The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28603989 |
53 |
a-Conotoxin [S9A]TxID Potently Discriminates betweena3ß4 anda6/a3ß4 Nicotinic Acetylcholine Receptors. |
Hainan University |
| 28337332 |
41 |
BMS-933043, a Selectivea7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia. |
Bristol-Myers Squibb |
| 28169167 |
137 |
Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 27958732 |
93 |
Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship. |
Bristol-Myers Squibb |
| 26706350 |
48 |
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3ß4 nicotinic acetylcholine receptor subtype. |
Universit£ |
| 26383127 |
13 |
Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities fora4ß2 neuronal nicotinic acetylcholine receptors. |
University Of Sassari |
| 26233800 |
8 |
Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3'-(substituted pyridinyl)-deschloroepibatidine analogs. |
Research Triangle Institute |
| 26164842 |
30 |
Bifunctional compounds targeting both D2 and non-a7 nACh receptors: design, synthesis and pharmacological characterization. |
Universit£ |
| 26225816 |
25 |
Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed asa4ß2-Nicotinic Acetylcholine Receptor Agonists. |
Universit£ |
| 26087938 |
17 |
Pharmacological profile of zacopride and new quaternarized fluorobenzamide analogues on mammaliana7 nicotinic acetylcholine receptor. |
Universit£ |
| 26142318 |
36 |
The twin drug approach for novel nicotinic acetylcholine receptor ligands. |
University Of Hawaii At Hilo |
| 25941557 |
4 |
Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. |
University Of Copenhagen |
| 25827398 |
47 |
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities ata7 nAChRs through incorporation of known structural motifs. |
The University Of Sydney |
| 25019477 |
11 |
Investigations of amide bond variation and biaryl modification in analogues ofa7 nAChR agonist SEN12333. |
The University Of Sydney |
| 24901260 |
12 |
Recent developments in novel antidepressants targetinga4ß2-nicotinic acetylcholine receptors. |
University Of Illinois At Chicago |
| 25408831 |
1 |
Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selectivea4ß2-nAChR Ligands. |
University Of Illinois At Chicago |
| 24904968 |
7 |
Design ofa7 nicotinic acetylcholine receptor ligands in quinuclidine, tropane and quinazoline series. Chemistry, molecular modeling, radiochemistry, in vitro and in rats evaluations of a [(18)F] quinuclidine derivative. |
Universit£ |
| 24844195 |
21 |
Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A. |
Georgetown University Medical Center |
| 24814197 |
63 |
Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines asa7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders. |
Critical Therapeutics |
| 24050653 |
59 |
Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors. |
The Johns Hopkins University School Of Medicine |
| 23414838 |
33 |
Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 23461628 |
9 |
(+)-Laburnamine, a natural selective ligand and partial agonist for the?4?2 nicotinic receptor subtype. |
Universit£ |
| 23540678 |
26 |
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selectivea4ß2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. |
Georgetown University Medical Center |
| 23256554 |
16 |
Synthesis, pharmacology, and biostructural characterization of novela4ß2 nicotinic acetylcholine receptor agonists. |
University Of Copenhagen |
| 22468936 |
49 |
Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789). |
Siena Biotech |
| 23126648 |
213 |
Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. |
Targacept |
| 23083093 |
25 |
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward ana7 nicotinic acetylcholine receptor agonist preclinical candidate. |
Siena Biotech |
| 23025891 |
169 |
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands. |
Targacept |
| 22742586 |
13 |
Synthesis and nicotinic acetylcholine receptor in vitro and in vivo pharmacological properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues of 2'-fluoro-3'-(4-nitrophenyl)deschloroepibatidine. |
Research Triangle Institute |
| 22148173 |
2 |
Identification of novela4ß2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. |
University Of Illinois At Chicago |
| 21919481 |
114 |
Discovery and development ofa7 nicotinic acetylcholine receptor modulators. |
Targacept |
| 22608919 |
3 |
5-(5-(6-[(11)C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin-2-yl)-1H-indole as a potential PET radioligand for imaging cerebrala7-nAChR in mice. |
The Johns Hopkins University School Of Medicine |
| 22410083 |
17 |
Consequences of linker length alteration of thea7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. |
The University Of Sydney |
| 20478710 |
13 |
Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes. |
Universit£ |
| 19954975 |
27 |
Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor. |
Abbott Laboratories |
| 19576766 |
86 |
Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
Pfizer |
| 19552432 |
90 |
Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity. |
Abbott Laboratories |
| 18989912 |
95 |
Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist. |
University Of Copenhagen |
| 8759171 |
4 |
Lycaconitine revisited: partial synthesis and neuronal nicotinic acetylcholine receptor affinities. |
Ohio Northern University |
| 18490160 |
13 |
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity. |
Pfizer |
| 18356044 |
3 |
Deconstructing cytisine: The syntheses of (+/-)-cyfusine and (+/-)-cyclopropylcyfusine, fused ring analogs of cytisine. |
Pfizer |
| 17470817 |
12 |
Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. |
University Of California |
| 18078760 |
8 |
Parallel synthesis of a series of potentially brain penetrant aminoalkyl benzoimidazoles. |
Siena Biotech |
| 16942873 |
5 |
Synthesis and alpha4beta2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes. |
Universit£ |
| 16934977 |
16 |
Epibatidine isomers and analogues: structure-activity relationships. |
University Of Leicester |
| 16765047 |
23 |
Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors. |
Virginia Commonwealth University |
| 16821797 |
21 |
(R)-3'-(3-methylbenzo[b]thiophen-5-yl)spiro[1-azabicyclo[2,2,2]octane-3,5'-oxazolidin]-2'-one, a novel and potent alpha7 nicotinic acetylcholine receptor partial agonist displays cognitive enhancing properties. |
Mitsubishi Pharma |
| 15801858 |
27 |
Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand. |
Mitsubishi Pharma |
| 15715459 |
3 |
Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. |
Pfizer |
| 15715488 |
21 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists. |
Research Triangle Institute |
| 16107155 |
56 |
Defunctionalized lobeline analogues: structure-activity of novel ligands for the vesicular monoamine transporter. |
University Of Kentucky |
| 16033252 |
84 |
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. |
The Danish University Of Pharmaceutical Sciences |
| 15887955 |
10 |
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation. |
Pfizer |
| 15317468 |
4 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues. Novel nicotinic antagonist. |
Research Triangle Institute |
| 15808471 |
144 |
2-(Arylmethyl)-3-substituted quinuclidines as selective alpha 7 nicotinic receptor ligands. |
Targacept |
| 11855986 |
24 |
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165. |
Institut F£R Pharmazeutische Chemie Der Philipps-Universit£T Marburg |
| 12361403 |
6 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2',3'-disubstituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes: epibatidine analogues. |
Research Triangle Institute |
| 12109907 |
8 |
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165. |
University Of Bath |
| 11741488 |
19 |
2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization. |
University Of Minnesota |
| 9435889 |
70 |
Neuronal nicotinic acetylcholine receptors as targets for drug discovery. |
Abbott Laboratories |
| 8941400 |
12 |
Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding. |
School Of Pharmacy And Pharmacology |
| 15050614 |
10 |
Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
University Of Florida |
| 12467625 |
32 |
N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors. |
Chinese Academy Of Sciences |
| 12372503 |
76 |
bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors. |
University Of Kentucky |
| 11354387 |
20 |
Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues. |
University Of Kentucky |
| 22281189 |
63 |
SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore. |
Abbott Laboratories |
| 22014558 |
21 |
New spirocyclic¿²-isoxazoline derivatives related to selective agonists ofa7 neuronal nicotinic acetylcholine receptors. |
Universit£ |
| 21942635 |
23 |
Unichiral 2-(2'-pyrrolidinyl)-1,4-benzodioxanes: the 2R,2'S diastereomer of the N-methyl-7-hydroxy analogue is a potenta4ß2- anda6ß2-nicotinic acetylcholine receptor partial agonist. |
Universit£ |
| 21986237 |
18 |
Docking studies of benzylidene anabaseine interactions witha7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of relateda7 selective ligands. |
Targacept |
| 20932609 |
26 |
Synthesis of novel chiral¿2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. |
Universit£ |
| 20979364 |
40 |
Novela3ß4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. |
Sri International |
| 20880707 |
13 |
Identification of 9-fluoro substituted (-)-cytisine derivatives as ligands with high affinity for nicotinic receptors. |
Ensicaen-Université |
| 20638843 |
3 |
Discovery of novel alpha7 nicotinic receptor antagonists. |
Intra-Cellular Therapies |
| 20236734 |
186 |
A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein. |
University Of Florida |
| 20472430 |
114 |
Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands. |
Abbott Laboratories |
| 20465311 |
36 |
Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914). |
Siena Biotech |
| 20038125 |
28 |
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl)epibatidine analogues. Nicotinic partial agonists. |
Research Triangle Institute |
| 20043678 |
92 |
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models. |
Pfizer |
| 19804970 |
7 |
Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies. |
Universit£ |
| 19515567 |
29 |
SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist. |
Wyeth Research |
| 18851914 |
2 |
Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release. |
University Of Kentucky |
| | 18 |
Corrigendum to Epibatidine structureactivity relationships |
TBA |
| 19548687 |
67 |
Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes. |
Università |
| 19097783 |
26 |
5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity. |
Università |
| 18938077 |
13 |
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors. |
Università |
| 18754612 |
12 |
Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function. |
University Of Queensland |
| 18644719 |
18 |
Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. |
Università |
| 17850058 |
19 |
Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands. |
University Of Florence |
| 17098430 |
6 |
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs. |
Research Triangle Institute |
| 16905316 |
42 |
Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters. |
University Of Kentucky |
| 16821801 |
35 |
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. |
Pfizer |
| 16005216 |
20 |
The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. |
University Of Florida |
| 15501049 |
18 |
Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers. |
Università |
| 15203161 |
18 |
(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor. |
Mitsubishi Pharma |
| 15050621 |
100 |
Epibatidine structure-activity relationships. |
Research Triangle Institute |
| 15050618 |
32 |
Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release. |
University Of Kentucky |
| 14971903 |
17 |
Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. |
The University Of Queensland |
| 14611837 |
18 |
Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity. |
University Of Bristol |
| 11063601 |
29 |
(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. |
Astrazeneca R&D Boston |
| 10522693 |
14 |
Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors. |
Institute Of Science And Technology |
| 22141460 |
12 |
2-Amino-3-cyanopyridine derivatives as carbonic anhydrase inhibitors. |
Gazi University |
| 27282729 |
22 |
4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor. |
Universit?? Di Napoli Federico Ii |
| 12941317 |
25 |
Anilinopyrazole as selective CDK2 inhibitors: design, synthesis, biological evaluation, and X-ray crystallographic analysis. |
Glaxosmithkline |
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