135 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27377864	55	Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.	Broad Institute Of Mit And Harvard
27186676	186	Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.	West China Hospital Of Sichuan University
27142751	22	Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.	China Pharmaceutical University
26996372	10	Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay.	Sungkyunkwan University
26890116	30	Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.	University Of Milan
26819662	13	Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.	Biofocus
27060764	30	Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.	Sungkyunkwan University
26443078	108	Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.	Sichuan University
26890114	56	Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.	Shanghai Institute Of Materia Medica
26814680	71	Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.	Shenyang Pharmaceutical University
26706171	138	Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.	Shenyang Pharmaceutical University
26689485	18	Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.	Orchid Chemicals & Pharmaceuticals
26741358	56	Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC.	China Pharmaceutical University
26629860	58	Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.	European Institute Of Oncology
26753813	22	Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.	University Of Minnesota
26639764	17	Synthesis and biological activity of diisothiocyanate-derived mercapturic acids.	Wroclaw University Of Technology
26475519	40	Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.	China Pharmaceutical University
26241876	1	Triazine as a promising scaffold for its versatile biological behavior.	Thapar University
26331334	99	Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.	Guangzhou Institute Of Biomedicine And Health
26086931	38	Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.	Shandong University
26264503	46	Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.	University Of Minnesota
26287310	87	Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.	University College London
25637120	94	Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).	St. Jude Children'S Research Hospital
22344701	30	Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).	Novartis Institutes For Biomedical Research
25147612	25	Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.	University Of Florida
26035239	1	Natural Product Primary Sulfonamides and Primary Sulfamates.	Griffith University
25906087	14	Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.	Shandong University
25905694	24	Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.	Istituto Ortopedico Rizzoli (Ior)
25811792	32	Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization.	Yonsei University
25800646	40	Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2.	Central South University
25113875	14	Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.	Taipei Medical University
25022972	24	Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.	University Of Rajshahi
24999749	1	A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.	University Of Oklahoma
24997578	41	Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.	University Of Rajshahi
24972008	36	1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.	Sapienza University Of Rome
24864038	112	Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.	Nippon Pharmaceutical Chemicals
25462271	33	Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.	Shandong University
25455492	22	Aurones as histone deacetylase inhibitors: identification of key features.	University Of Geneva
25454270	82	Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.	TBA
25238284	52	Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.	Roche Pharmaceutical Research And Early Development
25233084	247	ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.	R&D Sigma-Tau Industrie Farmaceutiche Riunite
25221651	12	Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.	University Of Bologna
25218912	103	Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.	Chinese Academy Of Sciences
25176189	7	Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death.	Csir-Indian Institute Of Integrative Medicine
24900838	30	Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor.	Merck Research Laboratories
24588105	56	Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.	Universit£
24565573	35	4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.	Universit£
24742384	90	Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.	Universit£
24694055	35	Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.	Shandong University
17196388	12	Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans.	Sapienza University Of Rome
24015327	42	Development of a chimeric c-Src kinase and HDAC inhibitor.	University Of Michigan
23368884	80	Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.	Broad Institute Of Mit And Harvard
23252603	35	Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.	Heinrich Heine Universit£T
23116147	30	Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.	Kyoto Prefectural University Of Medicine
23061376	63	Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.	Roche R & D Center China
23009203	39	Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.	University Of Illinois At Chicago
23021104	32	Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.	Graduate School Of Life Science And Systems Engineering
22642300	160	Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.	Kyoto Prefectural University Of Medicine
22541394	30	Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.	Guru Ghasidas University
21984958	83	Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ¿F508-CFTR.	TBA
21874153	54	Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.	Broad Institute Of Harvard And Mit
18809328	64	Optimization of a series of potent and selective ketone histone deacetylase inhibitors.	Irbm/Merck Research Laboratories
17956988	14	Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.	Istituto Di Ricerche Di Biologia Molecolare
18397826	18	Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.	Waseda University
18381238	4	Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.	Sapienza University Of Rome
18182289	127	Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).	Merck Research Laboratories
18247554	134	Histone deacetylase inhibitors: from bench to clinic.	Menarini Ricerche
16987657	45	A series of novel, potent, and selective histone deacetylase inhibitors.	Irbm/Merck Research Laboratories
15454224	15	Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.	Crest Research Project
14613312	106	Histone deacetylase inhibitors.	Aton Pharma
14584932	23	Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.	Sapienza University Of Rome
21417419	5	Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.	Dac
21548582	57	Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.	University Of Illinois At Chicago
21875805	5	Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8.	Drexel University
21793558	39	Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.	University Of Wisconsin-Milwaukee
21634430	218	Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.	S*Bio
21712146	20	Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.	Taipei Medical University
21696956	243	A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.	Broad Institute Of Harvard And Mit
21417297	220	Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.	Universita` Degli Studi Di Siena
21256006	11	Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.	Yonsei University
21073160	143	Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity	TBA
19966789	40	Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.	The Scripps Research Institute
20491440	12	Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.	Universidade De Vigo
20451378	107	Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.	S*Bio
20381359	17	Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.	Universit£
20205394	44	Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).	Novartis Institutes For Biomedical Research
20045316	18	Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.	Graduate School Of Life Science And Systems Engineering
20143778	70	Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.	Curis
19906529	22	Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.	Ortho-Biotech Oncology Research & Development
19822426	4	Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group.	China Pharmaceutical University
19699639	58	Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.	Methylgene
19359173	51	Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.	Sigma-Tau Research And Development
19410459	33	Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.	Irbm/Merck Research Laboratories
19285395	66	N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.	R&D Sigma-Tau
19268585	30	Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).	Merck Research Laboratories
19181524	46	N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.	S*Bio
18951790	109	SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).	Merck Research Laboratories
18930398	117	2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.	Irbm-Merck Research Laboratories Rome
18701301	38	Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents.	China Pharmaceutical University
18672316	41	Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.	Institute Of Organic Synthesis
18060775	67	Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).	Merck Research Laboratories
17900911	21	Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.	Graduate School Of Life Science And Systems Engineering
17881232	42	Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.	Graduate School Of Life Science And Systems Engineering
17588744	18	Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.	The University Of Tokyo
17447750	4	Bispyridinium dienes: histone deacetylase inhibitors with selective activities.	Universidade De Vigo
16884291	12	Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.	Nagoya City University
16137884	6	Design and synthesis of phthalimide-type histone deacetylase inhibitors.	The University Of Tokyo Yayoi
27416889	35	Design, synthesis, and preliminary bioactivity evaluation of N(1) -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors.	Shandong University
14500743	60	Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.	The Danish University Of Pharmaceutical Sciences
1586393	43	Localization and function of the D3 dopamine receptor.	U. 109
1554381	19	Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.	National Institutes Of Diabetes And Digestive And Kidney Diseases
1501121	12	Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist.	Sanofi Recherche
282646	50	Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.	TBA
15566305	14	Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel.	Merck Research Laboratories
25019596	24	Quinolone-based HDAC inhibitors.	Orchid Chemicals & Pharmaceuticals