The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 6313919 |
6 |
C4-substituted 1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidines as adenosine agonist analogues. |
TBA |
| 27836398 |
31 |
Discovery of 1,3-diethyl-7-methyl-8-(phenoxymethyl)-xanthine derivatives as novel adenosine A |
North-West University |
| 27933810 |
166 |
Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT |
National Institute Of Diabetes And Digestive And Kidney Diseases |
| 27485602 |
183 |
Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors. |
Jagiellonian University Medical College |
| 26356532 |
39 |
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. |
Georgia Institute Of Technology |
| 26776359 |
21 |
Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists. |
North-West University |
| 26392370 |
66 |
1,3,7-Triethyl-substituted xanthines--possess nanomolar affinity for the adenosine A1 receptor. |
North-West University |
| 26141910 |
1 |
Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study. |
Universit£ |
| 25181013 |
4 |
Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene. |
Universit£ |
| 24164628 |
186 |
Adenosine A2A receptor as a drug discovery target. |
Merck Research Laboratories |
| 9438021 |
97 |
Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model. |
National Institute Of Diabetes |
| 23245803 |
87 |
Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands. |
University Of Bonn |
| 1542091 |
38 |
A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor. |
Center For Bio-Pharmaceutical Sciences |
| 19682912 |
80 |
Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists. |
Universidade De Santiago De Compostela |
| 19346133 |
58 |
Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists. |
Universidade De A Coru£A |
| 16392813 |
329 |
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor. |
Universit£ |
| 22468757 |
171 |
Medicinal chemistry of A3 adenosine receptor modulators: pharmacological activities and therapeutic implications. |
Universit£ |
| 22889387 |
2 |
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor. |
Universit£ |
| 21664729 |
142 |
Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones. |
Jagiellonian University Medical College |
| 22486652 |
44 |
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. |
National Institute Of Diabetes And Digestive And Kidney Diseases |
| 24900277 |
36 |
Development of Polar Adenosine A2A Receptor Agonists for Inflammatory Bowel Disease: Synergism with A2B Antagonists. |
TBA |
| 21858244 |
62 |
Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element. |
TBA |
| 20598555 |
3 |
2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation. |
Freie Universit£T Berlin |
| 20188574 |
141 |
2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists. |
University Of Bonn |
| 19569717 |
251 |
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. |
Institute |
| 10757709 |
8 |
Luteolin, a compound with adenosine A(1) receptor-binding activity, and chromone and dihydronaphthalenone constituents from Senna siamea. |
Leiden University |
| 18424135 |
131 |
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. |
National Institute Of Diabetes And Digestive And Kidney Diseases |
| 18068994 |
4 |
New QSAR combined strategy for the design of A1 adenosine receptor agonists. |
Central University Of Las Villas |
| 15566292 |
153 |
Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists. |
Biogen Idec |
| 15771453 |
22 |
Development of spin-labeled probes for adenosine receptors. |
University Of Bonn |
| 15771443 |
94 |
Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
Biogen Idec |
| 15863334 |
6 |
Geometry, topology, and atom-weights assembly descriptors to predicting A1 adenosine receptors agonists. |
Experimental Sugar Cane Station |
| 15084123 |
24 |
Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative. |
University Of Bonn |
| 12646033 |
124 |
Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists. |
Universit£ |
| 11881988 |
16 |
Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues. |
Universit£ |
| 12383013 |
44 |
Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists. |
Universit£ |
| 11784146 |
9 |
2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor. |
Leiden/Amsterdam Center For Drug Research |
| 12139454 |
56 |
Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists. |
University Of Bonn |
| 11262085 |
92 |
Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists. |
Vrije Universiteit |
| 11170643 |
171 |
Design, synthesis, and evaluation of novel A2A adenosine receptor agonists. |
University Of Virginia |
| 11708915 |
52 |
Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. |
National Institute Of Diabetes And Digestive And Kidney Diseases |
| 11170630 |
46 |
Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins. |
Hokkaido University |
| 11520205 |
4 |
5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors. |
Leiden/Amsterdam Center For Drug Research |
| 10649980 |
52 |
N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor. |
Universit£ |
| 10841798 |
64 |
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. |
National Institute Of Diabetes |
| 10212125 |
14 |
N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor. |
Leiden/Amsterdam Center For Drug Research |
| 10212124 |
26 |
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. |
Leiden University |
| 9703464 |
40 |
Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. |
National Institute Of Diabetes |
| 9703463 |
102 |
Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists. |
Universit£ |
| 9667957 |
5 |
Nucleosides and nucleotides. 177. 9-(6,7-dideoxy-beta-D-allo-hept-5- ynofuranosyl)adenine: a selective and potent ligand for P3 purinoceptor-like protein. |
Hokkaido University |
| 9438026 |
41 |
5'-substituted adenosine analogs as new high-affinity partial agonists for the adenosine A1 receptor. |
Leiden/Amsterdam Center For Drug Research |
| 9371242 |
54 |
N6-cyclopentyl-3'-substituted-xylofuranosyladenosines: a new class of non-xanthine adenosine A1 receptor antagonists. |
University Of Ghent |
| 8691477 |
28 |
N6,C8-distributed adenosine derivatives as partial agonists for adenosine A1 receptors. |
Leiden/Amsterdam Center For Drug Research |
| 8576924 |
69 |
Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors. |
Universit£ |
| 8917655 |
72 |
6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists. |
National Institute Of Diabetes |
| 8863798 |
52 |
2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors. |
Universit£ |
| 8709132 |
92 |
Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors. |
National Institute Of Diabetes |
| 7739005 |
143 |
2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists. |
Universit£ |
| 7707320 |
99 |
Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. |
National Institute Of Diabetes |
| 7562934 |
38 |
Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor. |
Leiden University |
| 7658444 |
56 |
2-[N'-(3-arylallylidene)hydrazino]adenosines showing A2a adenosine agonist properties and vasodilation activity. |
Universit£ |
| 7752196 |
103 |
Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors. |
National Institute Of Diabetes |
| 8126704 |
79 |
Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists. |
National Institute Of Diabetes |
| 7996542 |
32 |
N6-substituted adenosine receptor agonists. Synthesis and pharmacological activity as potent antinociceptive agents. |
Carpibem |
| 7966162 |
39 |
Selective ligands for rat A3 adenosine receptors: structure-activity relationships of 1,3-dialkylxanthine 7-riboside derivatives. |
National Institute Of Diabetes |
| 7932588 |
48 |
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. |
National Institute Of Diabetes |
| 8201607 |
50 |
2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. |
Universit£ |
| 8246243 |
9 |
Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. |
Kyowa Hakko Kogyo |
| 8355252 |
54 |
Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance. |
Kyowa Hakko Kogyo |
| 1548682 |
126 |
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. |
Kyowa Hakko Kogyo |
| 1738138 |
62 |
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential. |
Niddk |
| 1433217 |
31 |
Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists. |
National Institute Of Diabetes |
| 1732541 |
60 |
Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects. |
Hokkaido University |
| 1501234 |
111 |
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. |
Kyowa Hakko Kogyo |
| 1495019 |
57 |
Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity. |
Hokkaido University |
| 1619615 |
71 |
2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors. |
Universit£ |
| 1613750 |
46 |
Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects. |
Yamasa Shoyu |
| 1895305 |
75 |
N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor. |
University Of South Florida |
| 1875349 |
94 |
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines. |
Ciba-Geigy |
| 2002461 |
37 |
1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists. |
Center For Bio-Pharmaceutical Sciences |
| 2002448 |
112 |
N6-substituted adenosine receptor agonists: potential antihypertensive agents. |
Warner-Lambert |
| 1766003 |
18 |
Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. |
University Of South Florida |
| 2374150 |
193 |
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants. |
Pfizer |
| 2362269 |
30 |
2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands. |
Ciba-Geigy |
| 2258897 |
23 |
A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors. |
Merrell Dow Research Institute |
| 2754711 |
102 |
Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors. |
Niddk |
| 2754691 |
43 |
C2,N6-disubstituted adenosines: synthesis and structure-activity relationships. |
Warner-Lambert |
| 2709373 |
63 |
Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors. |
Niddk |
| 2909748 |
18 |
N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor. |
Warner-Lambert |
| 3385722 |
42 |
N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor. |
Warner-Lambert |
| 3373486 |
44 |
Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives. |
Universit£ |
| 3351851 |
9 |
Photoaffinity labeling adenosine A1 receptors with an antagonist 125I-labeled aryl azide derivative of 8-phenylxanthine. |
University Of Virginia School Of Medicine |
| 3351850 |
46 |
125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors. |
University Of Virginia School Of Medicine |
| 3336027 |
32 |
N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor. |
Warner-Lambert |
| 2441057 |
22 |
Binary drugs: conjugates of purines and a peptide that bind to both adenosine and substance P receptors. |
TBA |
| 2888894 |
32 |
N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity. |
Parke-Davis Pharmaceutical Research Division |
| 3018244 |
91 |
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors. |
TBA |
| 3005574 |
34 |
Ribose-modified adenosine analogues as adenosine receptor agonists. |
TBA |
| 2993623 |
19 |
Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors. |
TBA |
| 2991519 |
98 |
Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application. |
TBA |
| 2984420 |
49 |
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors. |
TBA |
| 2995663 |
26 |
N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists. |
TBA |
| 6279840 |
53 |
Adenosine receptors: targets for future drugs. |
TBA |
| 12617898 |
13 |
Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands. |
Seoul National University |
| 11277527 |
2 |
Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'receptor knock-down' tool. |
Vrije Universiteit |
| 11392549 |
45 |
Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications. |
Niddk |
| 10714510 |
36 |
The discovery and synthesis of highly potent, A2a receptor agonists. |
Glaxowellcome Medicines Research Centre |
| 10999489 |
29 |
2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A1, A2A and A3 receptor subtypes. |
University Of Amsterdam |
| 9871585 |
23 |
Diimidazo[1,2-c:4',5'-e]pyrimidines: N6-N1 conformationally restricted adenosines. |
Griffith University |
| 9871584 |
13 |
Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry. |
Griffith University |
| 9873707 |
18 |
Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives. |
Glaxowellcome Medicines Research Center |
| | 31 |
New base-altered adenosine analogues: Synthesis and affinity at adenosine A1 and A2A receptors |
TBA |
| | 22 |
High selectivity of novel isoguanosine analogues for the adenosine A1 receptor |
TBA |
| 22182575 |
1 |
Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A¿? adenosine receptor. |
Universit£ |
| 20537438 |
101 |
Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods. |
East China University Of Science And Technology |
| 20116907 |
15 |
Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines--their potential as adenosine receptor ligands. |
Institute Of Chemical Technology |
| 20304654 |
79 |
Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process. |
National University Of Singapore |
| 19580286 |
44 |
Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5'-nucleotidase. |
University Of Bonn |
| 9214739 |
1 |
Adenosine-1 active ligands: cirsimarin, a flavone glycoside from Microtea debilis. |
University Of Antwerp |
| | 52 |
Adenosine A2A antagonists with potent anti-cataleptic activity |
TBA |
| | 8 |
Pyrazolo[3,4-d]pyrimidines: C4, C6 substitution leads to adenosine A1 receptor selectivity |
TBA |
| | 13 |
Discovery of FK453, a novel non-xanthine adenosine A1 receptor antagonist |
TBA |
| | 12 |
Pyrazolo[3,4-d]pyrimidines; adenosine receptor selectivity |
TBA |
| | 32 |
Synthesis of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c] pyrimidine and 1,2,3-triazolo[4,5-e]1,2,4-triazolo[1,5-c] pyrimidine displaying potent and selective activity as A2a adenosine receptor antagonists. |
TBA |
| | 52 |
The synthesis and biochemical evaluation of new A1 selective adenosine receptor agonists containing 6-hydrazinopurine moieties |
TBA |
| | 4 |
A note of caution in the use of receptor binding assays to screen marine organisms: the action of halistanol trisulphate on adenosine receptors. |
TBA |
| | 8 |
An explanation of the substituent effect of 1,3,8-trisubstituted xanthines on adenosine A1/A2 affinity. |
TBA |
| 19301821 |
55 |
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. |
Universita Di Firenze |
| 19230680 |
58 |
Synthesis, biological assays and QSAR studies of N-(9-benzyl-2-phenyl-8-azapurin-6-yl)-amides as ligands for A1 adenosine receptors. |
Università |
| 18729349 |
28 |
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor. |
Dipartimento Di Scienze Farmaceutiche |
| 18468446 |
55 |
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. |
Universita' Di Firenze |
| 18045744 |
16 |
N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors. |
Università |
| 17602796 |
5 |
Synthesis and adenosine receptor binding studies of some novel triazolothienopyrimidines. |
University College Of Pharmaceutical Sciences |
| 12398547 |
9 |
Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors. |
University Of Bonn |
| 12193019 |
2 |
Naturally occurring cembranes from an Australian sarcophyton species. |
Astrazeneca R&D Griffith University |
| 10757728 |
2 |
Isolation of psammaplin A 11'-sulfate and bisaprasin 11'-sulfate from the marine sponge Aplysinella rhax. |
Griffith University |
| 10757710 |
5 |
Anthoptilides A-E, new Briarane diterpenes from the Australian sea pen Anthoptilum cf. kukenthali. |
Griffith University |
| 10543913 |
1 |
Isolation of xestosterol esters of brominated acetylenic fatty acids from the marine sponge xestospongia testudinaria |
Griffith University |
| 10395519 |
1 |
Interference of linoleic acid fraction in some receptor binding assays. |
Leiden University |
| 9514015 |
6 |
Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp. |
Institut FüR Biowissenschaften |
| 17827019 |
86 |
Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands. |
Jagiellonian University Medical College |
| 17665891 |
60 |
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies. |
Università |
| 17499511 |
46 |
N9-benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors. |
Jagiellonian University |
| 17125265 |
49 |
Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists. |
Biogen Idec |
| 17125264 |
60 |
Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists. |
Biogen Idec |
| 16821798 |
62 |
A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists. |
University Of Bonn |
| 16153830 |
64 |
Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists. |
Biogen Idec |
| 15664803 |
46 |
Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists. |
Biogen Idec |
| 15341934 |
28 |
Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists. |
Biogen Idec |
| 15341933 |
40 |
Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles. |
Biogen Idec |
| 15294001 |
88 |
Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists. |
Biogen Idec |
| 14761205 |
56 |
Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. |
University Of Bonn |
| 14698198 |
31 |
Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF). |
Cv Therapeutics |
| 12166943 |
81 |
1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands. |
Nutrition Research Institute |
| 12166930 |
21 |
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist. |
TBA |
| 12014951 |
139 |
Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. |
National Institute Of Diabetes & Digestive & Kidney Diseases |
| 11960496 |
50 |
5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists. |
Ghent University |
| 11906291 |
129 |
1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. |
University Of Bonn |
| 11527718 |
9 |
Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings. |
Niddk |
| 11454470 |
17 |
Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor. |
Leiden/Amsterdam Center For Drug Research |
| 11206456 |
7 |
High-pressure synthesis of enantiomerically pure C-6 substituted pyrazol. |
Astrazeneca R&D Griffith University |
| 11170626 |
55 |
2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor. |
Eisai |
| 11101355 |
26 |
7-Deazaadenines bearing polar substituents: structure-activity relationships of new A(1) and A(3) adenosine receptor antagonists. |
University Of Leipzig |
| 11087559 |
7 |
Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography. |
University Of Milano-Bicocca |
| 10841801 |
33 |
Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor. |
Vrije Universiteit |
| 10737749 |
182 |
Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors. |
National Institute Of Diabetes |
| 10669571 |
24 |
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists. |
University Of WüRzburg |
| 10579811 |
70 |
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists. |
Università |
| 10514293 |
31 |
Selective A(3) adenosine receptor antagonists: water-soluble 3, 5-diacyl-1,2,4-trialkylpyridinium salts and their oxidative generation from dihydropyridine precursors. |
National Institute Of Diabetes |
| 10479294 |
13 |
Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding. |
Leiden/Amsterdam Center For Drug Research |
| 10479279 |
20 |
N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects. |
Novo Nordisk |
| 10476879 |
52 |
Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays. |
Cadus Pharmaceutical |
| 10450966 |
16 |
Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist. |
Fujisawa Pharmaceutical |
| 10447949 |
27 |
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists. |
National Institute Of Diabetes |
| 10052977 |
82 |
Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. |
National Institute Of Diabetes |
| 9873431 |
18 |
The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles. |
Novo Nordisk |
| 9767637 |
31 |
A novel class of adenosine A3 receptor ligands. 2. Structure affinity profile of a series of isoquinoline and quinazoline compounds. |
Vrije Universiteit |
| 9767636 |
38 |
A novel class of adenosine A3 receptor ligands. 1. 3-(2-Pyridinyl)isoquinoline derivatives. |
Vrije Universiteit |
| 9667972 |
119 |
Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. |
National Institute Of Diabetes |
| 9622554 |
59 |
Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists. |
Università |
| 9435909 |
90 |
Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists. |
Julius-Maximilians-UniversitäT WüRzburg |
| 9258367 |
99 |
Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists. |
National Institute Of Diabetes |
| 9191953 |
11 |
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine. |
Cv Therapeutics |
| 8863792 |
22 |
Synthesis and structure-activity relationship of pyrazolo[3,4-d]pyrimidines: potent and selective adenosine A1 receptor antagonists. |
Griffith University |
| 8863790 |
55 |
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. |
National Institute Of Diabetes |
| 8691445 |
70 |
Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists. |
Julius-Maximilians-UniversitäT WüRzburg |
| 8691424 |
61 |
Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. |
National Institute Of Diabetes |
| 8676354 |
42 |
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists. |
Università |
| 8576921 |
63 |
Interactions of flavonoids and other phytochemicals with adenosine receptors. |
National Institute Of Diabetes |
| 8558508 |
55 |
Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists. |
National Institute Of Diabetes |
| 8496902 |
139 |
Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists. |
National Institute Of Diabetes |
| 8410976 |
60 |
Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors. |
National Institutes Of Health |
| 8258823 |
16 |
Xanthines with C8 chiral substituents as potent and selective adenosine A1 antagonists. |
Marion Merrell Dow Research Institute |
| 8230124 |
92 |
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors. |
Pharmazeutische Chemie |
| 8182711 |
39 |
Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists. |
Eberhard-Karls-UniversitäT TüBingen |
| 8120866 |
54 |
Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine. |
Smithkline Beecham Pharmaceuticals |
| 7932565 |
92 |
Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors. |
National Institute Of Diabetes |
| 7731018 |
64 |
Tricyclic heteroaromatic systems. Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c] pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo[3,4-b]quinolin-4- ones, and 1-aryl-1H-imidazo[4,5-b]quinoxalines. |
Università |
| 6090665 |
28 |
Mesoionic xanthine analogues: antagonists of adenosine receptors. |
TBA |
| 3806606 |
49 |
Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists. |
TBA |
| 3806597 |
19 |
Xanthine functionalized congeners as potent ligands at A2-adenosine receptors. |
TBA |
| 3806581 |
68 |
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors. |
TBA |
| 3361572 |
38 |
Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists. |
Ciba-Geigy |
| 3361571 |
30 |
[1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: a new class of A1 receptor selective adenosine antagonists. |
Warner-Lambert |
| 3172141 |
35 |
Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists. |
Merrell Dow Research Institute |
| 3016270 |
40 |
Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents. |
TBA |
| 2993622 |
36 |
Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors. |
TBA |
| 2892936 |
21 |
Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. |
Warner-Lambert |
| 2875184 |
57 |
(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents. |
TBA |
| 2795597 |
43 |
Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists. |
University Of South Florida |
| 2724296 |
113 |
Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions. |
National Institutes Of Health |
| 2342066 |
5 |
A model for the antagonist binding site on the adenosine A1 receptor, based on steric, electrostatic, and hydrophobic properties. |
Center For Bio-Pharmaceutical Sciences |
| 2213835 |
66 |
7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists. |
National Institute Of Diabetes |
| 2213834 |
56 |
Imidazodiazepinediones: a new class of adenosine receptor antagonists. |
National Institute Of Diabetes |
| 2016719 |
68 |
1,3,8-trisubstituted xanthines. Effects of substitution pattern upon adenosine receptor A1/A2 affinity. |
Nova Pharmaceutical |
| 1895306 |
13 |
Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogues of 1-methylisoguanosine. |
Griffith University |
| 1613758 |
95 |
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists. |
Kyowa Hakko Kogyo |
| 1507211 |
28 |
Conformationally restrained, chiral (phenylisopropyl)amino-substituted pyrazolo[3,4-d]pyrimidines and purines with selectivity for adenosine A1 and A2 receptors. |
Marion Merrell Dow Research Institute |
| 28238723 |
39 |
Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. |
University Of Colorado |
| 25684690 |
22 |
Solid-Supported Synthesis and 5-HT7 /5-HT1A Receptor Affinity of Arylpiperazinylbutyl Derivatives of 4,5-dihydro-1,2,4-triazine-6-(1H)-one. |
Jagiellonian University Medical College |
| 25590533 |
245 |
Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. |
University Of North Carolina At Chapel Hill |
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