70 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28692292	73	Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.	Sichuan University And Collaborative Innovation Center For Biotherapy
28279847	40	Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors.	Carna Biosciences
28206758	76	Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma.	Qimr Berghofer Medical Research Institute
27789138	355	Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors.	Abbvie Bioresearch Center
28039836	41	Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities.	East China Normal University
27940419	31	Novel CLK1 inhibitors based on N-aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands.	Comenius University In Bratislava
28017532	140	Discovery of triazole aminopyrazines as a highly potent and selective series of PI3Kd inhibitors.	Astrazeneca
27816515	143	Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.	Merck
27676471	200	Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors.	Cnrs
27474927	76	Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors.	Paris-Sud University
26985319	36	Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo.	Astrazeneca
27019296	52	Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.	Universit£
26896709	113	Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2.	Saarland University
26762835	342	Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).	Icahn School Of Medicine At Mount Sinai
26142492	27	Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors.	Cnrs Umr 7311
26048785	15	Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents.	India Academy Of Scientific & Innovative Research (Acsir)
25730262	195	10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.	Technische Universit£T Braunschweig
25738750	84	Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.	Astrazeneca
25248682	18	Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors.	Universit£
25221649	47	Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4.	Saarland University
24798019	30	Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors.	Institut De Chimie Des Substances Naturelles
24973661	10	9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.	Technische Universit£T Braunschweig
24188002	41	Development of DANDYs, new 3,5-diaryl-7-azaindoles demonstrating potent DYRK1A kinase inhibitory activity.	Upr 2301, Cnrs
24239188	63	Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.	Hoffmann-La Roche
23454515	66	Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.	Universit£
23981088	10	Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.	Nagasaki University
23642479	277	Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.	University Of Kansas Specialized Chemistry Center
24900699	54	Tricyclic Pyrimidines As Inhibitors of DYRK1A/DYRK1B As Potential Treatment for Down's Syndrome or Alzheimer's Disease.	Dart Neuroscience
23237976	162	Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.	Universit£
23218601	100	Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.	University Of Paris
22982525	32	Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors.	TBA
23103095	125	Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors.	Abbott Laboratories
23083119	57	Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.	Universit£
22998443	69	Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.	Cnrs
22770529	7	Novel trisubstituted harmine derivatives with original in vitro anticancer activity.	University Of Namur (Fundp)
21413800	56	A one-pot synthesis and biological activity of ageladine A and analogues.	Macquarie University
22335895	41	Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.	Harvard Medical School
17850214	99	The selectivity of protein kinase inhibitors: a further update.	University Of Dundee
18271552	4	Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety.	Leibniz-Institute For Natural Product Research And Infection Biology
18077363	314	A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.	University Of Oxford
17935989	146	Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.	Abbott Laboratories
22154664	7	Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bioassay.	The Second Military Medical University
22037378	31824	Comprehensive analysis of kinase inhibitor selectivity.	Ambit Biosciences
21080703	20	A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.	Imperial College
21450467	261	Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk).	National Human Genome Research Institute
21391610	139	Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors.	Vertex Pharmaceuticals
21353776	5	8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment.	University Of Padova
21035334	55	Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors.	Martin-Luther-University Halle-Wittenberg
19654408	2521	AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).	Ambit Biosciences
20346655	117	Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.	Abbott Laboratories
20166671	85	Selectively nonselective kinase inhibition: striking the right balance.	Schering-Plough
19926477	100	2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.	Abbott Laboratories
19837585	46	Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).	National Human Genome Research Institute
19877644	6	Identification of death-associated protein kinases inhibitors using structure-based virtual screening.	Pharmadesign
19615897	28	Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors.	Laboratorio De Radicales Libres Y QuÍMica Computacional (Iqog, Csic)
19282176	36	QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors.	Inje University
18799313	20	Identification of novel protein kinase CK1 delta (CK1delta) inhibitors through structure-based virtual screening.	Università
16610779	10	Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.	Università
15955699	33	(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors.	Glaxosmithkline
15566294	5	Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.	Università
28487075	36	N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1?/? inhibitors: Synthesis, biological evaluation and molecular modeling studies.	Rajiv Gandhi Proudyogiki Vishwavidyalaya
28561591	20	Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.	German University In Cairo
19119014	12	Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.	Universita Degli Studi Di Firenze
12244092	12	Structural basis for Chk1 inhibition by UCN-01.	Glaxosmithkline
18540668	56	Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase.	Boehringer Ingelheim Pharmaceuticals