The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28523101 |
24 |
Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket. |
The University Of Tokyo |
| 27769621 |
109 |
Discovery of imidazopyridazines as potent Pim-1/2 kinase inhibitors. |
Amgen |
| 27255178 |
3 |
Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c. |
Universit£ |
| 26995528 |
60 |
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold. |
Novartis Institutes For Biomedical Research |
| 26890118 |
8 |
Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties. |
Mendeleyev University Of Chemical Technology |
| 26762835 |
342 |
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). |
Icahn School Of Medicine At Mount Sinai |
| 26459208 |
115 |
Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors. |
Genentech |
| 26526744 |
14 |
Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. |
Universit£ |
| 25616902 |
112 |
Discovery of 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines as potent PIM inhibitors. |
Amgen |
| 25597005 |
86 |
The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors. |
Amgen |
| 25087047 |
7 |
Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition. |
Clermont Universit£ |
| 25575657 |
48 |
Structure-based design of low-nanomolar PIM kinase inhibitors. |
Biogen Idec |
| 24139169 |
175 |
Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases. |
Nerviano Medical Sciences |
| 24775304 |
36 |
Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives. |
Keimyung University |
| 24900629 |
102 |
Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors. |
Novartis Institutes For Biomedical Research |
| 24091081 |
49 |
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach. |
Merck Research Laboratories |
| 24900749 |
6 |
Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo. |
Astrazeneca |
| 23735828 |
15 |
Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors. |
Clermont Universit£ |
| 23623490 |
54 |
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design. |
Genentech |
| 23499503 |
9 |
Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors. |
Clermont Universit£ |
| 22982527 |
6 |
Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors. |
TBA |
| 22924342 |
15 |
Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy. |
Cylene Pharmaceuticals |
| 22540945 |
19 |
Rational evolution of a novel type of potent and selective proviral integration site in Moloney murine leukemia virus kinase 1 (PIM1) inhibitor from a screening-hit compound. |
The University Of Tokyo |
| 22727640 |
68 |
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. |
Astrazeneca |
| 22543026 |
6 |
Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives. |
Clermont Universit£ |
| 22542012 |
155 |
The design, synthesis, and biological evaluation of PIM kinase inhibitors. |
Exelixis |
| 24900437 |
32 |
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. |
TBA |
| 18183025 |
12060 |
A quantitative analysis of kinase inhibitor selectivity. |
Ambit Biosciences |
| 17850214 |
99 |
The selectivity of protein kinase inhibitors: a further update. |
University Of Dundee |
| 22386260 |
9 |
Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors. |
Clermont Universit£ |
| 22266039 |
119 |
Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors. |
Spanish National Cancer Research Centre (Cnio) |
| 22136433 |
67 |
7,8-dichloro-1-oxo-ß-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. |
Ludwig-Maximilians University Of Munich |
| 21982499 |
180 |
7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity. |
Cylene Pharmaceuticals |
| 21945284 |
73 |
Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases. |
Novartis Institutes Of Biomedical Research |
| 22037378 |
31824 |
Comprehensive analysis of kinase inhibitor selectivity. |
Ambit Biosciences |
| 20728368 |
16 |
Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles. |
Clermont Université |
| 19654408 |
2521 |
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). |
Ambit Biosciences |
| 19837585 |
46 |
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). |
National Human Genome Research Institute |
| 19788246 |
11 |
Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors. |
Clermont Universit£ |
| 22545939 |
5 |
Synthesis, activity evaluation, and docking analysis of barbituric acid aryl hydrazone derivatives as RSK2 inhibitors. |
East China University Of Science And Technology |
| 21827363 |
20 |
Definition of peptide inhibitors from a synthetic peptide library by targeting gelatinase B/matrix metalloproteinase-9 (MMP-9) and TNF-a converting enzyme (TACE/ADAM-17). |
China Pharmaceutical University |
| 20235688 |
7 |
Design, synthesis, and urease inhibition studies of some 1,3,4-oxadiazoles and 1,2,4-triazoles derived from mandelic acid. |
Quaid-I-Azam University |
| 23935105 |
20 |
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. |
National Institutes Of Health, National Institutes Of Health Biomedical Research Center |
| 2547766 |
8 |
Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor. |
Merck Sharp And Dohme Research Laboratories |
| 11303056 |
2 |
Pharmacological characterization of KUR-1246, a selective uterine relaxant. |
Kissei Pharmaceutical |
| 16406782 |
9 |
Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. |
Cornell University |
| 16316253 |
5 |
Strong solute-solute dispersive interactions in a protein-ligand complex. |
University Of Leeds |
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