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68 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28199108 106 Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.EBI Vernalis (R&D) Ltd.
10340605 5 Synthesis and evaluation of geldanamycin-estradiol hybrids.EBI Sloan-Kettering Institute for Cancer Research
27783977 12 Targeting the entry region of Hsp90's ATP binding pocket with a novel 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl amide.EBI Keimyung University
27914802 12 Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors.EBI Korea University
27913182 5 Virtual screening and biophysical studies lead to HSP90 inhibitors.EBI University of Auckland
27003516 78 Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.EBI The University of Kansas
26112442 74 Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors.EBI Chengdu University of TCM
25799158 6 Volume of Distribution in Drug Design.EBI Pharmacokinetics
25901531 211 Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.EBI Sloan-Kettering
25677667 17 Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.EBI Vertex Pharmaceuticals Inc
25105924 5 Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.EBI Shandong University
25368984 14 Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990.EBI Novartis Institutes for Biomedical Research
25313505 35 Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.EBI Chinese Academy of Sciences
25277067 7 Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.EBI Shandong University
24751441 18 Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.EBI Chinese Academy of Sciences
24588105 56 Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.EBI Universit£ degli Studi di Siena
24580531 6 Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.EBI University of Geneva
24565573 35 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.EBI Universit£ degli Studi di Ferrara
24673104 185 Identification of novel HSP90a/ isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.EBI Vertex Pharmaceuticals , 11010 Torreyana Road, San Diego, California 92121, United States.
23362862 13 A chemical-biological study reveals C9-type iridoids as novel heat shock protein 90 (Hsp90) inhibitors.EBI Universit£ di Salerno
22938030 22 EC144 is a potent inhibitor of the heat shock protein 90.EBI Biogen Idec Inc.
21438541 45 Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrEBI Pfizer Inc.
20055425 29 Heat shock protein 90: inhibitors in clinical trials.EBI Biogen Idec Inc.
19231864 6 Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.EBI Kosan Biosciences Inc
16854066 44 Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.EBI Infinity Pharmaceuticals, Inc.
16165354 19 Structure-based design of 7-carbamate analogs of geldanamycin.EBI Kosan Biosciences, Inc.
9925731 4 Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.EBI University College London
22192591 17 Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.EBI Chugai Pharmaceutical Co., Ltd
21875802 33 Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.EBI Chugai Pharmaceutical Co., Ltd
21920765 12 Lead identification ofß-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.EBI Trinity College
21715165 31 Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.EBI Pfizer Inc.
21106457 41 N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.EBI Abbott Laboratories
21605975 31 Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.EBI Pfizer Inc.
21420297 19 Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.EBI Pfizer Inc.
20609590 10 Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents.EBI Hokkaido University
19168355 7 5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone.EBI Fermentas UAB
16797988 4 Synthesis of a red-shifted fluorescence polarization probe for Hsp90.EBI Memorial Sloan-Kettering Cancer Center
16621545 6 Synthesis of Hsp90 dimerization modulators.EBI Memorial Sloan-Kettering Cancer Center
16530412 13 High-throughput screening for Hsp90 ATPase inhibitors.EBI The University of Kansas
16480864 38 4-Amino derivatives of the Hsp90 inhibitor CCT018159.EBI Vernalis Ltd
15828828 136 Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.EBI Memorial Sloan-Kettering Cancer Center
15713410 2 Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.EBI Genomics Institute of the Novartis Research Foundation (GNF)
15239664 92 Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.EBI Conforma Therapeutics Corporation
14698151 14 Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures.EBI RiboTargets Ltd
14592488 2 Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.EBI Memorial Sloan-Kettering Cancer Center
11294389 27 LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.EBI Department of Molecular Oncogenesis
28933546 1 Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.EBI University of Minnesota
28816449 14 Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.EBI Ulsan National Institutes of Science and Technology (UNIST)
28500957 30 Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors.BDB Cairo University
10498829 62 Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.BDB Cerebrus Ltd
19374444 45 Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.BDB CSIC
18921992 9 Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications.BDB Pfizer
17125252 60 Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.BDB Human BioMolecular Research Institute
12694187 9 Optimization of P1-P3 groups in symmetric and asymmetric HIV-1 protease inhibitors.BDB Uppsala University
16420031 46 Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.BDB Instituto de Quimica Medica (CSIC)