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51 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27894870 141 A benzo[b]thiophene-based selective type 4 S1P receptor agonist.EBI Harvard Medical School
26985316 17 Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.EBI Bristol-Myers Squibb Company
27061986 128 Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.EBI Actelion Pharmaceuticals Ltd.
26751273 92 Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.EBI GlaxoSmithKline
26794040 24 Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.EBI Ono Pharmaceutical Co.
26384288 29 Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.EBI Ono Pharmaceutical Co.
25746814 80 Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives.EBI Ono Pharmaceutical Co.
25532755 46 Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.EBI Arena Pharmaceuticals Inc.
25516794 71 (7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.EBI Arena Pharmaceuticals, Inc.
25516790 37 Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.EBI Arena Pharmaceuticals, Inc.
23141913 40 Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists.EBI Rhône-Poulenc Rorer
23067318 17 An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.EBI Novartis Pharma AG
22633692 51 Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease.EBI Arena Pharmaceuticals
24900263 18 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.EBI TBA
17070046 24 Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.EBI Universit£ de Montr£al
15982878 45 Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.EBI University of Virginia
15341948 25 Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists.EBI University of Virginia
15341940 109 Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.EBI Merck Research Laboratories
15177460 135 The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.EBI Merck Research Laboratories
14505636 51 Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists.EBI University of Virginia
22405291 11 Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.EBI Daiichi Sankyo Co., Ltd.
22119461 31 Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists.EBI The Scripps Research Institute
22119341 10 Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.EBI Institute of Pharmacology& Toxicology
21852130 69 Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P¿? agonists.EBI Arena Pharmaceuticals
21982495 61 Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype.EBI The Scripps Research Institute
21838322 37 Discovery of a brain-penetrant S1P3-sparing direct agonist of the S1P¿? and S1P5 receptors efficacious at low oral dose.EBI GlaxoSmithKline
21783362 17 SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor.EBI The Scripps Research Institute
21570287 53 Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.EBI The Scripps Research Institute
20446681 158 2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.EBI Actelion Pharmaceuticals Ltd.
20304639 54 Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.EBI Praecis Pharmaceuticals Inc
20188554 46 Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.EBI BiogenIdec Inc.
20153186 44 S1P receptor mediated activity of FTY720 phosphate mimics.EBI Novartis Institutes for BioMedical Research
19954976 60 Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.EBI Novartis Institutes for BioMedical Research
19282175 88 Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.EBI Praecis Pharmaceuticals Inc
19081720 36 Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.EBI Praecis Pharmaceuticals Inc
17113298 45 Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.EBI University of Virginia
16697189 131 Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.EBI Merck Research Laboratories
16621543 59 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.EBI Merck Research Laboratories
16580205 63 2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.EBI Merck Research Laboratories
16078855 20 Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.EBI Novartis Institutes for BioMedical Research
15615513 129 A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.EBI Merck Research Laboratories
15177461 140 Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.EBI Merck Research Laboratories
15149705 60 Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.EBI Merck Research Laboratories
24636540 18 Synthesis and biologic evaluation of substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one derivatives as selective COX-2 inhibitors: molecular docking study.BDB Y. B. Chavan College of Pharmacy