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28 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
23594083 7 Evaluating the Role of Macrocycles in the Susceptibility of Hepatitis C Virus NS3/4A Protease Inhibitors to Drug Resistance.BDB University of Massachusetts Medical School
19054673 66 5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.BDB Anadys Pharmaceuticals
19022670 8 Potent inhibitors of HCV-NS3 protease derived from boronic acids.BDB Schering-Plough Research Institute
19154150 19 Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.BDB Schering-Plough Research Institute
19168351 18 Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings.BDB Schering-Plough Research Institute
19102654 32 Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.BDB Schering-Plough Research Institute
17444623 29 Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.BDB Schering-Plough Research Institute
16451065 31 Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.BDB Schering-Plough Research Institute
17004721 49 Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitorBDB Schering-Plough Research Institute
16387495 8 Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.BDB Schering-Plough Research Institute
16112862 9 Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency.BDB Schering-Plough Research Institute
16413182 18 Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid.BDB Schering-Plough Research Institute
15501035 12 Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex.BDB Schering-Plough Research Institute
16087332 33 Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.BDB Schering-Plough Research Institute
16420042 9 Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.BDB Schering-Plough Research Institute
16640336 16 Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.BDB Schering-Plough Research Institute
15239657 30 Novel azapeptide inhibitors of hepatitis C virus serine protease.BDB Boehringer Ingelheim (Canada) Ltd.