The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
15149697 |
10 |
Thiol-based SAHA analogues as potent histone deacetylase inhibitors. |
Nagoya City University |
15109664 |
4 |
Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. |
The University Of Tokyo |
15109636 |
14 |
Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides. |
University College London |
14643318 |
23 |
Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates. |
Nagoya City University |
14592473 |
35 |
Heterocyclic ketones as inhibitors of histone deacetylase. |
Abbott Laboratories |
12270175 |
13 |
Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC). |
Abbott Laboratories |
27541357 |
58 |
Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines. |
National University Of Singapore |
27186676 |
186 |
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities. |
West China Hospital Of Sichuan University |
27142751 |
22 |
Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors. |
China Pharmaceutical University |
26996372 |
10 |
Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay. |
Sungkyunkwan University |
26890116 |
30 |
Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity. |
University Of Milan |
27060764 |
30 |
Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity. |
Sungkyunkwan University |
27055940 |
2 |
A sub-milligram-synthesis protocol for in vitro screening of HDAC11 inhibitors. |
Nankai University |
26443078 |
108 |
Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer. |
Sichuan University |
26814680 |
71 |
Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy. |
Shenyang Pharmaceutical University |
26706171 |
138 |
Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study. |
Shenyang Pharmaceutical University |
26689485 |
18 |
Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts. |
Orchid Chemicals & Pharmaceuticals |
26741358 |
56 |
Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC. |
China Pharmaceutical University |
26629860 |
58 |
Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors. |
European Institute Of Oncology |
26753813 |
22 |
Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. |
University Of Minnesota |
26639764 |
17 |
Synthesis and biological activity of diisothiocyanate-derived mercapturic acids. |
Wroclaw University Of Technology |
26475519 |
40 |
Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase. |
China Pharmaceutical University |
26241876 |
1 |
Triazine as a promising scaffold for its versatile biological behavior. |
Thapar University |
26331334 |
99 |
Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities. |
Guangzhou Institute Of Biomedicine And Health |
26264503 |
46 |
Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia. |
University Of Minnesota |
26287310 |
87 |
Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit. |
University College London |
25637120 |
94 |
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT). |
St. Jude Children'S Research Hospital |
25147612 |
25 |
Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties. |
University Of Florida |
26035239 |
1 |
Natural Product Primary Sulfonamides and Primary Sulfamates. |
Griffith University |
25906087 |
14 |
Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor. |
Shandong University |
25905694 |
24 |
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. |
Istituto Ortopedico Rizzoli (Ior) |
25811792 |
32 |
Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization. |
Yonsei University |
25800646 |
40 |
Macrocyclic compounds as anti-cancer agents: design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2. |
Central South University |
25113875 |
14 |
Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity. |
Taipei Medical University |
25042254 |
7 |
Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines. |
H�Pital Kirchberg |
24999749 |
1 |
A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells. |
University Of Oklahoma |
25563890 |
49 |
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite. |
R&D Sigma-Tau Industrie Farmaceutiche Riunite |
25462271 |
33 |
Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity. |
Shandong University |
25455492 |
22 |
Aurones as histone deacetylase inhibitors: identification of key features. |
University Of Geneva |
25454270 |
82 |
Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform. |
TBA |
25380299 |
61 |
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles. |
Technical University Of Denmark |
25238284 |
52 |
Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors. |
Roche Pharmaceutical Research And Early Development |
25233084 |
247 |
ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors. |
R&D Sigma-Tau Industrie Farmaceutiche Riunite |
25218912 |
103 |
Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors. |
Chinese Academy Of Sciences |
25176189 |
7 |
Design, synthesis and biological evaluation ofß-boswellic acid based HDAC inhibitors as inducers of cancer cell death. |
Csir-Indian Institute Of Integrative Medicine |
24900838 |
30 |
Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. |
Merck Research Laboratories |
24588105 |
56 |
Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold. |
Universit£ |
24565573 |
35 |
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors. |
Universit£ |
24742384 |
90 |
Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors. |
Universit£ |
24694055 |
35 |
Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity. |
Shandong University |
24015327 |
42 |
Development of a chimeric c-Src kinase and HDAC inhibitor. |
University Of Michigan |
23252603 |
35 |
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells. |
Heinrich Heine Universit£T |
23061376 |
63 |
Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response. |
Roche R & D Center China |
23009203 |
39 |
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth. |
University Of Illinois At Chicago |
22642300 |
160 |
Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. |
Kyoto Prefectural University Of Medicine |
21984958 |
83 |
Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ¿F508-CFTR. |
TBA |
18182289 |
127 |
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). |
Merck Research Laboratories |
11206439 |
51 |
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2. |
Merck Research Laboratories |
11206438 |
48 |
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1. |
Merck Research Laboratories |
21548582 |
57 |
Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes. |
University Of Illinois At Chicago |
21634430 |
218 |
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. |
S*Bio |
21417297 |
220 |
Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation. |
Universita` Degli Studi Di Siena |
21073160 |
143 |
Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity |
TBA |
20451378 |
107 |
Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. |
S*Bio |
19906529 |
22 |
Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors. |
Ortho-Biotech Oncology Research & Development |
19359173 |
51 |
Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors. |
Sigma-Tau Research And Development |
19285395 |
66 |
N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. |
R&D Sigma-Tau |
19268585 |
30 |
Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2). |
Merck Research Laboratories |
19181524 |
46 |
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity. |
S*Bio |
14698179 |
58 |
Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group. |
The Scripps Research Institute |
14684344 |
49 |
(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors. |
Methylgene |
28501514 |
5 |
Stabilizing HDAC11 with SAHA to assay slow-binding benzamide inhibitors. |
Nankai University |
27416889 |
35 |
Design, synthesis, and preliminary bioactivity evaluation of N(1) -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors. |
Shandong University |
282646 |
50 |
Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. |
TBA |
25019596 |
24 |
Quinolone-based HDAC inhibitors. |
Orchid Chemicals & Pharmaceuticals |