The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
25782742 |
76 |
trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker. |
Novartis Pharma |
25754490 |
44 |
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker. |
Novartis Pharma |
25050166 |
58 |
Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors. |
Novartis Institutes For Biomedical Research |
23425156 |
24 |
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches. |
Novartis Pharma |
23360239 |
19 |
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore. |
Novartis Pharma |
2002469 |
80 |
Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics. |
Merck Sharp And Dohme Research Laboratories |
2566685 |
47 |
Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements. |
University Of Wisconsin-Madison |
3783611 |
55 |
Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin. |
TBA |
| 22 |
Novel pseudosymmetric inhibitors of HIV-1 protease |
TBA |
8410992 |
35 |
Renin inhibitors containing a pyridyl amino diol derived C-terminus. |
Hoechst |
8410973 |
75 |
Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation. |
University Of Florida |