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67 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27994765 95 Discovery of Highly Potent Liver X Receptor▀ Agonists.EBI Bristol-Myers Squibb
27815118 112 Discovery of phenoxyindazoles and phenylthioindazoles as ROR┐ inverse agonists.EBI Galderma R&D
27599745 106 Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.EBI Vitae Pharmaceuticals
27326332 66 Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.EBI Bristol-Myers Squibb Company
27283790 33 Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and▀-selectivity of liver X receptor agonist.EBI Kowa Co., Ltd
26990539 79 Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)▀ Agonist.EBI Vitae Pharmaceuticals, Inc.
27011007 17 Identification and in Vivo Evaluation of Liver X Receptor▀-Selective Agonists for the Potential Treatment of Alzheimer's Disease.EBI WuXi AppTec Company, Ltd.
26905831 11 Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.EBI The University of Tokyo
26288691 54 Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators.EBI The University of Tokyo
26321361 56 Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists.EBI Genentech
26238323 12 Discovery and structure-guided optimization of tert-butyl 6-(phenoxymethyl)-3-(trifluoromethyl)benzoates as liver X receptor agonists.EBI Daiichi Sankyo RD Novare Co., Ltd
26048793 91 Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists.EBI Genentech
25998501 79 Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptor▀-selective agonists.EBI Kowa Co., Ltd
25677664 30 Design and discovery of 2-oxochromene derivatives as liver X receptor▀-selective agonists.EBI Kowa Co., Ltd
25017032 62 Reduction in lipophilicity improved the solubility, plasma-protein binding, and permeability of tertiary sulfonamide RORc inverse agonists.EBI Genentech
24502334 123 Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-┐ (ROR┐ or RORc).EBI Genentech
25453817 130 A reversed sulfonamide series of selective RORc inverse agonists.EBI Argenta Discovery Ltd.
25435151 34 Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXR▀.EBI Bristol-Myers Squibb
25408828 4 Liver x receptor agonists for the treatment of coronary heart disease and other disorders.EBI Therachem Research Medilab (India) Pvt. Ltd.
25305688 41 Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for ROR▀ and ROR┐t.EBI Phenex Pharmaceuticals AG
24702856 84 Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (ROR┐)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand.EBI The University of Tokyo
24685544 75 Identification of tertiary sulfonamides as RORc inverse agonists.EBI Genentech
24239186 84 Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc.EBI Genentech
23769638 9 Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes.EBI Korea University
23246324 2 Induction of ABCA1 and ABCG1 expression by the liver X receptor modulator cineole in macrophages.EBI Korea University
20345102 34 Discovery of tertiary sulfonamides as potent liver X receptor antagonists.EBI GlaxoSmithKline
22579484 6 Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.EBI Korea University
22873709 45 Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton.EBI The University of Tokyo
22901900 92 Discovery and optimization of a series of liver X receptor antagonists.EBI Amgen Inc.
22406115 18 Discovery of a new binding mode for a series of liver X receptor agonists.EBI Amgen Inc.
21218783 117 Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.EBI Johnson& Johnson Pharmaceutical Research and Development
20005711 102 3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.EBI Wyeth Pharmaceuticals
15911262 38 Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.EBI Merck Research Laboratories
20638278 145 Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI Phenex Pharmaceuticals AG
20382019 51 Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.EBI Wyeth Pharmaceuticals
20350005 45 Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.EBI Wyeth Pharmaceuticals
20006495 62 1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonists.EBI Wyeth Pharmaceuticals
19962892 48 Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.EBI Wyeth Pharmaceuticals
19932617 46 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.EBI Wyeth Pharmaceuticals
19717304 29 The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.EBI GlaxoSmithKline
19539483 78 Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists.EBI The University of Tokyo
19394832 74 Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.EBI Wyeth Research
19264481 58 Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.EBI AstraZeneca R&D Södertälje
18800767 45 Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.EBI GlaxoSmithKline Research and Development
16180833 4 Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents.EBI Merck Research Laboratories
16124770 26 Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.EBI Merck Research Laboratories
15844964 2 Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.EBI Merck Research Laboratories
18023179 58 Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.EBI Wyeth Pharmaceuticals
17498949 4 Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.EBI University of Tokyo
16876993 192 Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.EBI F. Hoffmann-La Roche Ltd.
16529931 139 SAR studies: designing potent and selective LXR agonists.EBI Merck Research Laboratories
16125384 109 Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis.EBI Merck Research Laboratories
24936059 26 The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.BDB AstraZeneca R&D Boston
24917667 36 Digoxin derivatives with enhanced selectivity for the a2 isoform of Na,K-ATPase: effects on intraocular pressure in rabbits.BDB Weizmann Institute of Science
24891505 6 Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin.BDB Yale University
15368579 20 Bisubstrate inhibitors of the enzyme catechol O-methyltransferase (COMT): efficient inhibition despite the lack of a nitro group.BDB Laboratorium für Organische Chemie
7984267 675 Molecular biology of 5-HT receptors.BDB University of Alberta
7965790 38 Species orthologs of the alpha-2A adrenergic receptor: the pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors.BDB University of Nebraska
7910212 34 Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.BDB Yamanouchi Pharmaceutical Co. Ltd.
18311908 42 Characterization of Type II Ligands in CYP2C9 and CYP3A4.BDB AstraZeneca