The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27236015 |
60 |
Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists. |
Daegu-Gyeongbuk Medical Innovation Foundation |
| 27176944 |
26 |
Design, synthesis and evaluation of 6-aryl-indenoisoquinolone derivatives dual targeting ERa and VEGFR-2 as anti-breast cancer agents. |
China Pharmaceutical University |
| 27407030 |
8 |
Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles. |
Trinity College |
| 26881908 |
13 |
De Novo Design at the Edge of Chaos. |
Swiss Federal Institute Of Technology (Eth) |
| 27185013 |
10 |
Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator. |
National Institute Of Health Sciences |
| 26905830 |
4 |
Identification of novel estrogen receptor (ER) agonists that have additional and complementary anti-cancer activities via ER-independent mechanism. |
Kyung Hee University |
| 26897089 |
39 |
Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists. |
Vitae Pharmaceuticals |
| 26896706 |
18 |
Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism. |
German University In Cairo |
| 26819673 |
55 |
Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat. |
Astrazeneca |
| 26681208 |
21 |
Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer. |
University Of Illinois At Chicago |
| 26764190 |
4 |
Peptide-based inhibitors of protein-protein interactions. |
Wroclaw University Of Technology |
| 26407012 |
80 |
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist. |
Astrazeneca |
| 25992880 |
90 |
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health. |
University Of Bath |
| 26183544 |
16 |
Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription. |
National Institute Of Health Sciences |
| 25993269 |
140 |
Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer. |
Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Wuhan University) |
| 26003343 |
10 |
Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators. |
National Institute Of Health Sciences |
| 25879485 |
60 |
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts. |
Seragon Pharmaceuticals |
| 25941555 |
75 |
Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists. |
Merck Research Laboratories |
| 25790336 |
93 |
Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators. |
Astrazeneca |
| 25751283 |
79 |
Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities. |
Purdue University |
| 25706100 |
65 |
2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists. |
TBA |
| 25559213 |
14 |
Highly selective salicylketoxime-based estrogen receptorß agonists display antiproliferative activities in a glioma model. |
Universit£ |
| 25121964 |
18 |
3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration. |
Novartis Institutes For Biomedical Research |
| 24980053 |
153 |
Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists. |
Bristol-Myers Squibb |
| 25369367 |
25 |
ß-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand. |
Trinity College |
| 25305688 |
41 |
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t. |
Phenex Pharmaceuticals |
| 24837157 |
2 |
Novel estrogen receptor (ER) modulators containing various hydrophobic bent-core structures. |
Tohoku Pharmaceutical University |
| 24805199 |
10 |
Influence of the length and positioning of the antiestrogenic side chain of endoxifen and 4-hydroxytamoxifen on gene activation and growth of estrogen receptor positive cancer cells. |
Georgetown University |
| 24755427 |
107 |
The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation. |
Astrazeneca |
| 24738581 |
81 |
Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist. |
Pfizer |
| 24630411 |
38 |
Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series. |
Merck Research Laboratories |
| 24708493 |
50 |
Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor. |
Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Wuhan University) |
| 24630694 |
11 |
Design and synthesis of silicon-containing steroid sulfatase inhibitors possessing pro-estrogen antagonistic character. |
The University Of Tokyo |
| 23586645 |
48 |
Thiophene-core estrogen receptor ligands having superagonist activity. |
Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Wuhan University) |
| 22280402 |
12 |
"True" antiandrogens-selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions: novel tools for prostate cancer. |
Trinity College |
| 20812681 |
24 |
Synthesis and biochemical characterization of a series of 17a-perfluoroalkylated estradiols as selective ligands for estrogen receptora. |
Charles University In Prague |
| 15686893 |
84 |
QSAR of estrogen receptor modulators: exploring selectivity requirements for ER(alpha) versus ER(beta) binding of tetrahydroisoquinoline derivatives using E-state and physicochemical parameters. |
University Of Calcutta |
| 14761193 |
11 |
Effects of C2-alkylation, N-alkylation, and N,N'-dialkylation on the stability and estrogen receptor interaction of (4R,5S)/(4S,5R)-4,5-bis(4-hydroxyphenyl)-2-imidazolines. |
Free University Of Berlin |
| 12139447 |
6 |
(4R,5S)/(4S,5R)-4,5-Bis(4-hydroxyphenyl)-2-imidazolines: ligands for the estrogen receptor with a novel binding mode. |
Free University Of Berlin |
| 23079530 |
27 |
Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides. |
Pfizer |
| 23043242 |
29 |
Influence of chlorine or fluorine substitution on the estrogenic properties of 1-alkyl-2,3,5-tris(4-hydroxyphenyl)-1H-pyrroles. |
Freie Universit£T Berlin |
| 22652053 |
6 |
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins. |
Rwth Aachen University |
| 22647217 |
57 |
Discovery and structure-activity analysis of selective estrogen receptor modulators via similarity-based virtual screening. |
East China University Of Science And Technology |
| 22582136 |
8 |
Hydrophobic Interactions Improve Selectivity to ERa for Ben-zothiophene SERMs. |
TBA |
| 22608920 |
4 |
Synthesis and evaluation of 11ß-(4-substituted phenyl) estradiol analogs: transition from estrogen receptor agonists to antagonists. |
Northeastern University |
| 22283328 |
28 |
Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide. |
Wuhan University |
| 22405286 |
10 |
Recent advances in the synthesis of raloxifene: a selective estrogen receptor modulator. |
Torrey Pines Institute For Molecular Studies |
| 21073190 |
135 |
Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists. |
Bristol-Myers Squibb |
| 21218783 |
117 |
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents. |
Johnson & Johnson Pharmaceutical Research And Development |
| 20875743 |
90 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity rela |
Pfizer |
| 20598555 |
3 |
2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation. |
Freie Universit£T Berlin |
| 20672822 |
108 |
Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. |
Pfizer |
| 20510622 |
142 |
Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists. |
Chinese Academy Of Sciences |
| 20553023 |
46 |
Discovery of potent ligands for estrogen receptor beta by structure-based virtual screening. |
East China University Of Science And Technology |
| 19863083 |
25 |
The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. |
Wyeth Research |
| 19836949 |
31 |
Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone. |
Institute Of Experimental Genetics |
| 19824648 |
19 |
Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core. |
Fin-00014 University Of Helsinki |
| 19321341 |
101 |
Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators. |
Bristol-Myers Squibb |
| 18722119 |
55 |
1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators. |
Wyeth Research |
| 15568770 |
4 |
Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens. |
Ghent University |
| 18318463 |
53 |
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348). |
Wyeth Research |
| 18269232 |
4 |
Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta. |
Universita Di Pisa |
| 17890084 |
86 |
Androstene-3,5-dienes as ER-beta selective SERMs. |
Merck Research Laboratories |
| 17448656 |
80 |
Bridged androstenediol analogs as ER-beta selective SERMs. |
Merck Research Laboratories |
| 17696335 |
8 |
Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons. |
University Of Southern California |
| 16309907 |
129 |
Androstenediol analogs as ER-beta-selective SERMs. |
Merck Research Laboratories |
| 16451049 |
4 |
A selective estrogen receptor modulator for the treatment of hot flushes. |
Eli Lilly |
| 15887952 |
26 |
Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases. |
University Of Southern California |
| 15293993 |
172 |
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes. |
Abbott Laboratories |
| 12672240 |
18 |
De novo design, synthesis, and evaluation of novel nonsteroidal phenanthrene ligands for the estrogen receptor. |
Signalgene |
| 12036351 |
31 |
Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists. |
Pfizer |
| 15081034 |
76 |
Synthesis and structure-activity relationship of 3-arylbenzoxazines as selective estrogen receptor beta agonists. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 15080982 |
122 |
Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists. |
Abbott Laboratories |
| 14643316 |
11 |
6-(2-adamantan-2-ylidene-hydroxybenzoxazole)-O-sulfamate: a potent non-steroidal irreversible inhibitor of human steroid sulfatase. |
Novartis Forschungsinstitut |
| 11459643 |
20 |
Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. |
Kyoto Pharmaceutical University |
| 10673099 |
34 |
Synthesis and estrogenic activities of novel 7-thiosubstituted estratriene derivatives. |
Wyeth-Ayerst Research |
| 22122563 |
34 |
Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptorß-selective ligands. |
University Of Illinois |
| 22061644 |
10 |
Investigation of the diastereomerism of dihydrobenzoxathiin SERMs for ER alpha by molecular modeling. |
Zhejiang University |
| 21937153 |
46 |
Recent progress in synthesis and bioactivity studies of indolizines. |
University Of Botswana |
| 21899328 |
244 |
Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791 |
Bristol-Myers Squibb |
| 21885279 |
31 |
Sulfonamides as selective oestrogen receptorß agonists. |
Pfizer |
| 21839641 |
2 |
DNA site-specific N3-adenine methylation targeted to estrogen receptor-positive cells. |
University Of North Carolina At Wilmington |
| 21481497 |
12 |
Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes. |
Universit£ |
| 21510635 |
6 |
Estrogenic activity of chemical constituents from Tephrosia candida. |
National Research Centre |
| 21381753 |
24 |
Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach. |
Technische Universiteit Eindhoven |
| 21247762 |
13 |
Synthesis, modification, and evaluation of (R)-de-O-methyllasiodiplodin and analogs as nonsteroidal antagonists of mineralocorticoid receptor. |
Chinese Academy Of Sciences |
| 20527892 |
7 |
Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs. |
Institute Of Theoretical Studies Ggmbh |
| 20813948 |
63 |
Spiroindolones, a potent compound class for the treatment of malaria. |
Swiss Tropical And Public Health Institute |
| 20659801 |
6 |
A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements. |
University Of Delaware |
| 16520733 |
8 |
Virtual and biomolecular screening converge on a selective agonist for GPR30. |
University Of New Mexico Health Sciences Center |
| 20669983 |
1 |
Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. |
Xavier University Of Louisiana |
| 20621492 |
6 |
Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha. |
Instituto PolitéCnico Nacional 2508 |
| 19561619 |
5 |
Bioactivity-guided mapping and navigation of chemical space. |
Institut FüR Molekulare Physiologie |
| 20638278 |
145 |
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. |
Phenex Pharmaceuticals |
| 20493686 |
10 |
New estrogenic compounds isolated from Broussonetia kazinoki. |
Sookmyung Women'S University |
| 20462217 |
17 |
Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery. |
Pfizer |
| 20430618 |
21 |
Optimisation of a pyrazole series of progesterone antagonists; Part 1. |
Pfizer |
| 20408553 |
27 |
Stereochemical requirements for the mineralocorticoid receptor antagonist activity of dihydropyridines. |
Pfizer |
| 20408532 |
3 |
Synthesis and evaluation of 17alpha-arylestradiols as ligands for estrogen receptor alpha and beta. |
Academy Of Sciences Of The Czech Republic |
| 20144545 |
19 |
LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators. |
The University Of Tokyo |
| 19705860 |
2 |
Isoflavonoids from Erythrina poeppigiana: evaluation of their binding affinity for the estrogen receptor. |
University Of Athens |
| 19366247 |
239 |
Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms. |
Johnson & Johnson Pharmaceutical Research & Development |
| 20031420 |
13 |
Click synthesis of estradiol-cyclodextrin conjugates as cell compartment selective estrogens. |
University Of Illinois At Chicago |
| 19954971 |
40 |
Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer. |
Sumitomo Chemical |
| 19286283 |
22 |
Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta. |
University Of Illinois |
| 19394116 |
14 |
Phenethyl pyridines with non-polar internal substituents as selective ligands for estrogen receptor beta. |
University Of Illinois |
| 19606870 |
53 |
Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs). |
Merck Research Laboratories |
| 19394231 |
2 |
Steroidal bivalent ligands for the estrogen receptor: design, synthesis, characterization and binding affinities. |
University Of Illinois At Urbana-Champaign |
| 19359182 |
2 |
Synthesis and evaluation of aryl-substituted diarylpropionitriles, selective ligands for estrogen receptor beta, as positron-emission tomographic imaging agents. |
Institute Of Radiological And Medical Sciences |
| 19356928 |
5 |
Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta. |
University Of Pittsburgh |
| 19239259 |
66 |
Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration. |
Pfizer |
| 19128016 |
11 |
Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. |
Universita Di Pisa |
| 19014882 |
3 |
Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity. |
University Of Illinois |
| 18976929 |
33 |
Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor. |
University Of Illinois At Urbana-Champaign |
| 18942824 |
2 |
Cobalt-alkyne complexes with imidazoline ligands as estrogenic carriers: synthesis and pharmacological investigations. |
Freie Universitat Berlin |
| 18835176 |
32 |
Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators. |
Trinity College |
| 18785725 |
277 |
Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding. |
University Of Illinois At Urbana-Champaign |
| 18760603 |
2 |
Promising core structure for nuclear receptor ligands: design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton. |
Tohoku Pharmaceutical University |
| 18722117 |
24 |
Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands. |
Glaxosmithkline |
| 18457385 |
41 |
Recent developments in fragment-based drug discovery. |
Astex Therapeutics |
| 16499324 |
2 |
Bioactive compounds from Peperomia pellucida. |
Chinese Academy Of Sciences |
| 16441086 |
4 |
Isoflavonoids with antiestrogenic activity from Millettia pachycarpa. |
Meijo University |
| 12502307 |
6 |
Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis. |
Université |
| 11141112 |
2 |
Three new arylobenzofurans from Onobrychis ebenoides and evaluation of their binding affinity for the estrogen receptor. |
University Of Athens |
| 18038968 |
26 |
(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor. |
Eli Lilly |
| 17918820 |
6 |
Target specific virtual screening: optimization of an estrogen receptor screening platform. |
Trinity College |
| 17902637 |
2 |
Estrogen receptor dependent inhibitors of NF-kappaB transcriptional activation-1 synthesis and biological evaluation of substituted 2-cyanopropanoic acid derivatives: pathway selective inhibitors of NF-kappaB, a potential treatment for rheumatoid arthritis. |
Wyeth Research |
| 17574424 |
28 |
Aza analogues of equol: novel ligands for estrogen receptor beta. |
Chinese Academy Of Sciences |
| 17560105 |
6 |
Bicyclo[2.2.2]octanes: close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators. |
University Of Illinois |
| 17482463 |
34 |
Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety. |
Eli Lilly |
| 17379515 |
9 |
Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates. |
Université |
| 17289385 |
50 |
Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha. |
Merck Research Laboratories |
| 17275315 |
1 |
Synthesis, structure, and estrogenic activity of 4-amino-3-(2-methylbenzyl)coumarins on human breast carcinoma cells. |
Equipe De Chimie ThéRapeutique |
| 17188490 |
24 |
ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives. |
Wyeth Research |
| 17049855 |
36 |
Estrogen receptor beta ligands: design and synthesis of new 2-phenyl-isoindole-1,3-diones. |
Wyeth Research |
| 16942012 |
56 |
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies. |
Irbm (Merck Research Laboratories Rome) |
| 16884312 |
3 |
Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes. |
Università |
| 16815012 |
20 |
Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands. |
Merck Research Laboratories |
| 16777408 |
89 |
Triazolo-tetrahydrofluorenones as selective estrogen receptor beta agonists. |
Merck Research Laboratories |
| 16730987 |
106 |
Estrogen receptor beta-subtype selective tetrahydrofluorenones: use of a fused pyrazole as a phenol bioisostere. |
Merck Research Laboratories |
| 16722623 |
12 |
Novel chromene-derived selective estrogen receptor modulators useful for alleviating hot flushes and vaginal dryness. |
Johnson & Johnson Pharmaceutical Research & Development |
| 16632357 |
89 |
The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands. |
Merck Research Laboratories |
| 16412638 |
126 |
6H-Benzo[c]chromen-6-one derivatives as selective ERbeta agonists. |
Merck Research Laboratories |
| 16300947 |
60 |
Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands. |
Wyeth Research |
| 16219463 |
34 |
Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. |
Pfizer |
| 16203138 |
26 |
Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms. |
Merck Research Laboratories |
| 16162002 |
51 |
Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. |
University Of California |
| 16098741 |
50 |
ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives. |
Wyeth Research |
| 15943471 |
140 |
ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. |
Wyeth Research |
| 15911283 |
62 |
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity. |
Merck Research Laboratories |
| 15911274 |
26 |
Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators. |
Chinese Academy Of Sciences |
| 15876535 |
46 |
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones. |
Wyeth Research |
| 15745820 |
42 |
Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs. |
Merck Research Laboratories |
| 15713417 |
40 |
Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor alpha and their bioactivities in vivo. |
Chinese Academy Of Sciences |
| 15713407 |
52 |
Structure-activity relationships and sub-type selectivity in an oxabicyclic estrogen receptor alpha/beta agonist scaffold. |
Ligand Pharmaceuticals |
| 15664843 |
14 |
Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans. |
Merck Research Laboratories |
| 15658860 |
14 |
Investigations on the effects of basic side chains on the hormonal profile of (4R,5S)/(4S,5R)-4,5-bis(4-hydroxyphenyl)-2-imidazolines. |
Free University Of Berlin |
| 15588074 |
43 |
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. |
Wyeth Research |
| 15582421 |
54 |
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers. |
Merck Research Laboratories |
| 15456246 |
251 |
Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. |
Wyeth Research |
| 15341953 |
46 |
7-Substituted 2-phenyl-benzofurans as ER beta selective ligands. |
Wyeth Research |
| 15225686 |
34 |
Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains. |
Merck Research Laboratories |
| 15225685 |
34 |
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains. |
Merck Research Laboratories |
| 15203156 |
20 |
Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins. |
Merck Research Laboratories |
| 15203155 |
26 |
Estrogen receptor ligands. Part 5: The SAR of dihydrobenzoxathiins containing modified basic side chains. |
Merck Research Laboratories |
| 15125925 |
110 |
Estrogen receptor ligands. Part 4: The SAR of the syn-dihydrobenzoxathiin SERAMs. |
Merck Research Laboratories |
| 15125923 |
60 |
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists. |
Pfizer |
| 15109649 |
44 |
Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs. |
Merck Research Laboratories |
| 15084115 |
32 |
Estrogen receptor ligands. II. Discovery of benzoxathiins as potent, selective estrogen receptor alpha modulators. |
Merck Research Laboratories |
| 15006374 |
54 |
Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity. |
Merck Research Laboratories |
| 14980690 |
12 |
Comparison of 2-phenylspiroindenes and 2-phenylspiroindenediones as estrogen receptor ligands--modeling and binding data don't agree! |
Merck Research Laboratories |
| 14643309 |
12 |
B-ring unsaturated estrogens: biological evaluation of 17alpha-Dihydroequilein and novel B-Nor-6-thiaequilenins as tissue selective estrogens. |
Eli Lilly |
| 14592514 |
8 |
Utility of boron clusters for drug design. Relation between estrogen receptor binding affinity and hydrophobicity of phenols bearing various types of carboranyl groups. |
Tohoku Pharmaceutical University |
| 12954056 |
14 |
Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process. |
Università |
| 12877579 |
6 |
Identification of"latent hits" in compound screening collections. |
Organon Laboratories |
| 12824043 |
40 |
Constrained phytoestrogens and analogues as ERbeta selective ligands. |
Wyeth Research |
| 12749898 |
11 |
A novel estrogen receptor ligand template. |
Bayer |
| 12749895 |
37 |
Tetrahydroquinoline-based selective estrogen receptor modulators (SERMs). |
Eli Lilly |
| 12668015 |
6 |
Synthesis and estrogen receptor binding affinities of 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-ones containing a basic side chain. |
The Ohio State University |
| 12646017 |
1 |
Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents. |
The Feinberg School Of Medicine Of Northwestern University |
| 12565955 |
33 |
2-Phenylspiroindenes: a novel class of selective estrogen receptor modulators (SERMs). |
Merck Research Laboratories |
| 12459017 |
132 |
A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta. |
Glaxosmithkline |
| 12431063 |
8 |
Investigations on estrogen receptor binding. The estrogenic, antiestrogenic, and cytotoxic properties of C2-alkyl-substituted 1,1-bis(4-hydroxyphenyl)-2-phenylethenes. |
Free University Of Berlin |
| 11965371 |
4 |
Synthesis of a novel fluorescent probe for estrogen receptor. |
Abbott Laboratories |
| 11708925 |
44 |
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. |
University Of Illinois |
| 11549460 |
16 |
Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha. |
University Of Illinois |
| 11459665 |
36 |
2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor. |
Glaxo Wellcome Research And Development |
| 11356100 |
15 |
Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens. |
Wyeth-Ayerst Research |
| 10447957 |
5 |
Carboxylic acid analogues of tamoxifen: (Z)-2-[p-(1, 2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine. Estrogen receptor affinity and estrogen antagonist effects in MCF-7 cells. |
University Of Georgia |
| 10229620 |
3 |
Potent estrogenic agonists bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore. |
University Of Tokyo |
| 27908539 |
20 |
Design, synthesis, molecular docking, anti-Proteus mirabilis and urease inhibition of new fluoroquinolone carboxylic acid derivatives. |
Minia University |
| 27250740 |
15 |
Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase. |
University Of California Irvine |
| 15123280 |
12 |
Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox. |
Triad Therapeutics |
| 15123247 |
29 |
Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. |
Cyclacel |
| 14700626 |
35 |
Inhibitor specificity via protein dynamics: insights from the design of antibacterial agents targeted against thymidylate synthase. |
UniversitÀ |
| 1712395 |
43 |
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones. |
Boehringer Ingelheim Pharmaceuticals |
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