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54 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27783977 12 Targeting the entry region of Hsp90's ATP binding pocket with a novel 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl amide.EBI Keimyung University
27914802 12 Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors.EBI Korea University
27913182 5 Virtual screening and biophysical studies lead to HSP90 inhibitors.EBI University of Auckland
27003516 78 Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.EBI The University of Kansas
26112442 74 Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors.EBI Chengdu University of TCM
25901531 211 Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.EBI Sloan-Kettering
25677667 17 Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.EBI Vertex Pharmaceuticals Inc
25105924 5 Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.EBI Shandong University
25368984 14 Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990.EBI Novartis Institutes for Biomedical Research
25313505 35 Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.EBI Chinese Academy of Sciences
25277067 7 Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.EBI Shandong University
24751441 18 Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.EBI Chinese Academy of Sciences
24588105 56 Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.EBI Universit£ degli Studi di Siena
24580531 6 Differences in conformational dynamics between Plasmodium falciparum and human Hsp90 orthologues enable the structure-based discovery of pathogen-selective inhibitors.EBI University of Geneva
24565573 35 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.EBI Universit£ degli Studi di Ferrara
24673104 185 Identification of novel HSP90a/ isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.EBI Vertex Pharmaceuticals , 11010 Torreyana Road, San Diego, California 92121, United States.
23362862 13 A chemical-biological study reveals C9-type iridoids as novel heat shock protein 90 (Hsp90) inhibitors.EBI Universit£ di Salerno
22938030 22 EC144 is a potent inhibitor of the heat shock protein 90.EBI Biogen Idec Inc.
21438541 45 Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrEBI Pfizer Inc.
20055425 29 Heat shock protein 90: inhibitors in clinical trials.EBI Biogen Idec Inc.
19231864 6 Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.EBI Kosan Biosciences Inc
16165354 19 Structure-based design of 7-carbamate analogs of geldanamycin.EBI Kosan Biosciences, Inc.
9925731 4 Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.EBI University College London
22192591 17 Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors.EBI Chugai Pharmaceutical Co., Ltd
21875802 33 Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.EBI Chugai Pharmaceutical Co., Ltd
21920765 12 Lead identification ofß-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.EBI Trinity College
21715165 31 Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.EBI Pfizer Inc.
21106457 41 N-aryl-benzimidazolones as novel small molecule HSP90 inhibitors.EBI Abbott Laboratories
21605975 31 Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.EBI Pfizer Inc.
21420297 19 Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.EBI Pfizer Inc.
20609590 10 Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents.EBI Hokkaido University
19168355 7 5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone.EBI Fermentas UAB
16797988 4 Synthesis of a red-shifted fluorescence polarization probe for Hsp90.EBI Memorial Sloan-Kettering Cancer Center
15828828 136 Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.EBI Memorial Sloan-Kettering Cancer Center
15713410 2 Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.EBI Genomics Institute of the Novartis Research Foundation (GNF)
11294389 27 LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.EBI Department of Molecular Oncogenesis
27959508 56 Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.BDB The University of Kansas
19519743 6 Potent triazolothione inhibitor of heat-shock protein-90.BDB Bayer Healthcare,
17630989 9 Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.BDB Abbott Laboratories
18197612 9 Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.BDB Wyeth Research