The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28259528 |
177 |
Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy. |
Washington University |
28259626 |
90 |
Perfluorinated hydroxamic acids are potent and selective inhibitors of HDAC-like enzymes from Pseudomonas aeruginosa. |
University Of Applied Sciences Darmstadt |
28213282 |
57 |
Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors. |
Chinese Academy Of Sciences |
28131715 |
10 |
Design, synthesis and evaluation of antiproliferative activity of melanoma-targeted histone deacetylase inhibitors. |
Georgia Institute Of Technology |
28523102 |
19 |
Design and Synthesis of Mercaptoacetamides as Potent, Selective, and Brain Permeable Histone Deacetylase 6 Inhibitors. |
University Of Illinois At Chicago |
28109947 |
424 |
Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors. |
Washington University |
28038324 |
48 |
Ring-opened tetrahydro-¿-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms. |
Taipei Medical University |
15149697 |
10 |
Thiol-based SAHA analogues as potent histone deacetylase inhibitors. |
Nagoya City University |
15109664 |
4 |
Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. |
The University Of Tokyo |
15109636 |
14 |
Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. |
University College London |
14643318 |
23 |
Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates. |
Nagoya City University |
14592473 |
35 |
Heterocyclic ketones as inhibitors of histone deacetylase. |
Abbott Laboratories |
12270175 |
13 |
Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC). |
Abbott Laboratories |
28337317 |
30 |
Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity. |
Wayne State University |
27541357 |
58 |
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines. |
National University Of Singapore |
28057407 |
76 |
Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase. |
Georgia Institute Of Technology |
27769671 |
66 |
Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy. |
Tsinghua University |
27344487 |
16 |
2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase. |
Taipei Medical University |
27717544 |
75 |
Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors. |
Integral Biosciences |
27650925 |
15 |
Synthesis of a selective HDAC6 inhibitor active in neuroblasts. |
University Of Geneva |
27606546 |
218 |
Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease. |
University Of Navarra |
27377864 |
55 |
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. |
Broad Institute Of Mit And Harvard |
27186676 |
186 |
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities. |
West China Hospital Of Sichuan University |
27142751 |
22 |
Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors. |
China Pharmaceutical University |
26937828 |
137 |
Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. |
Martin-Luther University Of Halle-Wittenberg |
26996372 |
10 |
Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay. |
Sungkyunkwan University |
26890116 |
30 |
Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity. |
University Of Milan |
27060764 |
30 |
Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity. |
Sungkyunkwan University |
26443078 |
108 |
Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer. |
Sichuan University |
26890114 |
56 |
Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy. |
Shanghai Institute Of Materia Medica |
26681404 |
40 |
Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors. |
Washington University |
26653328 |
67 |
Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors. |
Albert-Ludwigs-University Of Freiburg |
26705137 |
31 |
Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors. |
Universidade Federal De Alfenas |
26814680 |
71 |
Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy. |
Shenyang Pharmaceutical University |
26804233 |
38 |
Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation. |
Massachusetts General Hospital |
26706171 |
138 |
Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study. |
Shenyang Pharmaceutical University |
26689485 |
18 |
Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts. |
Orchid Chemicals & Pharmaceuticals |
26741358 |
56 |
Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC. |
China Pharmaceutical University |
26629860 |
58 |
Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors. |
European Institute Of Oncology |
26753813 |
22 |
Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. |
University Of Minnesota |
26639764 |
17 |
Synthesis and biological activity of diisothiocyanate-derived mercapturic acids. |
Wroclaw University Of Technology |
26475519 |
40 |
Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase. |
China Pharmaceutical University |
26241876 |
1 |
Triazine as a promising scaffold for its versatile biological behavior. |
Thapar University |
26481659 |
18 |
New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation. |
Ronzoni Institute For Chemical And Biochem. Research |
26376355 |
14 |
Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors. |
University Of Milan |
26331334 |
99 |
Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities. |
Guangzhou Institute Of Biomedicine And Health |
26086931 |
38 |
Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators. |
Shandong University |
26264503 |
46 |
Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia. |
University Of Minnesota |
26287310 |
87 |
Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit. |
University College London |
26211462 |
71 |
Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors. |
The Walter And Eliza Hall Institute Of Medical Research |
25637120 |
94 |
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). |
St. Jude Children'S Research Hospital |
22344701 |
30 |
Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589). |
Novartis Institutes For Biomedical Research |
25147612 |
25 |
Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties. |
University Of Florida |
25261927 |
80 |
Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors. |
The Walter And Eliza Hall Institute Of Medical Research |
26054247 |
48 |
Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole. |
Colorado State University |
26100440 |
6 |
Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors. |
Shandong University |
25993269 |
140 |
Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer. |
Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Wuhan University) |
26035239 |
1 |
Natural Product Primary Sulfonamides and Primary Sulfamates. |
Griffith University |
25974739 |
17 |
Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release. |
University Of California |
25815139 |
18 |
Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors. |
Fujian University Of Traditional Chinese Medicine |
25971769 |
25 |
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors. |
Methylgene |
25906087 |
14 |
Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor. |
Shandong University |
25905694 |
24 |
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. |
Istituto Ortopedico Rizzoli (Ior) |
25811792 |
32 |
Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization. |
Yonsei University |
25899338 |
37 |
Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids. |
Georgia Institute Of Technology |
25800646 |
40 |
Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2. |
Central South University |
25734520 |
104 |
Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors. |
Roche Innovation Center Shanghai |
25113875 |
14 |
Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity. |
Taipei Medical University |
25042254 |
7 |
Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines. |
H�Pital Kirchberg |
24999749 |
1 |
A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. |
University Of Oklahoma |
24972008 |
36 |
1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells. |
Sapienza University Of Rome |
24864038 |
112 |
Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors. |
Nippon Pharmaceutical Chemicals |
25563890 |
49 |
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite. |
R&D Sigma-Tau Industrie Farmaceutiche Riunite |
25462271 |
33 |
Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity. |
Shandong University |
25455492 |
22 |
Aurones as histone deacetylase inhibitors: identification of key features. |
University Of Geneva |
25454270 |
82 |
Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform. |
TBA |
25380299 |
61 |
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles. |
Technical University Of Denmark |
25240614 |
6 |
The antileishmanial activity of isoforms 6- and 8-selective histone deacetylase inhibitors. |
Georgia Institute Of Technology |
25238284 |
52 |
Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors. |
Roche Pharmaceutical Research And Early Development |
25233084 |
247 |
ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors. |
R&D Sigma-Tau Industrie Farmaceutiche Riunite |
25221651 |
12 |
Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity. |
University Of Bologna |
25218912 |
103 |
Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors. |
Chinese Academy Of Sciences |
25176189 |
7 |
Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death. |
Csir-Indian Institute Of Integrative Medicine |
24944733 |
101 |
Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors. |
Chinese National Center For Drug Screening |
24900884 |
14 |
Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues. |
Nagoya University |
24900838 |
30 |
Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. |
Merck Research Laboratories |
24766560 |
16 |
Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells. |
Taipei Medical University |
24588105 |
56 |
Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold. |
Universit£ |
24565573 |
35 |
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors. |
Universit£ |
24742384 |
90 |
Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors. |
Universit£ |
24694055 |
35 |
Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity. |
Shandong University |
24015327 |
42 |
Development of a chimeric c-Src kinase and HDAC inhibitor. |
University Of Michigan |
23570542 |
48 |
Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment. |
National Taiwan University |
23547652 |
27 |
3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition. |
Georgia Institute Of Technology |
23368884 |
80 |
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
Broad Institute Of Mit And Harvard |
23493449 |
8 |
Development of |
Shandong University |
23252603 |
35 |
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. |
Heinrich Heine Universit£T |
23089527 |
6 |
The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position. |
Wayne State University |
23116147 |
30 |
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries. |
Kyoto Prefectural University Of Medicine |
23061376 |
63 |
Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response. |
Roche R & D Center China |
23009203 |
39 |
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. |
University Of Illinois At Chicago |
24900543 |
27 |
Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases. |
TBA |
23021104 |
32 |
Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases. |
Graduate School Of Life Science And Systems Engineering |
22642300 |
160 |
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. |
Kyoto Prefectural University Of Medicine |
24900500 |
21 |
Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group. |
TBA |
22738629 |
47 |
CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design. |
Chinese Academy Of Sciences |
22439863 |
21 |
Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo. |
Taipei Medical University |
22280363 |
104 |
Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. |
Imperial College |
22541394 |
30 |
Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors. |
Guru Ghasidas University |
22260166 |
17 |
Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors. |
Georgia Institute Of Technology |
22165909 |
48 |
Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells. |
University Of Illinois At Chicago |
21984958 |
83 |
Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ¿F508-CFTR. |
TBA |
21874153 |
54 |
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. |
Broad Institute Of Harvard And Mit |
16408003 |
7 |
Diversity-oriented synthesis: exploring the intersections between chemistry and biology. |
Memorial Sloan-Kettering Cancer Center |
20472442 |
25 |
On the inhibition of histone deacetylase 8. |
University Of Notre Dame |
20452225 |
49 |
Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids. |
Mcgill University |
20392637 |
159 |
Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity. |
Takeda California |
19705846 |
100 |
Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides. |
The Scripps Research Institute |
19854643 |
8 |
Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide. |
Georgia Institute Of Technology |
18809328 |
64 |
Optimization of a series of potent and selective ketone histone deacetylase inhibitors. |
Irbm/Merck Research Laboratories |
18430569 |
26 |
Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. |
The Broad Institute Of Harvard And Mit |
18397826 |
18 |
Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. |
Waseda University |
18054239 |
54 |
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). |
University Of Freiburg |
18182289 |
127 |
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
Merck Research Laboratories |
18247554 |
134 |
Histone deacetylase inhibitors: from bench to clinic. |
Menarini Ricerche |
16987657 |
45 |
A series of novel, potent, and selective histone deacetylase inhibitors. |
Irbm/Merck Research Laboratories |
15454224 |
15 |
Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones. |
Crest Research Project |
14613312 |
106 |
Histone deacetylase inhibitors. |
Aton Pharma |
14584932 |
23 |
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A. |
Sapienza University Of Rome |
11206439 |
51 |
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2. |
Merck Research Laboratories |
11206438 |
48 |
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1. |
Merck Research Laboratories |
21417419 |
5 |
Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors. |
Dac |
22182579 |
110 |
Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases. |
University Of Applied Sciences |
21721525 |
8 |
In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA). |
Harvard Medical School |
21548582 |
57 |
Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. |
University Of Illinois At Chicago |
21889343 |
6 |
The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity. |
Wayne State University |
21793558 |
39 |
Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities. |
University Of Wisconsin-Milwaukee |
21714538 |
2 |
Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities. |
Shandong University |
21634430 |
218 |
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. |
S*Bio |
21712146 |
20 |
Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors. |
Taipei Medical University |
21723733 |
12 |
Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. |
Novartis Institutes For Biomedical Research |
21745740 |
10 |
Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors. |
East China Normal University |
21696956 |
243 |
A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold. |
Broad Institute Of Harvard And Mit |
21080647 |
27 |
Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor. |
Chroma Therapeutics |
21476600 |
43 |
Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities. |
Shandong University |
21417297 |
220 |
Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation. |
Universita` Degli Studi Di Siena |
21256006 |
11 |
Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors. |
Yonsei University |
21073160 |
143 |
Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity |
TBA |
21080629 |
153 |
Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity. |
University Of Regensburg |
20947351 |
24 |
Inhibitors selective for HDAC6 in enzymes and cells. |
The University Of Queensland |
20883026 |
3 |
An o-aminoanilide analogue of 1a,25-dihydroxyvitamin D(3) functions as a strong vitamin D receptor antagonist. |
Mcgill University |
19966789 |
40 |
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. |
The Scripps Research Institute |
20637529 |
15 |
Design and synthesis of novel isoxazole-based HDAC inhibitors. |
Università |
20669972 |
18 |
Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton. |
Georgia Institute Of Technology |
20223566 |
23 |
Inside HDAC with HDAC inhibitors. |
Universit£ |
20451378 |
107 |
Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. |
S*Bio |
20381359 |
17 |
Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222. |
Universit£ |
20205394 |
44 |
Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). |
Novartis Institutes For Biomedical Research |
20055418 |
78 |
Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents. |
University Of Illinois At Chicago |
20045316 |
18 |
Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length. |
Graduate School Of Life Science And Systems Engineering |
20143778 |
70 |
Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer. |
Curis |
19906529 |
22 |
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
Ortho-Biotech Oncology Research & Development |
19699639 |
58 |
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. |
Methylgene |
19888759 |
42 |
Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy. |
Istituto Di Ricerche Di Biologia Molecolare |
19359173 |
51 |
Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. |
Sigma-Tau Research And Development |
19441846 |
35 |
Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties. |
Irbm/Merck Research Laboratories |
19419863 |
58 |
Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity. |
University Of Illinois At Chicago |
19419205 |
28 |
Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors. |
Nagoya City University |
19410459 |
33 |
Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model. |
Irbm/Merck Research Laboratories |
19301902 |
104 |
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases. |
University Of Regensburg |
19285395 |
66 |
N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. |
R&D Sigma-Tau |
19272776 |
63 |
Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors. |
Methylgene |
19268585 |
30 |
Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2). |
Merck Research Laboratories |
19181524 |
46 |
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity. |
S*Bio |
19114304 |
44 |
SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103). |
Methylgene |
19111466 |
42 |
Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. |
Methylgene |
19084395 |
45 |
Sulfamides as novel histone deacetylase inhibitors. |
Methylgene |
18952417 |
50 |
Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors. |
Irbm-Merck Research Laboratories Rome |
18951790 |
109 |
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
Merck Research Laboratories |
18930398 |
117 |
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors. |
Irbm-Merck Research Laboratories Rome |
18672316 |
41 |
Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR. |
Institute Of Organic Synthesis |
18642892 |
76 |
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. |
University Of Illinois At Chicago |
18558669 |
119 |
Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles. |
Nycomed |
18060775 |
67 |
Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2). |
Merck Research Laboratories |
17900911 |
21 |
Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides. |
Graduate School Of Life Science And Systems Engineering |
17761416 |
53 |
The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors. |
Merck Research Laboratories |
17588744 |
18 |
Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors. |
The University Of Tokyo |
17555962 |
26 |
Design of novel histone deacetylase inhibitors. |
Merck Research Laboratories |
17539623 |
65 |
Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies. |
University Of Illinois At Chicago |
17346959 |
14 |
Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. |
Ithaca College |
16884291 |
12 |
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. |
Nagoya City University |
16137884 |
6 |
Design and synthesis of phthalimide-type histone deacetylase inhibitors. |
The University Of Tokyo Yayoi |
14698179 |
58 |
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group. |
The Scripps Research Institute |
14684344 |
49 |
(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. |
Methylgene |
29499113 |
77 |
Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status. |
Medical University Of South Carolina |
29019676 |
12 |
Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin. |
Entremed |
28416100 |
19 |
Synthesis and biological evaluation of largazole zinc-binding group analogs. |
Duke University |
28415009 |
51 |
Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study. |
Shandong University |
28395150 |
30 |
4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo. |
Taipei Medical University (Tmu) |
28391133 |
6 |
Design, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents. |
Beijing University Of Chemical Technology |
28885834 |
80 |
Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors. |
Second Military Medical University |
28336407 |
8 |
Development of N-hydroxycinnamamide-based HDAC inhibitors with improved HDAC inhibitory activity and in vitro antitumor activity. |
Shandong University |
28581289 |
20 |
Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines. |
Heinrich-Heine-Universit£T D£Sseldorf |
28574690 |
98 |
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups. |
Heinrich-Heine-Universit£T D£Sseldorf |
28196613 |
34 |
Potent and Selective EphA4 Agonists for the Treatment of ALS. |
Sanford Burnham Prebys Medical Discovery Institute |
27416889 |
35 |
Design, synthesis, and preliminary bioactivity evaluation of N(1) -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors. |
Shandong University |
1586393 |
43 |
Localization and function of the D3 dopamine receptor. |
U. 109 |
1554381 |
19 |
Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase. |
National Institutes Of Diabetes And Digestive And Kidney Diseases |
1501121 |
12 |
Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist. |
Sanofi Recherche |
282646 |
50 |
Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. |
TBA |
37098 |
14 |
Binding characteristics of 3H-prazosin to rat brain alpha-adrenergic receptors. |
TBA |
18291323 |
20 |
Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites. |
University Of Amsterdam |
20545322 |
6 |
Site-specific orthogonal labeling of the carboxy terminus of alpha-tubulin. |
Binghamton University |
17825569 |
48 |
The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines. |
Polish Academy Of Sciences |
12643924 |
7 |
Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors. |
Fujisawa Pharmaceutical |
15664859 |
16 |
Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics. |
University Of Michigan |
25019596 |
24 |
Quinolone-based HDAC inhibitors. |
Orchid Chemicals & Pharmaceuticals |
11472208 |
24 |
Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase. |
Sapienza University Of Rome |