The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28279849 |
38 |
Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X |
The University Of Sydney |
27548392 |
76 |
Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor. |
Janssen Research And Development |
27096039 |
20 |
Promising Therapeutic Potential of P2X7 Modulators. |
Therachem Research Medilab (India) |
26707399 |
45 |
Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists. |
Janssen Research And Development |
26099534 |
72 |
Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists. |
Janssen Research And Development |
26099538 |
8 |
Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human. |
University Of Leeds |
24900736 |
1 |
Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release. |
University Of Cambridge |
17482819 |
36 |
Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists. |
Abbott Laboratories |
21536435 |
90 |
Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists. |
Abbott Laboratories |
20934331 |
23 |
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor. |
Glaxosmithkline |
20673717 |
30 |
Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor. |
Glaxosmithkline |
20579878 |
26 |
Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor. |
Glaxosmithkline |
20399651 |
34 |
Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor. |
Glaxosmithkline |
19191585 |
143 |
Antagonists of the P2X(7) receptor. From lead identification to drug development. |
Astrazeneca |
19397270 |
122 |
Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain. |
Abbott Laboratories |
18438986 |
71 |
Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists. |
Abbott Laboratories |
18272366 |
74 |
Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists. |
Abbott Laboratories |
16759108 |
40 |
Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists. |
Abbott Laboratories |
21207957 |
163 |
Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor. |
University Of Bonn |
18272365 |
57 |
Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists. |
Abbott Bioresearch Center |
12213051 |
207 |
Purine and pyrimidine (P2) receptors as drug targets. |
National Institute Of Diabetes |
22078214 |
29 |
Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 2. |
Merck Research Laboratories |
21634377 |
73 |
Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. |
Amgen |
20634071 |
41 |
Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists. |
Glaxosmithkline |
21570840 |
44 |
Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 1. |
Merck Research Laboratories |
19540765 |
10 |
Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening. |
University Of Sydney |
18595695 |
43 |
Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists. |
Abbott Bioresearch Center |
17963373 |
36 |
Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors. |
Astrazeneca R&D Charnwood |
18294842 |
29 |
Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors. |
Merck Research Laboratories |
17559203 |
161 |
Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. |
The Scripps Research Institute |
15901723 |
13 |
NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis. Crystal structure of the adenylation domain and identification of novel inhibitors. |
India Central Drug Research Institute |
15561838 |
6 |
Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim. |
Oklahoma State University At Stillwater |
9154973 |
20 |
Tyrosine kinase inhibitors. 11. Soluble analogues of pyrrolo- and pyrazoloquinazolines as epidermal growth factor receptor inhibitors: synthesis, biological evaluation, and modeling of the mode of binding. |
University Of Auckland |
| 120 |
SYNTHESIS AND BIOLOGICAL EVALUATION OF CONFORMATIONALLY CONSTRAINED BICYCLIC AND TRICYCLIC BALANOL ANALOGUES AS INHIBITORS OF PROTEIN KINASE C. |
Sphinx Laboratories |