88 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
26990539	79	Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)ß Agonist.	Vitae Pharmaceuticals
26683992	25	2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.	Eli Lilly
26218343	76	Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.	Eli Lilly
25978072	53	Synthesis and Biological Evaluation of Cyclopentaquinoline Derivatives as Nonsteroidal Glucocorticoid Receptor Antagonists.	TBA
25879485	60	Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts.	Seragon Pharmaceuticals
25941555	75	Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.	Merck Research Laboratories
24980053	153	Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.	Bristol-Myers Squibb
25516791	177	Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.	Boehringer Ingelheim Pharmaceuticals
25305688	41	Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORß and ROR¿t.	Phenex Pharmaceuticals
25187277	136	Discovery of 6-[5-(4-fluorophenyl)-3-methyl-pyrazol-4-yl]-benzoxazin-3-one derivatives as novel selective nonsteroidal mineralocorticoid receptor antagonists.	Takeda Pharmaceutical
24755427	107	The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation.	Astrazeneca
24738581	81	Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.	Pfizer
24630411	38	Mineralocorticoid receptor antagonists: identification of heterocyclic amide replacements in the oxazolidinedione series.	Merck Research Laboratories
24656565	73	Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore.	Boehringer Ingelheim Pharmaceuticals
24506830	91	Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects.	Boehringer Ingelheim Pharmaceuticals
24446728	30	Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.	Eli Lilly
24239189	85	Substituted phenyl as a steroid A-ring mimetic: providing agonist activity to a class of arylsulfonamide nonsteroidal glucocorticoid ligands.	Boehringer Ingelheim Pharmaceuticals
24215891	107	Function-regulating pharmacophores in a sulfonamide class of glucocorticoid receptor agonists.	Boehringer Ingelheim Pharmaceuticals
24157365	23	Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists.	Pfizer
24074876	17	Synthesis of sterically encumbered 11ß-aminoprogesterone derivatives and evaluation as 11ß-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists.	University Of Alberta
23953070	146	Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.	Ironwood Pharmaceuticals
23916594	92	Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.	Bristol-Myers Squibb
23958516	61	Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.	Takeda Pharmaceutical
23777778	101	Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists.	Merck Research Laboratories
23279862	1	Microwave-assisted synthesis of pyrimido[4,5-b][1,6]naphthyridin-4(3H)-ones with potential antitumor activity.	Universidad Del Valle
21129964	28	Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.	Merck Research Laboratories
20812681	24	Synthesis and biochemical characterization of a series of 17a-perfluoroalkylated estradiols as selective ligands for estrogen receptora.	Charles University In Prague
20727743	64	Discovery of quinolines as selective glucocorticoid receptor agonists.	Bayer Schering Pharma
20202837	51	The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.	Medicines Research Centre
18952422	5	The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.	Glaxosmithkline
23079530	27	Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.	Pfizer
22866979	19	Mineralocorticoid receptor antagonists for the treatment of hypertension and diabetic nephropathy.	Pfizer
21073190	135	Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists.	Bristol-Myers Squibb
20735001	145	Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics.	Boehringer Ingelheim Pharmaceuticals
20672822	108	Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.	Pfizer
20672820	92	Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists.	Pfizer
20638844	25	1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists.	Pfizer
20510622	142	Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.	Chinese Academy Of Sciences
19863083	25	The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.	Wyeth Research
18722119	55	1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators.	Wyeth Research
18504132	51	7-aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists.	Wyeth Research
18513967	103	Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines.	Ligand Pharmaceuticals
18032610	4	Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein-protein interaction profile.	Ligand Pharmaceuticals
18318463	53	Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).	Wyeth Research
17692519	108	Identification of dissociated non-steroidal glucocorticoid receptor agonists.	Boehringer Ingelheim Pharmaceuticals
17118655	73	Alpha-methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands.	Boehringer Ingelheim Pharmaceuticals
17181172	94	Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists.	Boehringer Ingelheim Pharmaceuticals
16250653	22	Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a noncanonical binding site? A molecular modeling study.	Universit£
16112571	93	Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand.	Boehringer Ingelheim Pharmaceuticals
15293993	172	Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.	Abbott Laboratories
12238914	48	6-Aryl-1,4-dihydro-benzo[d][1,3]oxazin- 2-ones: a novel class of potent, selective, and orally active nonsteroidal progesterone receptor antagonists.	Women'S Health Research Institute
8627601	169	Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.	Ligand Pharmaceuticals
15080982	122	Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.	Abbott Laboratories
12781198	108	Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.	Ligand Pharmaceuticals
12781197	59	Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.	Ligand Pharmaceuticals
10743938	103	Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.	Ligand Pharmaceuticals
22074142	89	Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.	Takeda Pharmaceutical
21963986	162	Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores.	Boehringer Ingelheim Pharmaceuticals
21899328	244	Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791	Bristol-Myers Squibb
21786805	130	Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11ß-hydroxysteroid dehydrogenase type 1.	Vitae Pharmaceuticals
21324689	74	Nonsteroidal 2,3-dihydroquinoline glucocorticoid receptor agonists with reduced PEPCK activation.	Ligand Pharmaceuticals
21349714	118	Tetrahydroquinolin-3-yl carbamate glucocorticoid receptor agonists with reduced PEPCK activation.	Ligand Pharmaceuticals
21316964	108	Discovery of orally available tetrahydroquinoline-based glucocorticoid receptor agonists.	Ligand Pharmaceuticals
24900294	72	Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids	TBA
21115247	64	Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity.	Ligand Pharmaceuticals
20638278	145	Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.	Phenex Pharmaceuticals
20430618	21	Optimisation of a pyrazole series of progesterone antagonists; Part 1.	Pfizer
20408553	27	Stereochemical requirements for the mineralocorticoid receptor antagonist activity of dihydropyridines.	Pfizer
19595590	49	Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.	Glaxosmithkline
19606870	53	Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs).	Merck Research Laboratories
18553958	28	A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3,4-f]quinoline.	Ligand Pharmaceuticals
18038968	26	(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.	Eli Lilly
17587578	45	Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators.	Argenta Discovery
17553679	148	5(Z)-benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators.	Ligand Pharmaceuticals
16759088	38	The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.	University Of Innsbruck
15081010	66	Discovery of novel nonsteroidal glucocorticoid receptor modulators.	Abbott Laboratories
12954062	140	5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.	Ligand Pharmaceuticals
11520196	81	Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.	Abbott Laboratories
10230628	95	Nonsteroidal androgen receptor agonists based on 4-(trifluoromethyl)-2H-pyrano[3,2-g]quinolin-2-one.	Ligand Pharmaceuticals
9871534	95	New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.	Ligand Pharmaceuticals
9784110	81	5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.	Ligand Pharmaceuticals
9464360	145	5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.	Ligand Pharmaceuticals
8709117	7	New steroidal diazo ketones as potential photoaffinity labeling reagents for the mineralocorticoid receptor: synthesis and biological activities.	Université
21250822	16	Synthesis and biological evaluation of novel N,N'-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.	Sun Yat-Sen University