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81 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27050782 16 Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas.EBI University of Pisa
27080185 46 Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.EBI Merck Research Laboratories
26764190 4 Peptide-based inhibitors of protein-protein interactions.EBI Wroclaw University of Technology
26115576 15 Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin.EBI University of East Anglia
26181851 26 Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.EBI Novartis Institutes for BioMedical Research
25396320 8 Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.EBI University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine
25384157 37 Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.EBI Amgen Inc.
25882531 8 Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor.EBI Daiichi Sankyo Co., Ltd.
25042256 33 Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.EBI Amgen Inc.
25496041 43 Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.EBI University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine
24934571 14 Diphenylpyrroles: Novel p53 activators.EBI Cairo University
24900882 30 Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor.EBI Merck Research Laboratories
24813735 17 Discovery of 1-arylpyrrolidone derivatives as potent p53-MDM2 inhibitors based on molecule fusing strategy.EBI Second Military Medical University
24852275 15 Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction.EBI Chinese Academy of Medical Science and Peking Union Medical College
24751445 15 Hot spot-based design of small-molecule inhibitors for protein-protein interactions.EBI University of Utah
24704029 14 Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction.EBI Novartis Institutes for BioMedical Research
24601644 113 Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.EBI Amgen Inc.
24548297 50 Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.EBI Amgen Inc.
24656661 11 Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction.EBI Merck Research Laboratories
24456472 67 Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.EBI Amgen Inc.
24113239 26 5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.EBI University of Nottingham
23808545 12 Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development.EBI Roche Research Center
23786219 20 A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.EBI University of Michigan
23726030 3 Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.EBI Kyoto University
23660015 5 Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction.EBI Southwest University
22789708 15 Benzimidazole-2-one: a novel anchoring principle for antagonizing p53-Mdm2.EBI University of Pittsburgh
23541651 8 Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic.EBI Sanofi
23597064 68 Rational design and binding mode duality of MDM2-p53 inhibitors.EBI Amgen Inc.
23477941 1 Synthesis and evaluation of an imidazole derivative-fluorescein conjugate.EBI The University of Texas Health Science Center at Houston
22524527 13 Structure-based design of novel inhibitors of the MDM2-p53 interaction.EBI Amgen Inc.
22227462 2 Chemical modulators working at pharmacological interface of target proteins.EBI Korea University College of Pharmacy Sejong-ro
22995624 20 Discovery of novel dihydroimidazothiazole derivatives as p53-MDM2 protein-protein interaction inhibitors: synthesis, biological evaluation and structure-activity relationships.EBI Daiichi Sankyo Co., Ltd
22694121 5 An ultrahigh affinity d-peptide antagonist Of MDM2.EBI University of Maryland
22624960 1 AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development.EBI University of Michigan Comprehensive Cancer Center
22230199 12 Unbiased binding assays for discovering small-molecule probes and drugs.EBI Broad Institute of Harvard and MIT
18752944 2 Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics.EBI Yale University
18680271 8 NMR screening for lead compounds using tryptophan-mutated proteins.EBI Institute for Biochemistry
18075579 9 Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.EBI University of California at San Francisco
21314128 91 Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency.EBI Newcastle University
21277201 35 Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition.EBI State University of New York
20638853 12 Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.EBI Purdue University
19928922 19 Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction.EBI University of Michigan
19856920 10 Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.EBI Amgen Inc.
18977148 5 Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.EBI National Cancer Institute-Frederick
15780621 6 Structure-based design, synthesis, and biological evaluation of novel 1,4-diazepines as HDM2 antagonists.EBI Johnson & Johnson Pharmaceutical Research and Development
19880322 56 N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.BDB NIH
16600594 23 Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design.BDB Johnson & Johnson Pharmaceutical
16630722 13 Enantiomerically pure 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists.BDB Johnson & Johnson Pharmaceutical
16647257 17 Novel 1,4-benzodiazepine-2,5-diones as Hdm2 antagonists with improved cellular activity.BDB Johnson & Johnson Pharmaceutical
15715460 2 Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.BDB Johnson & Johnson Pharmaceutical
15293988 1 A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells.BDB Virginia Commonwealth University
11148027 15 Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.BDB Max Planck Institute
19457663 1 Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking.BDB H. Lee Moffitt Cancer Center
17034127 45 Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold.BDB University of Newcastle upon Tyne
15246006 20 Fluorescence polarization assay and inhibitor design for MDM2/p53 interaction.BDB Schering-Plough Research Institute
16789731 3 Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.BDB University of Michigan
16759082 9 Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.BDB University of Michigan