The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27003516 |
78 |
Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold. |
The University Of Kansas |
| 26112442 |
74 |
Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors. |
Chengdu University Of Tcm |
| 25799158 |
6 |
Volume of Distribution in Drug Design. |
Pharmacokinetics |
| 25901531 |
211 |
Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. |
Sloan-Kettering Institute For Cancer Research |
| 25677667 |
17 |
Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors. |
Vertex Pharmaceuticals |
| 25105924 |
5 |
Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors. |
Shandong University |
| 25368984 |
14 |
Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990. |
Novartis Institutes For Biomedical Research |
| 25313505 |
35 |
Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. |
Chinese Academy Of Sciences |
| 25277067 |
7 |
Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors. |
Shandong University |
| 24751441 |
18 |
Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization. |
Chinese Academy Of Sciences |
| 24588105 |
56 |
Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold. |
Universit£ |
| 24580531 |
6 |
Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors. |
University Of Geneva |
| 24565573 |
35 |
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors. |
Universit£ |
| 24673104 |
185 |
Identification of novel HSP90a/ß isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease. |
Vertex Pharmaceuticals |
| 23362862 |
13 |
A chemical-biological study reveals C9-type iridoids as novel heat shock protein 90 (Hsp90) inhibitors. |
Universit£ |
| 22938030 |
22 |
EC144 is a potent inhibitor of the heat shock protein 90. |
Biogen Idec |
| 21438541 |
45 |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyr |
Pfizer |
| 20055425 |
29 |
Heat shock protein 90: inhibitors in clinical trials. |
Biogen Idec |
| 19231864 |
6 |
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus. |
Kosan Biosciences |
| 16854066 |
44 |
Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. |
Infinity Pharmaceuticals |
| 16165354 |
19 |
Structure-based design of 7-carbamate analogs of geldanamycin. |
Kosan Biosciences |
| 9925731 |
4 |
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. |
University College London |
| 22192591 |
17 |
Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors. |
Chugai Pharmaceutical |
| 21875802 |
33 |
Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design. |
Chugai Pharmaceutical |
| 21920765 |
12 |
Lead identification ofß-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90. |
Trinity College |
| 21715165 |
31 |
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model. |
Pfizer |
| 21106457 |
41 |
N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors. |
Abbott Laboratories |
| 21605975 |
31 |
Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model. |
Pfizer |
| 21420297 |
19 |
Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity. |
Pfizer |
| 20609590 |
10 |
Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents. |
Hokkaido University |
| 19168355 |
7 |
5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone. |
Fermentas |
| 16797988 |
4 |
Synthesis of a red-shifted fluorescence polarization probe for Hsp90. |
Memorial Sloan-Kettering Cancer Center |
| 16621545 |
6 |
Synthesis of Hsp90 dimerization modulators. |
Memorial Sloan-Kettering Cancer Center |
| 16530412 |
13 |
High-throughput screening for Hsp90 ATPase inhibitors. |
The University Of Kansas |
| 16480864 |
38 |
4-Amino derivatives of the Hsp90 inhibitor CCT018159. |
Vernalis |
| 15828828 |
136 |
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90. |
Memorial Sloan-Kettering Cancer Center |
| 15713410 |
2 |
Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles. |
Genomics Institute Of The Novartis Research Foundation |
| 15239664 |
92 |
Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90. |
Conforma Therapeutics |
| 14698151 |
14 |
Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures. |
Ribotargets |
| 14592488 |
2 |
Synthesis of novel fluorescent probes for the molecular chaperone Hsp90. |
Memorial Sloan-Kettering Cancer Center |
| 11294389 |
27 |
LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. |
Department Of Molecular Oncogenesis |
| 28500957 |
30 |
Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors. |
Cairo University |
| 10498829 |
62 |
Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. |
Cerebrus |
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