2D 3D TSV
8558536 3 Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase.EBI J Med Chem 39: 619-22 (1996) Zeneca Pharmaceuticals 2D 3D TSV
8558534 9 Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs.EBI J Med Chem 39: 609-13 (1996) Searle 2D 3D TSV
8558532 53 2-[(2-Aminobenzyl)sulfinyl]-1-(2-pyridyl)-1,4,5,6-tetrahydrocyclopent[d]imidazoles as a novel class of gastric H+/K+-ATPase inhibitors.EBI J Med Chem 39: 596-604 (1996) Tanabe Seiyaku Co., Ltd 2D 3D TSV
8558530 4 Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.EBI J Med Chem 39: 582-7 (1996) Hoechst-Roussel Pharmaceuticals Inc 2D 3D TSV
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI J Med Chem 39: 570-81 (1996) Hoechst-Roussel Pharmaceuticals Inc 2D 3D TSV
8558528 16 Discovery of 1,5-benzodiazepines with peripheral cholecystokinin (CCK-A) receptor agonist activity. 1. Optimization of the agonist"trigger".EBI J Med Chem 39: 562-9 (1996) Glaxo Wellcome 2D 3D TSV
8558526 6 9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore.BDB J Med Chem 39: 549-55 (1996) Purdue University 2D 3D TSV
8558525 60 N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain.EBI J Med Chem 39: 543-8 (1996) Research Biochemicals International 2D 3D TSV
8558522 26 2-Sulfonyl-4-chloroanilino moiety: a potent pharmacophore for the anti-human immunodeficiency virus type 1 activity of pyrrolyl aryl sulfones.BDB J Med Chem 39: 522-30 (1996) Universita di Roma 2D 3D TSV
8558518 38 Dual metalloprotease inhibitors. 6. Incorporation of bicyclic and substituted monocyclic azepinones as dipeptide surrogates in angiotensin-converting enzyme/neutral endopeptidase inhibitors.EBI J Med Chem 39: 494-502 (1996) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8558508 55 Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists.EBI J Med Chem 39: 398-406 (1996) National Institute of Diabetes 2D 3D TSV
8558507 7 A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.BDB J Med Chem 39: 392-7 (1996) Abbott Laboratories 2D 3D TSV
8558505 77 A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.EBI J Med Chem 39: 380-7 (1996) University of Missouri St. Louis 2D 3D TSV
8558504 43 2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series.EBI J Med Chem 39: 371-9 (1996) Organix Inc 2D 3D TSV
8558503 22 Synthesis and quantitative structure-activity relationship of a novel series of small conductance Ca(2+)-activated K+ channel blockers related to dequalinium.EBI J Med Chem 39: 359-70 (1996) University College London 2D 3D TSV
8558502 17 Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.EBI J Med Chem 39: 353-8 (1996) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8558460 11 YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist.BDB J Pharmacol Exp Ther 276: 84-92 (1996) Yamanouchi Pharmaceutical Co., Ltd 2D 3D TSV
8558445 17 Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.BDB J Pharmacol Exp Ther 276: 289-97 (1996) Abbott Laboratories 2D 3D TSV
8549774 6 Expression of functional mouse 5-HT5A serotonin receptor in the methylotrophic yeast Pichia pastoris: pharmacological characterization and localization.BDB FEBS Lett 377: 451-6 (1995) Max-Planck-Institut 2D 3D TSV
8544178 46 New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.EBI J Med Chem 38: 5023-30 (1996) Ciba-Geigy Corporation 2D 3D TSV
8544176 16 Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent.EBI J Med Chem 38: 5007-14 (1996) Warner-Lambert Company 2D 3D TSV
8544175 75 Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes.EBI J Med Chem 38: 4993-5006 (1996) CIRD GALDERMA 2D 3D TSV
8544174 19 Discovery of an orally bioavailable NK1 receptor antagonist, (2S,3S)-(2-methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with potent antiemetic activity.EBI J Med Chem 38: 4985-92 (1995) GSK UK 2D 3D TSV
8544173 37 Rational design and synthesis of small molecule, non-oligosaccharide selectin inhibitors: (alpha-D-mannopyranosyloxy)biphenyl-substituted carboxylic acids.EBI J Med Chem 38: 4976-84 (1996) Texas Biotechnology Corporation 2D 3D TSV
8544172 3 Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase.EBI J Med Chem 38: 4972-5 (1996) Glaxo Wellcome Research 2D 3D TSV
8544171 5 Structure-based design of sulfonamide-substituted non-peptidic HIV protease inhibitors.BDB J Med Chem 38: 4968-71 (1995) Upjohn 2D 3D TSV
8531090 1 Pharmacological evaluation of 1229U91, a novel high-affinity and selective neuropeptide Y-Y1 receptor antagonist.BDB J Pharmacol Exp Ther 275: 1261-6 (1995) Roche Bioscience 2D 3D TSV
8524985 69 D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs.BDB Psychopharmacology (Berl) 120: 365-8 (1995) Case Western Reserve University 2D 3D TSV
8523409 37 1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding.EBI J Med Chem 38: 4950-2 (1996) Neurogen Corporation 2D 3D TSV
8523408 7 The furoxan system as a useful tool for balancing"hybrids" with mixed alpha 1-antagonist and NO-like vasodilator activities.EBI J Med Chem 38: 4944-9 (1996) Universit£ degli Studi di Torino 2D 3D TSV
8523406 59 Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.BDB J Med Chem 38: 4929-36 (1995) Eli Lilly and Company 2D 3D TSV
8523405 176 3D-quantitative structure-activity relationships of human immunodeficiency virus type-1 proteinase inhibitors: comparative molecular field analysis of 2-heterosubstituted statine derivatives-implications for the design of novel inhibitors.EBI J Med Chem 38: 4917-28 (1996) SANDOZ Forschungsinstitut Ges.m.b.H. 2D 3D TSV
8523403 50 Cyclooxygenase-2 inhibitors. Synthesis and pharmacological activities of 5-methanesulfonamido-1-indanone derivatives.EBI J Med Chem 38: 4897-905 (1996) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
8523400 26 Nonsteroidal progesterone receptor ligands. 2. High-affinity ligands with selectivity for bone cell progesterone receptors.EBI J Med Chem 38: 4880-4 (1996) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
8523399 11 Nonsteroidal progesterone receptor ligands. 1. 3-Aryl-1-benzoyl-1,4,5,6-tetrahydropyridazines.EBI J Med Chem 38: 4878-9 (1996) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
8522988 39 Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.BDB J Neurochem 66: 47-56 (1996) University of Washington 2D 3D TSV
8521788 22 Molecular biology of somatostatin receptors.BDB Endocr Rev 16: 427-42 (1995) University of Pennsylvania 2D 3D TSV
8515429 16 (+/-) 3-Amino-6-carboxamido-1,2,3,4-tetrahydrocarbazole: a conformationally restricted analogue of 5-carboxamidotryptamine with selectivity for the serotonin 5-HT1D receptor.EBI J Med Chem 36: 1918-9 (1993) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8515428 2 Enantioselectivity of cocaine recognition sites: binding of (1S)- and (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane (beta-CIT) to monoamine transporters.EBI J Med Chem 36: 1914-7 (1993) Northeastern University 2D 3D TSV
8515427 43 Multiple binding modes for the receptor-bound conformations of cyclic AII agonists.EBI J Med Chem 36: 1902-13 (1993) Washington University 2D 3D TSV
8515426 12 Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.EBI J Med Chem 36: 1893-901 (1993) University of Toledo 2D 3D TSV
8515425 65 Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids.EBI J Med Chem 36: 1880-92 (1993) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8515423 26 Structure-based design of inhibitors of purine nucleoside phosphorylase. 2. 9-Alicyclic and 9-heteroalicyclic derivatives of 9-deazaguanine.EBI J Med Chem 36: 1847-54 (1993) BioCryst Pharmaceuticals Inc 2D 3D TSV
8515421 6 The solution conformation of (D)Phe-Pro-containing peptides: implications on the activity of Ac-(D)Phe-Pro-boroArg-OH, a potent thrombin inhibitor.EBI J Med Chem 36: 1831-8 (1993) DuPont Pharmaceuticals Company 2D 3D TSV
8515419 29 1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.EBI J Med Chem 36: 1802-10 (1993) Warner-Lambert Company 2D 3D TSV
8510101 37 Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.EBI J Med Chem 36: 1735-45 (1993) Warner-Lambert Company 2D 3D TSV
8510099 6 Transformation of monoamine oxidase-B primary amine substrates into time-dependent inhibitors. Tertiary amine homologues of primary amine substrates.EBI J Med Chem 36: 1711-5 (1993) Northwestern University 2D 3D TSV
8510008 67 Species differences in the pharmacology of the 5-hydroxytryptamine2 receptor: structurally specific differentiation by ergolines and tryptamines.BDB J Pharmacol Exp Ther 265: 1272-9 (1993) Eli Lilly and Company 2D 3D TSV
8496942 2 Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate.EBI J Med Chem 36: 631-2 (1993) Sandoz Research Institute 2D 3D TSV
8496941 23 5-HT3 receptor antagonists. 2. 4-Hydroxy-3-quinolinecarboxylic acid derivatives.EBI J Med Chem 36: 617-26 (1993) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
8496939 100 Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles.EBI J Med Chem 36: 591-609 (1993) Merck Research Laboratories 2D 3D TSV
8496938 38 Analogues of platelet activating factor. 8. Antagonists of PAF containing an aromatic ring linked to a pyridinium ring.EBI J Med Chem 36: 580-90 (1993) American Cyanamid Company 2D 3D TSV
8496937 30 Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility.EBI J Med Chem 36: 572-9 (1993) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
8496936 16 Synthesis and binding characteristics of potential SPECT imaging agents for sigma-1 and sigma-2 binding sites.EBI J Med Chem 36: 566-71 (1993) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8496935 25 Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.EBI J Med Chem 36: 544-51 (1993) University of North Carolina 2D 3D TSV
8496932 72 Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond.EBI J Med Chem 36: 1662-8 (1993) Warner-Lambert Company 2D 3D TSV
8496931 152 Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2.EBI J Med Chem 36: 1641-53 (1993) Eisai Company, Ltd 2D 3D TSV
8496930 76 Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity.EBI J Med Chem 36: 1630-40 (1993) Eisai Company, Ltd 2D 3D TSV
8496929 12 Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule.EBI J Med Chem 36: 1613-8 (1993) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
8496923 9 New mechanism-based inactivators of trypsin-like proteinases. Selective inactivation of urokinase by functionalized cyclopeptides incorporating a sulfoniomethyl-substituted m-aminobenzoic acid residue.EBI J Med Chem 36: 1539-47 (1993) CNRS-CERCOA 2D 3D TSV
8496922 92 Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.EBI J Med Chem 36: 1529-38 (1993) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
8496920 14 (S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.EBI J Med Chem 36: 1509-10 (1993) Wyeth Research (UK) 2D 3D TSV
8496919 15 N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors.EBI J Med Chem 36: 1501-4 (1993) Sandoz Research Institute 2D 3D TSV
8496917 72 Bridged gamma-carbolines and derivatives possessing selective and combined affinity for 5-HT2 and D2 receptors.EBI J Med Chem 36: 1488-95 (1993) Scios Nova Inc 2D 3D TSV
8496909 4 Mechanism-based inhibitors of prostaglandin omega-hydroxylase: (R)- and (S)-12-hydroxy-16-heptadecynoic acid and 2,2-dimethyl-12-hydroxy-16-heptadecynoic acid.EBI J Med Chem 36: 1418-24 (1993) University of California 2D 3D TSV
8496908 39 Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists.EBI J Med Chem 36: 1401-17 (1993) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8496907 8 Aromatase inhibitors: synthesis, biological activity, and binding mode of azole-type compounds.EBI J Med Chem 36: 1393-400 (1993) Ciba-Geigy Ltd 2D 3D TSV
8496906 127 Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.EBI J Med Chem 36: 1380-6 (1993) Hokuriku University 2D 3D TSV
8496905 6 Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes.EBI J Med Chem 36: 1369-79 (1993) CCIPE-Faculté de Pharmacie 2D 3D TSV
8496902 139 Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists.EBI J Med Chem 36: 1333-42 (1993) National Institute of Diabetes 2D 3D TSV
8496900 136 Comparison of 5-HT1A and dopamine D2 pharmacophores. X-ray structures and affinities of conformationally constrained ligands.EBI J Med Chem 36: 1301-15 (1993) Upjohn Laboratories 2D 3D TSV
8496821 2 Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist.BDB J Pharmacol Exp Ther 265: 752-8 (1993) Fujisawa Pharmaceutical Co., Ltd 2D 3D TSV
8496700 16 The Role of Receptor Binding in Drug DiscoveryEBI J Nat Prod 56: 441-455 (1993) TBA 2D 3D TSV
8494379 4 In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine.BDB Antimicrob Agents Chemother 37: 810-7 (1993) National Cancer Institute-Bethesda 2D 3D TSV
8487261 27 New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives.EBI J Med Chem 36: 1245-54 (1993) Zeneca Pharmaceuticals 2D 3D TSV
8487257 57 New indole derivatives as potent and selective serotonin uptake inhibitors.EBI J Med Chem 36: 1194-202 (1993) Centre de Recherches de Vitry-Alfortville 2D 3D TSV
8487256 33 Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists.EBI J Med Chem 36: 1175-87 (1993) Carpibem 2D 3D TSV
8487255 84 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.EBI J Med Chem 36: 1157-67 (1993) Universit£ Paris 7 2D 3D TSV
8487254 63 Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies.EBI J Med Chem 36: 1136-45 (1993) Institut f£r Toxikologie 2D 3D TSV
8478911 48 Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2-[[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines.EBI J Med Chem 36: 990-1000 (1993) Universit£ Paris 7 2D 3D TSV
8478910 26 Nonsymmetrical bipiperidyls as inhibitors of vesicular acetylcholine storage.EBI J Med Chem 36: 985-9 (1993) University of Minnesota 2D 3D TSV
8478908 22 Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere.EBI J Med Chem 36: 941-52 (1993) Upjohn Laboratories 2D 3D TSV
8478906 25 Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.EBI J Med Chem 36: 1090-9 (1993) Warner-Lambert Company 2D 3D TSV
8478905 53 Inhibition studies of some serine and thiol proteinases by new leupeptin analogues.EBI J Med Chem 36: 1084-9 (1993) University of Arkansas 2D 3D TSV
8478902 18 Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase.EBI J Med Chem 36: 1024-31 (1993) National Defense Medical Center 2D 3D TSV
8474103 123 Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung.EBI J Med Chem 36: 468-78 (1993) Abbott Laboratories 2D 3D TSV
8474102 29 Studies directed toward the design of orally active renin inhibitors. 2. Development of the efficacious, bioavailable renin inhibitor (2S)-2-benzyl-3- [[(1-methylpiperazin-4-yl)sulfonyl]propionyl]-3-thiazol-4-yl-L-alanine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane (A-725EBI J Med Chem 36: 460-7 (1993) Abbott Laboratories 2D 3D TSV
8474101 30 Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptides.EBI J Med Chem 36: 449-59 (1993) Abbott Laboratories 2D 3D TSV
8474100 8 Inactivation of monoamine oxidase B by analogues of the anticonvulsant agent milacemide (2-(n-pentylamino)acetamide).EBI J Med Chem 36: 446-8 (1993) Northwestern University 2D 3D TSV
8474099 3 Verapamil analogues with restricted molecular flexibility: synthesis and pharmacological evaluation of the four isomers of alpha-[1-[3-[N-[1- [2-(3,4-dimethoxyphenyl)ethyl]]-N-methylamino]cyclohexyl]]-alpha- isopropyl-3,4-dimethoxybenzene-acetonitrile.EBI J Med Chem 36: 439-45 (1993) Università di Firenze 2D 3D TSV
8474097 19 Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck.EBI J Med Chem 36: 425-32 (1993) National Cancer Institute-Bethesda 2D 3D TSV
8474008 58 Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.BDB J Pharmacol Exp Ther 265: 218-26 (1993) Virginia Commonwealth University 2D 3D TSV
8464047 14 Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.BDB J Med Chem 36: 924-7 (1993) Merck Research Laboratories 2D 3D TSV
8464042 4 Adenosine-5'-carboxaldehyde: a potent inhibitor of S-adenosyl-L-homocysteine hydrolase.EBI J Med Chem 36: 883-7 (1993) University of Kansas 2D 3D TSV
8464040 21 Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging.EBI J Med Chem 36: 855-62 (1993) Organix Inc 2D 3D TSV
8464039 12 Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography.EBI J Med Chem 36: 848-54 (1993) Oak Ridge National Laboratory 2D 3D TSV
8464038 14 Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.EBI J Med Chem 36: 842-7 (1993) University of Toledo 2D 3D TSV
8461029 21 Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese hamster ovary cells. [3H]spiperone discriminates between the G-protein-coupled and -uncoupled forms.BDB Biochem Pharmacol 45: 1003-9 (1993) University of Canterbury 2D 3D TSV
8459400 74 Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.EBI J Med Chem 36: 733-46 (1993) Agouron Pharmaceuticals Inc 2D 3D TSV
8459398 36 1,2-Cyclomethylenecarboxylic monoamide hydroxamic derivatives. A novel class of non-amino acid angiotensin converting enzyme inhibitors.EBI J Med Chem 36: 699-707 (1993) Laboratori Guidotti S.p.A. 2D 3D TSV
8459396 37 Centrally acting serotonergic agents. Synthesis and structure-activity relationships of C-1- or C-3-substituted derivatives of 8-hydroxy-2-(di-n-propylamino)tetralin.EBI J Med Chem 36: 671-82 (1993) Upjohn Laboratories 2D 3D TSV
8450829 29 Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.BDB Mol Pharmacol 43: 313-9 (1993) CNRS 2D 3D TSV
8437101 20 Expression and characterization of the rat D3 dopamine receptor: pharmacologic properties and development of antibodies.BDB J Pharmacol Exp Ther 264: 1002-11 (1993) University of Pennsylvania 2D 3D TSV
8426367 10 32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis.EBI J Med Chem 36: 410-6 (1993) Institute 2D 3D TSV
8426366 44 Defining structural requirements for neuropeptide Y receptors using truncated and conformationally restricted analogues.EBI J Med Chem 36: 385-93 (1993) Salk Institute 2D 3D TSV
8426364 30 Inhibition of the tetracycline efflux antiport protein by 13-thio-substituted 5-hydroxy-6-deoxytetracyclines.EBI J Med Chem 36: 370-7 (1993) Tufts University 2D 3D TSV
8426363 134 Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site.EBI J Med Chem 36: 343-52 (1993) Scios Nova Inc 2D 3D TSV
8426362 46 Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol.EBI J Med Chem 36: 320-30 (1993) Abbott Laboratories 2D 3D TSV
8426361 111 Highly selective tripeptide thrombin inhibitors.EBI J Med Chem 36: 314-9 (1993) Eli Lilly and Company 2D 3D TSV
8426360 1 Enantiospecific syntheses of alpha-(fluoromethyl)tryptophan analogues: interactions with tryptophan hydroxylase and aromatic L-amino acid decarboxylase.EBI J Med Chem 36: 305-13 (1993) Mayo Clinic 2D 3D TSV
8424846 7 LY248686, a new inhibitor of serotonin and norepinephrine uptake.BDB Neuropsychopharmacology 8: 23-33 (1993) Eli Lilly and Company 2D 3D TSV
8423602 15 Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series.EBI J Med Chem 36: 300-3 (1993) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8423600 13 3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.BDB J Med Chem 36: 292-4 (1993) Merck Research Laboratories 2D 3D TSV
8423599 26 Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere.BDB J Med Chem 36: 288-91 (1993) Monsanto Corporate Research 2D 3D TSV
8423595 2 (+)-Hemipalmitoylcarnitinium strongly inhibits carnitine palmitoyltransferase-I in intact mitochondria.EBI J Med Chem 36: 237-42 (1993) Louisiana State University 2D 3D TSV
8423594 39 Development of selective tight-binding inhibitors of leukotriene A4 hydrolase.EBI J Med Chem 36: 211-20 (1993) Scripps Research Institute 2D 3D TSV
8423593 6 Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 5. Synthesis and evaluation of enantiomers of 8-[[(4-chlorophenyl)sulfonyl]amino]-4-(3-pyridinylalkyl)octanoic acid.EBI J Med Chem 36: 205-10 (1993) Ciba-Geigy Corporation 2D 3D TSV
8421294 5 Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2.EBI J Med Chem 36: 95-100 (1993) Washington University 2D 3D TSV
8421293 32 Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.EBI J Med Chem 36: 87-94 (1993) University of Paris 2D 3D TSV
8421291 73 Structure-based design of inhibitors of purine nucleoside phosphorylase. 1. 9-(arylmethyl) derivatives of 9-deazaguanine.EBI J Med Chem 36: 55-69 (1993) BioCryst Pharmaceuticals Inc 2D 3D TSV
8421290 46 S-adenosylmethionine decarboxylase inhibitors: new aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone).EBI J Med Chem 36: 46-54 (1993) Ciba-Geigy AG 2D 3D TSV
8421286 44 Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction.BDB J Med Chem 36: 21-9 (1993) Roche Products Limited 2D 3D TSV
8421285 12 Hemicholinium and related lipids: inhibitors of protein kinase C.EBI J Med Chem 36: 177-8 (1993) Louisiana State University 2D 3D TSV
8421284 7 Phosphorus-containing inhibitors of endothelin converting enzyme: effects of the electronic nature of phosphorus on inhibitor potency.EBI J Med Chem 36: 173-6 (1993) Monsanto Corp 2D 3D TSV
8421283 43 CCK-B agonist or antagonist activities of structurally hindered and peptidase-resistant Boc-CCK4 derivatives.EBI J Med Chem 36: 166-72 (1993) University of Paris 2D 3D TSV
8421282 22 Synthesis and structure-activity relationship of some 5-[[[(dialkylamino)alkyl]-1-piperidinyl]acetyl]-10,11-dihydro-5H- benzo[b,e][1,4]diazepin-11-ones as M2-selective antimuscarinics.EBI J Med Chem 36: 162-5 (1993) George Washington University Medical Center 2D 3D TSV
8421274 27 Nonpeptide angiotensin II antagonists: N-phenyl-1H-pyrrole derivatives are angiotensin II receptor antagonists.EBI J Med Chem 36: 101-10 (1993) Searle & Company 2D 3D TSV
8413837 45 [3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments.BDB Neuropharmacology 32: 737-43 (1993) Boots Pharmaceuticals 2D 3D TSV
8411022 9 Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor.EBI J Med Chem 36: 3035-8 (1993) Mayo Foundation 2D 3D TSV
8411021 3 Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor.EBI J Med Chem 36: 3032-4 (1993) Hebrew University 2D 3D TSV
8411020 2 N-(carboxymethyl)-N-[3,5-bis(decyloxy)-phenyl]glycine (Ro 23-9358): a potent inhibitor of secretory phospholipases A2 with antiinflammatory activity.EBI J Med Chem 36: 3029-31 (1993) Roche Research Center 2D 3D TSV
8411019 6 Hydroxylated 2-(5'-salicyl)naphthalenes as protein-tyrosine kinase inhibitors.EBI J Med Chem 36: 3015-20 (1993) National Institutes of Health 2D 3D TSV
8411018 6 Inhibition of herpes simplex virus type 1 ribonucleotide reductase by substituted tetrapeptide derivatives.EBI J Med Chem 36: 3005-9 (1993) Bio-M£ga/Boehringer Ingelheim Research Inc. 2D 3D TSV
8411016 76 Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists.EBI J Med Chem 36: 2984-97 (1993) J. Uriach & Cía. S.A. 2D 3D TSV
8411014 20 Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1,4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition.EBI J Med Chem 36: 2964-72 (1993) Farmitalia Carlo Erba 2D 3D TSV
8411012 19 Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol.EBI J Med Chem 36: 2950-5 (1993) Purdue University 2D 3D TSV
8411011 23 Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel beta-ketoamides as hypocholesterolemic agents.EBI J Med Chem 36: 2943-9 (1993) Warner-Lambert Company 2D 3D TSV
8411007 392 Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands.EBI J Med Chem 36: 2908-20 (1993) Mayo Foundation 2D 3D TSV
8411005 42 2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents.EBI J Med Chem 36: 2891-8 (1993) University of Groningen 2D 3D TSV
8411004 48 3-Aryl-2-(3'-substituted-1',2',4'-oxadiazol-5'-yl)tropane analogues of cocaine: affinities at the cocaine binding site at the dopamine, serotonin, and norepinephrine transporters.EBI J Med Chem 36: 2886-90 (1993) Research Triangle Institute 2D 3D TSV
8411003 12 A structure-activity study of four dopamine D-1 and D-2 receptor antagonists, representing the phenylindan, -indene, and -indole structural classes of compounds.EBI J Med Chem 36: 2878-85 (1993) University of Lund 2D 3D TSV
8411002 67 Cholecystokinin peptidomimetics as selective CCK-B antagonists: design, synthesis, and in vitro and in vivo biochemical properties.EBI J Med Chem 36: 2868-77 (1993) University of Paris 2D 3D TSV
8410999 81 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.EBI J Med Chem 36: 2842-50 (1993) Eli Lilly and Company 2D 3D TSV
8410998 129 Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for mu- and kappa-opioid receptors.EBI J Med Chem 36: 2833-41 (1993) Eli Lilly and Company 2D 3D TSV
8410995 18 Synthesis and evaluation of a series of benzylaniline hydrochlorides as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerization.EBI J Med Chem 36: 2817-21 (1993) Purdue University 2D 3D TSV
8410993 24 Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8- difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarb oxylic acid and related derivatives.EBI J Med Chem 36: 2801-9 (1993) Sterling Winthrop Pharmaceuticals Research Division 2D 3D TSV
8410992 35 Renin inhibitors containing a pyridyl amino diol derived C-terminus.EBI J Med Chem 36: 2788-800 (1993) Hoechst AG 2D 3D TSV
8410991 88 Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.EBI J Med Chem 36: 2771-87 (1993) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
8410990 141 Stereospecific and selective 5-HT2 antagonism in a series of 5-substituted trans-1-piperazino-3-phenylindans.EBI J Med Chem 36: 2761-70 (1993) H. Lundbeck A/S 2D 3D TSV
8410989 58 Structure-affinity relationship studies on 5-HT1A receptor ligands. 1. Heterobicyclic phenylpiperazines with N4-alkyl substituents.EBI J Med Chem 36: 2751-60 (1993) Solvay Duphar Research Laboratories 2D 3D TSV
8410988 12 Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives.EBI J Med Chem 36: 2745-50 (1993) Universidad de Navarra 2D 3D TSV
8410983 7 (E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid: a novel high-affinity leukotriene B4 receptor antagonist.EBI J Med Chem 36: 2703-5 (1993) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8410982 5 Keto/enol epoxy steroids: a new structural class of HIV-1 Tat inhibitors.EBI J Med Chem 36: 2701-2 (1993) Sterling Winthrop Pharmaceuticals Research Division 2D 3D TSV
8410981 63 Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.EBI J Med Chem 36: 2689-700 (1993) Research Triangle Institute 2D 3D TSV
8410980 8 2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists.EBI J Med Chem 36: 2676-88 (1993) Abbott Laboratories 2D 3D TSV
8410977 43 2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists.EBI J Med Chem 36: 2645-57 (1993) Syntex Research 2D 3D TSV
8410976 60 Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.EBI J Med Chem 36: 2639-44 (1993) National Institutes of Health 2D 3D TSV
8410973 75 Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation.EBI J Med Chem 36: 2614-20 (1993) University of Florida 2D 3D TSV
8410972 52 Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.EBI J Med Chem 36: 2605-13 (1993) SRI International 2D 3D TSV
8410970 106 Structure-activity relationships of C-terminal endothelin hexapeptide antagonists.EBI J Med Chem 36: 2585-94 (1993) Warner-Lambert Company 2D 3D TSV
8398139 29 A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms.BDB Neuron 11: 449-58 (1993) The Scripps Research Institute 2D 3D TSV
8397408 27 Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.BDB Proc Natl Acad Sci U S A 90: 8547-51 (1993) U. 109 2D 3D TSV
8396931 11 Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor.BDB Biochem Biophys Res Commun 195: 902-9 (1993) National Children's Medical Research Center 2D 3D TSV
8394987 32 Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.BDB Mol Pharmacol 44: 229-36 (1993) CNRS 2D 3D TSV
8394936 11 Design of potent non-peptide competitive antagonists of the human bradykinin B2 receptor.EBI J Med Chem 36: 2583-4 (1993) Sterling Winthrop Pharmaceutical Research Division 2D 3D TSV
8394935 4 A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists.EBI J Med Chem 36: 2572-4 (1993) University of Minnesota 2D 3D TSV
8394934 9 Design of potent, cyclic peptide bradykinin receptor antagonists from conformationally constrained linear peptides.EBI J Med Chem 36: 2569-71 (1993) Scios Nova Inc 2D 3D TSV
8394902 11 Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.BDB J Pharmacol Exp Ther 266: 1018-28 (1993) Georgetown University 2D 3D TSV
8394362 99 Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.BDB J Biol Chem 268: 18200-4 (1993) National Institute of Neurological Disorders and Stroke 2D 3D TSV
8393489 25 A potent new class of kappa-receptor agonist: 4-substituted 1-(arylacetyl)-2-[(dialkylamino)methyl]piperazines.EBI J Med Chem 36: 2075-83 (1993) Glaxo Group Research Ltd. 2D 3D TSV
8393115 11 N-acyl-L-tryptophan benzyl esters: potent substance P receptor antagonists.EBI J Med Chem 36: 2044-5 (1993) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
8393113 114 Orally active, nonpeptide vasopressin V1 antagonists. A novel series of 1-(1-substituted 4-piperidyl)-3,4-dihdyro-2(1H)-quinolinone.EBI J Med Chem 36: 2011-7 (1993) Otsuka Pharmaceutical Co., Ltd 2D 3D TSV
8393112 12 Quinolone antibacterials: synthesis and biological activity of carbon isosteres of the 1-piperazinyl and 3-amino-1-pyrrolidinyl side chains.EBI J Med Chem 36: 1964-70 (1993) Warner-Lambert Company 2D 3D TSV
8391122 35 Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors.BDB Mol Pharmacol 43: 970-5 (1993) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
8390575 28 Non-peptide ligands for opioid receptors. Design of kappa-specific agonists.EBI J Med Chem 36: 1860-5 (1993) Universit£ di Catania 2D 3D TSV
8389876 11 Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists.EBI J Med Chem 36: 1726-34 (1993) Eli Lilly and Company 2D 3D TSV
8389875 34 Antitumor agents. 3. Synthesis and biological activity of 4 beta-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.EBI J Med Chem 36: 1689-99 (1993) Taiho Pharmaceutical Co., Ltd 2D 3D TSV
8388471 28 Tetrapeptide tachykinin antagonists: synthesis and modulation of the physicochemical and pharmacological properties of a new series of partially cyclic analogs.EBI J Med Chem 36: 1654-61 (1993) Institut de Recherches Servier 2D 3D TSV
8388469 3 NMR and computational evidence that high-affinity bradykinin receptor antagonists adopt C-terminal beta-turns.EBI J Med Chem 36: 1450-60 (1993) Scios Nova Inc 2D 3D TSV
8388468 37 Cyclic nucleotide phosphodiesterase inhibition by imidazopyridines: analogues of sulmazole and isomazole as inhibitors of the cGMP specific phosphodiesterase.EBI J Med Chem 36: 1387-92 (1993) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8388466 15 Amino- and guanidinoacylryanodines: basic ryanodine esters with enhanced affinity for the sarcoplasmic reticulum Ca(2+)-release channel.EBI J Med Chem 36: 1319-23 (1993) Indiana University 2D 3D TSV
8387599 1 Synthesis and phosphodiesterase activity of carboxylic acid mimetics of cyclic guanosine 3',5'-monophosphate.EBI J Med Chem 36: 1210-20 (1993) Schering-Plough Research Institute 2D 3D TSV
8387598 11 Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.EBI J Med Chem 36: 1146-56 (1993) Institute of Pharmaceutical Chemistry 2D 3D TSV
8387597 3 Bioactive ryanoids from nucleophilic additions to 4,12-seco-4,12-dioxoryanodine.EBI J Med Chem 36: 1128-35 (1993) University of California 2D 3D TSV
8386236 11 In vitro and in vivo pharmacological characterization of N6-cyclopentyl-9-methyladenine (N-0840): a selective, orally active A1 adenosine receptor antagonist.BDB J Pharmacol Exp Ther 265: 227-36 (1993) Whitby Research, Inc. 2D 3D TSV
8385226 7 The effect of NMeTyr5 substitution in luteinizing hormone-releasing hormone antagonists.EBI J Med Chem 36: 928-33 (1993) Abbott Laboratories 2D 3D TSV
8385225 16 Quinolone antibacterials containing the new 7-[3-(1-aminoethyl)-1- pyrrolidinyl] side chain: the effects of the 1-aminoethyl moiety and its stereochemical configurations on potency and in vivo efficacy.EBI J Med Chem 36: 871-82 (1993) Warner-Lambert Company 2D 3D TSV
8385224 9 Synthesis and anti-HIV evaluation of D4T and D4T 5'-monophosphate prodrugs.EBI J Med Chem 36: 826-30 (1993) URA CNRS 1309 2D 3D TSV
8384716 6 Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.BDB Proc Natl Acad Sci U S A 90: 2184-8 (1993) The Scripps Research Institute 2D 3D TSV
8384662 20 A topochemical approach to explain morphiceptin bioactivity.EBI J Med Chem 36: 708-19 (1993) University of California 2D 3D TSV
8383731 2 A new bastadin from the sponge Psammaplysilla purpurea.EBI J Nat Prod 56: 153-7 (1993) University of Hawaii 2D 3D TSV
8383730 7 New Leukotriene B4 Receptor Antagonist: Leucettamine A and Related Imidazole Alkaloids from the Marine Sponge Leucetta microraphisEBI J Nat Prod 56: 116-121 (1993) TBA 2D 3D TSV
8382063 12 Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1A receptors that are negatively coupled to adenylate cyclase in permanently transfected HeLa cells.BDB Biochem Pharmacol 45: 375-83 (1993) Janssen Research Foundation 2D 3D TSV
8381185 24 Nonsteroidal inhibitors of human type I steroid 5-alpha-reductase.EBI J Med Chem 36: 421-3 (1993) Eli Lilly and Company 2D 3D TSV
8381184 42 Substituted 3-(phenylmethyl)-1H-indole-5-carboxamides and 1-(phenylmethyl)indole-6-carboxamides as potent, selective, orally active antagonists of the peptidoleukotrienes.EBI J Med Chem 36: 394-409 (1993) ICI Pharmaceuticals Group 2D 3D TSV
8381183 35 Effect of N-methyl substitution of the peptide bonds in luteinizing hormone-releasing hormone agonists.BDB J Med Chem 36: 363-9 (1993) Abbott Laboratories 2D 3D TSV
8380639 24 Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.BDB Proc Natl Acad Sci U S A 90: 408-12 (1993) Synaptic Pharmaceutical Corporation 2D 3D TSV
8380614 6 A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists.EBI J Med Chem 36: 179-80 (1993) University of Minnesota 2D 3D TSV
8377012 2 Polycyclic guanidine alkaloids from the marine sponge Crambe crambe and Ca++ channel blocker activity of crambescidin 816.EBI J Nat Prod 56: 1007-15 (1993) University of Brussels 2D 3D TSV
8360888 14 Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11.EBI J Med Chem 36: 2420-3 (1993) Marion Merrell Dow Research Institute 2D 3D TSV
8360887 9 Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity.EBI J Med Chem 36: 2412-5 (1993) University of Minnesota 2D 3D TSV
8360886 4 A mechanism-based inactivation study of neutral endopeptidase 24.11.EBI J Med Chem 36: 2408-11 (1993) Salk Biotechnology/Industrial Associates 2D 3D TSV
8360884 134 Three-dimensional quantitative structure-activity relationship of angiotesin-converting enzyme and thermolysin inhibitors. II. A comparison of CoMFA models incorporating molecular orbital fields and desolvation free energies based on active-analog and complementary-receptor-field alignment rules.EBI J Med Chem 36: 2390-403 (1993) Washington University 2D 3D TSV
8360883 49 Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain"C-region".EBI J Med Chem 36: 2381-9 (1993) Sandoz Institute for Medical Research 2D 3D TSV
8360882 30 Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond"B-region".EBI J Med Chem 36: 2373-80 (1993) Sandoz Institute for Medical Research 2D 3D TSV
8360878 29 Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships.EBI J Med Chem 36: 2335-42 (1993) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8360876 9 A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the sequential incorporation of gamma-turn mimetics into a model substrate.EBI J Med Chem 36: 2321-31 (1993) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8360875 23 Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds.EBI J Med Chem 36: 2311-20 (1993) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8360874 19 Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.BDB J Med Chem 36: 2300-10 (1993) Merck Research Laboratories 2D 3D TSV
8360873 25 Synthesis and structure-activity studies of a series of spirooxazolidine-2,4-diones: 4-oxa analogues of the muscarinic agonist 2-ethyl-8-methyl-2,8-diazaspiro[4.5]decane-1,3-dione.EBI J Med Chem 36: 2292-9 (1993) Institute for Drug Discovery Research 2D 3D TSV
8360872 3 Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin-1(2H)-ones.EBI J Med Chem 36: 2279-91 (1993) Wellcome Research Laboratories 2D 3D TSV
8360871 86 Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-carEBI J Med Chem 36: 2253-65 (1993) Warner-Lambert Company 2D 3D TSV
8358562 29 Development of a radioligand binding assay for 5-HT4 receptors in guinea-pig and rat brain.BDB Br J Pharmacol 109: 618-24 (1993) Glaxo Group Research Ltd. 2D 3D TSV
8355256 11 Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities.EBI J Med Chem 36: 2575-7 (1993) Upjohn Company 2D 3D TSV
8355255 103 Triazolinones as nonpeptide angiotensin II antagonists. 1. Synthesis and evaluation of potent 2,4,5-trisubstituted triazolinones.EBI J Med Chem 36: 2558-68 (1993) Merck Research Laboratories 2D 3D TSV
8355253 74 Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist.EBI J Med Chem 36: 2519-25 (1993) Virginia Commonwealth University 2D 3D TSV
8355252 54 Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.EBI J Med Chem 36: 2508-18 (1993) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
8355251 8 Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site.EBI J Med Chem 36: 2499-507 (1993) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8355247 34 Tyrosine kinase inhibitors. 1. Structure-activity relationships for inhibition of epidermal growth factor receptor tyrosine kinase activity by 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acids and 2,2'-dithiobis(1H-indole-3-alkanoic acids).BDB J Med Chem 36: 2459-69 (1993) University of Auckland 2D 3D TSV
8355245 18 Activated ketone based inhibitors of human renin.EBI J Med Chem 36: 2431-47 (1993) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8340925 18 Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.EBI J Med Chem 36: 2235-7 (1993) Syntex Discovery Research 2D 3D TSV
8340923 7 Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.EBI J Med Chem 36: 2228-31 (1993) SRI International 2D 3D TSV
8340922 7 Synthesis and biological activity of cis-(3aR)-(-)-2,3,3a,4,5,9b-hexahydro- 3-propyl-1H-benz[e]indole-9-carboxamide: a potent and selective 5-HT1A receptor agonist with good oral availability.EBI J Med Chem 36: 2208-18 (1993) Upjohn Laboratories 2D 3D TSV
8340921 43 Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.EBI J Med Chem 36: 2182-95 (1993) Takeda Chemical Industries, Ltd 2D 3D TSV
8340920 43 Synthesis and structure-activity relationships of nonpeptide, potent triazolone-based angiotensin II receptor antagonists.EBI J Med Chem 36: 2172-81 (1993) Searle R&D 2D 3D TSV
8340919 4 4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-Adenosylmethionine decarboxylase.EBI J Med Chem 36: 2168-71 (1993) Ciba-Geigy AG 2D 3D TSV
8340918 4 Multiple copy simultaneous search and construction of ligands in binding sites: application to inhibitors of HIV-1 aspartic proteinase.EBI J Med Chem 36: 2142-67 (1993) Harvard University 2D 3D TSV
8340917 19 Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase.EBI J Med Chem 36: 2134-41 (1993) Merck Research Laboratories 2D 3D TSV
8340910 32 (S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.EBI J Med Chem 36: 2059-65 (1993) University of Göteborg 2D 3D TSV
8340909 14 Excursions in drug discovery.EBI J Med Chem 36: 2051-8 (1993) Merck Research Laboratories 2D 3D TSV
8336341 42 Synthesis and biological evaluation of antiplatelet 2-aminochromones.EBI J Med Chem 36: 2026-32 (1993) Upjohn Laboratories 2D 3D TSV
8335064 4 Characteristics of histamine H1 receptors on HeLa cells.BDB Eur J Pharmacol 245: 291-5 (1993) University of Cambridge 2D 3D TSV
8326323 7 Microbial transformation of L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease.EBI J Nat Prod 56: 755-61 (1993) Merck Research Laboratories 2D 3D TSV
8308869 5 Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition.EBI J Med Chem 37: 421-4 (1994) Merck Research Laboratories 2D 3D TSV
8308867 72 Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.EBI J Med Chem 37: 408-14 (1994) Ligand Pharmaceuticals Inc 2D 3D TSV
8308865 9 CNAD: a potent and specific inhibitor of alcohol dehydrogenase.EBI J Med Chem 37: 392-9 (1994) University of Rochester Medical Center 2D 3D TSV
8308857 19 The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide.EBI J Med Chem 37: 329-31 (1994) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8302837 4 Bound water molecules and conformational stabilization help mediate an antigen-antibody association.BDB Proc Natl Acad Sci USA 91: 1089-93 (1994) Institut Pasteur 2D 3D TSV
8302271 63 Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding.BDB Mol Pharmacol 45: 125-35 (1994) University of Toronto 2D 3D TSV
8301592 45 Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell lines.BDB J Pharmacol Exp Ther 268: 495-502 (1994) Washington University 2D 3D TSV
8301582 57 Expression and pharmacological characterization of the human D3 dopamine receptor.BDB J Pharmacol Exp Ther 268: 417-26 (1994) Neuroscience Research Centre 2D 3D TSV
8301575 55 Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists.BDB J Pharmacol Exp Ther 268: 337-52 (1994) Institut de Recherches Servier 2D 3D TSV
8295221 28 Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.EBI J Med Chem 37: 322-8 (1994) Warner-Lambert Company 2D 3D TSV
8295220 18 A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes.EBI J Med Chem 37: 314-21 (1994) National Institutes of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8295219 44 Tetrapeptide CCK agonists: structure-activity studies on modifications at the N-terminus.EBI J Med Chem 37: 309-13 (1994) Abbott Laboratories 2D 3D TSV
8295218 3 Adenosine deaminase inhibitors. Synthesis and biological evaluation of 4-amino-1-(2(S)-hydroxy-3(R)-nonyl)-1H-imidazo[4,5-c]pyridine (3-deaza-(+)-EHNA) and certain C1' derivatives.EBI J Med Chem 37: 305-8 (1994) University of Rhode Island 2D 3D TSV
8295217 7 Evaluation of a vitamin-cloaking strategy for oligopeptide therapeutics: biotinylated HIV-1 protease inhibitors.EBI J Med Chem 37: 293-304 (1994) Upjohn Laboratories 2D 3D TSV
8295214 21 Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.EBI J Med Chem 37: 268-74 (1994) Warner-Lambert Company 2D 3D TSV
8295213 59 Synthesis and structure-activity studies of N,N'-diarylguanidine derivatives. N-(1-naphthyl)-N'-(3-ethylphenyl)-N'-methylguanidine: a new, selective noncompetitive NMDA receptor antagonist.EBI J Med Chem 37: 260-7 (1994) Cambridge NeuroScience Inc 2D 3D TSV
8295212 31 Novel cAMP PDE III inhibitors: imidazo[4,5-b]pyridin-2(3H)-ones and thiazolo[4,5-b]pyridin-2(3H)-ones and their analogs.EBI J Med Chem 37: 248-54 (1994) Sterling Winthrop Pharmaceuticals Research Division 2D 3D TSV
8295211 35 3-substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitors.EBI J Med Chem 37: 240-7 (1994) Merck Research Laboratories 2D 3D TSV
8295207 2 Estrone sulfamates: potent inhibitors of estrone sulfatase with therapeutic potential.EBI J Med Chem 37: 219-21 (1994) University of Bath 2D 3D TSV
8295206 6 Design and synthesis of peptidomimetic inhibitors of HIV-1 protease and renin. Evidence for improved transport.BDB J Med Chem 37: 215-8 (1994) University of Pennsylvania 2D 3D TSV
8289207 30 Mixed 5-HT1A/D-2 activity of a new model of arylpiperazines: 1-aryl-4-[3-(1,2-dihydronaphthalen-4-yl)-n-propyl]piperazines. 1. Synthesis and structure-activity relationships.EBI J Med Chem 37: 99-104 (1994) Università di Bari 2D 3D TSV
8289199 105 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors.EBI J Med Chem 37: 26-39 (1994) Dr. Karl Thomae GmbH 2D 3D TSV
8289198 53 A recombinant human stromelysin catalytic domain identifying tryptophan derivatives as human stromelysin inhibitors.EBI J Med Chem 37: 206-9 (1994) Warner-Lambert Company 2D 3D TSV
8289197 20 Adenosine deaminase inhibitors: synthesis and structure-activity relationships of 2-hydroxy-3-nonyl derivatives of azoles.EBI J Med Chem 37: 201-5 (1994) Universit£ di Camerino 2D 3D TSV
8289196 7 New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.EBI J Med Chem 37: 195-200 (1994) University of North Carolina 2D 3D TSV
8289195 28 Isozyme-specific glutathione-S-transferase inhibitors: design and synthesis.EBI J Med Chem 37: 189-94 (1994) Terrapin Technologies 2D 3D TSV
8289190 31 Synthesis of novel N-phosphonoalkyl dipeptide inhibitors of human collagenase.EBI J Med Chem 37: 158-69 (1994) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8289189 1 Interaction of tetrahydrostilbazoles with monoamine oxidase A and B.EBI J Med Chem 37: 151-7 (1994) University of California 2D 3D TSV
8289188 30 Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.EBI J Med Chem 37: 146-50 (1994) University of Arizona 2D 3D TSV
8289187 47 Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors.EBI J Med Chem 37: 141-5 (1994) University of Arizona 2D 3D TSV
8289184 45 Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series.EBI J Med Chem 37: 113-24 (1994) AstraZeneca 2D 3D TSV
8289183 24 Synthesis and structure activity relationships of cis- and trans-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-c]pyridines for 5-HT receptor subtypes.EBI J Med Chem 37: 105-12 (1994) Abbott Laboratories 2D 3D TSV
8289063 5 Zaragozic Acids D and D2: Potent Inhibitors of Squalene Synthase and of Ras Farnesyl-Protein TransferaseEBI J Nat Prod 56: 1923-1929 (1993) TBA 2D 3D TSV
8278895 52 Evaluation of 5-[18F]fluoropropylepidepride as a potential PET radioligand for imaging dopamine D2 receptors.BDB Synapse 15: 169-76 (1993) Vanderbilt University 2D 3D TSV
8277514 46 6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase.EBI J Med Chem 36: 4313-5 (1994) Glaxo Inc. Research Institute 2D 3D TSV
8277513 4 Synthesis and optical resolution of (R)- and (S)-trans-7-Hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin: a new D3 dopamine receptor ligand.EBI J Med Chem 36: 4308-12 (1994) University of Pennsylvania 2D 3D TSV
8277511 57 Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides.EBI J Med Chem 36: 4293-301 (1994) Merck Research Laboratories 2D 3D TSV
8277510 233 Development of 1,4-benzodiazepine cholecystokinin type B antagonists.EBI J Med Chem 36: 4276-92 (1994) Merck Research Laboratories 2D 3D TSV
8277506 58 Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides.EBI J Med Chem 36: 4239-49 (1994) Merck Research Laboratories 2D 3D TSV
8277505 58 Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles.EBI J Med Chem 36: 4230-8 (1994) Merck Research Laboratories 2D 3D TSV
8277497 17 Studies on analogues of classical antifolates bearing the naphthoyl group in place of benzoyl in the side chain.EBI J Med Chem 36: 4161-71 (1994) Southern Research Institute 2D 3D TSV
8277496 77 Three-dimensional QSAR of human immunodeficiency virus (I) protease inhibitors. 1. A CoMFA study employing experimentally-determined alignment rules.EBI J Med Chem 36: 4152-60 (1994) Washington University 2D 3D TSV
8277318 7 Kinase inhibitors from Polygonum cuspidatum.EBI J Nat Prod 56: 1805-10 (1993) Purdue University 2D 3D TSV
8263508 9 Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit.BDB J Neurochem 62: 1-9 (1994) Allelix Biopharmaceuticals, Inc. 2D 3D TSV
8258837 8 (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 receptor antagonist derived from metoclopramide.EBI J Med Chem 36: 4121-3 (1994) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8258836 3 Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.EBI J Med Chem 36: 4113-20 (1994) University of Rhode Island 2D 3D TSV
8258834 46 Antipsoriatic anthrones with modulated redox properties. 1. Novel 10-substituted 1,8-dihydroxy-9(10H)-anthracenones as inhibitors of 5-lipoxygenase.EBI J Med Chem 36: 4099-107 (1994) Universität Regensburg 2D 3D TSV
8258833 17 Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor-associated tyrosine kinase activity.EBI J Med Chem 36: 4094-8 (1994) University of Paris 2D 3D TSV
8258832 22 Endothelin-1 analogues substituted at both position 18 and 19: highly potent endothelin antagonists with no selectivity for either receptor subtype ETA or ETB.EBI J Med Chem 36: 4087-93 (1994) Takeda Chemical Industries, Ltd 2D 3D TSV
8258830 87 Further studies of the structure-activity relationships of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine. Synthesis and evaluation of 1-(2-benzo[b]thienyl)-N,N-dialkylcyclohexylamines at dopamine uptake and phencyclidine binding sites.EBI J Med Chem 36: 4075-81 (1994) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8258829 13 2-Substituted 5-methoxy-N-acyltryptamines: synthesis, binding affinity for the melatonin receptor, and evaluation of the biological activity.EBI J Med Chem 36: 4069-74 (1993) University of Urbino 2D 3D TSV
8258828 15 Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 2. 4-(3-Pyridyl)-1(2H)-phthalazinones.EBI J Med Chem 36: 4061-8 (1994) Chugai Pharmaceutical Company, Ltd. 2D 3D TSV
8258826 42 6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships.EBI J Med Chem 36: 4040-51 (1994) Dr. Karl Thomae GmbH 2D 3D TSV
8258825 31 Synthesis of novel modified dipeptide inhibitors of human collagenase: beta-mercapto carboxylic acid derivatives.EBI J Med Chem 36: 4030-9 (1994) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8258823 16 Xanthines with C8 chiral substituents as potent and selective adenosine A1 antagonists.EBI J Med Chem 36: 4015-20 (1994) Marion Merrell Dow Research Institute 2D 3D TSV
8258822 102 Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: a comparison of the Hansch and CoMFA methods.EBI J Med Chem 36: 4006-14 (1993) University of Georgia 2D 3D TSV
8258821 491 Nanomolar-affinity, non-peptide oxytocin receptor antagonists.EBI J Med Chem 36: 3993-4005 (1994) Merck Research Laboratories 2D 3D TSV
8258820 47 A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.EBI J Med Chem 36: 3985-92 (1994) DuPont Pharmaceuticals Company 2D 3D TSV
8254628 17 Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.EBI J Med Chem 36: 3982-4 (1994) Eli Lilly and Company 2D 3D TSV
8254623 54 Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.EBI J Med Chem 36: 3947-55 (1994) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8254620 62 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.EBI J Med Chem 36: 3904-9 (1994) Tokushima Bunri University 2D 3D TSV
8254617 20 R2 C-terminal peptide inhibition of mammalian and yeast ribonucleotide reductase.EBI J Med Chem 36: 3859-62 (1994) University of Pennsylvania 2D 3D TSV
8254616 9 Novel inhibitors of prolyl 4-hydroxylase. 5. The intriguing structure-activity relationships seen with 2,2'-bipyridine and its 5,5'-dicarboxylic acid derivatives.EBI J Med Chem 36: 3853-8 (1994) Zeneca Pharmaceuticals 2D 3D TSV
8254615 1 Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antifilarial and antitumor agents. 2. 2-Arylamido and 2-alkylamido derivatives of 2-amino-4-(isothiocyanatomethyl)thiazole and 2-amino-4-(isothiocyanatomethyl)selenazole.EBI J Med Chem 36: 3849-52 (1994) University of Michigan 2D 3D TSV
8254612 10 Heterocyclic lactam derivatives as dual angiotensin converting enzyme and neutral endopeptidase 24.11 inhibitors.EBI J Med Chem 36: 3829-33 (1994) Ciba-Geigy Corporation 2D 3D TSV
8254611 12 Design and synthesis of an orally active macrocyclic neutral endopeptidase 24.11 inhibitor.EBI J Med Chem 36: 3821-8 (1994) Ciba-Geigy Corporation 2D 3D TSV
8254610 14 Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.EBI J Med Chem 36: 3809-20 (1994) Warner-Lambert Company 2D 3D TSV
8254609 61 Neuropeptide Y: Y1 and Y2 affinities of the complete series of analogues with single D-residue substitutions.EBI J Med Chem 36: 3802-8 (1994) Salk Institute 2D 3D TSV
8254607 36 Structure-based design of inhibitors of purine nucleoside phosphorylase. 3. 9-Arylmethyl derivatives of 9-deazaguanine substituted on the methylene group.EBI J Med Chem 36: 3771-83 (1994) BioCryst Pharmaceuticals Inc 2D 3D TSV
8254606 55 Cyclic GMP phosphodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline.EBI J Med Chem 36: 3765-70 (1994) Eisai Co., Ltd 2D 3D TSV
8254604 50 Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.EBI J Med Chem 36: 3748-56 (1994) University of Ferrara 2D 3D TSV
8254355 1 Isolation and Structure Elucidation of 34-Sulfatobastadin 13, an Inhibitor of the Endothelin A Receptor, from a Marine Sponge of the Genus IanthellaEBI J Nat Prod 56: 1613-1617 (1993) TBA 2D 3D TSV
8246246 13 A homologous series of permanently charged 1,4-dihydropyridines: novel probes designed to localize drug binding sites on ion channels.EBI J Med Chem 36: 3743-5 (1994) State University of New York 2D 3D TSV
8246245 26 (Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists.EBI J Med Chem 36: 3738-42 (1994) Merck Research Laboratories 2D 3D TSV
8246244 15 Synthesis and biological activity of some methoctramine-related tetraamines bearing a 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]-benzodiazepin-6-one moiety as antimuscarinics: a second generation of highly selective M2 muscarinic receptor antagonists.BDB J Med Chem 36: 3734-7 (1993) University of Bologna 2D 3D TSV
8246243 9 Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine.EBI J Med Chem 36: 3731-3 (1994) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
8246241 34 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.EBI J Med Chem 36: 3707-20 (1994) University of Pennsylvania 2D 3D TSV
8246239 84 Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI J Med Chem 36: 3693-9 (1994) Solvay Duphar B.V. 2D 3D TSV
8246237 30 HMG-CoA reductase inhibitors: design, synthesis, and biological activity of tetrahydroindazole-substituted 3,5-dihydroxy-6-heptenoic acid sodium salts.EBI J Med Chem 36: 3674-85 (1994) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
8246236 6 Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine.EBI J Med Chem 36: 3669-73 (1994) University of Minnesota 2D 3D TSV
8246234 13 Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.EBI J Med Chem 36: 3658-62 (1994) Glaxo Group Research Ltd. 2D 3D TSV
8246233 46 Inhibitors of cholesterol biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors.EBI J Med Chem 36: 3646-57 (1994) Glaxo Group Research Ltd. 2D 3D TSV
8246229 4 2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity.EBI J Med Chem 36: 3611-7 (1994) Polish Academy of Sciences 2D 3D TSV
8246228 11 Transformation of heterocyclic reversible monoamine oxidase-B inactivators into irreversible inactivators by N-methylation.EBI J Med Chem 36: 3606-10 (1994) Northwestern University 2D 3D TSV
8246227 57 Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates.EBI J Med Chem 36: 3595-605 (1994) Merck Research Laboratories 2D 3D TSV
8246226 89 Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.EBI J Med Chem 36: 3580-94 (1994) Ciba-Geigy Corporation 2D 3D TSV
8246225 20 Analysis of cocaine receptor site ligand binding by three-dimensional Voronoi site modeling approach.EBI J Med Chem 36: 3572-9 (1994) University of Michigan 2D 3D TSV
8246221 90 The synthesis and biochemical pharmacology of enantiomerically pure methylated oxotremorine derivatives.EBI J Med Chem 36: 3533-41 (1994) Medical Research Division of American Cyanamid Company 2D 3D TSV
8246219 16 Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses.EBI J Med Chem 36: 3503-10 (1994) Wellcome Research Laboratories 2D 3D TSV
8246171 54 [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus.BDB J Pharmacol Exp Ther 267: 961-70 (1993) Syntex Discovery Research 2D 3D TSV
8234299 8 Molecular cloning and characterization of the human A3 adenosine receptor.BDB Proc Natl Acad Sci U S A 90: 10365-9 (1993) Merck Research Laboratories 2D 3D TSV
8230139 165 Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases.EBI J Med Chem 36: 3472-80 (1993) Georgia Institute of Technology 2D 3D TSV
8230138 15 Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives.EBI J Med Chem 36: 3464-71 (1993) Wellcome Research Laboratories 2D 3D TSV
8230137 14 9-[(Phosphonoalkyl)benzyl]guanines. Multisubstrate analogue inhibitors of human erythrocyte purine nucleoside phosphorylase.EBI J Med Chem 36: 3455-63 (1993) Burroughs Wellcome Co. 2D 3D TSV
8230134 48 Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.EBI J Med Chem 36: 3437-43 (1993) Duquesne University 2D 3D TSV
8230132 7 New adenosine kinase inhibitors with oral antiinflammatory activity: synthesis and biological evaluation.EBI J Med Chem 36: 3424-30 (1993) University of California 2D 3D TSV
8230131 25 Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo.EBI J Med Chem 36: 3409-16 (1993) Medicinaregatan 2D 3D TSV
8230130 19 3-Nitro-3,4-dihydro-2(1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.EBI J Med Chem 36: 3397-408 (1993) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
8230127 52 A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists.EBI J Med Chem 36: 3371-80 (1993) Sanofi Recherche 2D 3D TSV
8230124 92 Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.EBI J Med Chem 36: 3341-9 (1993) Pharmazeutische Chemie 2D 3D TSV
8230123 7 Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist Leucettamine A and related analogues.EBI J Med Chem 36: 3333-40 (1993) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8230122 32 Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships.EBI J Med Chem 36: 3321-32 (1993) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8230121 15 Synthesis of structural analogs of leukotriene B4 and their receptor binding activity.EBI J Med Chem 36: 3308-20 (1993) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8230120 74 Inhibitors of acyl-Coa:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents.EBI J Med Chem 36: 3300-7 (1993) Warner-Lambert Company 2D 3D TSV
8230117 4 The crystal structure, absolute configuration, and phosphodiesterase inhibitory activity of (+)-1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)- 4-methoxyphenyl)-pyrrolidin-2-one.EBI J Med Chem 36: 3274-7 (1993) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8230115 16 Inhibitors of blood platelet cAMP phosphodiesterase. 4. Structural variation of the side-chain terminus of water-soluble 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives.EBI J Med Chem 36: 3251-64 (1993) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8230109 18 A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor.EBI J Med Chem 36: 3207-10 (1993) Merck Research Laboratories 2D 3D TSV
8230107 61 Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.EBI J Med Chem 36: 3188-96 (1993) University of Göteborg 2D 3D TSV
8230106 16 TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity.EBI J Med Chem 36: 3182-7 (1993) Clinical Research Institute of Montreal 2D 3D TSV
8230102 21 Synthesis of (R,S)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)amino]tetral in (trans-8-OH-PIPAT): a new 5-HT1A receptor ligand.EBI J Med Chem 36: 3161-5 (1993) University of Pennsylvania 2D 3D TSV
8230099 29 Synthesis and structure-activity relationships of a series of penicillin-derived HIV proteinase inhibitors containing a stereochemically unique peptide isostere.BDB J Med Chem 36: 3129-36 (1993) Glaxo Group Research Ltd. 2D 3D TSV
8230098 46 A series of penicillin derived C2-symmetric inhibitors of HIV-1 proteinase: synthesis, mode of interaction, and structure-activity relationships.BDB J Med Chem 36: 3120-8 (1993) Glaxo Group Research Ltd. 2D 3D TSV
8230097 7 A series of penicillin-derived C2-symmetric inhibitors of HIV-1 proteinase: structural and modeling studies.EBI J Med Chem 36: 3113-9 (1993) Glaxo Group Research Limited 2D 3D TSV
8230096 79 2,4-Diaminothieno[2,3-d]pyrimidine analogues of trimetrexate and piritrexim as potential inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.EBI J Med Chem 36: 3103-12 (1993) Harvard Medical School 2D 3D TSV
8230095 11 Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists.EBI J Med Chem 36: 3098-102 (1993) Sandoz Research Institute 2D 3D TSV
8230093 34 Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.EBI J Med Chem 36: 3077-86 (1993) Universit£ di Pisa 2D 3D TSV
8226867 41 Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.BDB J Biol Chem 268: 23422-6 (1993) Synaptic Pharmaceutical Corporation 2D 3D TSV
8224165 18 Cloning and characterization of the rat 5-HT5B receptor. Evidence that the 5-HT5B receptor couples to a G protein in mammalian cell membranes.BDB FEBS Lett 333: 25-31 (1993) University of Heidelberg ZMBH 2D 3D TSV
8201608 28 Molecular similarity, quantitative chirality, and QSAR for chiral drugs.EBI J Med Chem 37: 1727-32 (1994) University of Oxford 2D 3D TSV
8201607 50 2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.EBI J Med Chem 37: 1720-6 (1994) Universit£ di Camerino 2D 3D TSV
8201606 2 Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 2. 2-Phenoxy-, 2-(phenylthio)-, and 2-(phenylamino)alkanoic acid esters.EBI J Med Chem 37: 1712-9 (1994) Universit£ di Firenze 2D 3D TSV
8201605 3 Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters.EBI J Med Chem 37: 1704-11 (1994) Universit£ di Firenze 2D 3D TSV
8201604 96 Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues.EBI J Med Chem 37: 1696-703 (1994) Rhône-Poulenc Rorer 2D 3D TSV
8201603 5 Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin.EBI J Med Chem 37: 1689-95 (1994) University of Nottingham 2D 3D TSV
8201600 41 Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin--antiproliferative activity and 5-lipoxygenase inhibition.EBI J Med Chem 37: 1660-9 (1994) Universität Regensburg 2D 3D TSV
8201599 51 Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 7. Development of a series of substituted N-phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with enhanced hypocholesterolemic activity.EBI J Med Chem 37: 1652-9 (1994) Warner-Lambert Company 2D 3D TSV
8201598 15 Synthesis and carbonic anhydrase inhibitory activity of 4-substituted 2-thiophenesulfonamides.EBI J Med Chem 37: 1646-51 (1994) Allergan Inc 2D 3D TSV
8201597 10 Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.EBI J Med Chem 37: 1632-45 (1994) E. Merck 2D 3D TSV
8201595 12 Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.EBI J Med Chem 37: 1616-24 (1994) Eisai Company, Ltd 2D 3D TSV
8201592 27 [L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity.EBI J Med Chem 37: 1572-7 (1994) University of Arizona 2D 3D TSV
8201591 2 CCK-A-selective tetrapeptides containing lys(N epsilon)-amide residues: favorable in vivo and in vitro effects of N-methylation at the aspartyl residue.EBI J Med Chem 37: 1569-71 (1994) Abbott Laboratories 2D 3D TSV
8201590 20 Novel Asp32-replacement tetrapeptide analogues as potent and selective CCK-A agonists.EBI J Med Chem 37: 1562-8 (1994) Abbott Laboratories 2D 3D TSV
8201589 11 N-omega-fluoroalkyl analogs of (1R)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane (beta-CIT): radiotracers for positron emission tomography and single photon emission computed tomography imaging of dopamine transporters.EBI J Med Chem 37: 1558-61 (1994) Research Biochemicals International 2D 3D TSV
8201588 14 1,3-Diarylindan-2-carboxylic acids, potent and selective non-peptide endothelin receptor antagonists.EBI J Med Chem 37: 1553-7 (1994) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8201586 3 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long-lasting kappa antagonism in mice.EBI J Med Chem 37: 1547-9 (1994) University of Minnesota 2D 3D TSV
8190112 3 125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.BDB Mol Pharmacol 45: 978-82 (1994) Duke University 2D 3D TSV
8182712 14 Synthesis and characterization of radioiodinated N-(3-iodopropen-1-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropanes: potential dopamine reuptake site imaging agents.EBI J Med Chem 37: 1535-42 (1994) University of Tennessee at Knoxville 2D 3D TSV
8182711 39 Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.EBI J Med Chem 37: 1526-34 (1994) Eberhard-Karls-Universität Tübingen 2D 3D TSV
8182708 18 Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor.EBI J Med Chem 37: 1495-500 (1994) University of Minnesota 2D 3D TSV
8182702 14 Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors.EBI J Med Chem 37: 1439-45 (1994) University of Bonn 2D 3D TSV
8182701 39 Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies.EBI J Med Chem 37: 1427-38 (1994) Universit£ di Siena 2D 3D TSV
8182697 11 Synthesis and evaluation of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p- iodobenzamido]ethyl]piperazine (p-MPPI): a new iodinated 5-HT1A ligand.EBI J Med Chem 37: 1406-7 (1994) University of Pennsylvania 2D 3D TSV
8182696 10 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.EBI J Med Chem 37: 1402-5 (1994) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
8176711 18 Protein kinase C. Modeling of the binding site and prediction of binding constants.EBI J Med Chem 37: 1326-38 (1994) National Cancer Institute-Bethesda 2D 3D TSV
8176710 24 Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.EBI J Med Chem 37: 1320-5 (1994) CIFA Universidad de Navarra 2D 3D TSV
8176709 32 6-Alkyl- and 6-arylandrost-4-ene-3,17-diones as aromatase inhibitors. Synthesis and structure-activity relationships.EBI J Med Chem 37: 1312-9 (1994) Tohoku College of Pharmacy 2D 3D TSV
8176706 27 Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides: identification of 4-[[5-[((2R)-2-methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methyl indol- 3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a potent, orallEBI J Med Chem 37: 1282-97 (1994) Zeneca Pharmaceuticals Group 2D 3D TSV
8176705 25 Aromatase inhibitors. Syntheses and structure-activity studies of novel pyridyl-substituted indanones, indans, and tetralins.EBI J Med Chem 37: 1275-81 (1994) Universität des Saarlandes 2D 3D TSV
8176704 40 Synthesis of 2 beta-acyl-3 beta-aryl-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites in rat striatum and frontal cortex.EBI J Med Chem 37: 1262-8 (1994) Wake Forest University 2D 3D TSV
8176703 14 Design of orally active, non-peptidic inhibitors of human leukocyte elastase.EBI J Med Chem 37: 1259-61 (1994) Zeneca Pharmaceuticals Group 2D 3D TSV
8176701 4 Potent, selective, and systemically-available inhibitors of acyl-coenzyme A:cholesterol acyl transferase (ACAT).EBI J Med Chem 37: 1252-5 (1994) Pfizer Inc 2D 3D TSV
8176700 1 Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.EBI J Med Chem 37: 1233-51 (1994) Affymax Research Institute 2D 3D TSV
8176401 21 Anti-AIDS Agents, 11. Betulinic Acid and Platanic Acid as Anti-HIV Principles from Syzigium claviflorum, and the Anti-HIV Activity of Structurally Related TriterpenoidsEBI J Nat Prod 57: 243-247 (1994) TBA 2D 3D TSV
8171040 10 L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.BDB Proc Natl Acad Sci U S A 91: 4096-100 (1994) Merck Research Laboratories 2D 3D TSV
8169832 9 Characterization of a 5-hydroxytryptamine receptor in mouse neuroblastoma N18TG2 cells.BDB J Pharmacol Exp Ther 269: 246-55 (1994) University of Pennsylvania 2D 3D TSV
8164265 42 Secondary amine analogues of 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters and N-norcocaine exhibit enhanced affinity for serotonin and norepinephrine transporters.EBI J Med Chem 37: 1220-3 (1994) National Institute on Drug Abuse 2D 3D TSV
8164264 56 Structural features important for sigma 1 receptor binding.EBI J Med Chem 37: 1214-9 (1994) Virginia Commonwealth University 2D 3D TSV
8164262 38 Dibasic (amidinoaryl)propanoic acid derivatives as novel blood coagulation factor Xa inhibitors.EBI J Med Chem 37: 1200-7 (1994) Daiichi Pharmaceutical Company, Ltd. 2D 3D TSV
8164260 23 The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.BDB J Med Chem 37: 1177-88 (1994) Merck Research Laboratories 2D 3D TSV
8164259 44 Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.EBI J Med Chem 37: 1169-76 (1994) Duquesne University 2D 3D TSV
8164257 18 Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.EBI J Med Chem 37: 1153-64 (1994) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
8164256 6 Calculation of relative differences in the binding free energies of HIV1 protease inhibitors: a thermodynamic cycle perturbation approach.EBI J Med Chem 37: 1145-52 (1994) Agouron Pharmaceuticals Inc 2D 3D TSV
8164255 23 Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects.EBI J Med Chem 37: 1136-44 (1994) Clinical Research Institute of Montreal 2D 3D TSV
8164254 48 Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.EBI J Med Chem 37: 1126-35 (1994) School of Pharmacy 2D 3D TSV
8164252 18 Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics.EBI J Med Chem 37: 1109-14 (1994) Ciba-Geigy Corporation 2D 3D TSV
8164250 54 New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.EBI J Med Chem 37: 1070-83 (1994) University of Paris 2D 3D TSV
8164249 46 Application of the three-dimensional structures of protein target molecules in structure-based drug design.EBI J Med Chem 37: 1035-54 (1994) Abbott Laboratories 2D 3D TSV
8161940 9 Melatonin receptors: localization, molecular pharmacology and physiological significance.BDB Neurochem Int 24: 101-46 (1994) Rowett Research Institute 2D 3D TSV
8158166 2 Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.EBI J Nat Prod 57: 68-73 (1994) Virginia Polytechnic Institute and State University 2D 3D TSV
8158162 2 Verongamine, a Novel Bromotyrosine-Derived Histamine H3-Antagonist from the Marine Sponge Verongula giganteaEBI J Nat Prod 57: 175-177 (1994) TBA 2D 3D TSV
8155646 3 Selective activation of inhibitory G-protein alpha-subunits by partial agonists of the human 5-HT1A receptor.BDB Biochemistry 33: 4283-90 (1994) Medical University of South Carolina 2D 3D TSV
8151626 4 Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR.EBI J Med Chem 37: 988-98 (1994) DuPont Pharmaceuticals Company 2D 3D TSV
8151622 22 Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors.EBI J Med Chem 37: 950-62 (1994) H. Lundbeck A/S 2D 3D TSV
8151612 88 Dianilinophthalimides: potent and selective, ATP-competitive inhibitors of the EGF-receptor protein tyrosine kinase.EBI J Med Chem 37: 1015-27 (1994) Ciba-Geigy Limited 2D 3D TSV
8145238 4 The novel Ins(1,4,5)P3 analogue 3-amino-3-deoxy-Ins(1,4,5)P3: a pH-dependent Ins(1,4,5)P3 receptor partial agonist in SH-SY5Y neuroblastoma cells.EBI J Med Chem 37: 868-72 (1994) Mayo Foundation 2D 3D TSV
8145236 86 Structure-activity relationships in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions.EBI J Med Chem 37: 845-59 (1994) University of Paris 2D 3D TSV
8145235 9 Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives.EBI J Med Chem 37: 838-44 (1994) Wellcome Research Laboratories 2D 3D TSV
8145231 47 Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides.EBI J Med Chem 37: 804-10 (1994) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
8145228 15 Molecular modeling studies of aldose reductase inhibitors.EBI J Med Chem 37: 787-92 (1994) National Eye Institute 2D 3D TSV
8145226 45 Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation.EBI J Med Chem 37: 769-80 (1994) SmithKline Beecham Pharmaceuticals Research and Development 2D 3D TSV
8145225 2 Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor.EBI J Med Chem 37: 758-68 (1994) Upjohn Laboratories 2D 3D TSV
8145221 28 Pseudopeptide inhibitors of Ras farnesyl-protein transferase.EBI J Med Chem 37: 725-32 (1994) Merck Research Laboratories 2D 3D TSV
8145220 16 Second-generation benzodiazepine CCK-B antagonists. Development of subnanomolar analogs with selectivity and water solubility.EBI J Med Chem 37: 722-4 (1994) Merck Research Laboratories 2D 3D TSV
8145219 20 High-affinity and potent, water-soluble 5-amino-1,4-benzodiazepine CCKB/gastrin receptor antagonists containing a cationic solubilizing group.EBI J Med Chem 37: 719-21 (1994) Merck Sharp and Dohme Research Laboratories 2D 3D TSV
8145218 8 3-Alkoxybenzo[b]thiophene-2-carboxamides as inhibitors of neutrophil-endothelial cell adhesion.EBI J Med Chem 37: 717-8 (1994) Warner-Lambert Company 2D 3D TSV
8126709 49 Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.EBI J Med Chem 37: 689-95 (1994) Centre de Recherche Pierre Fabre Médicament 2D 3D TSV
8126708 113 Matrix metalloproteinase inhibitors containing a (carboxyalkyl)amino zinc ligand: modification of the P1 and P2' residues.EBI J Med Chem 37: 674-88 (1994) Glaxo Inc. Research Institute 2D 3D TSV
8126707 18 Haloperidol-based irreversible inhibitors of the HIV-1 and HIV-2 proteases.EBI J Med Chem 37: 665-73 (1994) University of California 2D 3D TSV
8126705 8 Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.EBI J Med Chem 37: 647-55 (1994) Universit£ di Perugia 2D 3D TSV
8126704 79 Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.EBI J Med Chem 37: 636-46 (1994) National Institute of Diabetes 2D 3D TSV
8126703 29 Tetrapeptide CCK-A agonists: effect of backbone N-methylations on in vitro and in vivo CCK activity.EBI J Med Chem 37: 630-5 (1994) Abbott Laboratories 2D 3D TSV
8126701 3 Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis.EBI J Med Chem 37: 616-24 (1994) Monash University 2D 3D TSV
8126697 30 Synthesis of naltrexone-derived delta-opioid antagonists. Role of conformation of the delta address moiety.EBI J Med Chem 37: 579-85 (1994) University of Minnesota 2D 3D TSV
8126695 35 1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo [2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperaz ine (L-368,899): an orally bioavailable, non-peptide oxytocin antagonist with potential utility for managing preterm labor.EBI J Med Chem 37: 565-71 (1994) Merck Research Laboratories 2D 3D TSV
8126693 2 Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity.EBI J Med Chem 37: 560-2 (1994) Warner-Lambert Company 2D 3D TSV
8126692 31 Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2.EBI J Med Chem 37: 557-9 (1994) Fisons plc 2D 3D TSV
8120872 2 Antiviral enantiomeric preference for 5'-noraristeromycin.EBI J Med Chem 37: 551-4 (1994) University of South Florida 2D 3D TSV
8120871 19 Pyrido[2,3-d]pyrimidine angiotensin II antagonists.EBI J Med Chem 37: 542-50 (1994) Wyeth-Ayerst Research 2D 3D TSV
8120869 10 Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.EBI J Med Chem 37: 512-8 (1994) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
8120868 22 N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors.EBI J Med Chem 37: 498-511 (1994) Ciba-Geigy Corporation 2D 3D TSV
8120867 70 Non-peptide renin inhibitors containing 2-(((3-phenylpropyl)phosphoryl)oxy)alkanoic acid moieties as P2-P3 replacements.EBI J Med Chem 37: 486-97 (1994) E. Merck Darmstadt 2D 3D TSV
8120866 54 Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.EBI J Med Chem 37: 476-85 (1994) SmithKline Beecham Pharmaceuticals Ltd 2D 3D TSV
8120863 47 Potent gastrin-releasing peptide (GRP) antagonists derived from GRP (19-27) with a C-terminal DPro psi [CH2NH]Phe-NH2 and N-terminal aromatic residues.EBI J Med Chem 37: 439-45 (1994) Burroughs Wellcome Company 2D 3D TSV
8114680 110 Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.BDB Mol Pharmacol 45: 330-4 (1994) University of Pennsylvania 2D 3D TSV
8105084 6 Non-amine based analogues of lavendustin A as protein-tyrosine kinase inhibitors.EBI J Med Chem 36: 3010-4 (1993) National Institutes of Health 2D 3D TSV
8102973 31 Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications.BDB Eur J Pharmacol 236: 483-6 (1993) Maryland Psychiatric Research Center 2D 3D TSV
8102785 91 Characterization of cloned somatostatin receptors SSTR4 and SSTR5.BDB Mol Pharmacol 44: 385-92 (1993) University of Pennsylvania 2D 3D TSV
8102651 53 Synthesis and pharmacological evaluation of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for a novel receptor with sigma-like neuromodulatory activity.EBI J Med Chem 36: 2542-51 (1993) University of North Carolina 2D 3D TSV
8101878 61 Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents.EBI J Med Chem 36: 2196-207 (1993) National Defense Medical Center 2D 3D TSV
8101877 80 New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.EBI J Med Chem 36: 2107-14 (1993) University of Liège 2D 3D TSV
8101876 28 Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.EBI J Med Chem 36: 2066-74 (1993) Upjohn Laboratories 2D 3D TSV
8100352 4 Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.BDB Mol Pharmacol 43: 894-901 (1993) University of Toronto 2D 3D TSV
8100350 137 Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides.BDB Mol Pharmacol 43: 838-44 (1993) University of Pennsylvania 2D 3D TSV
8100134 109 Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics.BDB Biochem Pharmacol 45: 2352-4 (1993) Mayo Foundation 2D 3D TSV
8099976 3 Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide.EBI J Med Chem 36: 1855-9 (1993) Cornell University 2D 3D TSV
8099194 2 Unique binding characteristics of antipsychotic agents interacting with human dopamine D2A, D2B, and D3 receptors.BDB Mol Pharmacol 43: 749-54 (1993) Astra Arcus AB 2D 3D TSV
8098771 19 Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.EBI J Med Chem 36: 1499-500 (1993) University of Pennsylvania 2D 3D TSV
8098066 39 Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites.EBI J Med Chem 36: 1188-93 (1993) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8097539 10 Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid.EBI J Med Chem 36: 1100-3 (1993) Oregon State University 2D 3D TSV
8097538 69 Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives.EBI J Med Chem 36: 1069-83 (1993) Upjohn Laboratories 2D 3D TSV
8097537 91 Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives.EBI J Med Chem 36: 1053-68 (1993) Upjohn Laboratories 2D 3D TSV
8097479 3 A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.BDB FEBS Lett 321: 279-84 (1993) University of Toronto 2D 3D TSV
8097160 35 Dopamine D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective.BDB Eur J Pharmacol 233: 173-4 (1993) University of Toronto 2D 3D TSV
8096548 27 Synthesis and dopamine antagonist activity of 2-thioether derivatives of the ergoline ring system.EBI J Med Chem 36: 912-8 (1993) Eli Lilly and Company 2D 3D TSV
8096246 70 Design and synthesis of highly potent and selective cyclic dynorphin A analogs. 2. New analogs.EBI J Med Chem 36: 750-7 (1993) University of Arizona 2D 3D TSV
8093908 15 Dibenz[b,e]oxepin derivatives: novel antiallergic agents possessing thromboxane A2 and histamine H1 dual antagonizing activity. 1.EBI J Med Chem 36: 417-20 (1993) Kyowa Hakko Kogyo Co., Ltd 2D 3D TSV
8093734 11 Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.EBI J Med Chem 36: 221-8 (1993) University of Pennsylvania 2D 3D TSV
8093723 20 Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties.BDB J Pharmacol Exp Ther 264: 158-65 (1993) Dainippon Pharmaceutical Co., Ltd 2D 3D TSV
8093626 13 o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents.EBI J Med Chem 36: 157-61 (1993) Università di Perugia 2D 3D TSV
8078486 15 Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.BDB Mol Pharmacol 46: 227-34 (1994) Eli Lilly and Company 2D 3D TSV
8071944 37 8-Azaxanthine derivatives as antagonists of adenosine receptors.EBI J Med Chem 37: 2970-5 (1994) Università di Camerino 2D 3D TSV
8071941 240 Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.EBI J Med Chem 37: 2930-41 (1994) Ligand Pharmaceuticals Inc 2D 3D TSV
8071940 32 Stereospecific synthesis of peptidyl alpha-keto amides as inhibitors of calpain.EBI J Med Chem 37: 2918-29 (1994) Alkermes, Inc. 2D 3D TSV
8071935 25 Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters.EBI J Med Chem 37: 2865-73 (1994) Research Triangle Institute 2D 3D TSV
8071934 30 Isothiocyanate-substituted kappa-selective opioid receptor ligands derived from N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl] phenylacetamide.EBI J Med Chem 37: 2856-64 (1994) University of Washington 2D 3D TSV
8071931 20 5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist.EBI J Med Chem 37: 2828-30 (1994) Medical College of Virginia/Virginia Commonwealth University 2D 3D TSV
8064808 202 Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity.EBI J Med Chem 37: 2808-24 (1994) Merck Research Laboratories 2D 3D TSV
8064804 3 Design, synthesis, and neurochemical evaluation of 2-amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.EBI J Med Chem 37: 2774-82 (1994) University of Toledo 2D 3D TSV
8064803 43 Structure-affinity relationship studies on 5-HT1A receptor ligands. 2. Heterobicyclic phenylpiperazines with N4-aralkyl substituents.EBI J Med Chem 37: 2761-73 (1994) Solvay Duphar Research Laboratories 2D 3D TSV
8064802 9 Structure-activity relationship studies of central nervous system agents. 13. 4-[3-(Benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)piperazine, a new putative 5-HT1A receptor antagonist, and its analogs.EBI J Med Chem 37: 2754-60 (1994) Polish Academy of Sciences 2D 3D TSV
8064801 232 Substituted (S)-phenylpiperidines and rigid congeners as preferential dopamine autoreceptor antagonists: synthesis and structure-activity relationships.EBI J Med Chem 37: 2735-53 (1994) University of G£teborg 2D 3D TSV
8064800 32 Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.EBI J Med Chem 37: 2721-34 (1994) Pfizer Inc 2D 3D TSV
8064799 16 Cyclic peptides with a phosphinic bond as potent inhibitors of a zinc bacterial collagenase.EBI J Med Chem 37: 2713-20 (1994) University of Athens 2D 3D TSV
8064798 44 Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors.EBI J Med Chem 37: 2704-12 (1994) University of South Florida 2D 3D TSV
8064797 118 Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.EBI J Med Chem 37: 2686-96 (1994) Vanderbilt University 2D 3D TSV
8064796 10 Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library.EBI J Med Chem 37: 2678-85 (1994) Chiron Corporation 2D 3D TSV
8064795 29 A novel nonpeptide HIV-1 protease inhibitor: elucidation of the binding mode and its application in the design of related analogs.BDB J Med Chem 37: 2664-77 (1994) Parke-Davis Pharmaceutical Research 2D 3D TSV
8064792 25 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular beta-type platelet-derived growth factor receptor tyrosine kinase.EBI J Med Chem 37: 2627-9 (1994) Sterling Winthrop Pharmaceuticals Research Division 2D 3D TSV
8064791 18 2,6-Disubstituted aryl carboxylic acids, leaving groups"par excellence" for benzisothiazolone inhibitors of human leukocyte elastase.EBI J Med Chem 37: 2623-6 (1994) Sterling Winthrop Pharmaceutical Research Division 2D 3D TSV
8064298 9 SB-202742, a novel beta-lactamase inhibitor isolated from Spondias mombin.EBI J Nat Prod 57: 654-7 (1994) SmithKline Beecham Pharmaceuticals 2D 3D TSV
8057300 28 Spirovesamicols: conformationally restricted analogs of 2-(4-phenylpiperidino)cyclohexanol (vesamicol, AH5183) as potential modulators of presynaptic cholinergic function.EBI J Med Chem 37: 2574-82 (1994) University of Minnesota 2D 3D TSV
8057299 66 Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp.EBI J Med Chem 37: 2537-51 (1994) Merck Research Laboratories 2D 3D TSV
8057297 24 5-[(3-nitropyrid-2-yl)amino]indoles: novel serotonin agonists with selectivity for the 5-HT1D receptor. Variation of the C3 substituent on the indole template leads to increased 5-HT1D receptor selectivity.EBI J Med Chem 37: 2509-12 (1994) Pfizer Inc 2D 3D TSV
8057296 4 Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.EBI J Med Chem 37: 2506-8 (1994) Merck Research Laboratories 2D 3D TSV
8057293 25 Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.EBI J Med Chem 37: 2477-80 (1994) Southern Research Institute 2D 3D TSV
8057292 83 Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives.EBI J Med Chem 37: 2461-76 (1994) Schering-Plough Research Institute 2D 3D TSV
8057289 17 Leukotriene B4 (LTB4) receptor antagonists: a series of (hydroxyphenyl)pyrazoles.EBI J Med Chem 37: 2411-20 (1994) Eli Lilly and Company 2D 3D TSV
8057287 77 Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 11. Structure-activity relationships of several series of compounds derived from N-(chlorocarbonyl) isocyanate.EBI J Med Chem 37: 2394-400 (1994) Warner-Lambert Company 2D 3D TSV
8057285 44 Synthesis and SAR studies of novel triazolopyrimidine derivatives as potent, orally active angiotensin II receptor antagonists.EBI J Med Chem 37: 2371-86 (1994) Carpibem 2D 3D TSV
8057283 126 6-Azasteroids: structure-activity relationships for inhibition of type 1 and 2 human 5 alpha-reductase and human adrenal 3 beta-hydroxy-delta 5-steroid dehydrogenase/3-keto-delta 5-steroid isomerase.EBI J Med Chem 37: 2352-60 (1994) Glaxo Inc. Research Institute 2D 3D TSV
8057282 2 Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription.EBI J Med Chem 37: 2343-51 (1994) Upjohn Laboratories 2D 3D TSV
8057281 100 Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3.EBI J Med Chem 37: 2334-42 (1994) Synaptic Pharmaceutical Corporation 2D 3D TSV
8057278 43 Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors.EBI J Med Chem 37: 2292-9 (1994) Takeda Chemical Industries, Ltd 2D 3D TSV
8057277 54 Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.EBI J Med Chem 37: 2285-91 (1994) National Institute on Drug Abuse-Intramural Research Program 2D 3D TSV
8057276 11 Crystal-structure-based design and synthesis of novel C-terminal inhibitors of HIV protease.BDB J Med Chem 37: 2274-84 (1994) Agouron Pharmaceuticals Inc 2D 3D TSV
8057274 18 Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders.EBI J Med Chem 37: 2262-5 (1994) Eli Lilly and Company 2D 3D TSV
8057273 9 Novel 3 alpha-(diphenylmethoxy)tropane analogs: potent dopamine uptake inhibitors without cocaine-like behavioral profiles.EBI J Med Chem 37: 2258-61 (1994) National Institutes of Health 2D 3D TSV
8057272 33 Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists.EBI J Med Chem 37: 2253-7 (1994) Glaxo Research and Development Ltd. 2D 3D TSV
8035432 5 Synthesis of substituted 3-carbamoylecgonine methyl ester analogues: irreversible and photoaffinity ligands for the cocaine receptor/dopamine transporter.EBI J Med Chem 37: 2249-52 (1994) University of Maryland 2D 3D TSV
8035428 30 Three-dimensional quantitative structure-activity relationship of human immunodeficiency virus (I) protease inhibitors. 2. Predictive power using limited exploration of alternate binding modes.EBI J Med Chem 37: 2206-15 (1994) Washington University 2D 3D TSV
8035427 51 Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase.EBI J Med Chem 37: 2198-205 (1994) Tohoku College of Pharmacy 2D 3D TSV
8035423 12 Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.EBI J Med Chem 37: 2167-74 (1994) Harvard Medical School 2D 3D TSV
8035422 17 S-(N-aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II.EBI J Med Chem 37: 2161-6 (1994) University of Maryland 2D 3D TSV
8035420 13 4-[(Alkylamino)methyl]furo[3,2-c]pyridines: a new series of selective kappa-receptor agonists.EBI J Med Chem 37: 2138-44 (1994) Glaxo Group Research Ltd. 2D 3D TSV
8035419 122 A new series of PDGF receptor tyrosine kinase inhibitors: 3-substituted quinoline derivatives.EBI J Med Chem 37: 2129-37 (1994) Rhône-Poulenc Rorer 2D 3D TSV
8035418 30 Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.EBI J Med Chem 37: 2125-8 (1994) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
8035417 23 Retro-binding tripeptide thrombin active-site inhibitors: discovery, synthesis, and molecular modeling.EBI J Med Chem 37: 2122-4 (1994) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
8035312 23 Ligand specificity of nicotinic acetylcholine receptors in rat spinal cord: studies with nicotine and cytisine.BDB J Pharmacol Exp Ther 270: 159-66 (1994) University of California 2D 3D TSV
8027993 4 Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid.EBI J Med Chem 37: 2112-5 (1994) Wellcome Research Laboratories 2D 3D TSV
8027992 49 Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity.EBI J Med Chem 37: 2106-11 (1994) Eisai Company, Ltd 2D 3D TSV
8027991 26 Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors.EBI J Med Chem 37: 2100-5 (1994) Harvard University 2D 3D TSV
8027990 25 Selective inhibitors of monoamine oxidase. 2. Arylamide SAR.EBI J Med Chem 37: 2085-9 (1994) Burroughs Wellcome Company 2D 3D TSV
8027989 28 Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives.EBI J Med Chem 37: 2079-84 (1994) Takeda Chemical Industries, Ltd 2D 3D TSV
8027988 37 New potent prolyl endopeptidase inhibitors: synthesis and structure-activity relationships of indan and tetralin derivatives and their analogues.EBI J Med Chem 37: 2071-8 (1994) Zeria Pharmaceutical Company, Ltd. 2D 3D TSV
8027987 1 N-substituted spirosuccinimide, spiropyridazine, spiroazetidine, and acetic acid aldose reductase inhibitors derived from isoquinoline-1,3-diones. 2.EBI J Med Chem 37: 2059-70 (1994) Wyeth-Ayerst Research Inc. 2D 3D TSV
8027986 30 Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.EBI J Med Chem 37: 2043-58 (1994) Wyeth-Ayerst Research 2D 3D TSV
8027985 66 Tyrosine kinase inhibitors. 3. Structure-activity relationships for inhibition of protein tyrosine kinases by nuclear-substituted derivatives of 2,2'-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide).BDB J Med Chem 37: 2033-42 (1994) University of Auckland 2D 3D TSV
8027984 93 3-(2-(3-Pyridinyl)thiazolidin-4-oyl)indoles, a novel series of platelet activating factor antagonists.EBI J Med Chem 37: 2011-32 (1994) Abbott Laboratories 2D 3D TSV
8027983 16 The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites.EBI J Med Chem 37: 2001-10 (1994) Organix Inc 2D 3D TSV
8027982 19 Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.EBI J Med Chem 37: 1996-2000 (1994) Pfizer Inc 2D 3D TSV
8027981 8 Synthesis and characterization of selective fluorescent ligands for the neurokinin NK2 receptor.EBI J Med Chem 37: 1991-5 (1994) Glaxo Institute for Molecular Biology 2D 3D TSV
8027978 50 Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.EBI J Med Chem 37: 1964-70 (1994) Albany Molecular Research, Inc. 2D 3D TSV
8027974 98 Influence of amine substituents on 5-HT2A versus 5-HT2C binding of phenylalkyl- and indolylalkylamines.EBI J Med Chem 37: 1929-35 (1994) Virginia Commonwealth University 2D 3D TSV
8022403 113 A binding site model and structure-activity relationships for the rat A3 adenosine receptor.BDB Mol Pharmacol 45: 1101-11 (1994) National Institute of Diabetes, Digestive and Kidney Diseases 2D 3D TSV
8021931 19 (6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.EBI J Med Chem 37: 1894-7 (1994) Merckle GmbH 2D 3D TSV
8021930 10 (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.EBI J Med Chem 37: 1889-93 (1994) University of Connecticut 2D 3D TSV
8021929 13 Synthesis and delta-opioid receptor antagonist activity of a naltrindole analogue with a regioisomeric indole moiety.EBI J Med Chem 37: 1886-8 (1994) University of Minnesota 2D 3D TSV
8021926 41 New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition.EBI J Med Chem 37: 1865-73 (1994) University of Paris 2D 3D TSV
8021923 27 A new series of photoactivatable and iodinatable linear vasopressin antagonists.EBI J Med Chem 37: 1841-9 (1994) UPR 9023 CNRS 2D 3D TSV
8021921 28 Dual angiotensin converting enzyme/thromboxane synthase inhibitors.EBI J Med Chem 37: 1823-32 (1994) Ciba-Geigy Corporation 2D 3D TSV
8021920 87 Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo.EBI J Med Chem 37: 1810-22 (1994) Parke-Davis Pharmaceutical Research 2D 3D TSV
8021917 84 Three-dimensional pharmacophores from binding data.EBI J Med Chem 37: 1769-78 (1994) Ciba-Geigy Corporation 2D 3D TSV
8021916 11 Aminodiol HIV protease inhibitors. 1. Design, synthesis, and preliminary SAR.BDB J Med Chem 37: 1758-68 (1994) Bristol-Myers Squibb Co. 2D 3D TSV
8021915 16 Newly discovered stereochemical requirements in the side-chain conformation of delta opioid agonists for recognizing opioid delta receptors.EBI J Med Chem 37: 1746-57 (1994) University of Arizona 2D 3D TSV
8021913 9 Synthesis and characterization of [125I]-N-(N-benzylpiperidin-4-yl)-4- iodobenzamide, a new sigma receptor radiopharmaceutical: high-affinity binding to MCF-7 breast tumor cells.EBI J Med Chem 37: 1737-9 (1994) George Washington University Medical Center 2D 3D TSV
8021912 7 2-Azetidinones as inhibitors of cholesterol absorption.EBI J Med Chem 37: 1733-6 (1994) Schering-Plough Research Institute 2D 3D TSV
8012715 38 GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.BDB Br J Pharmacol 111: 332-8 (1994) Glaxo Group Research Ltd. 2D 3D TSV

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