The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28319392 |
216 |
Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters. |
National Institute Of Diabetes And Digestive And Kidney Diseases |
| 2153204 |
6 |
Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules. |
Creighton University |
| 2709383 |
39 |
Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines. |
Anaquest Pharmaceuticals |
| 2536439 |
10 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist. |
University Of Innsbruck |
| 3039139 |
3 |
X-ray crystal structure of the opioid ligand naltrexonazine. |
TBA |
| 3012085 |
3 |
Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity. |
TBA |
| 3009813 |
3 |
Probes for narcotic receptor mediated phenomena. 9. Synthesis of (+/-)-(3 alpha,6a alpha,11a beta)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a- methanobenzofuro[2,3-c]azocin-10-ol, an oxide-bridged 5-(m-hydroxyphenyl)morphan. |
TBA |
| 3023609 |
14 |
Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology. |
TBA |
| 2876106 |
6 |
3,7-Diazabicyclane: a new narcotic analgesic. |
TBA |
| 3020246 |
11 |
Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine. |
TBA |
| 2863378 |
7 |
Acylmorphinans. A novel class of potent analgesic agents. |
TBA |
| 2409280 |
35 |
Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone. |
TBA |
| 2999399 |
4 |
Novel nonnarcotic analgesics with an improved therapeutic ratio. Structure-activity relationships of 8-(methylthio)- and 8-(acylthio)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines. |
TBA |
| 6094809 |
32 |
Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones. |
TBA |
| 6315939 |
2 |
14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone. |
TBA |
| 6600791 |
32 |
Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties. |
TBA |
| 6288945 |
28 |
Potential affinity labels for the opiate receptor based on fentanyl and related compounds. |
TBA |
| 6276546 |
12 |
Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone. |
TBA |
| 6268789 |
22 |
Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. |
TBA |
| 6268786 |
27 |
Opiate receptor interaction of compounds derived from or structurally related to fentanyl. |
TBA |
| 6273560 |
16 |
Preparation and analgesic properties of amino acid derivatives of (-)-5,9 alpha-diethyl-2'-hydroxybenzomorphan. |
TBA |
| 6249930 |
7 |
Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo[3.2.1]octanes. |
TBA |
| 6248644 |
4 |
Some spiro analogues of the potent analgesic ketobemidone. |
TBA |
| 27614411 |
25 |
Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents. |
University Of Pavia |
| 26071858 |
116 |
New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure. |
Institute Of Radiopharmaceutical Cancer Research |
| 23734634 |
33 |
Thes2 receptor: a novel protein for the imaging and treatment of cancer. |
Washington University |
| 8201608 |
28 |
Molecular similarity, quantitative chirality, and QSAR for chiral drugs. |
University Of Oxford |
| 23566245 |
15 |
Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives ass1 receptor ligands for positron emission tomography imaging. |
Key Laboratory Of Radiopharmaceuticals Beijing Normal University |
| 23414839 |
27 |
3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (s1) receptor. |
Northeast Ohio Medical University |
| 23199475 |
9 |
Synthesis and biological evaluation of¹8F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging. |
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University) |
| 2824774 |
3 |
Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and sigma receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines. |
University Of Lausanne |
| 23084435 |
17 |
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors. |
Savannah State University |
| 22959245 |
175 |
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs). |
The University Of Sydney |
| 23641311 |
38 |
From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design. |
TBA |
| 22853801 |
7 |
New positron emission tomography (PET) radioligand for imagings-1 receptors in living subjects. |
Stanford University |
| 22850210 |
20 |
Exploration of ring size in a series of cyclic vicinal diamines withs1 receptor affinity. |
The University Of Sydney |
| 22831799 |
22 |
Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT). |
Kanazawa University |
| 22515405 |
39 |
Thiophene bioisosteres of spirocyclics receptor ligands: relationships between substitution pattern ands receptor affinity. |
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster |
| 22607684 |
50 |
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands. |
The University Of Sydney |
| 24900272 |
14 |
Homology Model and Docking-Based Virtual Screening for Ligands of the s1 Receptor. |
TBA |
| 19842660 |
49 |
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28). |
Universita Degli Studi Di Bari |
| 19673530 |
41 |
Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives. |
University Of Trieste |
| 18278854 |
20 |
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. |
The University Of Mississippi |
| 18178434 |
1 |
Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization. |
Universit£ |
| 16366605 |
62 |
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor. |
Universit£ |
| 12801223 |
71 |
Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. |
Nida-Irp |
| 12383018 |
46 |
Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3. |
Pharmazeutisches Institut Der Universit£T Freiburg |
| 10649973 |
30 |
3,4-dihydro-2(1H)-quinolinone as a novel antidepressant drug: synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4- dihydro-5-methoxy-2(1H)-quinolinone and its derivatives. |
Otsuka Pharmaceutical |
| 10090790 |
131 |
Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine sigma ligands as potential antipsychotic drugs. |
Taisho Pharmaceutical |
| 10602703 |
73 |
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent. |
Warner-Lambert |
| 10543888 |
60 |
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. |
National Institute On Drug Abuse-Intramural Research Program |
| 9484497 |
17 |
Rigid phencyclidine analogues. Binding to the phencyclidine and sigma 1 receptors. |
University Of Illinois At Chicago |
| 9599242 |
23 |
(R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist. |
Astra Arcus |
| 9083484 |
84 |
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands. |
Cooperation Pharmaceutique Fran�Aise |
| 8568804 |
42 |
New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives. |
Universit£ |
| 7636860 |
48 |
Synthesis and sigma binding properties of 2'-substituted 5,9 alpha-dimethyl-6,7-benzomorphans. |
Research Triangle Institute |
| 7783132 |
82 |
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines. |
H. Lundbeck |
| 7783131 |
78 |
Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. |
H. Lundbeck |
| 8057277 |
54 |
Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. |
National Institute On Drug Abuse-Intramural Research Program |
| 8027978 |
50 |
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds. |
Albany Molecular Research |
| 1361578 |
99 |
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. |
Bristol-Myers Squibb |
| 1648139 |
34 |
Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors. |
Virginia Commonwealth University |
| 1848295 |
33 |
Identification and exploitation of the sigma-opiate pharmacophore. |
Virginia Commonwealth University |
| 1672156 |
81 |
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents. |
Hoechst-Roussel Pharmaceuticals |
| 2167979 |
43 |
Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor. |
Universit£ |
| 2542555 |
74 |
Phencyclidine-like effects of tetrahydroisoquinolines and related compounds. |
G. D. Searle |
| 2824773 |
92 |
N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors. |
University Of G£Teborg |
| 2888899 |
34 |
Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds. |
Istituto Superiore Di Sanit£ |
| 3007760 |
93 |
N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines. |
TBA |
| 10498200 |
40 |
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants. |
Pharmacia & Upjohn |
| 22075234 |
35 |
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities ass¿? receptor ligands. |
Universit£ |
| 22055714 |
9 |
Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand. |
University Of Wisconsin School Of Medicine And Public Health |
| 21871797 |
33 |
Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazines¿? receptor ligands. |
The University Of Sydney |
| 21899931 |
27 |
Synthesis and pharmacological evaluation of indole-based sigma receptor ligands. |
The University Of Mississippi |
| 21555222 |
25 |
Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (s) receptor ligands modulates off-target activity and subtype selectivity. |
The University Of Sydney |
| 21481592 |
6 |
Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging. |
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University) |
| 21146989 |
46 |
Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands. |
The University Of Sydney |
| 20889347 |
14 |
3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT). |
University Of Tours |
| 20812727 |
157 |
Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography. |
National Institute Of Mental Health |
| 20662542 |
64 |
Design, synthesis, and structure-affinity relationships of regioisomeric N-benzyl alkyl ether piperazine derivatives as sigma-1 receptor ligands. |
University Of Sydney |
| 20338757 |
6 |
The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands. |
University Of Maryland |
| 20045339 |
16 |
Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2). |
University Of Pavia |
| 20055417 |
62 |
Synthesis and opioid activity of enantiomeric N-substituted 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolines. |
National Taiwan University |
| | 48 |
(E) and (Z)-3-Styrylpiperidines as sigma ligands |
TBA |
| 18783208 |
11 |
Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. |
National Institute Of Mental Health |
| 18461921 |
65 |
Trifluoromethoxyl substituted phenylethylene diamines as high affinity sigma receptor ligands with potent anti-cocaine actions. |
University Of Maryland |
| 18440098 |
15 |
Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site. |
University Of Trieste |
| 18069094 |
7 |
Substituted benzylaminoalkylindoles with preference for the sigma2 binding site. |
University Of Trieste |
| 17988766 |
26 |
Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands. |
University Of Maryland |
| 16250661 |
13 |
11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors. |
University Of Milano/Bicocca |
| 12570387 |
60 |
Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands. |
Università |
| 11814827 |
10 |
N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents. |
University Of Maryland |
| 11784148 |
81 |
Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. |
Pharmazeutisches Institut Der UniversitäT Freiburg |
| 11150174 |
84 |
Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. |
Virginia Commonwealth University |
| 11052796 |
16 |
Radioiodinated N-(2-diethylaminoethyl)benzamide derivatives with high melanoma uptake: structure-affinity relationships, metabolic fate, and intracellular localization. |
University Of Heidelberg |
| 10425095 |
26 |
Hydroxylated decahydroquinolines as ligands for the vesicular acetylcholine transporter: synthesis and biological evaluation. |
University Of Minnesota |
| 9767631 |
19 |
N-[omega-(Tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine are highly potent and selective sigma1 or sigma2 ligands. |
Università |
| 9171875 |
32 |
Halogenated 4-(phenoxymethyl)piperidines as potential radiolabeled probes for sigma-1 receptors: in vivo evaluation of [123I]-1-(iodopropen-2-yl)-4-[(4-cyanophenoxy)methyl]pip eri dine. |
Ansto |
| 8411007 |
392 |
Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. |
Mayo Foundation |
| 8355251 |
8 |
Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site. |
National Institute Of Diabetes And Digestive And Kidney Diseases |
| 8246239 |
84 |
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. |
Solvay Duphar |
| 8230107 |
61 |
Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists. |
University Of GöTeborg |
| 7990123 |
30 |
Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors. |
University Of Pennsylvania |
| 7909336 |
27 |
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. |
R. W. Johnson Pharmaceutical Research Institute |
| 7837240 |
19 |
Preparation of 18F-labeled muscarinic agonist with M2 selectivity. |
National Institutes Of Health |
| 7636861 |
32 |
Synthesis and sigma binding properties of 1'- and 3'-halo- and 1',3'-dihalo-N-normetazocine analogues. |
Research Triangle Institute |
| 6313921 |
10 |
Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo. |
TBA |
| 3746815 |
15 |
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin. |
TBA |
| 2153212 |
87 |
Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom. |
Merck Sharp & Dohme Research Laboratories |
| 1323682 |
61 |
Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor. |
Upjohn |
| 16807364 |
18 |
Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. |
Queen'S University |
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