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101 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28231433 101 Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.EBI Pfizer Inc.
28236593 6 Kinase-independent phosphoramidate S1PEBI Cardiff University
27894870 141 A benzo[b]thiophene-based selective type 4 S1P receptor agonist.EBI Harvard Medical School
26985316 17 Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.EBI Bristol-Myers Squibb Company
27061986 128 Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.EBI Actelion Pharmaceuticals Ltd.
27027817 50 Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines.EBI Actelion Pharmaceuticals Ltd.
26924461 45 Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.EBI Bristol-Myers Squibb Research and Development
27055941 19 Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).EBI Bristol-Myers Squibb Research and Development
27068143 12 Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists.EBI Peking Union Medical College and Chinese Academy of Medical Sciences
26751273 92 Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.EBI GlaxoSmithKline
26794040 24 Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.EBI Ono Pharmaceutical Co.
26687487 69 Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists.EBI Boehringer Ingelheim Pharmaceuticals
26393276 2 Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists.EBI GlaxoSmithKline
26384288 29 Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.EBI Ono Pharmaceutical Co.
25699136 16 Novel Pyridyloxadiazole Agonists of Sphingosin-1-phosphate.EBI Dart Neuroscience LLC
25746814 80 Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives.EBI Ono Pharmaceutical Co.
25532755 46 Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.EBI Arena Pharmaceuticals Inc.
25072873 72 Discovery of oxazole and triazole derivatives as potent and selective S1P(1) agonists through pharmacophore-guided design.EBI Peking Union Medical College and Chinese Academy of Medical Sciences
24909680 18 Synthesis and SAR studies of benzyl ether derivatives as potent orally active S1P1 agonists.EBI Daiichi Sankyo Co, Ltd
25516794 71 (7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.EBI Arena Pharmaceuticals, Inc.
25516790 37 Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.EBI Arena Pharmaceuticals, Inc.
25431977 100 Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles.EBI GlaxoSmithKline
25241927 64 Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists.EBI Boehringer Ingelheim Pharmaceuticals
24900670 47 Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.EBI Genomics Institute of the Novartis Research Foundation
23245510 32 Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1.EBI Praecis Pharmaceuticals Incorporated (Currently GlaxoSmithKline)
22429468 60 Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.EBI GlaxoSmithKline Pharmaceuticals
23141913 40 Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists.EBI Rhône-Poulenc Rorer
23067318 17 An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.EBI Novartis Pharma AG
22500954 99 Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).EBI GlaxoSmithKline
22633692 51 Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease.EBI Arena Pharmaceuticals
24900374 34 Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.EBI TBA
22583616 67 Identification of benzoxazole analogs as novel, S1P(3) sparing S1P(1) agonists.EBI GlaxoSmithKline Pharmaceuticals
22487179 50 Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists.EBI Daiichi Sankyo Co., Ltd
22214363 78 Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists.EBI Exelixis
24900263 18 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.EBI TBA
22386243 83 Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor.EBI GlaxoSmithKline Pharmaceuticals
17379528 30 Synthesis and SAR studies of a novel class of S1P1 receptor antagonists.EBI Sankyo Co., Ltd
17070046 24 Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.EBI Universit£ de Montr£al
15982878 45 Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.EBI University of Virginia
15341948 25 Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists.EBI University of Virginia
15341940 109 Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.EBI Merck Research Laboratories
15177460 135 The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.EBI Merck Research Laboratories
14505636 51 Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists.EBI University of Virginia
22405291 11 Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.EBI Daiichi Sankyo Co., Ltd.
22264485 64 Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist.EBI Daiichi Sankyo Co., Ltd
22257889 52 Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.EBI Amgen Inc.
24900318 8 Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist.EBI TBA
22104144 37 Quinolinone-based agonists of S1P¿?: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.EBI USA.
22100314 38 Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P¿? agonists with in vivo lymphocyte-depleting activity.EBI Amgen Inc.
22153936 26 Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold.EBI Ono Pharmaceutical Co., Ltd
22119341 10 Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.EBI Institute of Pharmacology& Toxicology
21852130 69 Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P¿? agonists.EBI Arena Pharmaceuticals
21838322 37 Discovery of a brain-penetrant S1P3-sparing direct agonist of the S1P¿? and S1P5 receptors efficacious at low oral dose.EBI GlaxoSmithKline
21783362 17 SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor.EBI The Scripps Research Institute
21641216 28 Discovery of S1P agonists with a dihydronaphthalene scaffold.EBI Ono Pharmaceutical Co., Ltd
21570287 53 Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.EBI The Scripps Research Institute
21295477 24 Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-ß-alanine moiety.EBI Ono Pharmaceutical Co., Ltd
24900287 47 Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)EBI TBA
24900288 32 Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5EBI TBA
24900286 65 Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MSEBI TBA
20446681 158 2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.EBI Actelion Pharmaceuticals Ltd.
20337461 40 Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.EBI Mitsubishi Tanabe Pharma Corporation
20304639 54 Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.EBI Praecis Pharmaceuticals Inc
20188554 46 Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.EBI BiogenIdec Inc.
20153186 44 S1P receptor mediated activity of FTY720 phosphate mimics.EBI Novartis Institutes for BioMedical Research
20149651 73 Discovery of a novel series of potent S1P1 agonists.EBI Merck Serono SA
19954976 60 Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.EBI Novartis Institutes for BioMedical Research
19282175 88 Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.EBI Praecis Pharmaceuticals Inc
19081720 36 Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.EBI Praecis Pharmaceuticals Inc
17266196 18 Pharmacophore-based design of sphingosine 1-phosphate-3 receptor antagonists that include a 3,4-dialkoxybenzophenone scaffold.EBI TOA EIYO Ltd.
17113298 45 Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.EBI University of Virginia
16697189 131 Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.EBI Merck Research Laboratories
16682185 76 Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.EBI Merck & Co.
16621543 59 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.EBI Merck Research Laboratories
16580205 63 2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.EBI Merck Research Laboratories
16078855 20 Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.EBI Novartis Institutes for BioMedical Research
15615513 129 A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.EBI Merck Research Laboratories
15177461 140 Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.EBI Merck Research Laboratories
15149705 60 Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.EBI Merck Research Laboratories
28069264 15 Synthesis, in vitro ß-glucuronidase inhibitory activity and in silico studies of novel (E)-4-Aryl-2-(2-(pyren-1-ylmethylene)hydrazinyl)thiazoles.BDB University of Karachi
28165218 5 Perfluoro-tert-butyl Homoserine Is a Helix-Promoting, Highly Fluorinated, NMR-Sensitive Aliphatic Amino Acid: Detection of the Estrogen Receptor·Coactivator Protein-Protein Interaction by (19)F NMR.BDB University of Delaware
5353111 10 Nature of the active site of a subunit of the first component of human complement.BDB Michigan State University
23275348 8 The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.BDB John Innes Centre
19053776 9 Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.BDB Consiglio Nazionale delle Ricerche
19072053 35 Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors.BDB University of Southern California
17884497 14 The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors.BDB GlaxoSmithKline
1732526 101 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.BDB Roche Products Limited