The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28089347 |
6 |
Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRa from Drugbank database. |
Xiamen University |
| 27994765 |
95 |
Discovery of Highly Potent Liver X Receptorß Agonists. |
Bristol-Myers Squibb |
| 27326332 |
66 |
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist. |
Bristol-Myers Squibb |
| 27450787 |
2 |
Binding characterization, synthesis and biological evaluation of RXRa antagonists targeting the coactivator binding site. |
Xiamen University |
| 27261179 |
11 |
Identification of potent and selective retinoic acid receptor gamma (RAR¿) antagonists for the treatment of osteoarthritis pain using structure based drug design. |
Eli Lilly |
| 26990539 |
79 |
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)ß Agonist. |
Vitae Pharmaceuticals |
| 26820900 |
11 |
Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation. |
University Of Gothenburg |
| 26819660 |
82 |
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor. |
Central Pharmaceutical Research Institute |
| 26331194 |
20 |
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers. |
University Of Alabama At Birmingham |
| 25815156 |
5 |
Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists. |
Okayama University Graduate School Of Medicine |
| 24959987 |
2 |
Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene. |
Aichi Gakuin University |
| 24831826 |
59 |
Small molecule inhibitors targeting activator protein 1 (AP-1). |
University Of Texas Medical Branch |
| 25305688 |
41 |
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t. |
Phenex Pharmaceuticals |
| 24801499 |
31 |
Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. |
University Of Alabama At Birmingham |
| 23434637 |
10 |
Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation. |
Xiamen University |
| 23391145 |
7 |
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency. |
Okayama University Graduate School Of Medicine |
| 23472886 |
21 |
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential. |
Purdue University |
| 22712432 |
5 |
Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents. |
The University Of Illinois At Chicago |
| 24900488 |
1 |
RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists. |
TBA |
| 21218783 |
117 |
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents. |
Johnson & Johnson Pharmaceutical Research And Development |
| 18690216 |
5 |
Cytosporone B is an agonist for nuclear orphan receptor Nur77. |
Xiamen University |
| 24900241 |
15 |
Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers. |
TBA |
| 20667726 |
3 |
Fluorescent retinoid X receptor ligands for fluorescence polarization assay. |
Okayama University |
| 20656484 |
3 |
Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation. |
Okayama University |
| 20695472 |
1 |
Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor. |
Aichi Gakuin University |
| 20638278 |
145 |
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. |
Phenex Pharmaceuticals |
| 19791803 |
8 |
Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). |
Arizona State University |
| | 61 |
Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligands |
TBA |
| | 99 |
Synthesis and structure-activity relationships of potent retinoid X receptor ligands |
TBA |
| | 83 |
Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere |
TBA |
| | 31 |
Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogs |
TBA |
| | 54 |
Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acids |
TBA |
| | 35 |
Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs |
TBA |
| 19095448 |
24 |
Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity. |
Okayama University Graduate School Of Medicine |
| 17651969 |
96 |
Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure. |
Tsukuba Research Institute |
| 17651968 |
60 |
Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents. |
Tsukuba Research Institute |
| 17490875 |
24 |
Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia. |
Johnson And Johnson Pharmaceutical Research And Development |
| 17485209 |
14 |
RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia. |
Johnson And Johnson Pharmaceutical Research And Development |
| 16364638 |
99 |
Aza-retinoids as novel retinoid X receptor-specific agonists. |
Ligand Pharmaceuticals |
| 16190748 |
10 |
Ligand recognition by RAR and RXR receptors: binding and selectivity. |
Universidad De Santiago De Compostela |
| 15317450 |
7 |
Determinants of retinoid X receptor transcriptional antagonism. |
Institute |
| 15125928 |
44 |
Design and synthesis of benzofused heterocyclic RXR modulators. |
Eli Lilly |
| 15056000 |
82 |
Structure-based design of potent retinoid X receptor alpha agonists. |
Glaxosmithkline |
| 15006411 |
126 |
Design, synthesis and structure-activity relationship of novel RXR-selective modulators. |
Ligand Pharmaceuticals |
| 14592510 |
150 |
Design and synthesis of novel RXR-selective modulators with improved pharmacological profile. |
Ligand Pharmaceuticals |
| 12951091 |
36 |
Design and synthesis of fluorinated RXR modulators. |
Eli Lilly |
| 12801232 |
71 |
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. |
Ligand Pharmaceuticals |
| 12482435 |
75 |
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid. |
Ligand Pharmaceuticals |
| 12182871 |
3 |
Synthesis and characterization of a new RXR agonist based on the 6-tert-butyl-1,1-dimethylindanyl structure. |
Universidade De Vigo |
| 12161154 |
11 |
An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide. |
The Ohio State University |
| 11906293 |
7 |
Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. |
Takeda Chemical Industries |
| 11428923 |
39 |
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. |
Allergan |
| 10585206 |
45 |
Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid. |
Università |
| 10098670 |
24 |
Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands. |
Allergan |
| 10052980 |
138 |
Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells. |
Ligand Pharmaceuticals |
| 9733501 |
33 |
Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships. |
University Of Oklahoma Health Sciences Center |
| 9435893 |
46 |
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers. |
University Of Tokyo |
| 8809153 |
60 |
Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity. |
University Of Alabama At Birmingham |
| 8784454 |
76 |
Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid. |
Allergan |
| 8765503 |
39 |
Identification of the first retinoid X, receptor homodimer antagonist. |
Ligand Pharmaceuticals |
| 8709094 |
41 |
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells. |
Ligand Pharmaceuticals |
| 8410972 |
52 |
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity. |
Sri International |
| 8308867 |
72 |
Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties. |
Ligand Pharmaceuticals |
| 8071941 |
240 |
Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. |
Ligand Pharmaceuticals |
| 7650690 |
64 |
Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity. |
Sri International |
| 7636877 |
96 |
Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. |
Ligand Pharmaceuticals |
| 7636843 |
40 |
Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids. |
Allergan |
| 7608895 |
61 |
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity. |
University Of Alabama At Birmingham |
| 7490725 |
9 |
Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. |
Allergan |
| 15016836 |
90 |
The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells. |
Georgetown University |
| 9479476 |
10 |
Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR. |
University Of Texas Southwestern Medical Center |
| 19361210 |
44 |
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists. |
Bristol-Myers Squibb |
| 11020282 |
512 |
Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. |
Universita Degli Studi |
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