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60 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27541357 58 Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.EBI National University of Singapore
27186676 186 Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.EBI West China Hospital of Sichuan University
26890116 30 Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.EBI University of Milan
27060764 30 Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.EBI Sungkyunkwan University
26443078 108 Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.EBI Sichuan University
26689485 18 Orally available stilbene derivatives as potent HDAC inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.EBI Orchid Chemicals& Pharmaceuticals Ltd
26753813 22 Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.EBI University of Minnesota
26331334 99 Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities.EBI Guangzhou Institute of Biomedicine and Health
26264503 46 Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.EBI University of Minnesota
26287310 87 Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.EBI University College London
25637120 94 Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).EBI St Jude Children's Research Hospital
25147612 25 Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.EBI University of Florida
25905694 24 Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.EBI Istituto Ortopedico Rizzoli (IOR)
25042254 7 Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.EBI H�pital Kirchberg
25563890 49 Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
25454270 82 Histone deacetylase inhibitors derived from 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine and related heterocycles selective for the HDAC6 isoform.EBI TBA
25380299 61 Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.EBI Technical University of Denmark
25238284 52 Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.EBI Roche Pharmaceutical Research and Early Development
25233084 247 ST7612AA1, a thioacetate-(-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.EBI R&D Sigma-Tau Industrie Farmaceutiche Riunite SpA
25218912 103 Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors.EBI Chinese Academy of Sciences
24766560 16 Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.EBI Taipei Medical University
24588105 56 Synthesis and evaluation of new Hsp90 inhibitors based on a 1,4,5-trisubstituted 1,2,3-triazole scaffold.EBI Universit£ degli Studi di Siena
24565573 35 4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors.EBI Universit£ degli Studi di Ferrara
24742384 90 Influence of the adamantyl moiety on the activity of biphenylacrylohydroxamic acid-based HDAC inhibitors.EBI Universit£ di Milano
23061376 63 Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.EBI Roche R&D Center-China Ltd.
23009203 39 Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.EBI University of Illinois at Chicago
22642300 160 Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.EBI Kyoto Prefectural University of Medicine
22541394 30 Appraisal of GABA and PABA as linker: design and synthesis of novel benzamide based histone deacetylase inhibitors.EBI Guru Ghasidas University
21548582 57 Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.EBI University of Illinois at Chicago
21634430 218 Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.EBI S*BIO Pte Ltd.
21417297 220 Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.EBI Universita` degli Studi di Siena
19966789 40 Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.EBI The Scripps Research Institute
20637529 15 Design and synthesis of novel isoxazole-based HDAC inhibitors.EBI Università degli Studi di Milano
20223566 23 Inside HDAC with HDAC inhibitors.EBI Universit£ de Poitiers
20451378 107 Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.EBI S *BIO Pte Ltd
20055418 78 Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.EBI University of Illinois at Chicago
20143778 70 Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.EBI Curis Inc
19906529 22 Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.EBI Ortho-Biotech Oncology Research& Development
19359173 51 Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.EBI Sigma-Tau Research and Development
19419863 58 Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.EBI University of Illinois at Chicago
19285395 66 N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors.EBI R&D Sigma-Tau SpA
19181524 46 N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.EBI S *BIO Pte Ltd
18642892 76 Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.EBI University of Illinois at Chicago
17539623 65 Functional differences in epigenetic modulators-superiority of mercaptoacetamide-based histone deacetylase inhibitors relative to hydroxamates in cortical neuron neuroprotection studies.EBI University of Illinois at Chicago
24114842 25 The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.BDB Soochow University
23897821 60 Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.BDB Genentech, Inc.
27454931 24 Structural insights into HDAC6 tubulin deacetylation and its selective inhibition.BDB Friedrich Miescher Institute for Biomedical Research
25699604 74 Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.BDB University of Florida College of Medicine; Northwest Agriculture and Forestry University
16731764 10 CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo.BDB Celera Genomics
18494463 106 A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.BDB University of Illinois at Chicago