The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 8410977 |
43 |
2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists. |
Syntex Research |
| 1552497 |
38 |
Novel 5-HT3 antagonists: indol-3-ylspiro(azabicycloalkane-3,5'(4'H)-oxazoles). |
Merck Sharp And Dohme Research Laboratories |
| 1992112 |
53 |
Novel 5-HT3 antagonists. Indole oxadiazoles. |
Merck Sharp And Dohme Research Laboratories |
| | 18 |
Synthesis and serotonergic activity of benzofuran and dihydrogenzofuran analogues of 5-carboxamidotryptamine. |
TBA |
| 8642566 |
277 |
Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines. |
Universit£ |
| 7752204 |
98 |
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. |
Merck Sharp & Dohme Research Laboratories |
| 8496922 |
92 |
Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors. |
Merck Sharp And Dohme Research Laboratories |
| 2342053 |
20 |
Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site. |
Merrell Dow Research Institute |
| | 12 |
Quaternised renzapride as a potent and selective 5-HT4 receptor agonist |
TBA |
| 21486038 |
177 |
Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. |
H. Lundbeck |
| 24900351 |
19 |
Bivalent Ligands for the Serotonin 5-HT3 Receptor. |
TBA |
| 19831400 |
47 |
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. |
European Research Centre For Drug Discovery And Development (Natsyndrugs) |
| 18490160 |
13 |
Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity. |
Pfizer |
| 16451077 |
86 |
Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists. |
Pfizer |
| 15715459 |
3 |
Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. |
Pfizer |
| 15887964 |
47 |
Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties. |
Universit£ |
| 15482914 |
25 |
Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750. |
Pfizer |
| 12593651 |
107 |
Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity. |
Dainippon Pharmaceutical |
| 10229626 |
66 |
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors. |
Universit£ |
| 10585211 |
62 |
Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors. |
Universidad Complutense |
| 10425096 |
80 |
2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives. |
Faes |
| 9513601 |
53 |
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives. |
Universit£ |
| 9464362 |
19 |
5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists. |
Universit£ |
| 9685241 |
2 |
Benzoxazole derivatives as novel 5-HT3 receptor partial agonists in the gut. |
Pharmaceutical Research Center |
| 9046352 |
86 |
New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. |
Cnrs-Biocis |
| 9357534 |
49 |
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure. |
Universit£ |
| 9341912 |
43 |
Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding. |
Pharmacia & Upjohn |
| 7629808 |
64 |
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies. |
Universit£ |
| 8176710 |
24 |
Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties. |
Cifa Universidad De Navarra |
| 8496941 |
23 |
5-HT3 receptor antagonists. 2. 4-Hydroxy-3-quinolinecarboxylic acid derivatives. |
Kyowa Hakko Kogyo |
| 8410988 |
12 |
Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives. |
Universidad De Navarra |
| 1573641 |
60 |
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype. |
Searle Research And Development |
| 1312602 |
18 |
Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. |
Rh£Ne-Poulenc Rorer Central Research |
| 1479589 |
36 |
5-HT3 receptor antagonists. 1. New quinoline derivatives. |
Kyowa Hakko Kogyo |
| 1695682 |
41 |
Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists. |
Istituto De Angeli |
| 2362270 |
3 |
5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives. |
Beecham Pharmaceuticals Research Division |
| 2258903 |
23 |
Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors. |
Eli Lilly |
| 2296012 |
10 |
Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists. |
Pfizer |
| 2874226 |
27 |
Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives. |
TBA |
| 15050614 |
10 |
Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes. |
University Of Florida |
| 11755351 |
24 |
Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands. |
Universidad De Alcal£ |
| 9871571 |
44 |
A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin- 3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors. |
Dainippon Pharmaceutical |
| | 63 |
Serotoninergic 5-HT3 and 5-HT4 receptor activities of dihydrobenzofuran carboxylic acid derivatives |
TBA |
| | 26 |
Novel benzimidazole-4-carboxylic acid derivatives as potent and selective 5-HT3 receptor ligands |
TBA |
| | 24 |
Synthesis and pharmacological activity of a macrocyclic benzamide |
TBA |
| | 8 |
N-chloromethyl quinuclidinium derivatives: A new class of irreversible ligands for 5-HT3 receptors. |
TBA |
| | 25 |
Pyrazolo[1,5-a]pyridines and pyrazolo[1,5-b]pyridazines as 5ht3-antagonists |
TBA |
| | 7 |
Azaheteroaromatic ethers as carbonyl bioisosteres. Synthesis and evaluation of a novel class of 5-HT3 receptor antagonists |
TBA |
| | 14 |
New aza(nor)adamantanes are agonists at the newly identified serotonin 5-HT4 receptor and antagonists at the 5-HT3 receptor |
TBA |
| 22107017 |
47 |
Optimization of 5-pyridazin-3-one phenoxypropylamines as potent, selective histamine H3 receptor antagonists with potent cognition enhancing activity. |
Cephalon |
| 22029386 |
156 |
New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage. |
Universidad Complutense De Madrid |
| 19726200 |
37 |
Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors. |
Hungarian Academy Of Sciences |
| 15801844 |
54 |
Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors. |
TBA |
| | 21 |
Serotonin 5-HT4 agonist activity of a series of meso-azanoradamantane benzamides |
TBA |
| | 8 |
(S)-4-amino-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptor |
TBA |
| | 35 |
Design of a potent 5-HT4 receptor agonist with nanomolar affinity |
TBA |
| | 18 |
Derivatives of quinuclidine as 5-HT3 receptor antagonists: influence of an additional carbonyl group on the recognition of chirality by the receptor. |
TBA |
| | 18 |
Derivatives of naphthalimide: new potent conformationally restricted antagonists of 5-HT3 receptors. |
TBA |
| 19425598 |
61 |
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships. |
European Research Centre For Drug Discovery And Development (Natsyndrugs) |
| 17328523 |
36 |
Novel sigma receptor ligands: synthesis and biological profile. |
University Of Catania |
| 15341484 |
159 |
Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors. |
Merck |
| 15084129 |
52 |
4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity. |
Università |
| 12951088 |
22 |
Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands. |
Universidad Complutense |
| 12109911 |
47 |
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine. |
University Center For Pharmacy |
| 11934576 |
85 |
Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands. |
Université |
| 11462981 |
184 |
New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants. |
Universidad De Navarra |
| 10543880 |
63 |
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies. |
Universita' Degli Studi Di Salerno |
| 9873388 |
24 |
Synthesis of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)nicotinamides and their affinities for 5-HT3 and dopamine D2 receptors. |
Dainippon Pharmaceutical |
| 9046348 |
45 |
[[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT1A receptor ligands. |
Università |
| 8246239 |
84 |
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives. |
Solvay Duphar |
| 8071931 |
20 |
5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist. |
Medical College Of Virginia/Virginia Commonwealth University |
| 8064797 |
118 |
Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors. |
Vanderbilt University |
| 6581313 |
2 |
Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines. |
TBA |
| 26119990 |
19 |
Synthesis, biological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors. |
University Of Karachi |
| 26042530 |
40 |
Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis. |
The M. S. University Of Baroda |
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