The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
27100032 |
4 |
New N-phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATPase inhibitors of DNA gyrase. |
University Of Ljubljana |
27096044 |
30 |
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design. |
Cubist Pharmaceuticals |
26786695 |
12 |
Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB. |
Cubist Pharmaceuticals |
26949507 |
4 |
The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic-industrial partnership. |
University College London |
26487916 |
8 |
Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors. |
Cubist Pharmaceuticals |
26483137 |
2 |
Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria. |
Inter American University Of Puerto Rico |
26191374 |
4 |
Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV. |
Vertex Pharmaceuticals |
26098163 |
66 |
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site. |
University Of Ljubljana |
25137573 |
7 |
Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity. |
University Of Leeds |
24959892 |
152 |
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). |
Astrazeneca |
24629449 |
2 |
Computer-aided identification of novel 3,5-substituted rhodanine derivatives with activity against Staphylococcus aureus DNA gyrase. |
University Of The Sciences |
24098982 |
39 |
Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents. |
Astrazeneca R&D Boston |
23968485 |
67 |
Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity. |
Actelion Pharmaceuticals |
24900376 |
5 |
Combatting Drug-Resistant Bacteria with Gyrase and Topoisomerase IV Inhibitors: Patent Highlight. |
TBA |
22814212 |
10 |
Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV. |
Astrazeneca |
22041057 |
14 |
Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy. |
Astrazeneca R&D Boston |
18690678 |
66 |
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships. |
Vertex Pharmaceuticals |