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52 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27353888 30 Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-▀-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.EBI University of Delhi
27190601 71 Structure-Activity Relationship Studies of Isomeric 2,4-Diaminoquinazolines on▀-Amyloid Aggregation Kinetics.EBI University of Waterloo
27061983 48 Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.EBI Guangzhou Medical University
26945113 9 Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry.EBI University of Waterloo
26783181 24 Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.EBI Linyi People's Hospital
26632651 70 Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.EBI China Pharmaceutical University
26719209 7 Structural insights into mechanisms for inhibiting amyloid▀42 aggregation by non-catechol-type flavonoids.EBI Kyoto University
26598460 14 Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid.EBI Dalhousie University
26288690 1 Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects.EBI Virginia Commonwealth University
26177091 138 Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands fora-Synuclein Fibrils.EBI Washington University School of Medicine
26099993 5 3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease.EBI Sun Yat-sen University
26078011 7 NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease.EBI Universit£ degli Studi di Torino
25978520 9 Nodulisporiviridins A-H, Bioactive Viridins from Nodulisporium sp.EBI Jinan University
24878198 4 Naturally occurring polyphenolic inhibitors of amyloid beta aggregation.EBI CSIRO Manufacturing Flagship (Biomedical)
24944730 20 Imidazo[2,1]thiazol-3-one Derivatives Useful as Diagnostic Agents for Alzheimer's Disease.EBI Temple University School of Pharmacy
24131448 7 Oxidative stress in Alzheimer's disease: are we connecting the dots?EBI University of Bologna
24657049 5 Polyfluorinated bis-styrylbenzenes as amyloid-▀ plaque binding ligands.EBI Leiden University Medical Center
18954037 40 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.EBI University of Bologna
18793854 25 Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation.EBI Institute of Science and Technology
17004725 13 Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging.EBI Sungkyunkwan University School of Medicine
16162001 12 F-18 stilbenes as PET imaging agents for detecting beta-amyloid plaques in the brain.EBI University of Pennsylvania
21145738 5 Diphenylpropynone derivatives as probes for imagingß-amyloid plaques in Alzheimer's brains.EBI Kyoto University
20223661 48 Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.EBI Princ
19959359 46 Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.EBI Wyeth Research
19275964 64 (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.EBI Pfizer Global Research & Development
17761417 50 Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.EBI Schering-Plough Research Institute
17418571 23 Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.EBI Pharmacopeia Drug Discovery, Inc.
16640346 24 Synthesis of biphenyltrienes as probes for beta-amyloid plaques.EBI University of Pennsylvania
16640332 8 Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.EBI Nagasaki University
16574411 4 Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease.EBI Emory University
16473009 23 Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
16325402 15 Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging.EBI University of Pennsylvania
16279784 12 Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain.EBI Nagasaki University
16134939 67 Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.EBI Chiesi Farmaceutici S.p.A.
15780628 15 Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors.EBI Wyeth Research
12801237 19 Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.EBI University of Pittsburgh
12519062 11 Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.EBI University of Pennsylvania
11428920 6 Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain.EBI University of Pennsylvania
11384236 26 Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.EBI University of Pennsylvania
10882355 5 Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease.EBI Amgen
17988101 7 Solution-phase parallel synthesis of carbamates as gamma-secretase inhibitors.BDB Schering-Plough Research Institute