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37 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26395057 48 From carbohydrates to drug-like fragments: Rational development of novela-amylase inhibitors.EBI Freie Universit£t Berlin
26112442 74 Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors.EBI Chengdu University of TCM
25901531 211 Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.EBI Sloan-Kettering
24984936 28 Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.EBI Tufts University
24980703 296 Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors.EBI Nerviano Medical Sciences
24745965 22 Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors.EBI Montclair State University
24580531 6 Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.EBI University of Geneva
24763261 35 Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.EBI China Pharmaceutical University
24673104 185 Identification of novel HSP90a/ isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.EBI Vertex Pharmaceuticals , 11010 Torreyana Road, San Diego, California 92121, United States.
23394126 170 Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).EBI Exelixis
23186287 1 Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.EBI Seoul National University
22835870 29 Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.EBI AstraZeneca
23018093 41 Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.EBI Vernalis Ltd.
22632933 65 Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.EBI Merck Serono Research
22386527 23 Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.EBI Serenex Inc.
20055425 29 Heat shock protein 90: inhibitors in clinical trials.EBI Biogen Idec Inc.
19405528 45 Potent cytotoxic C-11 modified geldanamycin analogues.EBI Kosan Biosciences, Inc.
19017562 45 Discovery and development of heat shock protein 90 inhibitors.EBI Memorial Sloan-Kettering Cancer Center
22066525 65 Novel 3,4-isoxazolediamides as potent inhibitors of chaperone heat shock protein 90.EBI Universit£ degli Studi di Ferrara
22014826 3 A small molecule that preferentially binds the closed conformation of Hsp90.EBI San Diego State University
21972823 10 Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.EBI Sanofi-Aventis Research and Development
21920765 12 Lead identification ofß-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.EBI Trinity College
20608738 7 ATPases as drug targets: insights from heat shock proteins 70 and 90.EBI Vernalis R&D Ltd.
19331414 1 Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.EBI Trinity College
18457385 41 Recent developments in fragment-based drug discovery.EBI Astex Therapeutics Ltd.
16392823 39 Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.EBI Memorial Sloan-Kettering Cancer Center
18785742 18 A novel class of small molecule inhibitors of Hsp90.BDB Yale University
19610616 29 Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.BDB Vernalis (R&D) Ltd
18020435 55 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.BDB Vernalis (R&D) Ltd
17488003 32 Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.BDB Biogen Idec
16913725 33 7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors.BDB Conforma Therapeutics Corporation
16420067 16 Orally active purine-based inhibitors of the heat shock protein 90.BDB Conforma Therapeutics Corporation
16202589 11 Structure-based discovery of a new class of Hsp90 inhibitors.BDB Vernalis (R&D) Ltd
16213716 16 3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone.BDB Vernalis (R&D) Ltd
15974572 14 Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.BDB Vernalis (R&D) Ltd