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111 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
8101878 61 Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents.EBI National Defense Medical Center
1495016 3 2-Substituted 1-azabicycloalkanes, a new class of non-opiate antinociceptive agents.EBI R.W. Johnson Pharmaceutical Research Institute
1671705 126 Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors.EBI Syntex Research
2153822 77 1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the alpha 2-adrenoceptor and the 5-HT1A receptor.EBI Syntex Research
2153820 86 Affinity of 2-(tetrahydroisoquinolin-2-ylmethyl)- and 2-(isoindolin-2-ylmethyl)imidazolines for alpha-adrenoceptors. Differential affinity of imidazolines for the [3H]idazoxan-labeled alpha 2-adrenoceptor vs the [3H]yohimbine-labeled site.EBI Syntex Research
2570150 10 (8a alpha,12a alpha,13a alpha)-5,8,8a,9,10,11,12,12a,13,13a-decahydro- 3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridi ne, a potent and highly selective alpha 2-adrenoceptor antagonist.EBI Syntex Research
2567783 1 Heteroaromatic analogues of the alpha 2-adrenoreceptor partial agonist clonidine.EBI Reckitt& Colman plc
2542561 48 New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.EBI Institut de Pharmacologie (UA 589 CNRS)
2900899 4 Structure-activity relationships among benextramine-related tetraamine disulfides. Chain length effect on alpha-adrenoreceptor blocking activity.EBI University of Camerino
2896247 14 Indoline analogues of idazoxan: potent alpha 2-antagonists and alpha 1-agonists.EBI Reckitt and Colman plc
2896246 5 1,3-Diamino-6,7-dimethoxyisoquinoline derivatives as potential alpha 1-adrenoceptor antagonists.EBI Pfizer Inc.
2896245 19 2,4-Diamino-6,7-dimethoxyquinoline derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.EBI Pfizer Inc.
2894465 18 2,4-Diamino-6,7-dimethoxyquinazolines. 4. 2-[4-(substituted oxyethoxy) piperidino] derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.EBI Pfizer Inc.
2887657 52 Alpha 2-adrenergic agonists/antagonists: the synthesis and structure-activity relationships of a series of indolin-2-yl and tetrahydroquinolin-2-yl imidazolines.EBI TBA
3039138 23 Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives.EBI TBA
2884316 34 2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.EBI TBA
2884313 10 Conformationally defined adrenergic agents. 5. Resolution, absolute configuration, and pharmacological characterization of the enantiomers of 2-(5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline: a potent agonist at alpha-adrenoceptors.EBI TBA
2888896 20 2,4-Diamino-6,7-dimethoxyquinazolines. 3. 2-(4-Heterocyclylpiperazin-1-yl) derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.EBI Pfizer Inc.
2879919 21 2,4-diamino-6,7-dimethoxyquinazolines. 1. 2-[4-(1,4-benzodioxan-2-ylcarbonyl)piperazin-1-yl] derivatives as alpha 1-adrenoceptor antagonists and antihypertensive agents.EBI TBA
3016265 94 4-Amino-6-chloro-2-piperazinopyrimidines with selective affinity for alpha 2-adrenoceptors.EBI TBA
2879913 5 Two stereoisomeric imidazoline derivatives: synthesis and optical and alpha 2-adrenoceptor activities.EBI TBA
2870187 20 Conformationally defined adrenergic agents. 2. Catechol imidazoline derivatives: biological effects at alpha 1 and alpha 2 adrenergic receptors.EBI TBA
2876101 18 Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists.EBI TBA
2863377 10 6,7-Dihydro-5-[[(cis-2-hydroxy-trans-3-phenoxycyclopentyl)amino] methyl]-2-methylbenzo[b]thiophen-4(5H)-one: a novel alpha 1-adrenergic receptor antagonist and renal vasodilator.EBI TBA
3973904 30 Octahydrobenzo[g]quinolines: potent dopamine agonists which show the relationship between ergolines and apomorphine.EBI TBA
2999398 2 Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors.EBI TBA
4045929 30 Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.EBI TBA
2864446 66 Conformationally defined adrenergic agents. 1. Design and synthesis of novel alpha 2 selective adrenergic agents: electrostatic repulsion based conformational prototypes.EBI TBA
6094811 56 Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.EBI TBA
6133954 6 Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones.EBI TBA
6124637 18 Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.EBI TBA
6296387 15 alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.EBI TBA
6123600 10 1-(alkylamino)isochromans: hypotensives with peripheral and central activities.EBI TBA
7328588 9 Synthesis and adrenoceptor affinity of some highly polar beta-substituted catecholamines.EBI TBA
6248642 38 Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.EBI TBA
12482437 42 Discovery of a series of (4,5-dihydroimidazol-2-yl)-biphenylamine 5-HT7 agonists.EBI Pfizer Inc.
11814815 13 alpha(1)-Adrenoceptor antagonists. Rational design, synthesis and biological evaluation of new trazodone-like compounds.EBI Universit£ di Pisa
10091706 176 Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.EBI University of Kansas
23353740 21 Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.EBI Universidade Federal de Goi£s
3373482 50 Graphics computer-aided receptor mapping as a predictive tool for drug design: development of potent, selective, and stereospecific ligands for the 5-HT1A receptor.EBI Merrell Dow Research Institute
9871765 14 Search for alpha 1-adrenoceptor subtypes selective antagonists: design, synthesis and biological activity of cystazosin, an alpha 1D-adrenoceptor antagonist.EBI University of Bologna
19831400 47 Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.EBI European Research Centre for Drug Discovery and Development
12930145 77 Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.EBI Universit£ di Siena
9171869 114 Substituted hexahydrobenzo[f]thieno[c]quinolines as dopamine D1-selective agonists: synthesis and biological evaluation in vitro and in vivo.EBI Abbott Laboratories
7707315 58 3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873).EBI Hoechst-Roussel Pharmaceuticals Inc
7562902 114 Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.EBI SmithKline Beecham Pharmaceuticals
7658429 31 (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).EBI Abbott Laboratories
7608898 4 The serotonin 5-HT4 receptor. 1. Design of a new class of agonists and receptor map of the agonist recognition site.EBI Sandoz Pharma Limited
8254623 54 Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8246241 34 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.EBI University of Pennsylvania
8230093 34 Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.EBI Universit£ di Pisa
1573641 60 SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.EBI Searle Research and Development
1313109 40 Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.EBI Universit£ di Pisa
1361578 99 Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.EBI Bristol-Myers Squibb Co.
1995885 15 Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds.EBI Dainippon Pharmaceutical Company, Ltd.
1671416 15 Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones.EBI Warner-Lambert Company
2213824 20 Thiazole as a carbonyl bioisostere. A novel class of highly potent and selective 5-HT3 receptor antagonists.EBI Pfizer central Research
2542551 89 The thieno[3,2-c]pyridine and furo[3,2-c]pyridine rings: new pharmacophores with potential antipsychotic activity.EBI Bristol-Myers Company
3039136 328 Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships.EBI TBA
2869146 72 Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.EBI TBA
6142954 70 Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.EBI TBA
6139481 32 alpha-Adrenergic activities of some substituted 2-(aminomethyl)imidazolines.EBI TBA
14695828 107 Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.EBI Universit£ degli Studi di Siena
 48 Novel pyridazino[4,5-b][1,5]oxazepines and -thiazepines as 5-HT1A receptor ligandsEBI TBA
 21 Serotonin 5-HT4 agonist activity of a series of meso-azanoradamantane benzamidesEBI TBA
19425598 61 Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.EBI European Research Centre for Drug Discovery and Development
17181165 2 Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action.EBI Dipartimento di Scienze Farmaceutiche
16722631 87 An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI Predix Pharmaceuticals Ltd.
15771426 34 Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1.EBI University of Kansas
15013010 9 Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.EBI Virginia Commonwealth University
15013009 28 Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.EBI Virginia Commonwealth University
14698196 8 Binding of an imidazopyridoindole at imidazoline I2 receptors.EBI Virginia Commonwealth University
12951084 8 1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists.EBI F. Hoffmann-La Roche Ltd.
12482441 45 Development of a presynaptic 5-HT1A antagonist.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12482417 23 alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus.EBI Università di Pisa
11294383 16 Cis- and trans-N-benzyl-octahydrobenzo[g]quinolines. Adrenergic and dopaminergic activity studies.EBI University of Crete
10753480 27 Alpha(2) adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the alpha(2D) adrenergic receptor.EBI The R. W. Johnson Pharmaceutical Research Institute
10743949 76 (1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents.EBI Università di Perugia
10741563 4 Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.EBI University of Bristol
10715142 35 alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor.EBI The R. W. Johnson Pharmaceutical Research Institute
10479303 36 Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists.EBI Warner-Lambert Company
10464021 59 N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.EBI Knoll Pharmaceuticals
10360740 35 N-substituted-3-arylpyrrolidines: potent and selective ligands at serotonin 1A receptor.EBI POSTECH
9876110 58 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).EBI Centro de Investigación Grupo Ferrer
9873377 54 Isoindolinone enantiomers having affinity for the dopamine D4 receptor.EBI Parke-Davis Pharmaceutical Research
9871719 144 Serotonergic ergoline derivatives.EBI Pharmacia & Upjohn S.p.A.-CNS Research
9191952 63 Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists.EBI Warner-Lambert Company
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8496920 14 (S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.EBI Wyeth Research (UK)
8411007 392 Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands.EBI Mayo Foundation for Medical Education and Research
8410999 81 3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.EBI Lilly Research Laboratories
8246239 84 Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI Solvay Duphar B.V.
7658428 94 Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.EBI SmithKline Beecham Pharmaceuticals
6192241 15 Synthesis and biological properties of thiophene ring analogues of mianserin.EBI TBA
3746815 15 In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.EBI TBA
2999400 12 N-(1,3,4,6,7,12b-hexahydro-2H-benzo[b]furo[2,3-a]quinolizin -2-yl)-N- methyl-2-hydroxyethane-sulfonamide: a potent and selective alpha 2-adrenoceptor antagonist.EBI TBA
2892936 21 Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.EBI Warner-Lambert Company
2875184 57 (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.EBI TBA
1827843 27 Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors.EBI University of California
1652023 179 Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor.EBI Abbott Laboratories
26851737 36 One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies.BDB University of Karachi