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11 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25987375 20 Discovery of a novel Kv7 channel opener as a treatment for epilepsy.EBI Pfizer
25286150 75 Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists.EBI Astrazeneca
25087753 240 Prediction of Thorough QT study results using action potential simulations based on ion channel screens.EBI University Of Oxford
24937104 30 GPR103 antagonists demonstrating anorexigenic activity in vivo: design and development of pyrrolo[2,3-c]pyridines that mimic the C-terminal Arg-Phe motif of QRFP26.EBI Astrazeneca
22793372 66 Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a potent, brain penetrant K(v)7.2 channel inhibitor.EBI Vanderbilt University Medical Center
24900334 89 N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy.EBI TBA
22607672 28 MK-8825: a potent and selective CGRP receptor antagonist with good oral activity in rats.EBI Merck Research Laboratories
11356099 20 Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.EBI Abbott Laboratories
21942426 113 Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.EBI Merck
21493064 69 Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.EBI Merck
11689069 18 Synthesis and activity of novel and selective I(Ks)-channel blockers.EBI Aventis Pharma Deutschland