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38 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26985301 55 Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.EBI GlaxoSmithKline
26685731 33 Structure-Activity Relationship of Azaindole-Based Glucokinase Activators.EBI Servier Research Institute of Medicinal Chemistry
25815149 24 Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM.EBI Yuhan Research Institute
25001129 89 Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket.EBI Amgen, Inc.
25516785 26 C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators.EBI Amgen, Inc.
25203462 49 Discovery of 2-pyridylureas as glucokinase activators.EBI Array BioPharma Inc.
24588963 21 Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus.EBI Yuhan Research Institute
24583379 2 Discovery of novel urea derivatives as dual-target hypoglycemic agents that activate glucokinase and PPAR┐.EBI Chinese Academy of Medical Sciences& Peking Union Medical College
24405172 35 Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.EBI Amgen, Inc.
24405213 60 Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.EBI Amgen Inc.
24239482 9 Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.EBI Pfizer Inc.
24015910 18 Identification of a new class of glucokinase activators through structure-based design.EBI Array BioPharma
23831135 29 Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.EBI Pfizer Inc.
23434031 51 Design, synthesis and SAR of novel glucokinase activators.EBI Takeda California
23218712 29 Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus.EBI Yuhan Research Institute
23149230 22 The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold.EBI AstraZeneca
23089526 21 The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.EBI Pfizer Inc.
22196621 17 Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.EBI Pfizer Inc.
22459213 29 Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators.EBI Chinese Academy of Sciences
19435665 33 Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle.EBI Pfizer Inc.
21515051 23 Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life.EBI AstraZeneca R&D
20472448 25 Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators.EBI Chinese Academy of Sciences
19736020 32 The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators.EBI Banyu Tsukuba Research Institute
19726182 60 Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators.EBI Banyu Tsukuba Research Institute
19540111 24 Discovery of novel 2-(pyridine-2-yl)-1H-benzimidazole derivatives as potent glucokinase activators.EBI Banyu Tsukuba Research Institute
19427223 68 Structure-activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy.EBI Banyu Tsukuba Research Institute
19362831 11 Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.EBI Banyu Tsukuba Research Institute
19282189 50 Discovery of potent and orally active 3-alkoxy-5-phenoxy-N-thiazolyl benzamides as novel allosteric glucokinase activators.EBI Banyu Tsukuba Research Institute
19188063 66 Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators.EBI Banyu Tsukuba Research Institute
18588279 13 SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1.EBI Oxford OX4 6LT
16503142 6 Design of a potent, soluble glucokinase activator with excellent in vivo efficacy.EBI AstraZeneca R&D
15808477 23 Discovery, synthesis and biological evaluation of novel glucokinase activators.EBI AstraZeneca UK
23534475 27 De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.BDB University of Dundee
19758809 66 Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase.BDB Shanghai Institutes for Biological Sciences