The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 15267228 |
20 |
Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1. |
Leiden University |
| 15055985 |
22 |
Inhibitors of farnesyltransferase: a rational approach to cancer chemotherapy? |
Merck Research Laboratories |
| 12825937 |
63 |
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. |
Merck Research Laboratories |
| 11784157 |
14 |
Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors. |
Universit£ |
| 10508429 |
14 |
Novel farnesol and geranylgeraniol analogues: A potential new class of anticancer agents directed against protein prenylation. |
Parke-Davis Pharmaceutical Research |
| 9301658 |
53 |
Ras farnesyltransferase: a new therapeutic target. |
Warner-Lambert |
| 8568811 |
22 |
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors. |
University Of Pittsburgh |
| 11755366 |
24 |
Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase. |
University College London |
| 11294379 |
63 |
2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase. |
Merck Research Laboratories |
| 11412990 |
2 |
Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I. |
Wayne State University |
| 20822181 |
189 |
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. |
Yale University |
| | 3 |
A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli |
TBA |
| | 51 |
Cysteine and methionine linked by carbon pseudopeptides inhibit farnesyl transferase |
TBA |
| 16289818 |
90 |
Guiding farnesyltransferase inhibitors from an ECLiPS library to the catalytic zinc. |
Pharmacopeia |
| 15745827 |
10 |
Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I. |
Janssen Research Foundation |
| 15380198 |
46 |
Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor. |
Abbott Laboratories |
| 14741259 |
62 |
Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I. |
Merck Research Laboratories |
| 14643335 |
12 |
Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity. |
Università |
| 14643327 |
17 |
Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors. |
Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&Jprd) |
| 14592494 |
123 |
Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation. |
Abbott Laboratories |
| 14552788 |
36 |
Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor. |
Abbott Laboratories |
| 14552752 |
16 |
Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I. |
Imperial College |
| 12749902 |
5 |
Antifungal activity of a Candida albicans GGTase I inhibitor-alanine conjugate. Inhibition of Rho1p prenylation in C. albicans. |
Gpc Biotech |
| 12699757 |
72 |
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. |
Abbott Laboratories |
| 12699751 |
18 |
5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors. |
Johnson & Johnson Pharmaceutical Research & Development |
| 12657283 |
37 |
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency. |
Abbott Laboratories |
| 12657267 |
65 |
Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor. |
Abbott Laboratories |
| 12113834 |
64 |
The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases. |
Merck Research Laboratories |
| 11965368 |
64 |
Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I. |
Merck Research Laboratories |
| 11844687 |
11 |
A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor. |
Banyu Tsukuba Research Institute |
| 11754590 |
53 |
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold. |
Yale University |
| 11714612 |
19 |
A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase). |
Lgci |
| 11520202 |
130 |
Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency. |
Merck Research Laboratories |
| 11459639 |
74 |
Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase. |
Merck Research Laboratories |
| 11392531 |
79 |
Diaryl ether inhibitors of farnesyl-protein transferase. |
Merck Research Laboratories |
| 11378366 |
40 |
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I. |
Merck Research Laboratories |
| 11229765 |
16 |
Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase. |
Merck Research Laboratories |
| 11020273 |
33 |
Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 10508426 |
13 |
N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity. |
Merck Research Laboratories |
| 10450968 |
22 |
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase. |
Merck Research Laboratories |
| 10212118 |
44 |
Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I. |
Yale University |
| 9435898 |
32 |
Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds. |
Schering-Plough Research Institute |
| 9406600 |
102 |
Identification of novel farnesyl protein transferase inhibitors using three-dimensional database searching methods. |
Schering-Plough Research Institute |
| 8691464 |
9 |
Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins. |
Università |
| 8568812 |
36 |
Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
| 8558502 |
17 |
Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase. |
Bristol-Myers Squibb Pharmaceutical Research Institute |
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