101 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28231433	101	Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.	Pfizer
28236593	6	Kinase-independent phosphoramidate S1P	Cardiff University
27894870	141	A benzo[b]thiophene-based selective type 4 S1P receptor agonist.	Harvard Medical School
26985316	17	Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.	Bristol-Myers Squibb
27061986	128	Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.	Actelion Pharmaceuticals
27027817	50	Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.	Actelion Pharmaceuticals
26924461	45	Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.	Bristol-Myers Squibb Research And Development
27055941	19	Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).	Bristol-Myers Squibb Research And Development
27068143	12	Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists.	Peking Union Medical College And Chinese Academy Of Medical Sciences
26751273	92	Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.	Glaxosmithkline
26794040	24	Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.	Ono Pharmaceutical
26687487	69	Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists.	Boehringer Ingelheim Pharmaceuticals
26393276	2	Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists.	Glaxosmithkline
26384288	29	Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.	Ono Pharmaceutical
25699136	16	Novel Pyridyloxadiazole Agonists of Sphingosin-1-phosphate.	Dart Neuroscience
25746814	80	Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives.	Ono Pharmaceutical
25532755	46	Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.	Arena Pharmaceuticals
25072873	72	Discovery of oxazole and triazole derivatives as potent and selective S1P(1) agonists through pharmacophore-guided design.	Peking Union Medical College And Chinese Academy Of Medical Sciences
24909680	18	Synthesis and SAR studies of benzyl ether derivatives as potent orally active S1P1 agonists.	Daiichi Sankyo
25516794	71	(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.	Arena Pharmaceuticals
25516790	37	Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.	Arena Pharmaceuticals
25431977	100	Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.	Glaxosmithkline
25241927	64	Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists.	Boehringer Ingelheim Pharmaceuticals
24900670	47	Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.	Genomics Institute Of The Novartis Research Foundation
23245510	32	Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1.	Praecis Pharmaceuticals Incorporated (Currently Glaxosmithkline)
22429468	60	Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.	Glaxosmithkline
23141913	40	Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists.	RhôNe-Poulenc Rorer
23067318	17	An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.	Novartis Pharma
22500954	99	Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).	Glaxosmithkline
22633692	51	Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease.	Arena Pharmaceuticals
24900374	34	Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.	TBA
22583616	67	Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists.	Glaxosmithkline
22487179	50	Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists.	Daiichi Sankyo
22214363	78	Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists.	Exelixis
24900263	18	4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.	TBA
22386243	83	Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor.	Glaxosmithkline
17379528	30	Synthesis and SAR studies of a novel class of S1P1 receptor antagonists.	Sankyo
17070046	24	Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.	Universit£
15982878	45	Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.	University Of Virginia
15341948	25	Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists.	University Of Virginia
15341940	109	Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.	Merck Research Laboratories
15177460	135	The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.	Merck Research Laboratories
14505636	51	Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists.	University Of Virginia
22405291	11	Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.	Daiichi Sankyo
22264485	64	Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.	Daiichi Sankyo
22257889	52	Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.	Amgen
24900318	8	Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist.	TBA
22104144	37	Quinolinone-based agonists of S1P¿?: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.	Amgen
22100314	38	Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P¿? agonists with in vivo lymphocyte-depleting activity.	Amgen
22153936	26	Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.	Ono Pharmaceutical
22119341	10	Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.	Institute Of Pharmacology & Toxicology
21852130	69	Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P¿? agonists.	Arena Pharmaceuticals
21838322	37	Discovery of a brain-penetrant S1P3-sparing direct agonist of the S1P¿? and S1P5 receptors efficacious at low oral dose.	Glaxosmithkline
21783362	17	SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor.	The Scripps Research Institute
21641216	28	Discovery of S1P agonists with a dihydronaphthalene scaffold.	Ono Pharmaceutical
21570287	53	Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.	The Scripps Research Institute
21295477	24	Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-ß-alanine moiety.	Ono Pharmaceutical
24900287	47	Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)	TBA
24900288	32	Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5	TBA
24900286	65	Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS	TBA
20446681	158	2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.	Actelion Pharmaceuticals
20337461	40	Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.	Mitsubishi Tanabe Pharma
20304639	54	Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.	Praecis Pharmaceuticals
20188554	46	Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.	Biogen Idec
20153186	44	S1P receptor mediated activity of FTY720 phosphate mimics.	Novartis Institutes For Biomedical Research
20149651	73	Discovery of a novel series of potent S1P1 agonists.	Merck Serono
19954976	60	Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.	Novartis Institutes For Biomedical Research
19282175	88	Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.	Praecis Pharmaceuticals
19081720	36	Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.	Praecis Pharmaceuticals
17266196	18	Pharmacophore-based design of sphingosine 1-phosphate-3 receptor antagonists that include a 3,4-dialkoxybenzophenone scaffold.	Toa Eiyo
17113298	45	Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.	University Of Virginia
16697189	131	Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.	Merck Research Laboratories
16682185	76	Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.	Merck
16621543	59	2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.	Merck Research Laboratories
16580205	63	2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.	Merck Research Laboratories
16078855	20	Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.	Novartis Institutes For Biomedical Research
15615513	129	A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.	Merck Research Laboratories
15177461	140	Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.	Merck Research Laboratories
15149705	60	Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.	Merck Research Laboratories
28069264	15	Synthesis, in vitro ß-glucuronidase inhibitory activity and in silico studies of novel (E)-4-Aryl-2-(2-(pyren-1-ylmethylene)hydrazinyl)thiazoles.	University Of Karachi
28165218	5	Perfluoro-tert-butyl Homoserine Is a Helix-Promoting, Highly Fluorinated, NMR-Sensitive Aliphatic Amino Acid: Detection of the Estrogen Receptor·Coactivator Protein-Protein Interaction by (19)F NMR.	University Of Delaware
5353111	10	Nature of the active site of a subunit of the first component of human complement.	Michigan State University
23275348	8	The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.	John Innes Centre
19053776	9	Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.	Consiglio Nazionale Delle Ricerche
19072053	35	Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors.	University Of Southern California
17884497	14	The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors.	Glaxosmithkline
1732526	101	Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.	Roche Products