The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 323484 |
8 |
Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates. |
TBA |
| 17275316 |
11 |
The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR. |
Polish Academy Of Sciences |
| 9154971 |
15 |
Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). |
The Institute Of Cancer Research |
| 1372358 |
18 |
Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates. |
Institute Of Cancer Research |
| 11714600 |
10 |
Cyclopenta[g]quinazoline-based antifolates: the effect of the chirality at the 6-position on the inhibition of thymidylate synthase (TS). |
The Institute Of Cancer Research |
| 11101356 |
23 |
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
Polish Academy Of Sciences |
| 8917645 |
20 |
Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity. |
University Of Minnesota |
| 7932557 |
25 |
The synthesis and thymidylate synthase inhibitory activity of L-gamma-L-linked dipeptide and L-gamma-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). |
Institute Of Cancer Research |
| 1447744 |
2 |
A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. |
Princeton University |
| 1495009 |
32 |
Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents. |
Ici Pharmaceuticals Group |
| 2033585 |
37 |
Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications. |
Ici Pharmaceuticals Group |
| 2362285 |
23 |
Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines. |
Warner-Lambert |
| 3373483 |
39 |
Linear free energy relationship studies of enzyme active site binding: thymidylate synthase. |
University Of Kansas |
| 3470522 |
16 |
Folate analogues as inhibitors of thymidylate synthase. |
TBA |
| 3100797 |
21 |
Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives. |
TBA |
| 21330014 |
28 |
Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase. |
University Of Thessaly |
| | 8 |
Carboxylic acid bioisosteres of γ-linked dipeptide analogues of the folate-based thymidylate synthase (TS) inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) |
TBA |
| 12166942 |
4 |
The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent. |
The Institute Of Cancer Research |
| 11728193 |
12 |
Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs. |
Purdue University |
| 10821704 |
22 |
Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,). |
The Institute Of Cancer Research |
| 10508430 |
38 |
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
Astrazeneca |
| 8576912 |
34 |
Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent. |
Zeneca Pharma |
| 8568829 |
22 |
Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). |
Institute Of Cancer Research |
| 8246229 |
4 |
2-Thio derivatives of dUrd and 5-fluoro-dUrd and their 5'-monophosphates: synthesis, interaction with tumor thymidylate synthase, and in vitro antitumor activity. |
Polish Academy Of Sciences |
| 7699716 |
41 |
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series. |
Zeneca Pharmaceuticals |
| 7086836 |
1 |
Inhibition by 5-(substituted-benzyl)-2,4-diaminopyrimidines of murine tumor (L5178Y) cell cultures sensitive to and resistant to methotrexate. Further evidence for the sensitivity of resistant cells to hydrophobic drugs. |
TBA |
| 4045922 |
4 |
Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent. |
TBA |
| 3754284 |
13 |
Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications. |
TBA |
| 3599032 |
22 |
Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. |
TBA |
| 3027341 |
10 |
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies. |
TBA |
| 2704030 |
16 |
Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency. |
Institute Of Cancer Research |
| 2231608 |
41 |
Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series. |
Ici Pharmaceuticals Group |
| 2231607 |
10 |
Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
Institute Of Cancer Research |
| 2231606 |
39 |
Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
Ici Pharmaceuticals Group |
| 2066994 |
25 |
Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series. |
Ici Pharmaceuticals Group |
| 2002476 |
5 |
Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues. |
Institute Of Cancer Research |
| 1635061 |
4 |
N-[4-[[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-6- yl)methyl]amino]benzoyl]-L-glutamic acid, a novel A-ring analogue of 2-desamino-5,8-dideazafolic acid. |
Harvard Medical School |
| 1613755 |
12 |
Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues. |
Institute Of Cancer Research |
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