The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 25752984 |
32 |
Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptorß agonists. |
Eli Lilly |
| 24745969 |
36 |
Identification of the first potent, selective and bioavailable PPARa antagonist. |
Inception Sciences |
| 24712661 |
47 |
Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptorß agonist in clinical trials for the treatment of dyslipidemia. |
Madrigal Pharmaceuticals |
| 24290064 |
44 |
Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptorß agonists. |
Sanwa Kagaku Kenkyusho |
| 24799995 |
54 |
Development of novel Vitamin D Receptor-Coactivator Inhibitors. |
University Of Wisconsin-Milwaukee |
| 23414840 |
285 |
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction. |
St. Jude Children'S Research Hospital |
| 24040486 |
30 |
Identification of Potent and Selective Diphenylpropanamide ROR? Inhibitors. |
New York University School Of Medicine |
| 23276448 |
46 |
Design, synthesis, and structure-activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptorß (TRß) selective agonists. |
Kissei Pharmaceutical |
| 17467994 |
136 |
2D QSAR studies on thyroid hormone receptor ligands. |
Universidade De S£O Paulo |
| 17524652 |
84 |
QSAR study of selective ligands for the thyroid hormone receptor beta. |
University Of Insubria |
| 22512468 |
13 |
Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia. |
Zydus Research Centre |
| 22324546 |
55 |
Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors. |
Institut Pasteur Korea |
| 22542282 |
25 |
Discovery of novel indane derivatives as liver-selective thyroid hormone receptorß (TRß) agonists for the treatment of dyslipidemia. |
Kissei Pharmaceutical |
| 17988877 |
60 |
Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents. |
University Of California San Francisco |
| 15293993 |
172 |
Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes. |
Abbott Laboratories |
| 19900809 |
12 |
Thyroid receptor agonists for the treatment of androgenetic alopecia. |
Pfizer |
| 19469546 |
208 |
Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors. |
St. Jude Children'S Hospital |
| 18975928 |
54 |
Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. |
Metabasis Therapeutics |
| 18585912 |
6 |
Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor beta (TR-beta) selective ligands. |
Zydus Research Centre |
| 17878314 |
8 |
Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. |
Metabasis Therapeutics |
| 16338239 |
26 |
Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta. |
Karo Bio |
| 16099653 |
28 |
A new class of high affinity thyromimetics containing a phenyl-naphthylene core. |
Pharmaceutical Research Institute |
| 15780617 |
20 |
Novel heterocyclic thyromimetics. |
Bayer Healthcare |
| 15177480 |
42 |
Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines. |
Eli Lilly |
| 12825953 |
12 |
Structural determinants of selective thyromimetics. |
University Of California |
| 12565933 |
30 |
Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics. |
Pfizer |
| 12109914 |
24 |
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. |
University Of California |
| 11806713 |
8 |
Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone. |
Karo Bio |
| 11597408 |
12 |
A designed antagonist of the thyroid hormone receptor. |
University Of California |
| 15054115 |
11 |
DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted mu opioid agonist with antihyperalgesic activity: I. In vitro pharmacological characterization and pharmacokinetic properties. |
Purdue Pharma Discovery Research |
| 14517179 |
5 |
WAY-855 (3-amino-tricyclo[2.2.1.02.6]heptane-1,3-dicarboxylic acid): a novel, EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake. |
Wyeth Research |
| 14522054 |
98 |
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. |
Brigham And Women'S Hospital |
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