The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 26918635 |
11 |
Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv."Cascade"). |
University Of Naples Federico Ii |
| 26922224 |
23 |
4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP). |
Gazi University |
| 26899595 |
32 |
A potent and selective inhibitor targeting human and murine 12/15-LOX. |
University Of California |
| 26708113 |
33 |
Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition. |
Second University Of Naples |
| 26753816 |
8 |
Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents. |
Lomonosov Moscow State University |
| 26197161 |
40 |
Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors. |
University Of Ferrara |
| 26123643 |
90 |
Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase. |
University Of Jena |
| 26088337 |
43 |
Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol. |
University Of Innsbruck |
| 25686392 |
3 |
Myxochelins target human 5-lipoxygenase. |
Leibniz-Institute For Natural Product Research And Infection Biology |
| 25765759 |
195 |
Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes. |
University Of Naples |
| 25599836 |
14 |
Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity. |
Boehringer Ingelheim (Canada) |
| 25553540 |
6 |
1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold. |
University Of Mississippi |
| 25575659 |
124 |
SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease. |
Goethe-University Frankfurt |
| 25037914 |
76 |
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARa/¿ activation and dual 5-LO/mPGES-1 inhibition. |
Goethe-University Frankfurt |
| 25036790 |
60 |
Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism. |
Goethe-University Frankfurt |
| 24924423 |
21 |
Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes. |
University Of California |
| 25462262 |
98 |
Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy. |
Goethe-University Frankfurt |
| 24920381 |
77 |
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. |
University Jena |
| 24794107 |
32 |
Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1. |
Peking University |
| 24871899 |
31 |
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase. |
University Of Naples |
| 24697244 |
23 |
Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase. |
Friedrich-Schiller-University |
| 24684213 |
56 |
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. |
Harvard Medical School |
| 24685113 |
44 |
Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors. |
Peking University |
| 24568174 |
3 |
One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor. |
University Of Athens |
| 24393039 |
97 |
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. |
National Institutes Of Health |
| 24508141 |
30 |
Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors. |
Guru Nanak Dev University |
| 23871907 |
64 |
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase. |
University Of Salerno |
| 24368208 |
13 |
Inhibition of LOX by flavonoids: a structure-activity relationship study. |
Universidade Do Porto |
| 24295787 |
5 |
Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities. |
Medical University Of South Carolina |
| 24900624 |
18 |
Exploring the chemical space of multitarget ligands using aligned self-organizing maps. |
Goethe University |
| 24231650 |
2 |
Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection. |
University Of Groningen |
| 24171493 |
95 |
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo. |
Goethe-University Frankfurt |
| 24074025 |
3 |
Investigating the selectivity of metalloenzyme inhibitors. |
University Of California San Diego |
| 23260349 |
51 |
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation. |
Pfizer |
| 23356879 |
50 |
Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase. |
Goethe-University Frankfurt |
| 23337599 |
7 |
N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations. |
Guru Nanak Dev University |
| 1848292 |
116 |
Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. |
Ici Pharmaceuticals Group |
| 22789707 |
8 |
Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases. |
Groningen Research Institute Of Pharmacy |
| 22992107 |
34 |
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX. |
Eberhard-Karls University |
| 21591611 |
107 |
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid. |
Zafes/Liff/Goethe University Frankfurt |
| 22380511 |
73 |
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. |
Peking University |
| 22537178 |
5 |
Charting, navigating, and populating natural product chemical space for drug discovery. |
Max Planck Institute Of Molecular Physiology |
| 21800856 |
50 |
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. |
University Of Innsbruck |
| 22819942 |
2 |
Synthesis of benzo-annulated tryptanthrins and their biological properties. |
Yeungnam University |
| 22683242 |
47 |
Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors. |
University Of Salerno |
| 24900445 |
10 |
Dual-target virtual screening by pharmacophore elucidation and molecular shape filtering. |
TBA |
| 22551629 |
72 |
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors. |
Zafes/Liff/Osf Goethe-University Frankfurt |
| 21341744 |
141 |
A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors. |
Goethe-University Frankfurt |
| 20451397 |
55 |
Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. |
Universit£ |
| 19848434 |
27 |
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. |
University Of California Santa Cruz |
| 19053751 |
89 |
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase. |
Eberhard Karls University Tuebingen |
| 18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
University Of Oxford |
| 18276139 |
44 |
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. |
Merck Frosst Centre For Therapeutic Research |
| 16220969 |
219 |
Designed multiple ligands. An emerging drug discovery paradigm. |
Organon Laboratories |
| 16134928 |
34 |
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. |
The Scripps Research Institute |
| 10691695 |
85 |
Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors. |
Abbott Laboratories |
| 9288168 |
12 |
Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010. |
Merck Frosst Centre For Therapeutic Research |
| 9207936 |
198 |
Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors. |
Abbott Laboratories |
| 8831761 |
53 |
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability. |
Merck Frosst Centre For Therapeutic Research |
| 7490726 |
10 |
(R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. |
Abbott Laboratories |
| 1324317 |
21 |
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid. |
R. W. Johnson Pharmaceutical Research Institute |
| 1321908 |
44 |
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors. |
Ici Pharmaceuticals Group |
| 1635053 |
47 |
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors. |
Wyeth-Ayerst Research |
| 9990449 |
7 |
A study of novel antiallergic agents with eosinophilic infiltration inhibiting action. |
Tokushima Bunri University |
| 9871729 |
7 |
Synthesis and anti-inflammatory activity of chalcone derivatives. |
Universidad De Valencia |
| 22326163 |
63 |
SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase. |
Zafes/Liff/Osf Goethe-University Frankfurt |
| 22118829 |
13 |
Structure based drug design, synthesis and evaluation of 4-(benzyloxy)-1-phenylbut-2-yn-1-ol derivatives as 5-lipoxygenase inhibitors. |
University Of Hyderabad |
| 22059882 |
206 |
5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor. |
Amira Pharmaceuticals |
| 21958738 |
6 |
Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase. |
Universiti Putra Malaysia |
| 21958737 |
24 |
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors. |
National Taiwan University |
| 21868137 |
69 |
Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils. |
Gazi University |
| 21739938 |
72 |
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. |
National Human Genome Research Institute |
| 21696952 |
41 |
Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase. |
Bristol-Myers Squibb Research And Development |
| 21570310 |
74 |
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1. |
Eberhard Karls University Tuebingen |
| 21466167 |
47 |
Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1). |
University Of Innsbruck |
| 21319773 |
8 |
Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro. |
University Of Veterinary And Pharmaceutical Sciences Brno |
| 21323313 |
45 |
Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents. |
University Of Salerno |
| 21310608 |
55 |
A novel class of dual mPGES-1/5-LO inhibitors based on thea-naphthyl pirinixic acid scaffold. |
Goethe-University Frankfurt |
| 21189019 |
22 |
Identifying chelators for metalloprotein inhibitors using a fragment-based approach. |
University Of California |
| 21044840 |
47 |
Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286. |
Merck Frosst Centre For Therapeutic Research |
| 20866075 |
87 |
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. |
National Human Genome Research Institute |
| 20667741 |
11 |
Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors. |
University Of Hyderabad |
| 19561619 |
5 |
Bioactivity-guided mapping and navigation of chemical space. |
Institut FüR Molekulare Physiologie |
| 20236826 |
6 |
Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro. |
University Of Graz |
| 20056549 |
12 |
Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production. |
National Taiwan University |
| 19481465 |
31 |
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. |
Karl-Franzens-Universit£T Graz |
| | 39 |
O-alkylcarboxylate oxime and N-hydroxyurea analogs of substituted indole leukotriene biosynthesis inhibitors |
TBA |
| | 76 |
2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis |
TBA |
| | 14 |
Benzoxepin and benzothiepin derivatives as potent, orally active inhibitors of 5-lipoxygenase |
TBA |
| | 13 |
Design of pyrrolo-1,4-benzoxazine derivatives as inhibitors of 5-lipoxygenase and PAF antagonists with anthihistaminic properties |
TBA |
| | 4 |
Synthesis and Biological Evaluation of New Leukotriene Analogs. |
TBA |
| | 8 |
Synthesis and biological evaluation of new arachidonic acid analogs |
TBA |
| | 4 |
Design and synthesis of achiral 5-lipoxygenase inhibitors employing the cyclobutyl group |
TBA |
| | 25 |
Justicidin E: A new leukotriene biosynthesis inhibitor. |
TBA |
| | 32 |
Structure-activity relationships of the pyridazinone series of 5-lipoxygenase inhibitors |
TBA |
| | 21 |
1-Phenyl-[2H]-tetrahydropyridazin-3-one, A-53612, a selective orally active 5-lipoxygenase inhibitor |
TBA |
| | 6 |
Phenothiazine and phenoxazine derivatives of nafazatrom. In vitro evaluation as 5-lipoxygenase and iron-dependent lipid peroxidation inhibitors. |
TBA |
| | 12 |
Enzymic and nonenzymic lipid peroxidation: inhibition by substituted phenoxazines |
TBA |
| 19152786 |
5 |
Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters. |
Université |
| 18976930 |
10 |
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. |
National Institute Of Advanced Industrial Science And Technology (Aist) |
| 18701276 |
97 |
Highly functionalized 7-azaindoles as selective PPAR gamma modulators. |
Merck Research Laboratories |
| 18541424 |
4 |
Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors. |
University Of Alberta |
| 11678654 |
3 |
Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives. |
Universidad De Murcia |
| 10978197 |
3 |
Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues. |
Institute Of Pharmaceutical Sciences |
| 9544564 |
16 |
5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea. |
Heinrich-Heine-UniversitäT DüSseldorf |
| 17461565 |
39 |
Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. |
Johann Wolfgang Goethe-UniversitäT |
| 17378609 |
29 |
Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. |
Tahitian Noni International |
| 16464579 |
36 |
Substituted coumarins as potent 5-lipoxygenase inhibitors. |
Merck Frosst Centre For Therapeutic Research |
| 15863327 |
9 |
5-Lipoxygenase inhibitors: convenient synthesis of 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues. |
Pfizer |
| 15686917 |
21 |
5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds. |
Ucb Pharma |
| 15566290 |
60 |
New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy. |
Université |
| 15482930 |
22 |
Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. |
Ucb Pharma |
| 15081022 |
20 |
5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity. |
Ucb Pharma |
| 14736252 |
12 |
4-[5-Fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]phenyl]-3,4,5,6- tetrahydro-2H-pyran-4-carboxamide, an orally active inhibitor of 5-lipoxygenase with improved pharmacokinetic and toxicology characteristics. |
Pfizer |
| 11859001 |
30 |
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor. |
Laboratoires Innothera |
| 11212092 |
1 |
Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation. |
Universidade Federal Do Rio De Janeiro |
| 9871745 |
8 |
Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530. |
Merck Frosst Centre For Therapeutic Research |
| 9719605 |
62 |
New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position. |
Procter & Gamble Pharmaceuticals |
| 9544211 |
39 |
New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent. |
Procter & Gamble Pharmaceuticals |
| 9111294 |
1 |
Novel indole-2-carboxamide and cycloalkeno[1,2-b]indole derivatives. Structure-activity relationships for high inhibition of human LDL peroxidation. |
Université |
| 9057869 |
25 |
Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors. |
Abbott Laboratories |
| 8831760 |
108 |
5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones. |
Abbott Laboratories |
| 8410991 |
88 |
Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. |
Merck Frosst Centre For Therapeutic Research |
| 8289184 |
45 |
Conformational analysis of 5-lipoxygenase inhibitors: role of the substituents in chiral recognition and on the active conformations of the (methoxyalkyl)thiazole and methoxytetrahydropyran series. |
Astrazeneca |
| 8246226 |
89 |
Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors. |
Ciba-Geigy |
| 8201600 |
41 |
Antipsoriatic anthrones with modulated redox properties. 2. Novel derivatives of chrysarobin and isochrysarobin--antiproliferative activity and 5-lipoxygenase inhibition. |
UniversitäT Regensburg |
| 8164257 |
18 |
Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. |
Merck Frosst Centre For Therapeutic Research |
| 8120869 |
10 |
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids. |
Merck Frosst Centre For Therapeutic Research |
| 8021931 |
19 |
(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. |
Merckle |
| 7861415 |
3 |
Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application in asthma. |
Solvay Pharma |
| 7837242 |
24 |
Derivatives of 2-[[N-(Aminocarbonyl)-N-hydroxyamino]methyl]-1,4- benzodioxan as orally active 5-lipoxygenase inhibitors. |
Ciba-Geigy |
| 7562928 |
35 |
Chiral dioxolane inhibitors of leukotriene biosynthesis: structure-activity relationships and syntheses using asymmetric dihydroxylation. |
Zeneca Pharmaceuticals |
| 7473582 |
29 |
Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase. |
Merck Frosst Centre For Therapeutic Research |
| 6298421 |
10 |
Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds. |
TBA |
| 3669017 |
8 |
Phenylephrine derivatives as leukotriene D4 antagonists. |
Wyeth Laboratories |
| 3346867 |
6 |
Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors. |
Wellcome Research Laboratories |
| 2542553 |
31 |
Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224. |
Merck Frosst Canada |
| 2502629 |
90 |
Differential effects of a series of hydroxamic acid derivatives on 5-lipoxygenase and cyclooxygenase from neutrophils and 12-lipoxygenase from platelets and their in vivo effects on inflammation and anaphylaxis. |
Rorer Central Research |
| 2465410 |
3 |
Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides. |
Dainippon Pharmaceutical |
| 2329571 |
12 |
Studies on hindered phenols and analogues. 2. 1,3-Benzoxathioles having SRS-A inhibiting activity. |
Sankyo |
| 2319562 |
12 |
Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes. |
Molecular Therapeutics |
| 2157009 |
49 |
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships. |
Rorer Central Research |
| 2113949 |
126 |
Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors. |
Boehringer Ingelheim Pharmaceuticals |
| 2066991 |
40 |
Syntheses of 5,7,8- and 5,6,7-trioxygenated 3-alkyl-3',4'-dihydroxyflavones and their inhibitory activities against arachidonate 5-lipoxygenase. |
University Of Tokushima |
| 2066989 |
89 |
4-hydroxythiazole inhibitors of 5-lipoxygenase. |
Abbott Laboratories |
| 1648621 |
55 |
(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity. |
Ici Pharmaceuticals Group |
| 15530990 |
6 |
Synthesis and biological evaluation of 4-imidazolylflavans as nonsteroidal aromatase inhibitors. |
BiomolÉCules Et Cibles Cellulaires Tumorales |
| 21439476 |
12 |
Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors. |
University Of Luxembourg |
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