The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 26938274 |
52 |
Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis. |
University Of Bologna |
| 26819663 |
34 |
Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. |
Bristol-Myers Squibb Research And Development |
| 26288685 |
59 |
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys. |
Merck Research Laboratories |
| 26005536 |
92 |
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys. |
Merck Research Laboratories |
| 25711516 |
118 |
Novel pyridyl substituted 4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines as potent and selective aldosterone synthase inhibitors with improved in vitro metabolic stability. |
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 25591066 |
23 |
Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer. |
University Of Maryland |
| 25528333 |
32 |
Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase. |
Saarland University |
| 25462231 |
85 |
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11ß-hydroxylase. |
Universit£ |
| 24775307 |
42 |
Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. |
Viamet Pharmaceuticals |
| 24025069 |
36 |
Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors. |
University Of Padova |
| 23859149 |
76 |
Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases. |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 23713567 |
13 |
Systematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer. |
University Of Maryland |
| 23363058 |
68 |
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition. |
University Of Bologna |
| 22861193 |
60 |
Selective dual inhibitors of CYP19 and CYP11B2: targeting cardiovascular diseases hiding in the shadow of breast cancer. |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 22788843 |
46 |
Novel imidazol-1-ylmethyl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-ones as potent and selective CYP11B1 inhibitors for the treatment of Cushing's syndrome. |
Saarland University And Helmholtz Institute For Pharmaceutical Research Saarland (Hips) |
| 24900520 |
14 |
Substituted benzimidazole and imidazopyridine compounds useful as cyp17 modulators: patent highlight. |
TBA |
| 21316976 |
62 |
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors. |
Takeda Pharmaceutical |
| 20550118 |
69 |
Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. |
Saarland University |
| 20568782 |
16 |
Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation. |
University Of Bologna |
| 18061460 |
10 |
Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure. |
Saarland University |
| 15828836 |
13 |
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. |
University Of Maryland |
| 12773039 |
37 |
Three dimensional pharmacophore modeling of human CYP17 inhibitors. Potential agents for prostate cancer therapy. |
Accelrys |
| 11063622 |
60 |
Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2. |
University Of The Saarland |
| 9876107 |
9 |
The 16,17-double bond is needed for irreversible inhibition of human cytochrome p45017alpha by abiraterone (17-(3-pyridyl)androsta-5, 16-dien-3beta-ol) and related steroidal inhibitors. |
Institute Of Cancer Research |
| 21978946 |
45 |
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer. |
Takeda Pharmaceutical |
| 21429754 |
75 |
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors. |
Takeda Pharmaceutical |
| 21384875 |
67 |
Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives. |
Saarland University |
| 21341743 |
42 |
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-a-hydroxylase/C17-20 lyase. |
Universita` Degli Studi Di Bari Aldo Moro |
| 21129965 |
18 |
N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). |
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland |
| 20684610 |
73 |
Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. |
Saarland University |
| 19211174 |
15 |
Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls. |
Saarland University |
| 19049427 |
98 |
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. |
Saarland University |
| 18763754 |
57 |
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. |
Saarland University |
| 18674917 |
40 |
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge. |
Saarland University |
| 18672861 |
91 |
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity. |
Saarland University |
| 18024111 |
2 |
Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17. |
Saarland University |
| 11262078 |
19 |
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. |
University Of Bologna |
| 11087568 |
55 |
Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17). |
University Of The Saarland |
| 9526564 |
21 |
Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer. |
University Of Maryland |
| 9379450 |
51 |
17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha). |
University Of Maryland |
| 8863811 |
56 |
Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase. |
University Of Maryland |
| 8765515 |
37 |
3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer. |
Cancer Research Campaign Centre For Cancer Therapeutics |
| 8340925 |
18 |
Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering. |
Syntex Discovery Research |
| 7608911 |
35 |
Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. |
Institute Of Cancer Research |
| 7473546 |
61 |
Esters of 3-pyridylacetic acid that combine potent inhibition of 17 alpha-hydroxylase/C17,20-lyase (cytochrome P45017 alpha) with resistance to esterase hydrolysis. |
Crc Laboratory |
| 2016706 |
29 |
Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones. |
Ciba-Geigy |
| 1848629 |
42 |
gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands. |
Georgetown University |
| 18665584 |
32 |
Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. |
Bryn Mawr College |
| 18522384 |
11 |
Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives. |
Peking University |
| 15355974 |
6 |
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. |
The Scripps Research Institute |
| 18433114 |
28 |
4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. |
Vu University Amsterdam |
| 18419108 |
37 |
2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice. |
Biovitrum |
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