The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
2785211 |
18 |
Synthesis and biological evaluation of [125I]- and [123I]-4-iododexetimide, a potent muscarinic cholinergic receptor antagonist. |
Johns Hopkins Medical Institutions |
3020246 |
11 |
Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine. |
TBA |
3020245 |
4 |
Synthesis and biological activity of analogues of beta-chlornaltrexamine and beta-funaltrexamine at opioid receptors. |
TBA |
6319699 |
5 |
Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity. |
TBA |
6209395 |
8 |
Diastereomeric 6-desoxy-6-spiro-alpha-methylene-gamma-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted michael acceptor ligand. |
TBA |
6292421 |
6 |
N-Methylnalorphine: definition of N-allyl conformation for antagonism at the opiate receptor. |
TBA |
6292420 |
6 |
Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol. |
TBA |
26299827 |
43 |
Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. |
University Of Arizona |
26252963 |
15 |
Novel diazabicycloalkane delta opioid agonists. |
Istituto Di Farmacologia Traslazionale |
25283554 |
43 |
Design, synthesis, and structure-activity relationship of novel opioid¿ receptor selective agonists:a-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. |
Kitasato University |
25147605 |
52 |
Synthesis and Pharmacology of a Novel¿ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton. |
Kitasato University |
25783191 |
87 |
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands. |
Virginia Commonwealth University |
25562563 |
18 |
Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies. |
National Research Council |
25248680 |
67 |
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. |
Kitasato University |
24900842 |
71 |
Novel delta opioid receptor agonists with oxazatricyclodecane structure. |
Kitasato University |
23477419 |
64 |
Design, synthesis, and pharmacological characterization of novel endomorphin-1 analogues as extremely potentµ-opioid agonists. |
Lanzhou University |
23200250 |
36 |
The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives. |
Kitasato University |
23131341 |
50 |
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet). |
Kitasato University |
23103094 |
39 |
Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies. |
Kitasato University |
22734622 |
78 |
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associatedµ opioid receptor (MOR-1) splice variants. |
Memorial Sloan-Kettering Cancer Center |
21978284 |
42 |
Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixedµ/d opioid receptor agonistic properties. |
Vrije Universiteit Brussel |
23585918 |
16 |
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. |
TBA |
22967810 |
102 |
Synthesis of quinolinomorphinan derivatives as highly selectived opioid receptor ligands. |
Kitasato University |
22742909 |
24 |
Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies. |
Kitasato University |
22460026 |
39 |
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain. |
Kitasato University |
22445285 |
26 |
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies. |
Kitasato University |
18990576 |
11 |
Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology. |
Kitasato University |
18337104 |
7 |
Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies. |
Kitasato University |
17962026 |
3 |
The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans. |
University Of Maryland |
18062664 |
13 |
Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. |
Biological Research Center Of The Hungarian Academy Of Sciences |
15780604 |
2 |
18F-labeled sufentanil for PET-imaging of mu-opioid receptors. |
Technische Universit£T M£Nchen |
10891118 |
6 |
Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability. |
University Of Northern Colorado |
9397176 |
28 |
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors. |
University Of Arizona |
9379438 |
31 |
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept. |
Smithkline Beecham |
9207938 |
15 |
Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity. |
University Of Minnesota |
9171881 |
17 |
7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. |
University Of Minnesota |
7932569 |
116 |
Antipodal alpha-N-(methyl through decyl)-N-normetazocines (5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphans): in vitro and in vivo properties. |
Virginia Commonwealth University |
8246236 |
6 |
Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine. |
University Of Minnesota |
1333013 |
29 |
Opioid agonist and antagonist activities of morphindoles related to naltrindole. |
University Of Minnesota |
2549247 |
39 |
Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity. |
Ciba-Geigy |
6296388 |
68 |
Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. |
TBA |
9873568 |
22 |
Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity. |
Merck |
| 36 |
Pyrrolooctahydroisoquinolines as potent and selective opioid receptor ligands: SAR analysis and docking studies |
TBA |
22197670 |
51 |
Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists. |
Kitasato University |
21889335 |
27 |
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet). |
Kitasato University |
20850307 |
27 |
Design and synthesis of KNT-127, ad-opioid receptor agonist effective by systemic administration. |
Kitasato University |
20413312 |
17 |
Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans. |
University Of Debrecen |
19646882 |
72 |
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways. |
University Of Medicine And Dentistry Of New Jersey-Robert Wood Johnson Medical School And The Informatics Institute Of Umdnj |
15857130 |
37 |
Ligand-based prediction of active conformation by 3D-QSAR flexibility descriptors and their application in 3+3D-QSAR models. |
University Of Szeged |
15482911 |
65 |
Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists. |
Johnson And Johnson Pharmaceutical Research And Development |
14736254 |
70 |
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. |
Biological Research Center Of The Hungarian Academy Of Sciences |
12408719 |
21 |
Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB). |
Daiichi Fine Chemical |
11150174 |
84 |
Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. |
Virginia Commonwealth University |
10639279 |
26 |
Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. |
The University Of Arizona |
10579841 |
113 |
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. |
Synaptic Pharmaceutical |
9986710 |
28 |
Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration. |
Sapienza University Of Rome |
9301669 |
24 |
7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
University Of Minnesota |
8410989 |
58 |
Structure-affinity relationship studies on 5-HT1A receptor ligands. 1. Heterobicyclic phenylpiperazines with N4-alkyl substituents. |
Solvay Duphar Research Laboratories |
8254604 |
50 |
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors. |
University Of Ferrara |
7932577 |
24 |
Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group. |
Smithkline Beecham Farmaceutici |
7658453 |
16 |
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics. |
Institute Of Materia Medica |
6313921 |
10 |
Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo. |
TBA |
6090663 |
1 |
Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues. |
TBA |
1972964 |
40 |
Design and synthesis of highly potent and selective cyclic dynorphin A analogues. |
University Of Arizona |
1648141 |
21 |
Naphtho and benzo analogues of the kappa opioid agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide. |
University Of Notre Dame |
26520885 |
21 |
Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents. |
Hazara University |
25996453 |
4 |
Synthesis of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives and their biological evaluation against protein tyrosine phosphatase 1B. |
Jiangnan University |