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33 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
4068006 46 Inhibition of human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin by elasnin and other 4-hydroxy-2-pyrones.EBI TBA
11931626 124 A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.EBI Northwestern University
11312928 62 Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase.EBI Welfide Corporation
11312927 64 Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.EBI Welfide Corporation
2120440 22 Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.EBI Kissei Pharmaceutical Company, Ltd.
10915051 43 The design and synthesis of thrombin inhibitors: analogues of MD805 containing non-polar surrogates for arginine at the P1 position.EBI Novartis Horsham Research Centre
 2 Enzymatic synthesis of peptidyl amino alcohols and peptidyl amino aldehydes-serine proteinase inhibitorsEBI TBA
15896959 14 Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors.EBI Development Center for Biotechnology
14592513 24 Structure-activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors.EBI Toa Eiyo Ltd.
12372533 69 P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
11425539 23 Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones.EBI Shionogi & Co., Ltd.
11378359 57 Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.EBI 3-Dimensional Pharmaceuticals Inc.
11212109 14 The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase.EBI Roche Discover Welwyn
11206478 18 Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.EBI Institute of Molecular and Cell Biology
11078187 36 Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors.EBI Shionogi & Co., Ltd
10915052 20 The design and synthesis of thrombin inhibitors: the introduction of in vivo efficacy and oral bioavailability into benzthiazolylalanine inhibitors.EBI Novartis Horsham Research Centre
10636250 20 Non-peptidic phenyl-based thrombin inhibitors: exploring structural requirements of the S1 specificity pocket with amidines.EBI 3-Dimensional Pharmaceuticals
10636229 27 Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.EBI 3-Dimensional Pharmaceuticals
9873654 37 5,5-trans lactone-containing inhibitors of serine proteases: identification of a novel, acylating thrombin inhibitor.EBI GlaxoWellcome Research and Development
9873397 37 In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors.EBI 3-Dimensional Pharmaceuticals
9871512 20 Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.EBI Green Cross Research Laboratories
9379436 46 Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.EBI ZENECA Pharmaceuticals
8176703 14 Design of orally active, non-peptidic inhibitors of human leukocyte elastase.EBI ZENECA Pharmaceuticals Group
7932558 30 Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones.EBI ZENECA Pharmaceuticals Group
3806568 21 Structure-activity study of 6-substituted 2-pyranones as inactivators of alpha-chymotrypsin.EBI TBA
3735315 5 5-(Halomethyl)-2-pyranones as irreversible inhibitors of alpha-chymotrypsin.EBI TBA
3512826 3 Enol lactone inhibitors of serine proteases. The effect of regiochemistry on the inactivation behavior of phenyl-substituted (halomethylene)tetra- and -dihydrofuranones and (halomethylene)tetrahydropyranones toward alpha-chymotrypsin: stable acyl enzyme intermediate.EBI TBA
2724298 11 Acid-sensitive latent inhibitors for proteolytic enzymes: synthesis and characterization.EBI Amherst College
18341296 7 Diversity-oriented fluorescence library approach (DOFLA) to the discovery of chymotrypsin sensor.BDB New York University
18569346 3 alpha-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn.BDB University of Karachi
17850059 195 N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.BDB Montana State University
9468142 60 Design of potent selective zinc-mediated serine protease inhibitors.BDB Arris