The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28215783 |
7 |
Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification. |
Universidade Federal De Minas Gerais |
| 27994740 |
41 |
Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain. |
Universitat Jaume I |
| 27475533 |
6 |
Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi. |
Federal University Of Alagoas |
| 26549870 |
1 |
Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi. |
Universidade Federal De Pernambuco |
| 26144347 |
27 |
Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. |
University Of California |
| 26231082 |
4 |
Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain. |
Universidade Federal De Pernambuco |
| 25707014 |
2 |
Computer-guided drug repurposing: identification of trypanocidal activity of clofazimine, benidipine and saquinavir. |
National University Of La Plata (Unlp) |
| 25147146 |
9 |
2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation. |
Universidade Federal De Pernambuco |
| 25072876 |
2 |
Trends in research of antitrypanosomal agents among synthetic heterocycles. |
Danylo Halytsky Lviv National Medical University |
| 25375026 |
14 |
Structures and bioactivities of dihydrochalcones from Metrodorea stipularis. |
Universidade Federal De S£O Carlos |
| 24929292 |
2 |
Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity. |
Universidade De S£O Paulo (Usp) |
| 24533839 |
24 |
Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents. |
Universidade De S£O Paulo |
| 23611656 |
9 |
Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis. |
Universit£ |
| 23437772 |
35 |
Colloidal aggregation causes inhibition of G protein-coupled receptors. |
University Of North Carolina At Chapel Hill |
| 12031337 |
16 |
CoMFA and HQSAR of acylhydrazide cruzain inhibitors. |
Universidade Federal Do Rio De Janeiro |
| 23167554 |
28 |
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice. |
Universidade Federal De Pernambuco |
| 23006639 |
3 |
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice. |
Universidade Federal De Pernambuco |
| 22727447 |
8 |
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. |
Instituto De Tecnologia Em F£Rmacos - Farmanguinhos |
| 20426472 |
44 |
Colloid formation by drugs in simulated intestinal fluid. |
University Of California San Francisco |
| 17996450 |
29 |
2D QSAR and similarity studies on cruzain inhibitors aimed at improving selectivity over cathepsin L. |
Universidade De S£O Paulo |
| 18333608 |
38 |
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. |
University Of California San Francisco |
| 17977725 |
8 |
Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain. |
Universitat Jaume I |
| 15713380 |
16 |
cis-6-oxo-hexahydro-2-oxa-1,4-diazapentalene and cis-6-oxo-hexahydropyrrolo[3,2-c]pyrazole based scaffolds: design rationale, synthesis and cysteinyl proteinase inhibition. |
Amura Therapeutics |
| 21041084 |
102 |
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease. |
Merck Research Laboratories |
| 20961766 |
6 |
Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents. |
Federal University Of Pernambuco |
| 20945905 |
4 |
Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids asß-lactamase inhibitors. |
University Of California San Francisco |
| 20540517 |
16 |
Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. |
University Of California San Francisco |
| 19773167 |
30 |
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. |
University Of California |
| 20088534 |
10 |
Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. |
University Of California |
| 19908842 |
84 |
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. |
National Human Genome Research Institute |
| 19908840 |
71 |
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. |
National Human Genome Research Institute |
| 19606868 |
2 |
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania. |
University Of Bologna |
| 19637873 |
104 |
Divergent modes of enzyme inhibition in a homologous structure-activity series. |
University Of California |
| 18996017 |
9 |
Convergent synthesis and cruzain inhibitory activity of novel 2-(N'-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines. |
Universidade Federal De Santa Maria |
| 18585034 |
6 |
Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. |
Scripps Florida |
| 18547811 |
9 |
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle. |
Unviersidad De La RepÚBlica |
| 18055204 |
17 |
Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes. |
University Of California |
| 17960923 |
2 |
In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives. |
Universidad De La RepúBlica |
| 16781147 |
20 |
Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease. |
Baylor University |
| 15582423 |
30 |
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. |
University Of California San Francisco |
| 15163200 |
33 |
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. |
University Of California San Francisco |
| 14505663 |
43 |
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. |
University Of Cape Town |
| 12270191 |
36 |
General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain. |
University Of California |
| 12061873 |
79 |
Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. |
University Of California San Francisco |
| 11806719 |
61 |
Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis. |
University Of California |
| 31306906 |
2 |
2-(phenylthio)ethylidene derivatives as anti-Trypanosoma cruzi compounds: Structural design, synthesis and antiparasitic activity. |
Universidade De Pernambuco |
| 31434040 |
3 |
Synthesis, structure-activity relationship and trypanocidal activity of pyrazole-imidazoline and new pyrazole-tetrahydropyrimidine hybrids as promising chemotherapeutic agents for Chagas disease. |
Instituto Oswaldo Cruz |
| 32125159 |
60 |
Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity. |
Texas A&M University |
| 30830783 |
13 |
Potential Anticancer Agents Characterized from Selected Tropical Plants. |
The Ohio State University |
| 31539239 |
33 |
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and |
The University Of Jordan |
| 31361135 |
17 |
Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity? |
University Of S£O Paulo |
| 31561938 |
64 |
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement. |
Universidade De S£O Paulo |
| 7650671 |
15 |
Vinyl sulfones as mechanism-based cysteine protease inhibitors. |
Khepri Pharmaceuticals |
| 30029081 |
31 |
New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8. |
Johannes Gutenberg-Universit£T Mainz |
| 30037754 |
64 |
Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates. |
Universitat Jaume I |
| 29054358 |
16 |
A comparative study of warheads for design of cysteine protease inhibitors. |
Universidade De S£O Paulo |
| 29031078 |
2 |
Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi. |
Universidade Federal De Pernambuco - Ufpe |
| 28499168 |
5 |
Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties. |
Instituto De Qu£Mica M£Dica |
| 22468751 |
2 |
Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor. |
Federal University Of Sao Paulo |
| 22613098 |
3 |
Novel Cruzain Inhibitors for the Treatment of Chagas' Disease. |
University Of California San Diego |
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