new BindingDB logo
myBDB logout

74 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28045525 54 A Macrocyclic Agouti-Related Protein/[NleEBI University of Minnesota
26218460 264 Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors.EBI University of Arizona
25699148 41 Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist.EBI Vrije Universiteit Brussel
22335602 93 Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selectivea-melanocyte-stimulating hormone (a-MSH) analogues.EBI Novo Nordisk A/S
20329799 176 Discovery of a selective small-molecule melanocortin-4 receptor agonist with efficacy in a pilot study of sexual dysfunction in humans.EBI Pfizer Global Research and Development
19473029 110 Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.EBI University of Arizona
18412316 52 Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.EBI University of Arizona
18032040 49 Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor.EBI Neurocrine Biosciences, Inc.
18479920 68 Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators.EBI Merck Research Laboratories
18088090 72 Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor.EBI University of Arizona
15771429 104 Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues.EBI University of Arizona
15808454 49 2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists.EBI Merck Research Laboratories
15582434 37 Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist.EBI Merck Research Laboratories
15482933 55 Piperazinebenzylamines as potent and selective antagonists of the human melanocortin-4 receptor.EBI Neurocrine Biosciences, Inc.
12904077 75 Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R.EBI University of Arizona
12431055 52 Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.EBI University of Arizona
12036373 72 Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors.EBI University of Arizona
11150170 30 D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity.EBI University of Arizona
9216831 60 Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R.EBI University of Michigan Medical Center
9171884 52 Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.EBI University of Michigan Medical Center
14643340 41 Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype.EBI Merck Research Laboratories
14552781 45 Aryl piperazine melanocortin MC4 receptor agonists.EBI Neurocrine Biosciences Inc.
12467633 58 Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: histidine substitution.EBI Roche Research Center
11909712 124 N-alkylaminoacids and their derivatives interact with melanocortin receptors.EBI Uppsala University
22011200 24 Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand.EBI H. Lee Moffitt Cancer Center& Research Institute
21486697 17 Cyclic lactam hybrida-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors.EBI University of Arizona
21439820 43 Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.EBI Merck Research Laboratories
21277204 16 Serendipitous discovery of a new class of agonists for the melanocortin 1 and 4 receptors and a new class of cyclophanes.EBI Novo Nordisk
20621473 56 Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.EBI Merck Research Laboratories
20598533 71 Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.EBI Merck Research Laboratories
20207541 18 Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.EBI Merck Research Laboratories
18682322 93 Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.EBI Neurocrine Biosciences, Inc.
18417348 82 Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists.EBI Neurocrine Biosciences, Inc.
17994683 55 Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor.EBI Neurocrine Biosciences, Inc.
17933528 68 Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor.EBI Neurocrine Biosciences, Inc.
17918824 39 Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia.EBI Neurocrine Biosciences, Inc.
17822895 110 Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor.EBI Neurocrine Biosciences, Inc.
17768046 70 Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.EBI Merck & Co.
17618123 674 Design and synthesis of a library of tertiary amides: evaluation as mimetics of the melanocortins' active core.EBI Uppsala University
17574418 117 Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor.EBI Institut Henri Beaufour
17544282 39 Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity.EBI Neurocrine Biosciences Inc
17455928 171 Potent and selective agonists of human melanocortin receptor 5: cyclic analogues of alpha-melanocyte-stimulating hormone.EBI Merck Research Laboratories
17314042 40 Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold.EBI Vrije Universiteit Brussel
17154518 27 Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor.EBI University of Arizona
16931008 72 Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors.EBI University of Arizona
16824757 67 Propionylpiperazines as human melanocortin-4 receptor ligands.EBI Neurocrine Biosciences, Inc.
16777413 65 Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor.EBI Neurocrine Biosciences, Inc.
16697187 46 Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor.EBI Neurocrine Biosciences, Inc.
16539382 136 Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities.EBI University of Arizona
16364639 101 Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands.EBI Merck Research Laboratories
16297618 32 Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor.EBI Lilly Research Laboratories
16169218 30 Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides.EBI Roche Research Center
16005624 97 Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: discovery of the dihydropyridazinone motif.EBI Merck Research Laboratories
15982875 46 Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist.EBI Merck Research Laboratories
15951175 28 1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.EBI Merck Research Laboratories
15950470 69 Structure-activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor.EBI Neurocrine Biosciences, Inc.
15863313 65 A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice.EBI Neurocrine Biosciences, Inc.
15857110 96 Discovery of a beta-MSH-derived MC-4R selective agonist.EBI Lilly Research Laboratories
15745810 39 Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides.EBI Amgen Inc.
15664867 33 Identification of agonists and antagonists of the human melanocortin-4 receptor from piperazinebenzylamines.EBI Neurocrine Biosciences, Inc.
15615531 30 4-{(2R)-[3-Aminopropionylamido]-3-(2,4-dichlorophenyl)propionyl}-1-{2-[(2-thienyl)ethylaminomethyl]phenyl}piperazine as a potent and selective melanocortin-4 receptor antagonist--design, synthesis, and characterization.EBI Neurocrine Biosciences, Inc.
15357964 90 Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor.EBI Neurocrine Biosciences, Inc.
15317471 42 New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of"THIQ".EBI Uppsala University
15267247 55 Phenylguanidines as selective nonpeptide melanocortin-5 receptor antagonists.EBI Neurocrine Biosciences, Inc.
14736255 68 Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.EBI Lilly Research Laboratories
14584947 108 Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues.EBI University of Arizona
12657270 57 Structure-activity relationship of cyclic peptide penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2) at the human melanocortin-1 and -4 receptors: His(6) substitution.EBI Roche Research Center
12646021 35 Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
12361385 34 Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist.EBI Merck & Co.
11909711 86 Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors.EBI Uppsala University
11606131 92 Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.EBI Merck Research Laboratories