The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28076827 |
27 |
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity. |
Universit£ |
27591006 |
24 |
Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptora/d (PPARa/d) dual agonistic activity. |
The University Of Tokyo |
27660684 |
18 |
PPAR Agonists, Compounds, Pharmaceutical Compositions, and Methods of Use Thereof. |
Temple University |
27326332 |
66 |
Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist. |
Bristol-Myers Squibb |
27450788 |
3 |
Syringaresinol induces mitochondrial biogenesis through activation of PPARß pathway in skeletal muscle cells. |
Korea University |
26988304 |
12 |
Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptorß/d agonists with neuroprotective activity. |
Texas Tech University Health Sciences Center |
26819660 |
82 |
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR¿ Inhibitor. |
Central Pharmaceutical Research Institute |
26731300 |
3 |
Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
Max Planck Institute For Molecular Genetics |
26595749 |
77 |
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor¿ Modulators. |
Goethe-University Frankfurt |
26707398 |
2 |
Characterization of isobutylhydroxyamides with NGF-potentiating activity from Zanthoxylum bungeanum. |
Northwest A & F University |
26707845 |
16 |
Synthesis of 5-trifluoromethyl-2-sulfonylpyridine PPARß/d antagonists: Effects on the affinity and selectivity towards PPARß/d. |
University Of Oslo |
25982078 |
13 |
Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor¿/d agonists. |
Sookmyung Women'S University |
25583100 |
107 |
Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands. |
Goethe-University Frankfurt |
25768705 |
4 |
Synthesis, biological evaluation and molecular modeling studies of the PPARß/d antagonist CC618. |
University Of Oslo |
24881566 |
140 |
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). |
Glaxosmithkline |
25491112 |
19 |
Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-a (PPAR-a) agonists. |
National Institute Of Pharmaceutical Education And Research (Niper) |
25462281 |
17 |
Structural development studies of PPARs ligands based on tyrosine scaffold. |
Universit£&Quot;G. D'Annunzio&Quot |
25305688 |
41 |
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t. |
Phenex Pharmaceuticals |
25255039 |
45 |
Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist. |
Goethe-University Frankfurt |
24745969 |
36 |
Identification of the first potent, selective and bioavailable PPARa antagonist. |
Inception Sciences |
9836620 |
94 |
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. |
Glaxo Wellcome Research And Development |
23286787 |
18 |
Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor¿. |
Helmholtz Centre For Infection Research |
23265844 |
18 |
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists. |
The University Of Sydney |
23265881 |
49 |
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿. |
Pfizer |
24900572 |
54 |
Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes. |
Pfizer |
21414782 |
178 |
Phenoxyacetic acids as PPARd partial agonists: synthesis, optimization, and in vivo efficacy. |
Glaxosmithkline |
20128594 |
51 |
Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist. |
Glaxosmithkline |
22081932 |
32 |
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. |
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot |
23130964 |
25 |
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors. |
Zafes/Liff/Osf Goethe-University Frankfurt |
23031596 |
21 |
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-¿B activation and PPAR transcriptional activity. |
Chungnam National University |
23022278 |
14 |
Design, synthesis and in vitro evaluation of a series ofa-substituted phenylpropanoic acid PPAR¿ agonists to further investigate the stereochemistry-activity relationship. |
Okayama University |
22582973 |
21 |
Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds. |
Trinity College |
22564380 |
624 |
Activity landscape modeling of PPAR ligands with dual-activity difference maps. |
Universidad Nacional Aut£Noma De M£Xico |
22534184 |
87 |
Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptord agonists as potent anti-obesity agents in vivo. |
Seoul National University |
22579420 |
45 |
Total synthesis and dual PPARa/¿ agonist effects of amorphastilbol and its synthetic derivatives. |
Korea Institute Of Science And Technology |
22503460 |
37 |
Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR)¿ Agonists. |
Takeda Pharmaceutical |
22381047 |
30 |
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii. |
Chungnam National University |
21218783 |
117 |
Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents. |
Johnson & Johnson Pharmaceutical Research And Development |
21128600 |
16 |
Design, synthesis, and structural analysis of phenylpropanoic acid-type PPAR¿-selective agonists: discovery of reversed stereochemistry-activity relationship. |
Okayama University |
18155554 |
87 |
Synthesis and structure-activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors alpha/delta dual agonists. |
Johnson & Johnson Pharmaceutical Research And Development |
17964792 |
31 |
Structure-activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists. |
Nippon Shinyaku |
18162399 |
37 |
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail. |
University Of Tokyo |
18280733 |
27 |
Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor alpha (PPARalpha) agonists. |
Nippon Shinyaku |
18029176 |
66 |
Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. |
Johnson & Johnson |
17560785 |
12 |
Design of a partial PPARdelta agonist. |
Novo Nordisk |
17005393 |
35 |
Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents. |
Eli Lilly |
16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
16134928 |
34 |
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. |
The Scripps Research Institute |
22185225 |
2 |
Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype. |
The University Of Tokyo |
22070604 |
150 |
Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor¿ (PPAR¿) modulators. |
Merck Research Laboratories |
22209730 |
73 |
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR)¿ agonists: design and synthesis of benzylpyrazole acylsulfonamides. |
Takeda Pharmaceutical |
22133631 |
76 |
Discovery of cyclic amine-substituted benzoic acids as PPARa agonists. |
Kyorin Pharmaceutical |
22051054 |
18 |
Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516. |
University Of Oslo |
21514830 |
39 |
Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: relationship between absolute configuration and subtype selectivity. |
The University Of Tokyo |
21344906 |
54 |
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry. |
The University Of Tokyo |
21530275 |
42 |
Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR)a-selective agonists. |
Okayama University |
21515063 |
60 |
Biological evaluation of novel benzisoxazole derivatives as PPARd agonists. |
Nippon Chemiphar |
21094606 |
24 |
Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARd agonists. |
Astrazeneca R&D Charnwood |
21112784 |
15 |
Synthesis of a novel human PPARd selective agonist and its stimulatory effect on oligodendrocyte differentiation. |
Nippon Chemiphar |
21215640 |
21 |
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists. |
Zydus Research Centre |
21074432 |
25 |
Selective peroxisome proliferator-activated receptord isosteric selenium agonists as potent anti-atherogenic agents in vivo. |
Seoul National University |
20843696 |
12 |
Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR)d-selective partial agonists by disruption of molecular planarity/symmetry. |
The University Of Tokyo |
20638278 |
145 |
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. |
Phenex Pharmaceuticals |
20452212 |
26 |
Glycine amides as PPARalpha agonists. |
Bayer-Schering Pharma |
20218621 |
131 |
Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). |
Bristol-Myers Squibb |
19928766 |
425 |
Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists. |
The Genomics Institute Of The Novartis Research Foundation |
19853439 |
21 |
Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) delta selective antagonists. |
The University Of Tokyo |
20079636 |
78 |
Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators. |
Glaxosmithkline |
19556125 |
42 |
Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists. |
Goethe-University Frankfurt |
19349176 |
137 |
Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes. |
F. Hoffmann-La Roche |
19301897 |
63 |
Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists. |
National Health Research Institutes |
19275963 |
26 |
Selective, potent PPARgamma agonists with cyclopentenone core structure. |
Universidade De Vigo |
18947994 |
102 |
The discovery of equipotent PPARalpha/gamma dual activators. |
Glaxosmithkline |
18821746 |
10 |
Discovery of novel PPAR ligands by a virtual screening approach based on pharmacophore modeling, 3D shape, and electrostatic similarity screening. |
University Of Innsbruck |
18701276 |
97 |
Highly functionalized 7-azaindoles as selective PPAR gamma modulators. |
Merck Research Laboratories |
18662876 |
45 |
Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part. |
The University Of Tokyo |
18321611 |
64 |
CoMFA analysis of dual/multiple PPAR activators. |
National Institute Of Pharmaceutical Education And Research |
18060776 |
100 |
Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
Glaxosmithkline |
18029178 |
188 |
Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists. |
Eli Lilly |
17553681 |
50 |
Novel selective PPARdelta agonists: optimization of activity by modification of alkynylallylic moiety. |
Re&D Vufb |
17553678 |
97 |
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor alpha agonists. |
Kowa |
17532641 |
57 |
Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists. |
University Of Tokyo |
17524643 |
14 |
Phenylpropanoic acid derivatives bearing a benzothiazole ring as PPARdelta-selective agonists. |
Nagoya City University |
17524639 |
73 |
Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists. |
Johnson And Johnson Pharmaceutical Research And Development |
17512197 |
101 |
Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists. |
Pfizer |
17498950 |
69 |
Discovery of highly potent and selective benzyloxybenzyl-based peroxisome proliferator-activator receptor (PPAR) delta agonists. |
Pfizer |
17379517 |
45 |
Design of potent PPARalpha agonists. |
Novo Nordisk |
17343371 |
27 |
Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo. |
Novo Nordisk |
17157013 |
74 |
Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups--new classes of PPAR gamma/delta and PPAR alpha/gamma/delta agonists. |
Bayer Pharmaceuticals |
17129725 |
90 |
Design and synthesis of a novel class of dual PPARgamma/delta agonists. |
Eli Lilly |
17034149 |
22 |
Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists. |
National Health Research Institutes |
16970391 |
88 |
Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile. |
Eli Lilly |
16797985 |
26 |
Studies towards the conception of new selective PPARbeta/delta ligands. |
Université |
16750626 |
51 |
3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists: Part 1. |
The Genomics Institute Of The Novartis Research Foundation |
16737814 |
112 |
Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists. |
F. Hoffmann-La Roche |
16546385 |
81 |
1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists. |
The Genomics Institute Of The Novartis Research Foundation |
16529931 |
139 |
SAR studies: designing potent and selective LXR agonists. |
Merck Research Laboratories |
16451087 |
41 |
Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies. |
National Health Research Institutes |
16384704 |
86 |
Design and synthesis of potent and subtype-selective PPARalpha agonists. |
Merck Research Laboratories |
16366601 |
82 |
Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities. |
National Health Research Institutes |
16275077 |
27 |
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists. |
University Of Tokyo |
16216504 |
8 |
Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents. |
Novartis Institutes For Biomedical Research |
16107159 |
106 |
Novel 2,3-dihydrobenzofuran-2-carboxylic acids: highly potent and subtype-selective PPARalpha agonists with potent hypolipidemic activity. |
Merck Research Laboratories |
15950464 |
146 |
(2R)-2-methylchromane-2-carboxylic acids: discovery of selective PPARalpha agonists as hypolipidemic agents. |
Merck Research Laboratories |
15713415 |
13 |
Structure-activity relationships of dimeric PPAR agonists. |
Novo Nordisk |
15603954 |
37 |
Benzoyl 2-methyl indoles as selective PPARgamma modulators. |
Merck Research Laboratories |
15582409 |
46 |
2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents. |
Eli Lilly |
15177462 |
38 |
Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators. |
Research Institute Of Tsinghua University |
15163205 |
94 |
(2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents. |
Merck Research Laboratories |
15115385 |
68 |
Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists. |
Eli Lilly |
14613314 |
53 |
Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. |
Eli Lilly |
14584939 |
32 |
Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo. |
Novo Nordisk |
14505666 |
99 |
Aryloxazolidinediones: identification of potent orally active PPAR dual alpha/gamma agonists. |
Merck Research Laboratories |
12904063 |
69 |
Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators. |
Kyorin Pharmaceutical |
12873517 |
90 |
5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents. |
Merck Research Laboratories |
12729668 |
106 |
5-Aryl thiazolidine-2,4-diones as selective PPARgamma agonists. |
Merck Research Laboratories |
12699745 |
49 |
Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. |
Glaxosmithkline |
12657263 |
46 |
Phenylacetic acid derivatives as hPPAR agonists. |
Merck Research Laboratories |
12617924 |
140 |
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists. |
Merck Research Laboratories |
12482434 |
52 |
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template. |
Novo Nordisk |
11831892 |
46 |
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity. |
Novo Nordisk |
11720854 |
48 |
Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight. |
Glaxosmithkline |
11677135 |
21 |
Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis. |
Glaxosmithkline |
11527737 |
70 |
Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta. |
Glaxosmithkline |
11354382 |
42 |
Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
Glaxosmithkline |
10691680 |
72 |
The PPARs: from orphan receptors to drug discovery. |
Glaxo Wellcome Research & Development |
10508427 |
42 |
A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
Glaxo Wellcome Research & Development |
29446942 |
98 |
Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR)?/?/? Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate. |
Inventiva |
28539218 |
25 |
Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor?/? (PPAR?/?) dual agonists. |
The University Of Tokyo |
28799755 |
51 |
Polypharmacology of N |
Sahmyook University |
21671327 |
5 |
Triptolide directly inhibits dCTP pyrophosphatase. |
Yale University |
8474008 |
58 |
Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities. |
Virginia Commonwealth University |
19827080 |
10 |
A fragment-based approach to probing adenosine recognition sites by using dynamic combinatorial chemistry. |
University Of Cambridge |
8461029 |
21 |
Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese hamster ovary cells. [3H]spiperone discriminates between the G-protein-coupled and -uncoupled forms. |
University Of Canterbury |
8450829 |
29 |
Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. |
Cnrs |
8413837 |
45 |
[3H]paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments. |
Boots Pharmaceuticals |
8394987 |
32 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. |
Cnrs |
19361209 |
30 |
Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists. |
Bristol-Myers Squibb |