The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 18053726 |
364 |
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. |
Johnson & Johnson Pharmaceutical Research & Development |
| 17665896 |
30 |
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity. |
Lek Pharmaceuticals |
| 9767634 |
15 |
Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins. |
F. Hoffmann-La Roche |
| 8809160 |
132 |
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases. |
F. Hoffmann-La Roche |
| 15026061 |
1 |
The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives. |
University Of Huddersfield |
| 11012024 |
44 |
The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors. |
The R. W. Johnson Pharmaceutical Research Institute |
| | 51 |
The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins |
TBA |
| 21664132 |
47 |
Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii. |
Merck |
| 21392987 |
25 |
Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors. |
Anacor Pharmaceuticals |
| 20921316 |
10 |
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor. |
Novexel |
| 20299220 |
4 |
4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: first boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity. |
Merck |
| | 10 |
Synthesis and biological activity of novel penem sulfoxides and sulfones |
TBA |
| | 2 |
Mechanistic support for the stepwise process for inactivation of class A β-lactamases by clavulanate |
TBA |
| 16854068 |
59 |
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods. |
Wyeth Research |
| 15588091 |
25 |
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates. |
Wyeth Research |
| 12801220 |
16 |
Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone. |
Wyeth Research |
| 12039585 |
52 |
Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent. |
Southern Methodist University |
| 10890171 |
6 |
Synthesis and biological activities of an alpha-methyl and a beta-methyl carbapenem and the corresponding unsubstituted compound. |
University Of Munich |
| 7699694 |
66 |
Synthesis and biological activity of 7-alkylidenecephems. |
Southern Methodist University |
| 3039137 |
20 |
Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives. |
TBA |
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