47 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28523094	4	Modulation of the Inhibitors of Apoptosis Proteins (IAPs) Activities for Cancer Treatment.	Therachem Research Medilab (India)
26191364	10	Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.	Bristol-Myers Squibb Research
26218264	24	Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.	Astex Pharmaceuticals
26181851	26	Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.	Novartis Institutes For Biomedical Research
25278234	25	Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists.	Bristol-Myers Squibb Research & Development
24631189	86	Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.	Astrazeneca
24169315	9	Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.	Takeda Pharmaceutical
24093940	85	Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.	Hoffmann-La Roche
24083782	48	Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain.	Hoffmann-La Roche
23928071	3	Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.	Takeda Pharmaceutical
23886811	4	Solid phase synthesis of Smac/DIABLO-derived peptides using a 'Safety-Catch' resin: identification of potent XIAP BIR3 antagonists.	Queen'S University Of Belfast
23743278	58	Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.	Sanford-Burnham Medical Research Institute
23651223	61	A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice.	University Of Michigan
23298277	26	Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.	Takeda Pharmaceutical
23062821	51	Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.	Fondazione Irccs Istituto Nazionale Dei Tumori
22148838	125	Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents.	University Of Michigan
21443232	24	A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.	University Of Michigan
22413863	21	Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).	Genentech
21241056	6	Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.	University Of Pittsburgh
15115387	13	Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.	University Of Michigan Comprehensive Cancer Center
22342627	36	Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.	Cisi
22264476	60	Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.	Astrazeneca R&D Boston
21664815	4	DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides.	Humboldt Universit£T Zu Berlin
21680182	64	Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.	Sanford-Burnham Medical Research Institute
21462933	155	Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.	University Of Michigan
21087868	3	In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3.	University Of Innsbruck
20684551	40	Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.	University Of Michigan
20443226	15	Cyclopeptide Smac mimetics as antagonists of IAP proteins.	University Of Michigan
20189383	70	Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.	Genentech
19819692	2	Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain.	Institute For Medical Research
19138149	15	Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.	Chinese Academy Of Sciences
28492317	35	Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).	Astex Pharmaceuticals
28406627	110	Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84.	University Of Bonn
23402383	6	Discovery of new HER2/EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agents.	Msa University
24607578	11	Development of novel pyrazolone derivatives as inhibitors of aldose reductase: an eco-friendly one-pot synthesis, experimental screening and in silico analysis.	Swami Ramanand Teerth Marathwada University
10692507	41	5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors.	National Institute On Drug Abuse