37 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28252961	13	Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.	Goethe-University Frankfurt
27423639	8	Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7.	Gazi University
26922224	23	4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP).	Gazi University
26004579	1	Recent advances for FLAP inhibitors.	Astrazeneca
25671290	106	Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).	Boehringer Ingelheim Pharmaceuticals
23266122	47	Novel benzoxazole inhibitors of mPGES-1.	Pfizer
22607880	54	Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).	Gazi University
22578458	84	Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors.	Merck Research Laboratories
18276139	44	Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.	Merck Frosst Centre For Therapeutic Research
8709092	21	Modulators of leukotriene biosynthesis and receptor activation.	Abbott Laboratories
22059882	206	5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.	Amira Pharmaceuticals
21044840	47	Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: discovery of MK-5286.	Merck Frosst Centre For Therapeutic Research
20566292	6	5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.	Amira Pharmaceuticals
20144869	90	Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template.	Pfizer
19914828	37	5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.	Amira Pharmaceuticals
19739647	52	5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).	Amira Pharmaceuticals
19719242	13	Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX).	Eberhard Karls University Tuebingen
	39	O-alkylcarboxylate oxime and N-hydroxyurea analogs of substituted indole leukotriene biosynthesis inhibitors	TBA
	17	Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors	TBA
	4	A new class of leukotriene biosynthesis inhibitors: The discovery of MK0591	TBA
18459759	9	Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target.	Merck Frosst Centre For Therapeutic Research
15953724	38	Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.	Merck Frosst Centre For Therapeutic Research
10476875	36	Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors.	Merck Frosst Center For Therapeutic Research
8410991	88	Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.	Merck Frosst Centre For Therapeutic Research
7473582	29	Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.	Merck Frosst Centre For Therapeutic Research
22380777	16	Synthesis and HIV-1 RT inhibitory action of novel (4/6-substituted benzo[d]thiazol -2-yl)thiazolidin-4-ones. Divergence from the non-competitive inhibition mechanism.	Aristotle University Of Thessaloniki
22168126	43	Carbonic anhydrase inhibitors: in vitro inhibition of a isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids.	Ondokuz Mayis University
16970397	24	Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.	Yale University
8765512	25	Paracyclophanes: a novel class of water-soluble inhibitors of HIV proteinase.	Sandoz Research Institute
15491144	22	Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance.	University Of Alabama At Birmingham