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30 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
10206553 55 Combined NK1 and NK2 tachykinin receptor antagonists: synthesis and structure-activity relationships of novel oxazolidine analogues.EBI Sankyo Co., Ltd.
12877589 2 Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a potent and orally active dual neurokinin NK(1)/NK(2) receptor antagonist.EBI Novartis Pharma AG
9046350 8 Conformational analysis of three NK1 tripeptide antagonists: a proton nuclear magnetic resonance study.EBI Universit£ degli Studi di Napoli Federico II
7678430 23 Cyclic peptides as selective tachykinin antagonists.EBI Merck Sharp and Dohme Research Laboratories
 6 Peptide azoles: A new class of biologically-active dipeptide mmetics.EBI TBA
9703462 98 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models.EBI Novartis Institute for Medical Sciences
7518002 38 Studies on neurokinin antagonists. 4. Synthesis and structure-activity relationships of novel dipeptide substance P antagonists: N2-[(4R)-4-hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl]-N- methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and its related compounds.EBI Fujisawa Pharmaceutical Co., Ltd.
7693945 6 Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand.EBI Pfizer Central Research
1331460 54 Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists.EBI Glaxo Group Research
1375965 47 Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists.EBI Fujisawa Pharmaceutical Co., Ltd.
12127519 40 Identification of a novel 1'-[5-((3,5-dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4'-bipiperidine) as a dual NK(1)/NK(2) antagonist.EBI The Schering Plough Research Institute
11266174 51 Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold.EBI Novartis Institute for Medical Sciences
9873386 15 Synthesis and NK1 receptor antagonistic activity of (+/-)-1-acyl-3-(3,4- dichlorophenyl)-3-[2-(spiro-substituted piperidin-1'-yl)ethyl]piperidines.EBI Yamanouchi Pharmaceutical Co., Ltd.
 52 Synthesis and sar of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/tachykinin NK1 receptor antagonist activityEBI TBA
 31 An SAR study for the non-peptide substance P receptor (NK1) antagonist, CP-96,345.EBI TBA
 76 Use of CoMFA in validating the conformation used in designing 4-(1H-benzimidazole-2-carbonyl)piperidines with H1/NK1 receptor antagonist activityEBI TBA
 42 Synthesis and structure-activity relationships for a series of substituted pyrrolidine NK1/NK2 receptor antagonistsEBI TBA
 4 Perhydrothiopyranopyrroles derivatives : A novel series of potent and selective nonpeptide NK1 antagonists.EBI TBA
 13 Alternative strategies towards the identification of chemical lead compounds by rational designEBI TBA
 23 Methionine replacements in biologically active peptidesEBI TBA
10937720 24 Combined tachykinin receptor antagonist: synthesis and stereochemical structure-activity relationships of novel morpholine analogues.EBI Sankyo Co., Ltd.
8759639 33 Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance P.EBI Hebrew University of Jerusalem
8576917 79 3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists.EBI Lilly Research Laboratories
7689652 6 Studies on neurokinin antagonists. 3. Design and structure-activity relationships of new branched tripeptides N alpha-(substituted L-aspartyl, L-ornithyl, or L-lysyl)-N-methyl-N-(phenylmethyl)-L-phenylalaninamides as substance P antagonists.EBI Fujisawa Pharmaceutical Co., Ltd.
2433445 4 [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype.EBI TBA
1714957 12 Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.EBI Hebrew University of Jerusalem
1694545 28 Potent and highly selective neurokinin antagonists.EBI Glaxo Group Research Ltd.