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289 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28337317 30 Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity.EBI Wayne State University
27541357 58 Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.EBI National University of Singapore
28057407 76 Bifunctional conjugates with potent inhibitory activity towards cyclooxygenase and histone deacetylase.EBI Georgia Institute of Technology
27769671 66 Synthesis and investigation of novel 6-(1,2,3-triazol-4-yl)-4-aminoquinazolin derivatives possessing hydroxamic acid moiety for cancer therapy.EBI Tsinghua University
27344487 16 2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase.EBI Taipei Medical University
27717544 75 Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.EBI Integral BioSciences Pvt. Ltd
27665180 14 Design and synthesis of novel HDAC8 inhibitory 2,5-disubstituted-1,3,4-oxadiazoles containing glycine and alanine hybrids with anti cancer activity.EBI Acharya Nagarjuna University
27650925 15 Synthesis of a selective HDAC6 inhibitor active in neuroblasts.EBI University of Geneva
27606546 218 Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.EBI University of Navarra
27377864 55 Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.EBI Broad Institute of MIT and Harvard
27186676 186 Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.EBI West China Hospital of Sichuan University
27142751 22 Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.EBI China Pharmaceutical University
27190592 24 Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs.EBI IRBM Science Park
27177826 2 Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.EBI Yale University
26937828 137 Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.EBI Martin-Luther University of Halle-Wittenberg
26890116 30 Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.EBI University of Milan
27060764 30 Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.EBI Sungkyunkwan University
26443078 108 Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.EBI Sichuan University
26890114 56 Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.EBI Shanghai Institute of Materia Medica
26681404 40 Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors.EBI Washington University School of Medicine
26653328 67 Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.EBI Albert-Ludwigs-University Freiburg
26705137 31 Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors.EBI Universidade Federal de Alfenas
26814680 71 Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in vitro and in vivo anti-tumor efficacy.EBI Shenyang Pharmaceutical University
26804233 38 Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.EBI Massachusetts General Hospital
26706171 138 Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.EBI Shenyang Pharmaceutical University
26689485 18 Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.EBI Orchid Chemicals& Pharmaceuticals Ltd
26741358 56 Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC.EBI China Pharmaceutical University
26753813 22 Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.EBI University of Minnesota
26005563 2 Discovery of a new class of histone deacetylase inhibitors with a novel zinc binding group.EBI Medical University of South Carolina
26475519 40 Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.EBI China Pharmaceutical University
26481659 18 New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation.EBI Ronzoni Institute for Chemical and Biochem. Research
26376355 14 Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors.EBI University of Milan
26331334 99 Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.EBI Guangzhou Institute of Biomedicine and Health
26086931 38 Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators.EBI Shandong University
26264503 46 Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.EBI University of Minnesota
26287310 87 Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.EBI University College London
26211462 71 Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors.EBI The Walter and Eliza Hall Institute of Medical Research
25637120 94 Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).EBI St Jude Children's Research Hospital
22344701 30 Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).EBI Novartis Institutes for BioMedical Research
25147612 25 Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.EBI University of Florida
25261927 80 Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors.EBI The Walter and Eliza Hall Institute of Medical Research
26054247 48 Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.EBI Colorado State University
26140961 11 Design, synthesis and antiproliferative activities of novel benzamides derivatives as HDAC inhibitors.EBI Academy of Military Medical Sciences
26100440 6 Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors.EBI Shandong University
25993269 140 Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer.EBI Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
25953722 102 Discovery, bioactivity and docking simulation of Vorinostat analogues containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors and antitumor agents.EBI Southeast University
25974739 17 Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release.EBI University of California
25815139 18 Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors.EBI Fujian University of Traditional Chinese Medicine
25971769 25 Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.EBI MethylGene Inc.
25906087 14 Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.EBI Shandong University
25905694 24 Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.EBI Istituto Ortopedico Rizzoli (IOR)
25874326 60 Discovery and preliminary evaluation of 2-aminobenzamide and hydroxamate derivatives containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors.EBI Southeast University
25899338 37 Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids.EBI Georgia Institute of Technology
25805446 30 Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.EBI East China Normal University
25734520 104 Design and synthesis of orally bioavailable aminopyrrolidinone histone deacetylase 6 inhibitors.EBI Roche Innovation Center Shanghai
25070421 33 Evaluation of class I HDAC isoform selectivity of largazole analogues.EBI Duke University
25042254 7 Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.EBI H�pital Kirchberg
25022972 24 Bicyclic tetrapeptides as potent HDAC inhibitors: effect of aliphatic loop position and hydrophobicity on inhibitory activity.EBI University of Rajshahi
24997578 41 Design and synthesis of CHAP31, trapoxin B and HC-toxin based bicyclic tetrapeptides disulfide as potent histone deacetylase inhibitors.EBI University of Rajshahi
24972008 36 1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.EBI Sapienza University of Rome
24864038 112 Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors.EBI Nippon Pharmaceutical Chemicals Co., Ltd
25563890 49 Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
25462271 33 Development of 3-hydroxycinnamamide-based HDAC inhibitors with potent in vitro and in vivo anti-tumor activity.EBI Shandong University
25455492 22 Aurones as histone deacetylase inhibitors: identification of key features.EBI University of Geneva
25454270 82 Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.EBI TBA
25380299 61 Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.EBI Technical University of Denmark
25238284 52 Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.EBI Roche Pharmaceutical Research and Early Development
25233084 247 ST7612AA1, a thioacetate-(-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite SpA
25221651 12 Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity.EBI University of Bologna
25218912 103 Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.EBI Chinese Academy of Sciences
25182565 21 Design, synthesis and evaluation of novel HDAC inhibitors as potential antitumor agents.EBI Shanghai Huilun Life Sciences& Technology Co. Ltd
24944733 101 Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors.EBI Chinese National Center for Drug Screening
24900884 14 Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues.EBI Nagoya University
24766560 16 Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.EBI Taipei Medical University
24588105 56 Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.EBI Universit£ degli Studi di Siena
24565573 35 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.EBI Universit£ degli Studi di Ferrara
24742384 90 Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.EBI Universit£ di Milano
24694055 35 Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.EBI Shandong University
17196388 12 Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans.EBI Universit£ degli Studi di Roma La Sapienza
23570542 48 Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.EBI National Taiwan University
23547652 27 3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition.EBI Georgia Institute of Technology
23368884 80 Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.EBI Broad Institute of MIT and Harvard
23313638 6 Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.EBI Tohoku Pharmaceutical University
23252603 35 Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.EBI Heinrich Heine Universit£t
23206867 12 Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.EBI The General Hospital of Chinese People's Liberation Army
22932316 8 Amide-based derivatives ofß-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects.EBI University of Sydney
23089527 6 The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.EBI Wayne State University
23116147 30 Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.EBI Kyoto Prefectural University of Medicine
23061376 63 Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.EBI Roche R&D Center-China Ltd.
23009203 39 Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.EBI University of Illinois at Chicago
23010266 24 Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.EBI University of Illinois at Chicago
23021104 32 Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.EBI Graduate School of Life Science and Systems Engineering
22642300 160 Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.EBI Kyoto Prefectural University of Medicine
22771007 64 Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.EBI University of Illinois at Chicago
22738629 47 CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.EBI Chinese Academy of Sciences
22705022 32 Synthesis, biological evaluation and molecular docking studies of 3-(1,3-diphenyl-1H-pyrazol-4-yl)-N-phenylacrylamide derivatives as inhibitors of HDAC activity.EBI Nanjing University
22439863 21 Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.EBI Taipei Medical University
22280363 104 Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.EBI Imperial College London
22541394 30 Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.EBI Guru Ghasidas University
22260166 17 Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors.EBI Georgia Institute of Technology
22465091 28 A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)-disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: design, synthesis and molecular modeling study.EBI Dalian University of Technology
22165909 48 Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.EBI University of Illinois at Chicago
22276693 5 Trichostatin analogues JBIR-109, JBIR-110, and JBIR-111 from the marine sponge-derived Streptomyces sp. RM72.EBI Biomedicinal Information Research Center (BIRC)
21650221 57 Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.EBI Novartis Institutes for Biomedical Research
21874153 54 Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.EBI Broad Institute of Harvard and MIT
20472442 25 On the inhibition of histone deacetylase 8.EBI University of Notre Dame
20392637 159 Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity.EBI Takeda San Diego
19705846 100 Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.EBI The Scripps Research Institute
18809328 64 Optimization of a series of potent and selective ketone histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
18397826 18 Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells.EBI Waseda University
18381238 4 Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.EBI Sapienza Universit£ di Roma
18381239 1 Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: a cyclic tetrapeptide scaffold.EBI San Diego State University
18054239 54 Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).EBI University of Freiburg
18182289 127 Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18160287 23 Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors.EBI MethylGene Inc.
18247554 134 Histone deacetylase inhibitors: from bench to clinic.EBI Menarini Ricerche
16987657 45 A series of novel, potent, and selective histone deacetylase inhibitors.EBI IRBM/Merck Research Laboratories
15454224 15 Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.EBI CREST Research Project
14613312 106 Histone deacetylase inhibitors.EBI Aton Pharma, Inc
14584932 23 Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.EBI Universit£ degli Studi di Roma"La Sapienza"
15109626 20 Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.EBI Institute of Technology
22321215 16 Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.EBI Kansai University
21417419 5 Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.EBI DAC SRL
22182579 110 Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases.EBI University of Applied Sciences
21721525 8 In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).EBI Harvard Medical School
21548582 57 Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.EBI University of Illinois at Chicago
21924799 38 Design, synthesis and primary activity assay of tripeptidomimetics as histone deacetylase inhibitors with linear linker and branched cap group.EBI Shandong University
21889343 6 The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.EBI Wayne State University
21875796 24 2,5-Disubstituted-1,3,4-oxadiazoles/thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors.EBI Guru Ghasidas University
21634430 218 Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.EBI S*BIO Pte Ltd.
21712146 20 Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.EBI Taipei Medical University
21723733 12 Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.EBI Novartis Institutes for Biomedical Research
21745740 10 Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors.EBI East China Normal University
21742496 85 The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.EBI Novartis Institutes for Biomedical Research
21696956 243 A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.EBI Broad Institute of Harvard and MIT
21080647 27 Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.EBI Chroma Therapeutics Ltd.
21417297 220 Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.EBI Universita` degli Studi di Siena
21256006 11 Structure and property based design, synthesis and biological evaluation of¿-lactam based HDAC inhibitors.EBI Yonsei University
21145737 12 Application of p21 and klf2 reporter gene assays to identify selective histone deacetylase inhibitors for cancer therapy.EBI Roche R&D Center China Ltd
21080629 153 Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.EBI University of Regensburg
20947351 24 Inhibitors selective for HDAC6 in enzymes and cells.EBI The University of Queensland
19966789 40 Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.EBI The Scripps Research Institute
20637529 15 Design and synthesis of novel isoxazole-based HDAC inhibitors.EBI Università degli Studi di Milano
20491440 12 Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.EBI Universidade de Vigo
20452226 15 New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group.EBI Kansai University
20223566 23 Inside HDAC with HDAC inhibitors.EBI Universit£ de Poitiers
20451378 107 Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.EBI S *BIO Pte Ltd
20381359 17 Synthesis and biological activity of cyclotetrapeptide analogues of the natural HDAC inhibitor FR235222.EBI Universit£ degli Studi di Salerno
20158243 2 Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii.EBI Harbor Branch Oceanographic Institute at Florida Atlantic University
20205394 44 Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).EBI Novartis Institutes for Biomedical Research
20143840 28 Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring.EBI UMR CNRS 6026-Universit£ Rennes 1
20055418 78 Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.EBI University of Illinois at Chicago
20045316 18 Bicyclic peptides as potent inhibitors of histone deacetylases: optimization of alkyl loop length.EBI Graduate School of Life Science and Systems Engineering
20143778 70 Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.EBI Curis Inc
19906529 22 Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.EBI Ortho-Biotech Oncology Research& Development
19822426 4 Novel N-hydroxybenzamide-based HDAC inhibitors with branched CAP group.EBI China Pharmaceutical University
19699639 58 Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.EBI MethylGene Inc.
19888759 42 Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.EBI Istituto Di Ricerche Di Biologia Molecolare
19359173 51 Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.EBI Sigma-Tau Research and Development
19136179 22 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment.EBI China Pharmaceutical University
19362838 16 Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.EBI The Scripps Research Institute
19457659 22 Non-isotopic dual parameter competition assay suitable for high-throughput screening of histone deacetylases.EBI University of G£ttingen
19441846 35 Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.EBI IRBM/Merck Research Laboratories
19419863 58 Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.EBI University of Illinois at Chicago
19419205 28 Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.EBI Nagoya City University
19410459 33 Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.EBI IRBM/Merck Research Laboratories
19301902 104 Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.EBI University of Regensburg
19285395 66 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.EBI R&D Sigma-Tau SpA
19272776 63 Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.EBI MethylGene Inc.
19268585 30 Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
19181524 46 N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.EBI S *BIO Pte Ltd
19114304 44 SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103).EBI MethylGene Inc.
19084395 45 Sulfamides as novel histone deacetylase inhibitors.EBI MethylGene Inc.
19007204 2 Histone deacetylase inhibitors through click chemistry.EBI The Ohio State University
18952417 50 Studies of the metabolic stability in cells of 5-(trifluoroacetyl)thiophene-2-carboxamides and identification of more stable class II histone deacetylase (HDAC) inhibitors.EBI IRBM-Merck Research Laboratories Rome
18951790 109 SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).EBI Merck Research Laboratories
18930398 117 2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.EBI IRBM-Merck Research Laboratories Rome
18701301 38 Design, synthesis and biological evaluation of novel compounds with conjugated structure as anti-tumor agents.EBI China Pharmaceutical University
18672316 41 Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.EBI Institute of Organic Synthesis
18642892 76 Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.EBI University of Illinois at Chicago
18558669 119 Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles.EBI Nycomed GmbH
18207391 28 4-(Heteroarylaminomethyl)-N-(2-aminophenyl)-benzamides and their analogs as a novel class of histone deacetylase inhibitors.EBI MethylGene Inc.
18060775 67 Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).EBI Merck Research Laboratories
17977726 19 N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors.EBI MethylGene Inc.
17900911 21 Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.EBI Graduate School of Life Science and Systems Engineering
17881232 42 Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.EBI Graduate School of Life Science and Systems Engineering
17761416 53 The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors.EBI Merck Research Laboratories
17691763 20 2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.EBI University of Regensburg
17606370 2 Trithiocarbonates: exploration of a new head group for HDAC inhibitors.EBI Altana Pharma AG
17588744 18 Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.EBI The University of Tokyo
17576064 30 Benzo[b]thiophene-based histone deacetylase inhibitors.EBI Merck Research Laboratories
17555962 26 Design of novel histone deacetylase inhibitors.EBI Merck Research Laboratories
17539623 65 Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.EBI University of Illinois at Chicago
17507219 17 Aminosuberoyl hydroxamic acids (ASHAs): a potent new class of HDAC inhibitors.EBI Merck Research Laboratories
17447750 4 Bispyridinium dienes: histone deacetylase inhibitors with selective activities.EBI Universidade de Vigo
17419603 6 Design and synthesis of a potent histone deacetylase inhibitor.EBI Virginia Tech
17346959 14 Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.EBI Ithaca College
17257837 3 Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor.EBI Nagoya City University
17107790 40 Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.EBI Argenta Discovery Ltd
17095213 25 Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.EBI Argenta Discovery Ltd
17046252 17 Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase.EBI University College London
17004718 62 Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.EBI Università degli Studi di Roma La Sapienza
16884291 12 Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.EBI Nagoya City University
16713259 30 Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors.EBI MethylGene Inc.
16137884 6 Design and synthesis of phthalimide-type histone deacetylase inhibitors.EBI The University of Tokyo Yayoi
15189037 6 On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors.EBI University of Notre Dame
15163181 1 Antiproliferative and phenotype-transforming antitumor agents derived from cysteine.EBI University of Queensland
14998325 15 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.EBI Università degli Studi di Roma "La Sapienza"
14698179 49 Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.EBI The Scripps Research Institute
14684344 26 (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.EBI MethylGene Inc.
12593661 34 Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors.EBI MethylGene Inc.
12061890 26 Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors.EBI MethylGene Inc.
11960489 10 Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.EBI Università degli Studi di Roma La Sapienza
11597413 46 Design and synthesis of a novel class of histone deacetylase inhibitors.EBI MethylGene Inc.
27943581 8 Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads from Enzyme-Mediated Fragmentation of Natural Products.BDB The University of Sydney
24114842 25 The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.BDB Soochow University
23897821 60 Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.BDB Genentech, Inc.
23853092 3 Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages.BDB University of Queensland
27977115 24 LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation.BDB Wayne State University
27416889 35 Design, synthesis, and preliminary bioactivity evaluation of N(1) -hydroxyterephthalamide derivatives with indole cap as novel histone deacetylase inhibitors.BDB Shandong University
27235003 10 PXD101 analogs with L-phenylglycine-containing branched cap as histone deacetylase inhibitors.BDB Shandong University
27454931 24 Structural insights into HDAC6 tubulin deacetylation and its selective inhibition.BDB Friedrich Miescher Institute for Biomedical Research
27064299 8 Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.BDB Broad Institute
26640968 60 An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in -Cell Protection.BDB Broad Institute of Harvard and MIT
25699604 74 Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.BDB University of Florida College of Medicine; Northwest Agriculture and Forestry University
25797804 18 An efficient synthesis of SK-658 and its analogs as potent histone deacetylase inhibitors.BDB Kyushu Institute of Technology
23581848 8 Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity.BDB Shandong University
19138845 44 Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization.BDB Merck Research Laboratories
19093884 36 Non-peptide macrocyclic histone deacetylase inhibitors.BDB Georgia Institute of Technology
18378449 12 Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors.BDB AstraZeneca
18378451 13 Design and campaign synthesis of pyridine-based histone deacetylase inhibitors.BDB AstraZeneca
18440229 175 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors.BDB IRBM/Merck
18308563 39 Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.BDB IRBM/Merck
18370373 48 A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo.BDB IRBM/Merck
18570366 9 Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor.BDB MethylGene Inc.
16731764 10 CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.BDB Celera Genomics
18494463 106 A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.BDB University of Illinois at Chicago
18412327 9 Structural Origin of Selectivity in Class II-Selective Histone Deacetylase Inhibitors.BDB University of Notre Dame
17941625 50 Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.BDB MethylGene Inc
16439135 24 Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases.BDB Kyushu Institute of Technology
17958342 12 The First Biologically Active Synthetic Analogues of FK228, the Depsipeptide Histone Deacetylase Inhibitor.BDB University of Southampton
17929798 57 Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors.BDB Nagoya City University